Dr. Shuai Wang

Research Associate, Morsani College of Medicine

Contact Info

• 4001 E Fletcher Ave.
  Byrd Alzheimer’s Center and Research Institute
  Tampa FL 33613
• Academic Email: shuaiwang@usf.edu
• Academic Phone: (813) 396-0697
• View My C.V. | View My Website

Education

Interdisciplinary and Emerging Signature Programs

• Neurodegenerative Disease
• Neuroscience
• Cellular and Molecular Biology

Research Interests

• 1. Spatial transcriptomic profiling of Alzheimer's disease-associated GWAS risk factor BIN1 in the tau neuropathology model.
• 2. The role of m6A RNA methylation in neuroinflammation.

Recent Publications

• Shuai Wang, Moorthi Ponnusamy, Om Patel, Mitchell Hansen, Lisa Collier, Shane Collier, Gopal Thinakaran Spatiotemporal transcriptomic profiling reveals metabolic dysfunction prior to overt tauopathy in the PS19 mouse model Experimental & Molecular Medicine. , 2025.
• Abdul Aziz Khan, Shuai Wang, Ziying Wang, Zainab Rehman, Lei Chen, Yifang Kuang, Xu Zhang, Yuting Li, Jiarun Yang, Jun Ye, Xianda Ma, Qian Zhao, Ying Ding, Tatsuo Suzuki,Zhaohui Lan, Weidong Li Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 gene Molecular Brain. 18, 2025.
• Blazier, Danielle M.|Lewandowski, Eric M.|Ram, Natasha|Zhang, Xiujun|Wang, Shuai|Patel, Om|Collier, Lisa|Defilippi, Paola|Chen, Yu|Thinakaran, Gopal A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap Journal of Biological Chemistry [00219258]. 301(10) , 2025.
• McMillan, Joseph D.|Wang, Shuai|Wohlfahrt, Jessica|Guergues, Jennifer|Stevens, Stanley M.|Thinakaran, Gopal Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactome Molecular and Cellular Proteomics [15359476]. 24(9) , 2025.
• Daniel Moreira-Silva, Melike Yuksel, Moorthi Ponnusamy, Mitchell T Hansen, Joseph D McMillan, Sneha Geethakrishnan, Shuai Wang, Lisa A Collier, Gopal Thinakaran Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity Genes & Diseases. , 2025.
• Niat T Gebru, Jennifer Guergues, Laura A Verdina, Jessica Wohlfahrt, Shuai Wang, Debra S Armendariz, Marsilla Gray, David Beaulieu‐Abdelahad, Stanley M Stevens Jr, Danielle Gulick, Laura J Blair Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice Aging Cell. , 2024.
• Chen, Lei|Li, Yuting|Liu, Minggang|Lan, Zhaohui|Zhang, Xu|Yang, Xiujuan|Zhao, Qian|Wang, Shuai|Xu, Longyong|Zhou, Ying|Kuang, Yifang|Suzuki, Tatsuo|Tabuchi, Katsuhiko|Takahashi, Eiki|Zhou, Miou|Chen, Charlie Degui|Xu, Tianle|Li, Weidong Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome General Psychiatry [2517729X]. 37(5) , 2024.
• Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakaran Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model Brain. , 2023.
• He, P. Cody|He, Chuan|Wei, Jiangbo|Dou, Xiaoyang|Harada, Bryan T.|Ge, Ruiqi|Liu, Chang|Zhang, Li-Sheng|Yu, Xianbin|Lyu, Ruitu|Zou, Zhongyu|Zhang, Zijie|Chen, Mengjie|Wang, Shuai Exon architecture controls mRNA m 6 A suppression and gene expression Science [00368075]. 379(6633) , 2023.
• Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia Molecular neurodegeneration. , 2022.
• Zhang, Xu|Chu, Xixia|Chen, Lei|Fu, Juan|Wang, Shuai|Song, Jinjing|Kan, Guanghan|Jiang, Weizhong|He, Guang|Chen, Xiaoping|Li, Weidong Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque Molecular Brain [17566606]. 12(1) , 2019.
• Chen, Xuemei|Wang, Shuai|Zhou, Ying|Han, Yanfei|Li, Shengtian|Xu, Qing|Xu, Longyong|Zhu, Ziqi|Deng, Youming|Yu, Lu|Song, Lulu|Chen, Adele Pin|Song, Juan|Takahashi, Eiki|He, Guang|He, Lin|Li, Weidong|Chen, Charlie Degui Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway Nature Communications [20411723]. 9(1) , 2018.
• Chen, Lei|Serdyuk, Tatiana|Yang, Beimeng|Wang, Shuai|Chen, Shiqing|Chu, Xixia|Zhang, Xu|Song, Jinjing|Bao, Hechen|Zhou, Chengbin|Wang, Xiang|Dong, Shuangle|Song, Lulu|Chen, Fujun|He, Guang|He, Lin|Zhou, Ying|Li, Weidong Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice Molecular Brain [17566606]. 10(1) , 2017.
• Chu, Xixia|Zhou, Ying|Hu, Zhiqiang|Lou, Jingyu|Song, Wei|Li, Jing|Liang, Xiao|Chen, Chen|Wang, Shuai|Yang, Beimeng|Chen, Lei|Zhang, Xu|Song, Jinjing|Dong, Yujie|Chen, Shiqing|He, Lin|Xie, Qingguo|Chen, Xiaoping|Li, Weidong 24-hour-restraint stress induces long-term depressive-like phenotypes in mice Scientific Reports [20452322]. 6(1) , 2016.
• Dong, Yujie|Zhou, Ying|Chu, Xixia|Chen, Shiqing|Chen, Lei|Yang, Beimeng|Zhang, Xu|Wang, Lin|Wang, Shuai|Lou, Jingyu|Deng, Qing|Wang, Li|Cao, Zheyi|Wang, Jianan|Xie, Jiaxin|Serdyuk, Tatiana|Li, Shengtian|He, Lin|Chen, Xiaoping|Li, Weidong Dental noise exposed mice display depressive-like phenotypes Molecular Brain [17566606]. 9(1) , 2016.
• Song, Wei|Zhang, Kai|Sun, Jinhua|Ma, Lina|Jesse, Forrest Fabian|Teng, Xiaochun|Zhou, Ying|Bao, Hechen|Chen, Shiqing|Wang, Shuai|Yang, Beimeng|Chu, Xixia|Ding, Wenhua|Du, Yasong|Cheng, Zaohuo|Wu, Bin|Chen, Shanguang|He, Guang|He, Lin|Chen, Xiaoping|Li, Weidong A Simple Spatial Working Memory and Attention Test on Paired Symbols Shows Developmental Deficits in Schizophrenia Patients Neural Plasticity [20905904]. 2013, 2013.

Positions Held

• Postdoctoral Scholar (Morsani College of Medicine, University of South Florida 2020 - 2023)
• Postdoctoral Scholar (University of Chicago 2018 - 2020)