Andreas Seyfang, Ph.D.

Professor, Molecular Medicine, Morsani College of Medicine

Professor (Joint Appointment)

Professor (Joint Appointment), Department of Neurosurgery, College of Medicine

Professor (Joint Appointment), Department of Global Health, College of Public Health

Professor (Joint Appointment), School of Physical Therapy & Rehabilitation Sciences, College of Medicine

Contact Info

• Molecular Medicine, MDC Box 07
  12901 Bruce B. Downs Blvd.
  Tampa FL 33612
• Academic Email: seyfang@usf.edu
• Academic Phone: (813) 974-2332
• View My C.V. | View My Website | View My Lab Site

Education

Interdisciplinary and Emerging Signature Programs

• Allergy, Immunology & Infectious Disease
• Cardiovascular
• Neuroscience

Awards/Honors

• Distinguished Educator Award (USF MCOM Academy of Distinguished Educators - 2022)
• GPIBS Award for Excellence in Teaching (USF PhD and Master's graduate students - 2019)
• Outstanding Freshman Instructor Award (USF Second-year MD student class - 2019)
• Outstanding Pre-Clinical Teaching Award (USF Third-year MD student class - 2017)
• Outstanding Freshman Instructor Award (USF Second-year MD student class - 2017)
• Recognition of Outstanding Dedication to Teaching (USF Morsani College of Medicine - 2015)
• Robert J. Grasso Award for Outstanding Dedication to Graduate Education (USF College of Medicine - 2009)
• AHA Fellowship (American Heart Association - 1997)
• Alexander von Humboldt Fellow (Alexander von Humboldt Foundation - 1995)
• FRM Fellowship (Fondation pour la Recherche Médicale (France) - 1994)
• EMBO Fellowship (European Molecular Biology Organization - 1993)
• PhD, Biochemistry with Magna cum laude (University of Tübingen - 1993)
• DAAD Fellowship (German Academic Exchange Service - 1984)
• Outstanding Freshman Instructor Award (USF Second-year MD student class - 2023)

Memberships

• Member (International Association of Medical Science Educators (IAMSE), 2012 - Present)
• Member (Association of Biochemistry Educators (ABE), 2012 - Present)
• Member (American Association for the Advancement of Science (AAAS), 2008 - Present)
• Member (American Society for Biochemistry and Molecular Biology (ASBMB), 2008 - Present)
• Member (American Society for Microbiology (ASM), 2008 - Present)
• Member (Society for Neuroscience (SfN), 2008 - Present)

