Molecular Medicine

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* (Molecular Medicine Joint Affiliate Faculty Profile)

Shyam Mohapatra

Shyam Mohapatra, PHD, MBA

Associate Dean, Graduate Programs, College of Pharmacy

Division Director and Associate Dean, College of Medicine Internal Medicine

Distinguished Health Professor, Internal Medicine

Director, Ctr for Rsch and Education in Nanobioeng, Internal Medicine, Medicine

Director, Div Translational Medicine, Internal Medicine

Senior Research Career Scientist, Research and Development

Contact Info

Education

  • MBA, Leadership & Management, University of South Florida, 1999
  • PHD, Botany, Australian National University, 1984
  • MS, Genetics/Statistics, GB Plant University of Agril & Technology, 1978
  • BS, Biology, Orissa univeristy of Agril & Technology, 1976

Academic Philosophy

"My passion for academia is based on my personal belief that each student has the potential to bring something unique and special to the world.I believe in “no student left behind”. Through education each student must self-discover his/her potential."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Asthma Center of Excellence
  • Biomedical Engineering & Nanomedicine
  • Cancer Biology
  • Neurodegenerative Disease
  • Other
  • Women & Children's Health

Research Interests

  • My research focuses on immunology and inflammation in immunologic and infectious viral diseases and cancers. Current research projects focus on molecular mechanisms of virus infection, development of nanoparticle enabled prophylactic/therapeutic gene transfer, development of nano particulate antivirals, molecular basis of genetic predisposition to inflammatory diseases including traumatic brain injury and cancers and application of nanobio technology to develop new diagnostics and therapeutics.

Awards/Honors

  • Conference Chair, November 15-17, 2019 (Nano-Florida International Conference - 2019)
  • Founding President (Florida Association for Nanotechnology - 2018)
  • Organizer (VA field-based Meeting on Precision Oncology for Colorectal Cancer, Chicago, May 6 - 2017)
  • Founder and Director (VA Colorectal Cancer cell-genomics Consortium (VA4C) - 2017)
  • Elected as a Fellow of the American Association of Advances in Science (AAAS) (American Association of Advances in Science - 2016)
  • Elected as a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) (American Institute of Medical and Biological Engineering - 2015)
  • Global Corporate Awards in Nanotechnology (Global Corporate Awards - 2014)
  • Inductee Florida Inventors Hall of Fame (Florida Inventors Hall of Fame - 2014)
  • Chartered Fellow (National Academy of Inventors - 2013)
  • VA Career Scientist Award (James A Haley Veterans Hospital - 2007)
  • Outstanding Biotech Achievement Award (University of South Florida - 2005)
  • Outstanding Faculty Research Achievement Award (University of South Floirda - 2005)
  • Oustanding Faculty Research Award Sigma Xi (University of South Florida - 2004)
  • Outstanding Biotechnology Recognition Award (University of South Florida - 2004)
  • Shyam Mohapatra (American Who's Who - 2000)
  • Research Grant Award (American Heart Association - 1999)
  • Veteran Administration Merit Review Award (James A Haley Veterans Hospital - 1999)
  • Career Development Award (American Lung Association - 1998)
  • Presidential Honored Research Faculty Recognition (University of South Florida - 1997)
  • Merit Award (University of Manitoba - 1992)
  • Allergy Research Foundation Award (Pharmacia - 1992)
  • Alexander von Humboldt Research Award (AvH Foundation - 1984)

Memberships

  • Fellow (American Association for the Advancement of Science, 2016 - Present)
  • Fellow (American Institute of Medical and Biological Engineering, 2015 - Present)
  • Member (American Association for the Advancement of Science, 2011 - Present)
  • Member (National Academy of Inventors, 2010 - Present)
  • Member (USF Academy of Inventors, 2009 - Present)
  • Member (American Thoracic Society, 1999 - Present)
  • Honorary Member (Mexican Society of Allergy and Immunology, 1998 - Present)
  • Fellow (American Academy of Allergy and Clinical Immunology, 1998 - Present)
  • Member (Pharmacia Allergy Research Foundation, 1992 - Present)
  • Member (American Academy of Allergy and Clinical Immunology, 1992 - Present)
  • Member (American Association of Immunogists, 1992 - Present)
  • Member (European Academy of Allergology and Clinical Immunology, 1995 - 1995)
  • Member (Canadian Society of Allergy and Immunology, 1990 - 1995)
  • Member (Canadian Society of Immunology, 1988 - 1995)

