Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)

Funding Opportunity Number: PAR-25-211
Due date: June 02, 2027
Relevance to Microbiomes: The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate the development of effective precision probiotic interventions using a milestone-driven, biphasic award mechanism. It aims to identify, understand, and develop strategies to address barriers in precision probiotic interventions to account for the heterogeneity in humans that often causes inconsistent probiotic therapeutic responses. Specifically, this NOFO solicits applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders, which may then help enhance probiotic clinical outcomes.
For more information click HERE.

Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)

Funding Opportunity Number: PAR-26-040
Due Date: February 05, 2027
Relevance to Microbiomes: For this NOFO, areas of bioinformatics and computational biology for which methodological advances are of interest include, but are not limited to:

• Various types of omics and multi-omics studies, including genomics, transcriptomics, proteomics,    epigenomics, structural or spatial omics, comparative omics, and multimodal integrations of those.

• Microbiome studies, including studies on host-microbiome interactions.

• Metagenomic and/or metaproteomic studies.

For more information click HERE.

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)

Due Date: February 05, 2027
Relevance to microbiomes: “For analysis of exposures, including environmental and chemical exposures, and cancer-relevant microbiome and virome; host-microbiome interactions, and tools for gene-environment interaction”.
For more information click HERE.

Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)

Due Date: February 05, 2027
Relevance to microbiomes: Evaluation of cancer risk associated with exogenous (e.g., chemical agents, infectious agents, radiation, medication, nutrition, tobacco, and drug use) and endogenous (e.g., metabolome, microbiome, adductome) factors, mixtures and interaction of these factors, and effects during early life and critical periods across the life course.
For more information click HERE.

Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)

Due Date: October 16, 2026 
Relevance to Microbiomes: “DCCPS supports research in the areas of cancer surveillance, psychological, social, and behavioral risk factors, health care delivery, and epidemiologic studies. Evidence generated by these studies has been useful in providing the basis for the design and testing of many preventive and therapeutic interventions and their integration into cancer care. Large biorepositories established by cancer epidemiology cohorts already support genetic and epigenetic studies as well as microbiome, proteomic, and metabolomic studies.”

For more information click HERE. 

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

Due Date: October 20, 2026
Relevance to microbiomes: Research interests include: Studies that examine the effects of prebiotics/probiotics and other natural products on gut microbiome-brain interactions. Of particular interest are studies of prebiotics/probiotics for depression, anxiety disorders, irritable bowel syndrome (IBS), or chronic pain.
For more information:  https://grants.nih.gov/grants/guide/pa-files/PAR-25-270.html

Notice of Special Interest (NOSI): Leveraging Microbial Exposure for Improving Mouse Models of Human Immunity

Due date: November 16, 2027
Relevance to microbiomes: Research interests include “Applications of cohort studies assessing associations of psychosocial and behavioral factors with -omics changes (including epigenetic modifications to the human genome and/or oral microbiome alterations) and impact of the associations upon oral diseases and conditions; Applications of cohort studies that analyze interaction of the human genome and oral microbiome in response to environmental stimuli and impact of the interaction on oral diseases and conditions.”
For more information: https://grants.nih.gov/grants/guide/notice-files/NOT-AI-24-078.html

Plant Biotic Interactions

Notice Number: NSF 18-590
Due Date: Continuous
Approximate Funding Amount: $18,500,000 depending on availability of funds$10.5M from NSF for new standard or continuing grant awards, and approximately $8M from USDA/NIFA for new awards. Both estimates depend on availability of appropriations. USDA/NIFA will support projects for up to four years in duration. Although there are no formal upper or lower limits to award amounts, they typically range from $50,000 to $300,000 per year, with durations of two to four years (and five years for CAREER awards). Enactment of additional continuing resolutions or an appropriations act may affect the availability or level of funding for this program.
For more information:   https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=505267 

Transitions to Excellence in Molecular and Cellular Biosciences Research (Transitions) 

Notice Number: NSF 21-508
Due Date: Continuous
Anticipated Funding Amount: $6,000,000 Pending availability of funds
For more information: https://www.nsf.gov/pubs/2021/nsf21508/nsf21508.htm

Physiological and Structural Systems (PSS)

Due Date: Continuous
For more information: https://beta.nsf.gov/funding/opportunities/physiological-structural-systems-pss

Mathers Grant Awards Program

Sponsor: G. Harold & Leila Y. Mathers Foundation  
Due Dates:  Nominations/Portal Registrations: January 28, 2027.  LOI: February 11, 2027.  Invited Formal Proposals: April 15, 2027.
Relevance to Microbiomes: Research areas supported include: Immunology, Microbiome, Structural Biology, Cellular Physiology, Cancer Biology, Genetics, Genomics, Microbiology & Infectious Diseases, Stem Cell Biology, and Neuroscience.
For more information click HERE.

Diet-Microbiome Interactions Shaping Immune Function in the Treatment of Human Disease.
Sponsor: Biocodex Microbiota Foundation
Due Date:  November 30, 2026
For more information click HERE.

Microbiota & Women's Health International Call for Projects
Sponsor: Biocodex Microbiota Foundation
Due Date: January 15, 2027
For more information click HERE.

American Gastroenterological Association Grants
Due Date: Varies
For list of Grants: https://gastro.org/research-and-awards/apply-for-awards/  

American Society of Transplantation Research Grants
Due Dates: Varies
For more information: https://www.myast.org/research/research-grant-opportunities    

Crohn’s & Colitis Foundation Grants & Fellowships
Due Dates: Varies
For more information: https://www.crohnscolitisfoundation.org/research/grants-fellowships

Investigator - Initiated Studies + Educational Grants - Bausch & Lomb
Due Date: Continuous
For more information: https://www.bausch.com/product-innovation/independent-research-cme-grants/

AbbVie - Investigator-Initiated Studies
Due Date: Continuous
For more information: https://www.abbvie.com/science/clinical-trials/investigator-initiated-studies.html

Pfizer Grant Opportunities
Due date: Varies
For more information: https://www.pfizer.com/about/programs-policies/grants