Moorthi Ponnusamy, Ph.D.

Research Associate, College of Medicine Molecular Medicine

Contact Info

• 4001 E Fletcher Avenue
  MDC 36
  Tampa FL 33613
• Academic Email: moorthip@usf.edu
• View My Website

Education

Memberships

• Member (Society for Neuroscience, 2019 - Present)
• Member (ISTAART, 2023 - Present)
• Associate Member (Indian Academy of Neurosciences, 2013 - 2018)
• Annual member (Alzheimer’s & Related Disorders Society of India, 2014 - 2017)

Recent Publications

• Wang, S., Ponnusamy, M*., Patel, O., Hansen, M., Collier, L., & Collier, S. Thinakaran, G. Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model. Experimental & Molecular Medicine. : 1-14, 2026.
• Kozlova, A., Zhang, S., Sudwards, A., Zhang, H., Smirnou, S., Sun, X., Stephenson, K., Zhao, X., Jamison, B., Ponnusamy, M., He, X., Pang, Z., Sanders, A., Bellen, H., Thinakaran, G., & Duan, J. PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia. Nature. 646(8087) : 1178-1186, 2025.
• Moreira-Silva, Daniel|Yuksel, Melike|Ponnusamy, Moorthi|Hansen, Mitchell T.|McMillan, Joseph D.|Geethakrishnan, Sneha|Wang, Shuai|Collier, Lisa A.|Thinakaran, Gopal Moreira-Silva D, Yuksel M, Ponnusamy M, Hansen MT, McMillan JD, Geethakrishnan S, Wang S, Collier LA, Thinakaran G. Genes & Diseases. 12(5) : 101602, 2025.
• Wang S, Ponnusamy M, Patel O, Hansen M, Collier L, Collier S, Thinakaran G. Spatiotemporal transcriptomic profiling reveals metabolic dysfunction prior to overt tauopathy in the PS19 mouse model. Research Square. : rs. 3. rs-6941464, 2025.
• Ponnusamy M, Wang S, Yuksel M, Patel O, Hansen M, Collier L, Thinakaran G. BIN1 regulation of brain region‐specific tau pathogenesis and propagation. Alzheimer's & Dementia. 20(S1) : e087067, 2024.
• Ponnusamy M, Wang S, Yuksel M, Hansen MT, Blazier DM, McMillan JD, Zhang X, Dammer EB, Collier L, Thinakaran G. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain. 146(4) : 1561-1579, 2023.
• Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X. BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Molecular Neurodegeneration. 17(1) : 33, 2022.
• Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J. Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention. The Journal of Experimental Medicine. 218(4) : e20202560, 2021.
• De Rossi P, Andrew RJ, Musial TF, Buggia‐Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l’Estoile V, Valin T. Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic models. Brain Pathology. 29(4) : 485-501, 2019.
• Sathya M, Moorthi P, Premkumar P, Kandasamy M, Jayachandran KS, Anusuyadevi M. Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer’s Disease. Journal of Alzheimer’s Disease.. 60(s1) : S3-S23, 2017.
• Moorthi P, Premkumar P, Priyanka R, Jayachandran KS, Anusuyadevi M. Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: Positive clue toward SAD. Neuroscience. 301: 90-105, 2015.
• Udayar V, Buggia-Prevot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J, Guerreiro R, Brás J. A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production Cell Reports. 5(6) : 1536-1551, 2013.
• Sanphui P, Pramanik SK, Chatterjee N, Moorthi P, Banerji B, Biswas SC. Efficacy of Cyclin Dependent Kinase 4 Inhibitors as Potent Neuroprotective Agents against Insults Relevant to Alzheimer’s Disease. PLoS ONE. 8(11) : e78842, 2013.
• Sathya M, Premkumar P, Karthick C, Moorthi P, Jayachandran KS, Anusuyadevi M. BACE1 in Alzheimer's disease. Clinica chimica acta. 414: 171-178, 2012.