Recent Publications

  • 3, Wang T Green R Guldiken R Mohapatra S and Mohapatra S. Multiple-Layer Guided Surface Acoustic Wave (SAW)-Based pH Sensing in Longitudinal FiSS-Tumoroid Culture J Biosensor and Bioelectronics. 124: 244-252, 2019.
  • 2, Wang T Green R Guldiken R Wang J Mohapatra S and Mohapatra S. Finite Element Analysis for Surface Acoustic Wave Device Characteristic Properties and Sensitivity Sensors. 19(8) : 1749, 2019.
  • 1, Das M Tang X Mohapatra SS Mohapatra . Vision impairment after traumatic brain injury: present knowledge and future directions Reviews in the Neurosciences. 30(3) : 305-315, 2019.
  • Denmark DJ Bustos-Perez X Swain A Phan M Mohapatra S Mohapatra SS, . Readiness of magnetic nanobiosensors for point-of-care commercialization. J Elec Mater.. , 2019.
  • Mehta M Allen-Gipson D Mohapatra S Kindy M Limayem A, . Study on the therapeutic index and synergistic effect of Chitosan-zinc oxide nanomicellar composites for drug-resistant bacterial biofilm inhibition. Int J Pharm. 565: 472-480, 2019.
  • Green R, Howell M, Khalil R, Nair R, Yan J, Foran E, Katiri S, Banerjee J, Singh M, Bharadwaj S, Mohapatra SS, Mohapatra S. Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway. Scientific reports. 9(1) : 18177, 2019.
  • Mehta M, Allen-Gipson D, Mohapatra S, Kindy M, Limayem A. Study on the therapeutic index and synergistic effect of Chitosan-zinc oxide nanomicellar composites for drug-resistant bacterial biofilm inhibition. International journal of pharmaceutics. 565: 472-480, 2019.
  • Quarni W, Dutta R, Green R, Katiri S, Patel B, Mohapatra SS, Mohapatra S. Mithramycin A Inhibits Colorectal Cancer Growth by Targeting Cancer Stem Cells. Scientific reports. 9(1) : 15202, 2019.
  • Das Mohapatra SS, Sarma P, Sangma CA, Tayab S, Paul S, Borgohain M. Re: Hutnik et al.: Selective laser trabeculoplasty versus argon laser trabeculoplasty in glaucoma patients treated previously with 360° selective laser trabeculoplasty: a randomized, single-blind, equivalence clinical trial (Ophthalmology. 2019;126:223-232). Ophthalmology. 126(11) : e83, 2019.
  • Wang T, Murphy R, Wang J, Mohapatra SS, Mohapatra S, Guldiken R. Perturbation Analysis of a Multiple Layer Guided Love Wave Sensor in a Viscoelastic Environment. Sensors (Basel, Switzerland). 19(20) , 2019.
  • Das M, Mayilsamy K, Tang X, Han JY, Foran E, Willing AE, Mohapatra SS, Mohapatra S. Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats. Scientific reports. 9(1) : 13646, 2019.
  • Das M, Mayilsamy K, Mohapatra SS, Mohapatra S. Mesenchymal stem cell therapy for the treatment of traumatic brain injury: progress and prospects. Reviews in the neurosciences. 30(8) : 839-855, 2019.
  • Das M, Tang X, Han JY, Mayilsamy K, Foran E, Biswal MR, Tzekov R, Mohapatra SS, Mohapatra S. CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies. Journal of neuroinflammation. 16(1) : 115, 2019.
  • Dutta R, Khalil R, Green R, Mohapatra SS, Mohapatra S. (Ashwagandha) and Withaferin A: Potential in Integrative Oncology. International journal of molecular sciences. 20(21) , 2019.
  • Das T, Nair RR, Green R, Padhee S, Howell M, Banerjee J, Mohapatra SS, Mohapatra S. Actinomycin D Down-regulates SOX2 Expression and Induces Death in Breast Cancer Stem Cells. Anticancer research. 37(4) : 1655-1663, 2017.
  • Nair RR, Padhee S, Das T, Green R, Howell M, Mohapatra SS, Mohapatra S. Three- and Four-Dimensional Spheroid and FiSS Tumoroid Cultures: Platforms for Drug Discovery and Development and Translational Research Critical reviews in therapeutic drug carrier systems. 34(3) : 185-208, 2017.
  • Cheung MB Sampayo-Escobar V Green R Moore ML Mohapatra S and Mohapatra SS. Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity via Interferon Beta and Indoleamine-2,3 Dioxygenase. PloS One. 11(10) : e0163709. doi: 10.1371/journal.pone.0163709., 2016.
  • Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, Irvin CG, Mohapatra S, Peters SP, Rayapudi S, Sugar EA, Wise RA. Reply. The Journal of allergy and clinical immunology. 136(1) : 212-3, 2015.
  • Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, Irvin CG, Mohapatra S, Peters SP, Rayapudi S, Sugar EA, Wise RA. Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma. The Journal of allergy and clinical immunology. 135(3) : 701-9.e5, 2015.
  • Zhao L Wei Q Wu H Li H Li D and Mohapatra SS. Portable and quantitative evaluation of stem cell therapy toward damaged hepatocytes. RSC Advances,. 5: 19439-44, DOI 10.1039/c5ra00191a,, 2015.
  • Boyapalle S Xu W Raulji P Mohapatra S Mohapatra SS. A Multiple siRNA-Based Anti-HIV/SHIV Microbicide Shows Protection in Both In Vitro and In Vivo Models. PLoS One.. 10(9) : e0135288, 2015.
  • Limayem A Micciche A Haller E Zhang C and Mohapatra SS. Nanotherapeutics for mutating multi-drug resistant fecal bacteria. J Nanotec Nanosci,. 1: 100106, 2015.
  • 6. Wang T, Green R, Nair RR, Howell M, Mohapatra S, Guldiken R and Mohapatra SS Surface Acoustic Waves (SAW)-Based Biosensing for Quantification of Cell Growth in 2D and 3D Cultures. Sensors (Basel). 15(12) : 32045-55, 2015.
  • Wong TM, Boyapalle S, Sampayo V, Nguyen HD, Bedi R, Kamath SG, Moore ML, Mohapatra S, Mohapatra SS. Respiratory syncytial virus (RSV) infection in elderly mice results in altered antiviral gene expression and enhanced pathology. PloS one. 9(2) : e88764, 2014.
  • Das M, Wang C, Bedi R, Mohapatra SS, Mohapatra S. Magnetic micelles for DNA delivery to rat brains after mild traumatic brain injury. Nanomedicine : nanotechnology, biology, and medicine. 10(7) : 1539–1548, 2014.
  • Lloyd MC, Burke N, Kalantarpour F, Niesen MI, Hall A, Pennypacker K, Citron B, Pick CG, Adams V, Das M, Mohapatra S, Cualing H, Blanck G. QUANTITATIVE MORPHOLOGICAL AND MOLECULAR PATHOLOGY OF THE HUMAN THYMUS CORRELATE WITH INFANT CAUSE OF DEATH Technol Innov. 16(1) : 55–62, 2014.
  • Anne E. Dixon, Mario Castro, Rubin I. Cohen, Lynn B. Gerald, Janet T. Holbrook, Charles G. Irvin, Shyam Mohapatra, Stephen P. Peters, Sobharani Rayapudi, Elizabeth A. Sugar, Robert A. Wise. Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma Journal of Allergy and Clinical Immunology. : http://dx.doi.org/10.1016/j.jaci.2014.06.038, 2014.
  • Bird GH, Boyapalle S, Wong T, Opoku-Nsiah K, Bedi R, Crannell WC, Perry AF, Nguyen H, Sampayo V, Devareddy A, Mohapatra S, Mohapatra SS, Walensky LD. Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. The Journal of clinical investigation. 124(5) : 2113-24, 2014.
  • Girard YK, Wang C, Ravi S, Howell MC, Mallela J, Alibrahim M, Green R, Hellermann G, Mohapatra SS, Mohapatra S. A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. PloS one. 8(10) : e75345, 2013.
  • Yin JJ, Sharma S, Shumyak SP, Wang ZX, Zhou ZW, Zhang Y, Guo P, Li CZ, Kanwar JR, Yang T, Mohapatra SS, Liu W, Duan W, Wang JC, Li Q, Zhang X, Tan J, Jia L, Liang J, Wei MQ, Li X, Zhou SF. Synthesis and biological evaluation of novel folic acid receptor-targeted, β-cyclodextrin-based drug complexes for cancer treatment. PloS one. 8(5) : e62289, 2013.
  • Mallela J, Ravi S, Jean Louis F, Mulaney B, Cheung M, Sree Garapati U, Chinnasamy V, Wang C, Nagaraj S, Mohapatra SS, Mohapatra S. Natriuretic peptide receptor A signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis. Stem cells (Dayton, Ohio). 31(7) : 1321-9, 2013.
  • Mhaskar R, Alandikar V, Emmanuel P, Djulbegovic B, Patel S, Patel A, Naik E, Mohapatra S, Kumar A. Adherence to antiretroviral therapy in India: a systematic review and meta-analysis. Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine. 38(2) : 74-82, 2013.
  • Huls NF, Phan MH, Kumar A, Mohapatra S, Mohapatra S, Mukherjee P, Srikanth H. Transverse susceptibility as a biosensor for detection of Au-Fe₃O₄ nanoparticle-embedded human embryonic kidney cells. Sensors (Basel, Switzerland). 13(7) : 8490-500, 2013.
