CONCLUSION: Our findings demonstrate the association of IgM with naturally acquired transmission-blocking immunity and highlight potential targets of P. vivax transmission-reducing antibodies. Further investigations are needed to validate the targets, elucidate the underlying mechanisms and facilitate the research on transmission-blocking vaccines.

Several lines of evidence suggest that the cellular isoform of prion protein (PrP^(C)) plays one or more roles in Alzheimer's Disease (AD). We previously found, in mouse neuroblastoma N2a cells that express human APP carrying the Swedish mutation (N2a-APPswe), that PrP^(C) expression correlated with the secretion of Aβ(42) peptide, the product of proteolytic processing of the amyloid precursor protein (APP) that is central to AD. To determine whether PrP^(C) modulates APP processing to affect...

CONCLUSIONS: These findings identify trophoblast IL-1RAP as an amplifier of IL-1β-mediated inflammatory signaling and support further investigation of IL-1RAP in inflammation-associated preterm birth.

Gerstmann-Straussler-Scheinker (GSS) disease is a rare hereditary autosomal dominant prion disease characterized by cerebellar ataxia, dysarthria, and progressive dementia. We report a case of GSS disease in a 46-year-old patient who presented with four to six months of ataxia, dysarthria, intermittent tongue biting, and frontal headaches. His DaTscan (dopamine transporter scan) showed absent dopamine uptake in the left putamen and mildly decreased activity in the right putamen, a finding that..