CONCLUSIONS: We conclude that SerpinA3N serves as a key mediator of cardiorenal syndrome type 3 pathogenesis, by inhibiting granzyme B, which promotes profibrotic remodeling in the heart following AKI. Targeting SerpinA3N could be a potential therapeutic approach that restores balanced extracellular matrix turnover and mitigates cardiac fibrosis.

MOTIVATION: Accurate identification of protein-ligand binding sites is critical for mechanistic biology and drug discovery, yet predictive performance varies substantially across ligand families and data-availability regimes. We present a systematic ligand-aware benchmark and evaluation framework for residue-level binding-site prediction across three settings: overrepresented ligands with abundant examples, underrepresented ligands with limited examples, and zero-shot ligands unseen during...

CONCLUSION: Inferior shoulder dislocations are rare; severe hyperglycemia in diabetics is not an absolute contraindication to procedural sedation, but the patient may need individualized risk-benefit assessment.

CONCLUSIONS: Most individuals with confirmed malaria in Thailand were diagnosed within a relatively short period following symptom onset, although delays persisted among migrants, individuals with non-P. vivax infections, and residents of elimination-phase settings. Targeted interventions to improve access to care and awareness among mobile populations and low-transmission areas could further reduce treatment-seeking delays and support Thailand's malaria elimination goals.