  • Terianne M. Wong, Sandhya Boyapalle, Siddarth Kamath, Huy Nguyen, Subhra Mohapatra, Shyam S. Mohapatra. Differential Gene Expression in Young Vs Aged Mice Infected with Respiratory Syncytial Virus (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB8, 2013.
  • Chunyan Wang, Sowndharya Ravi, Ujjwala Sree Garapati, Mahasweta Das, Mark Howell, Jaya Mallela, Subbiah Alwarappan, Shyam S. Mohapatra. Multifunctional chitosan magnetic-graphene (CMG) nanoparticles: a theranostic platform for tumor-targeted co-delivery of drugs, genes and MRI contrast agents J. Mater. Chem. B. 1: 4396-4405, 2013.
  • Michael B. Cheung, Subhra Mohapatra, Shyam S. Mohapatra. Respiratory Syncytial Virus (RSV) Infection and Replication in Mesenchymal Stem Cells (MSCs)(meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB74, 2013.
  • Suraj Dixit, Mahasweta Das, Subbiah Alwarappan, Nancy L. Goicochea, Mark Howell, Subhra Mohapatra, Shyam Mohapatra. Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery RSC Adv. 3(8) : 2727-2735, 2013.
  • Alwarappan, Subbiah; Das, Mahaswetha; Mohapatra, Shyam; Li, Chen-Zhong. Peripheral Neural Devices: State-of-the-Art Journal of Neuroscience and Neuroengineering. 2(6) : 517-531, 2013.
  • Subhra Mohapatra, Srinivas Nagaraj, Shyam S. Mohapatra. Nano/bio interface: impact on drug delivery applications Drug Delivery and Translational Research. 3(4) : 295-296, 2013.
  • Srinivas Nagaraj, Allison Nelson, Subhra Mohapatra, and Shyam Mohapatra. Role of NPRA in MDSC mediated suppression in cancer (P2071) (meeting abstract) Journal of Immunology. 190: 53.36, 2013.
  • Aljubran SA, Cox R, Tamarapu Parthasarathy P, Kollongod Ramanathan G, Rajanbabu V, Bao H, Mohapatra SS, Mohapatra SM, Lockey R, Kolliputi N. Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PloS one. 7(5) : e37712, 2012.
  • Subbiah Alwarappan Kyle Cissell Suraj Dixit Chen-Zhong Li Shyam Mohapatr. Chitosanmodified graphene electrodes for DNA mutation analysis. J of Electroanalytical Chemistry. , 2012.
  • Boyapalle S, Wong T, Garay J, Teng M, San Juan-Vergara H, Mohapatra S, Mohapatra S. Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. PloS one. 7(2) : e29386, 2012.
  • Brar T, Nagaraj S, Mohapatra S. Microbes and asthma: the missing cellular and molecular links. Current opinion in pulmonary medicine. 18(1) : 14-22, 2012.
  • San-Juan-Vergara H, Sampayo-Escobar V, Reyes N, Cha B, Pacheco-Lugo L, Wong T, Peeples ME, Collins PL, Castaño ME, Mohapatra SS. Cholesterol-rich microdomains as docking platforms for respiratory syncytial virus in normal human bronchial epithelial cells. Journal of virology. 86(3) : 1832-43, 2012.
  • Mohapatra SS and Hellerman G. Infections and asthma. Immunology and allergy clinics of North America.. 30(4) : xiii-xviii, 2010.
  • Alwarappan S, Cissell K, Dixit S, Mohapatra S, Li CZ. Chitosan-Modified Graphene Electrodes for DNA Mutation Analysis. Journal of electroanalytical chemistry (Lausanne, Switzerland). 686: 69-72, 2012.
  • Kumar A, Jena PK, Behera S, Lockey RF, Mohapatra S, Mohapatra S. Multifunctional magnetic nanoparticles for targeted delivery. Nanomedicine : nanotechnology, biology, and medicine. 6(1) : 64-9, 2010.
  • Das M, Mohapatra S, Mohapatra SS. New perspectives on central and peripheral immune responses to acute traumatic brain injury. Journal of neuroinflammation. 9: 236, 2012.
  • Leonardo CC, Musso J, Das M, Rowe DD, Collier LA, Mohapatra S, Pennypacker KR. CCL20 Is Associated with Neurodegeneration Following Experimental Traumatic Brain Injury and Promotes Cellular Toxicity In Vitro. Translational stroke research. 3(3) : 357-63, 2012.
  • Subbiah Alwarappan, Sandhya Boyapalle, Ashok Kumar, Chen-Zhong Li, and Shyam Mohapatra. Comparative Study of Single-, Few-, and Multilayered Graphene toward Enzyme Conjugation and Electrochemical Response Journal of Physical Chemistry C. 116(11) : 6556-6559, 2012.