Recent Publications

• Simmons CF, Gibbons J, Zhang M, Oberstaller J, Pires CV, Casandra D, Wang C, Seyfang A, Otto TD, Rayner JC, Adams JH. Protein KIC5 is a novel regulator of artemisinin stress response in the malaria parasite Plasmodium falciparum. Scientific reports. 13(1) : 399, 2023.
• Banday MM Rao SB Shankar S Khanday MA Finan J O’Neill E Coppolino A Seyfang A Kumar A Rinewalt DE Goldberg HJ Woolley A Mallidi HR Visner G Gaggar A Patel KN Sharma NS. IL-33 Mediates Pseudomonas Induced Airway Fibrogenesis and Is Associated with CLAD. The Journal of heart and lung transplantation. 42(1) : 53-63, 2023.
• Mutka T, Seyfang A, Yoo JY, Dutra SVO, Ji M, Louis-Jacques A, Bruder K, Prescott S, Kim K, Groer M. Adverse pregnancy outcomes in Toxoplasma gondii seropositive Hispanic women. The journal of obstetrics and gynaecology research. , 2022.
• Banday MM, Kumar A, Vestal G, Sethi J, Patel KN, O''Neill EB, Finan J, Cheng F, Lin M, Davis NM, Goldberg H, Coppolino A, Mallidi HR, Dunning J, Visner G, Gaggar A, Seyfang A, Sharma NS. N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 40(6) : 447-457, 2021.
• Sharma NS, Vestal G, Wille K, Patel KN, Cheng F, Tipparaju S, Tousif S, Banday MM, Xu X, Wilson L, Nair VS, Morrow C, Hayes D, Seyfang A, Barnes S, Deshane JS, Gaggar A. Differences in airway microbiome and metabolome of single lung transplant recipients. Respiratory research. 21(1) : 104, 2020.
• Lim SJ, Seyfang A, Dutra S, Kane B, Groer M. Gene expression responses to Zika virus infection in peripheral blood mononuclear cells from pregnant and non-pregnant women. MicrobiologyOpen. 9(12) : e1134, 2020.
• Duffy AR, O''Connell JR, Pavlovich M, Ryan KA, Lowry CA, Daue M, Raheja UK, Brenner LA, Markon AO, Punzalan CM, Dagdag A, Hill DE, Pollin TI, Seyfang A, Groer MW, Mitchell BD, Postolache TT. Serointensity and Seropositivity: Heritability and Household-Related Associations in the Old Order Amish. International journal of environmental research and public health. 16(19) , 2019.
• Duffy AR, Beckie TM, Brenner LA, Beckstead JW, Seyfang A, Postolache TT, Groer MW. Relationship Between Toxoplasma gondii and Mood Disturbance in Women Veterans. Military Medicine. 180(6) : 621-5, 2015.
• Seyfang, A., Saporta, S. & Johnson, W.E. Effect of Pre-Medical Education on Student Performance in a First-Year Medical School Curriculum. Medical Science Educator. 23(4) : 712, 2013.
• Seyfang, A., Nazian, S.J., Saporta, S., Doupnik, C.A., Johnson, W.E. & Stevenson, F.T. Assessment of an Adjusted vs. Fixed Pass Line for Student Performance in a Medical School Curriculum. Medical Science Educator. 22(4) : 270-271, 2012.
• Groër MW, Yolken RH, Xiao JC, Beckstead JW, Fuchs D, Mohapatra SS, Seyfang A, Postolache TT. Prenatal depression and anxiety in Toxoplasma gondii-positive women. American journal of obstetrics and gynecology. 204(5) : 433.e1-7, 2011.
• Xue C, Liu T, Chen L, Li W, Liu I, Kronstad JW, Seyfang A, Heitman J. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. mBio. 1(1) : e00084-10, 2010.
• Liu L, Bailey SM, Okuka M, Muñoz P, Li C, Zhou L, Wu C, Czerwiec E, Sandler L, Seyfang A, Blasco MA, Keefe DL. Telomere lengthening early in development. Nature Cell Biology. 9(12) : 1436-41, 2007.
• Lin T, Gao L, Seyfang A, Oliver JH. ''Candidatus Borrelia texasensis'', from the American dog tick Dermacentor variabilis. International Journal of Systematic and Evolutionary Microbiology. 55(Pt 2) : 685-93, 2005.
• Mongan TP, Ganapasam S, Hobbs SB, Seyfang A. Substrate specificity of the Leishmania donovani myo-inositol transporter: critical role of inositol C-2, C-3 and C-5 hydroxyl groups. Molecular and Biochemical Parasitology. 135(1) : 133-41, 2004.
• Seyfang A, Jin JH. Multiple site-directed mutagenesis of more than 10 sites simultaneously and in a single round. Analytical Biochemistry. 324(2) : 285-91, 2004.
• Jin JH, Seyfang A. High-affinity myo-inositol transport in Candida albicans: substrate specificity and pharmacology. Microbiology. 149(Pt 12) : 3371-81, 2003.
• Ling J, Pi W, Yu X, Bengra C, Long Q, Jin H, Seyfang A, Tuan D. The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function. Nucleic Acids Research. 31(15) : 4582-96, 2003.
• Seyfang A, Landfear SM. Four conserved cytoplasmic sequence motifs are important for transport function of the Leishmania inositol/H(+) symporter. The Journal of Biological Chemistry. 275(8) : 5687-93, 2000.
• Seyfang A, Landfear SM. Substrate depletion upregulates uptake of myo-inositol, glucose and adenosine in Leishmania. Molecular and Biochemical Parasitology. 104(1) : 121-30, 1999.
• Barrett MP, Tetaud E, Seyfang A, Bringaud F, Baltz T. Trypanosome glucose transporters. Molecular and Biochemical Parasitology. 91(1) : 195-205, 1998.
• Vasudevan G, Carter NS, Drew ME, Beverley SM, Sanchez MA, Seyfang A, Ullman B, Landfear SM. Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant. Proceedings of the National Academy of Sciences of the United States of America. 95(17) : 9873-8, 1998.
• Seyfang A, Kavanaugh MP, Landfear SM. Aspartate 19 and glutamate 121 are critical for transport function of the myo-inositol/H+ symporter from Leishmania donovani. The Journal of Biological Chemistry. 272(39) : 24210-5, 1997.
• Wille U, Seyfang A, Duszenko M. Glucose uptake occurs by facilitated diffusion in procyclic forms of Trypanosoma brucei. European Journal of Biochemistry / FEBS. 236(1) : 228-33, 1996.
• Bakalara N, Seyfang A, Davis C, Baltz T. Characterization of a life-cycle-stage-regulated membrane protein tyrosine phosphatase in Trypanosoma brucei. European Journal of Biochemistry / FEBS. 234(3) : 871-7, 1995.
• Barrett MP, Tetaud E, Seyfang A, Bringaud F, Baltz T. Functional expression and characterization of the Trypanosoma brucei procyclic glucose transporter, THT2. The Biochemical Journal. 312 ( Pt 3): 687-91, 1995.
• Bakalara N, Seyfang A, Baltz T, Davis C. Trypanosoma brucei and Trypanosoma cruzi: life cycle-regulated protein tyrosine phosphatase activity. Experimental Parasitology. 81(3) : 302-12, 1995.
• Seyfang A, Duszenko M. Functional reconstitution of the Trypanosoma brucei plasma-membrane D-glucose transporter. European Journal of Biochemistry / FEBS. 214(2) : 593-7, 1993.
• Duszenko, M. Seyfang, A. Endocytosis and Intracellular Transport of Variant Surface Glycoproteins in Trypanosomes. Advances in Cell and Molecular Biology of Membranes: Membrane Traffic in Protozoa. JAI Press. Greenwich(Plattner, H.; Ed.) : 227-258, 1993.
• Seyfang A, Duszenko M. Specificity of glucose transport in Trypanosoma brucei. Effective inhibition by phloretin and cytochalasin B. European Journal of Biochemistry / FEBS. 202(1) : 191-6, 1991.
• Seyfang A, Mecke D, Duszenko M. Degradation, recycling, and shedding of Trypanosoma brucei variant surface glycoprotein. The Journal of Protozoology. 37(6) : 546-52, 1990.
• Frommel TO, Seyfang A, Balber AE. Trypanosoma brucei sspp.: cleavage of variant specific and common glycoproteins during exposure of live cells to trypsin. Experimental Parasitology. 66(2) : 213-24, 1988.