  • Subbiah Alwarappan, Shree R Singh, Shreekumar Pillai, Ashok Kumar, Shyam Mohapatra. Direct Electrochemistry of Glucose Oxidase at a Gold Electrode Modified with Graphene Nanosheets Analytical Letters. 45(7) : 746-753, 2012.
  • Mahasweta Das, Subhra Mohapatra and Shyam S Mohapatra. New perspectives on central and peripheral immune responses to acute traumatic brain injury Journal of Neuroinflammation. 9: 236, 2012.
  • Tina Brar, Srinivas Nagaraj, and Shyam Mohapatra. Microbes and Asthma in the Elderly: The Missing Cellular and Molecular Links Curr Opin Pulm Med. 18(1) : 14-22, 2012.
  • Allison Nelson, Jim Parkerson, Richard F. Lockey, Subhra Mohapatra, Shyam Mohapatra, and Srinivas Nagaraj. Role of Myeloid Derived Suppressor Cells in Asthma (meeting abstract) World Allergy Organ J. 5: S26, 2012.
  • Jia-Wang Wang, Kunyu Li, Gary Hellermann, Richard F. Lockey, Subhra Mohapatra, and Shyam Mohapatra. MIR-150 Suppresses Lung Inflammation in a Mouse Model of Experimental Asthma World Allergy Organ J. 5: S26, 2012.
  • Jia-Wang Wang, Kunyu Li, Richard F. Lockey, Subhra Mohapatra, and Shyam Mohapatra. A Highly Sensitive and Specific Universal Mirna Profiling Method World Allergy Organ J. 5: S55, 2012.
  • Michel Alkhalil, Mathew Varghese, Gary Hellermann, Shyam Mohapatra, Ahmed Butt, and Richard F. Lockey. Measurement of Long-acting Natriuretic Peptide (Lanp) in Exacerbation of Asthma (meeting abstract) World Allergy Organ J. 5: S195–S196, 2012.
  • Boyapalle S, Mohapatra S, Mohapatra S. Nanotechnology Applications to HIV Vaccines and Microbicides. Journal of global infectious diseases. 4(1) : 62-8, 2012.
  • Das M, Leonardo CC, Rangooni S, Pennypacker KR, Mohapatra S, Mohapatra SS. Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats. Journal of neuroinflammation. 8: 148, 2011.
  • Wang X, Raulji P, Mohapatra SS, Patel R, Hellermann G, Kong X, Vera PL, Meyer-Siegler KL, Coppola D, Mohapatra S. Natriuretic peptide receptor a as a novel target for prostate cancer. Molecular cancer. 10: 56, 2011.
  • Groër MW, Yolken RH, Xiao JC, Beckstead JW, Fuchs D, Mohapatra SS, Seyfang A, Postolache TT. Prenatal depression and anxiety in Toxoplasma gondii-positive women. American journal of obstetrics and gynecology. 204(5) : 433.e1-7, 2011.
  • Zhang W, Cao X, Chen D, Wang JW, Yang H, Wang W, Mohapatra S, Hellermann G, Kong X, Lockey RF, Mohapatra SS. Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells. Genetic vaccines and therapy. 9(1) : 3, 2011.
  • Das M Pennypacker K Mohapatra S and Mohapatra SS. CCL-20 plays an important role in LFPIinduced traumatic brain injury in rats. J Neuroinflammation. 8: 148, 2011.
  • Wang J-W Li K, Hellermann G Lockey RF Mohapatra S, and Mohapatra SS. Regulating the Regulators: microRNA and asthma. World Allergy Org J. 4(6) : 94-103, 2011.
  • Mohapatra SS Mohapatra S Boyapalle S and Hellermann G. Multifunctional Chitosan- Nanocarriers for Gene Therapy. Technology & Innovation. 13: 27-37, 2011.
  • Mohapatra S. (Preface) Editorial: Nanobio collaborative explores nano-bio interface Technology and Innovation. 13: 1-3, 2011.
  • Davis Y Mohapatra SS and Mohapatra S. Three dimensional scaffolds in Nano-bio interphase research. Technology & Innovation. 13: 51-62, 2011.
  • Kumar A, Glaum M, El-Badri N, Mohapatra S, Haller E, Park S, Patrick L, Nattkemper L, Vo D, Cameron DF. Initial observations of cell-mediated drug delivery to the deep lung. Cell transplantation. 20(5) : 609-18, 2011.
  • Wong T, Hellermann G, Mohapatra S. The infectious march: the complex interaction between microbes and the immune system in asthma. Immunology and allergy clinics of North America. 30(4) : 453-80, v, 2010.
  • Mohapatra S, Hellermann G. Infectious Diseases and Asthma. Preface. Immunology and allergy clinics of North America. 30(4) : xiii-xviii, 2010.
  • Mohapatra SS, Qazi M, Hellermann G. Immunotherapy for allergies and asthma: present and future. Current opinion in pharmacology. 10(3) : 276-88, 2010.
  • Kandasamy R Park SJ Hellermann GR Lockey RF Mohapatra SS. Isatin down-regulates expression of atrial natriuretic peptide receptor A and inhibits airway inflammation in a mouse model of allergic asthma. International Immunopharmacology. 10: 218-225, 2010.
  • Wang X, Xu W, Kong X, Chen D, Hellermann G, Ahlert TA, Giaimo JD, Cormier SA, Li X, Lockey RF, Mohapatra S, Mohapatra SS. Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma. Respiratory research. 10: 66, 2009.
  • Shirley SA, Montpetit AJ, Lockey RF, Mohapatra SS. Curcumin prevents human dendritic cell response to immune stimulants. Biochemical and biophysical research communications. 374(3) : 431-6, 2008.
  • Mohapatra S, Juan HS. Designer monoclonal antibodies as drugs: the state of the art. Expert review of clinical immunology. 4(3) : 305-7, 2008.
  • Kong X, Hellermann GR, Zhang W, Jena P, Kumar M, Behera A, Behera S, Lockey R, Mohapatra SS. Chitosan Interferon-gamma Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 4(3) : 95-105, 2008.
  • Mohapatra SS, Boyapalle S. Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma. Clinical microbiology reviews. 21(3) : 495-504, 2008.
  • Lee D, Mohapatra SS. Chitosan nanoparticle-mediated gene transfer. Methods in molecular biology (Clifton, N.J.). 433: 127-40, 2008.
  • Mohapatra SS, Lockey RF, Polo F. Weed pollen allergens. Clinical allergy and immunology. 21: 127-39, 2008.
  • Mohapatra SS, San-Juan-Vergara H, Wopfner N, Ferreira F. Experimental forms of allergen immunotherapy with modified allergens and adjuvants. Clinical allergy and immunology. 21: 393-413, 2008.
  • Mohapatra SS and Boyapalle S. Respiratory Syncytial Virus Infection and Asthma: A critical appraisal of epidemiologic, experimental and clinical link Clin Microbiol Rev. (in press) , 2008.
  • Lima J., Mohapatra SS. Polymorphisms in the NPPA gene associate with Asthma Clinical Experimental Allergy. (in press) , 2008.
  • Mohapatra SS and Lockey RF. Respiratory Syncytial Virus Infection from biology to prophylaxis: A perspective World Allergy Organization Journal. (in press) , 2008.
  • Kumar A., Fal-Miyar V., Garcia JA., Cerdeira A., Mohapatra SS. Magnetoimpidance biosensor for uptake control in drug delivery Appl Phys Lett. (In Press) , 2008.
  • Kong X., Hellermann GR, Zhang W., Jena PK, Kumar M, Behera A, Behera S, Lockey RF, Mohapatra SS. Chitosan IFN-gamma Nanogene (CIN) Therapy for Lung Disease: Modulation of T Cell and Dendritic Cell Immune Responses Allergy Asthma and Immunology. (In Press) , 2008.
  • Kong X, Wang X, Xu W, Behera S, Hellermann G, Kumar A, Lockey RF, Mohapatra S, Mohapatra SS. Natriuretic peptide receptor a as a novel anticancer target. Cancer research. (1) , 2008.
  • Wang X, Xu W, Mohapatra S, Kong X, Li X, Lockey RF, Mohapatra SS. Prevention of airway inflammation with topical cream containing imiquimod and small interfering RNA for natriuretic peptide receptor. Genetic vaccines and therapy. (1) , 2008.
  • Kumar A, Aravamudhan S, Gordic M, Bhansali S, Mohapatra SS. Ultrasensitive detection of cortisol with enzyme fragment complementation technology using functionalized nanowire. Biosensors & bioelectronics. (9-10) , 2007.
  • Mohapatra SS. Role of natriuretic peptide signaling in modulating asthma and inflammation. Canadian journal of physiology and pharmacology. 85(7) : 754-9, 2007.
  • Kumar A, Sahoo B, Montpetit A, Behera S, Lockey RF, Mohapatra SS. Development of hyaluronic acid-Fe2O3 hybrid magnetic nanoparticles for targeted delivery of peptides. Nanomedicine : nanotechnology, biology, and medicine. (2) , 2007.
  • Kong X, Zhang W, Lockey RF, Auais A, Piedimonte G, Mohapatra SS. Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene. Genetic vaccines and therapy. , 2007.
  • Lee D, Zhang W, Shirley SA, Kong X, Hellermann GR, Lockey RF, Mohapatra SS. Thiolated chitosan/DNA nanocomplexes exhibit enhanced and sustained gene delivery. Pharmaceutical research. (1) , 2007.
  • Aravamudhan S, Kumar A, Mohapatra S, Bhansali S. Sensitive estimation of total cholesterol in blood using Au nanowires based micro-fluidic platform. Biosensors & bioelectronics. 22(9-10) : 2289-94, 2007.
  • Lee D., Lockey RF., Mohapatra SS. Folate Receptor-mediated cancer cell specific gene delivery using folic acid-conjugated oligochitosans Journal of Nanoscience and Nanotechnology. (6) , 2006.
  • Lee DW, Shirley SA, Lockey RF, Mohapatra SS. Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline. Respiratory research. , 2006.
  • Lee D, Lockey R, Mohapatra S. Folate receptor-mediated cancer cell specific gene delivery using folic acid-conjugated oligochitosans. Journal of nanoscience and nanotechnology. 6(9-10) : 2860-6, 2006.
  • Zhang W., Lockey RF., Mohapatra SS. Respiratory Syncytial virus: Immunopathology and control Expert Review of Clinical Immunology. (2) , 2006.
  • Kumar A., Jena PK., Behera S., Lockey RF., Mohapatra SS. Efficient DNA and Peptide Delivery by Functionalized Chitosan-coated Single Walled carbon Nanotubes Journal of Biomedical Nanotechnology. (1) , 2006.
  • Zhang W, Lockey RF, Mohapatra SS. Respiratory syncytial virus: immunopathology and control. Expert review of clinical immunology. 2(1) : 169-79, 2006.
  • Singam R, Jena PK, Behera S, Hellermann GR, Lockey RF, Ledford D, Mohapatra SS. Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice. Virology journal. 3: 32, 2006.
  • Zhang W, Yang H, Kong X, Mohapatra S, San Juan-Vergara H, Hellermann G, Behera S, Singam R, Lockey RF, Mohapatra SS. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nature medicine. (1) , 2005.
  • Kong X, Hellermann GR, Patton G, Kumar M, Behera A, Randall TS, Zhang J, Lockey RF, Mohapatra SS. An immunocompromised BALB/c mouse model for respiratory syncytial virus infection. Virology journal. 2: 3, 2005.
  • Kong, X. Hellermann, G., Patton, G., Kumar, M., Behera A, Randall TS, Zhang J. Lockey R.F., and Mohapatra SS. An Immunocompromised BALB/c Mouse Model for Respiratory Syncytial Virus Infection Virology Journal. 2: 3, 2005.
  • Mohapatra SS, Lockey RF, Shirley S. Immunobiology of grass pollen allergens. Current allergy and asthma reports. 5(5) : 381-7, 2005.
  • San-Juan-Vergara H, Peeples ME, Lockey RF, Mohapatra SS. Protein kinase C-alpha activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells. Journal of virology. (24) , 2004.
  • Zhang W, Singam R, Hellermann G, Kong X, Juan HS, Lockey RF, Wu SJ, Porter K, Mohapatra SS. Attenuation of dengue virus infection by adeno-associated virus-mediated siRNA delivery. Genetic vaccines and therapy. 2(1) : 8, 2004.
  • King MJ, Bukantz SC, Phillips S, Mohapatra SS, Tamulis T, Lockey RF. Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients. Allergy and asthma proceedings : the official journal of regional and state allergy societies. 25(5) : 321-5, 2004.
  • Hellermann G, Kong X, Gunnarsdóttir J, San Juan H, Singam R, Behera S, Zhang W, Lockey RF, Mohapatra SS. Mechanism of bronchoprotective effects of a novel natriuretic hormone peptide. The Journal of allergy and clinical immunology. 113(1) : 79-85, 2004.
  • Larché M, Ferreira F, Mohapatra SS. Modifying allergens and using adjuvants for specific immunotherapy. Clinical allergy and immunology. 18: 641-61, 2004.
  • Mohapatra SS, Lockey RF, Vesely DL, Gower WR. Natriuretic peptides and genesis of asthma: an emerging paradigm? The Journal of allergy and clinical immunology. 114(3) : 520-6, 2004.
  • Ravi Kumar M, Hellermann G, Lockey RF, Mohapatra SS. Nanoparticle-mediated gene delivery: state of the art. Expert opinion on biological therapy. (8) , 2004.
  • Kong X, San Juan H, Behera A, Peeples ME, Wu J, Lockey RF, Mohapatra SS. ERK-1/2 activity is required for efficient RSV infection. FEBS letters. (1-3) , 2004.
  • Mohapatra SS, Lockey RF, Polo F. Weed pollen allergens. Clinical allergy and immunology. 18: 207-22, 2004.
  • Mohapatra SS. American Academy of Allergy, Asthma and Immunology--60th annual meeting. Advances in allergy and asthma therapy: 2003 AAAI updates. 7-12 March 2003, Denver, CO, USA. IDrugs : the investigational drugs journal. 6(5) : 423-5, 2003.
  • Kong X, San Juan H, Kumar M, Behera AK, Mohapatra A, Hellermann GR, Mane S, Lockey RF, Mohapatra SS. Respiratory syncytial virus infection activates STAT signaling in human epithelial cells. Biochemical and biophysical research communications. 306(2) : 616-22, 2003.
  • Hellermann GR, Mohapatra SS. Genetic therapy: on the brink of a new future. Genetic vaccines and therapy. 1(1) : 1, 2003.
  • Matsuse H, Kong X, Hu J, Wolf SF, Lockey RF, Mohapatra SS. Intranasal IL-12 produces discreet pulmonary and systemic effects on allergic inflammation and airway reactivity. International immunopharmacology. 3(4) : 457-68, 2003.
  • Kumar M, Kong X, Behera AK, Hellermann GR, Lockey RF, Mohapatra SS. Chitosan IFN-gamma-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma. Genetic vaccines and therapy. 1(1) : 3, 2003.
  • Mohapatra SS. Mucosal gene expression vaccine: a novel vaccine strategy for respiratory syncytial virus. The Pediatric infectious disease journal. 22(2 Suppl) : S100-3; discussion S103-4, 2003.
  • Kuderer NM, San-Juan-Vergara HG, Kong X, Esch R, Lockey RF, Mohapatra SS. Mite and cockroach proteases activate p44/p42 MAP kinases in human lung epithelial cells. Clinical and molecular allergy : CMA. 1(1) : 1, 2003.
  • Kumar M, Behera AK, Lockey RF, Vesely DL, Mohapatra SS. Atrial natriuretic peptide gene transfer by means of intranasal administration attenuates airway reactivity in a mouse model of allergic sensitization. The Journal of allergy and clinical immunology. 110(6) : 879-82, 2002.
  • Hellermann GR, Nagy SB, Kong X, Lockey RF, Mohapatra SS. Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells. Respiratory research. 3: 22, 2002.
  • Kumar M, Behera AK, Lockey RF, Zhang J, Bhullar G, De La Cruz CP, Chen LC, Leong KW, Huang SK, Mohapatra SS. Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection. Human gene therapy. 13(12) : 1415-25, 2002.
  • Behera AK, Kumar M, Lockey RF, Mohapatra SS. 2''-5'' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells. The Journal of biological chemistry. 277(28) : 25601-8, 2002.
  • Mohapatra SS. Gene transfer and transcription factors. 1-6 March 2002, New York City, NY, USA. IDrugs : the investigational drugs journal. 5(4) : 312-5, 2002.
  • Behera AK, Kumar M, Lockey RF, Mohapatra SS. Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling. Human gene therapy. 13(14) : 1697-709, 2002.
  • Matsuse H, Behera AK, Kumar M, Lockey RF, Mohapatra SS. Differential cytokine mRNA expression in Dermatophagoides farinae allergen-sensitized and respiratory syncytial virus-infected mice. Microbes and infection / Institut Pasteur. (7) , 2000.
  • Mohapatra SS. Is cross-reactivity a real or an imaginary concept? The Journal of allergy and clinical immunology. 99(5) : 724, 1997.
  • Mohapatra SS. IL-12 possibilities. Science (New York, N.Y.). 269(5230) : 1499, 1995.

Positions Held

  • Associate Professor (Medical Microbiology & Immunology, University of South Florida 1996 - 1999)
  • Associate Professor (Internal Medicine, University of South Florida 1996 - 1999)
  • Associate Professor (with tenure) (Immunology, University of Manitoba 1992 - 1995)
  • Assistant Professor (Immunology, University of Manitoba 1988 - 1991)
  • Research Associate (Biology Department, McGill University 1986 - 1987)
  • Alexander von Humboldt rEsearch Fellow (Genetics Institute, University of Bielefeld 1984 - 1986)