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Barbara Hansen

Barbara Hansen, PHD

Professor, College of Medicine Pediatrics

Professor, College of Medicine Internal Medicine

Contact Info

Education

  • PHD, Physiology/Psychology, University of Washington, 1971

Academic Philosophy

"Collaborate, collaborate, collaborate! With those around you, with those in other institutions, with those in other disciplines, with those in other countries, and with students/residents/trainees. All bring assets to any collaboration."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular Sciences
  • Metabolic Regulation and Disorders

Research Interests

  • Dr. Hansen is the Director of the Obesity, Diabetes and Aging Research Center of the College of Medicine and Professor of Internal Medicine and Pediatrics at the University of South Florida Tampa. Her research has addressed the physiological, cellular, and molecular defects underlying the development of obesity and diabetes mellitus and their prevention, as well as the long-term prevention of diabetic complications. Dr. Hansen has developed nonhuman primate models of obesity, the metabolic syndrome, diabetes and diabetic complications, and these models are applied to studies of the underlying mechanisms of these disorders, their natural history, and their mitigation/treatment and prevention by pharmaceutical and non- pharmaceutical approaches. Her research program has informed patient/human studies as well, for extension of non-human primate findings to human health and disease mechanisms is of greatest importance.

Awards/Honors

  • Fellow (American Society for Nutrition - 2015)
  • Fellow (American Physiological Society - 2015)
  • Fellow (American Association for the Advancement of Science - 2014)
  • Charter member (National Academy of Inventors - 2012)
  • Best Abstract Award (genetics, molecular and physiology (European Association for the Study of Obesity - 2011)
  • Member (National Academy of Medicine - 1981)

Memberships

  • Chair, Section 3 Membership Committee (National Academy of Medicine, 2014 - Present)
  • Fellow and Charter member (National Academy of Inventors, 2012 - Present)
  • member (Gerontological Society of America, 1990 - Present)
  • member (American Society for Nutrition, 1981 - Present)
  • Cooperative Medical Science Commission (NIH US-Japan Nutrition and Metabolism Panel of the United States-Japan Cooperative Medical Science, 1991 - 2011)
  • Board of Directors (American Aging Association, 1997 - 2002)
  • First President (International Association for the Study of Obesity, 1986 - 1990)

Recent Publications

  • Sajan M, P, Hansen B, C, Ivey R, A, III Sajan J, P, Ari C, Song S, Braun U, Leitges M, Farese- Higgs M, G, and Farese R, V. Brain insulin signaling is increased in insulin-resistant states and decreases in FoxOs and PGC-1α and increases in Aβ1-40.42 and Phospho-Tau may abet Alzheimer development. Diabetes,. 65: 1892-1903, 2016.
  • Ryan DH, Hansen BC, Cefalu WT. George A. Bray, MD: Progress in Obesity-Multidisciplinary Research, Multidimensional Man. Diabetes care. 39(9) : 1481-5, 2016.
  • Ryan DH Hansen BC Cefalu WT, George A, Bray MD. Progress in Obesity- Multidisciplinary Research, Multidimensional Man. Diabetes Care.. 39(9) : 1481-5, 2016.
  • Luca G, Arato I, Mancuso F, Calvitti M, Falabella G, Murdolo G, Basta G, Cameron DF, Hansen BC, Fallarino F, Baroni T, Aglietti MC, Tortoioli C, Bodo M, Calafiore R. Xenograft of microencapsulated Sertoli cells restores glucose homeostasis in db/db mice with spontaneous diabetes mellitus. Xenotransplantation. 23(6) : 429-439, 2016.
  • Gografe SI, Hansen BC, Hansen KD. Deep subconjunctival injection of gentamicin for the treatment of bacterial conjunctivitis in macaques (Macaca mulatta and Macaca fascicularis). Lab animal. 44(3) : 92-6, 2015.
  • Spijker HS, Song H, Ellenbroek JH, Roefs MM, Engelse MA, Bos E, Koster AJ, Rabelink TJ, Hansen BC, Clark A, Carlotti F, de Koning EJ. Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits. Diabetes. 64(8) : 2928-38, 2015.
  • Luca G, Cameron DF, Arato I, Mancuso F, Linden EH, Calvitti M, Falabella G, Szekeres K, Bodo M, Ricci G, Hansen BC, Calafiore R. Xenograft of microencapsulated Sertoli cells for the cell therapy of type 2 diabetes mellitus in spontaneously diabetic nonhuman primates: preliminary data. Transplantation proceedings. 46(6) : 1999-2001, 2014.
  • Hansen BC. Patient-pet interactions. Lab animal. 43(4) : 121, 2014.
  • Levitsky DA, Brown AW, Hansen BC, Atkinson RL, Byrne N, Cheskin LJ, Allison DB. An unjustified conclusion from self-report-based estimates of energy intake. The American journal of medicine. 127(12) : e33, 2014.
  • Dhurandhar, N. V., Scoeller, D., Brown, A. W., Heymsfield, S. B., Thomas, D., Sorensen, T. I. A., Speakman, J. R., Jeansonne, M., Allison, D. B. and The Energy Balance Measurement Working Group. Energy balance measurement: when something is not better than nothing. Int. J. Obes. (In Press). , 2014.
  • Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Myers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A. LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys. PloS one. 8(6) : e65763, 2013.
  • Hansen BC. Nonhuman primate advances in nutrition research. The American journal of clinical nutrition. 98(2) : 264-5, 2013.
  • Wang X, Hansen BC, Shi D, Fang Y, Du F, Wang B, Chen YM, Gregoire FM, Wang YX. Quantification of β-cell insulin secretory function using a graded glucose infusion with C-peptide deconvolution in dysmetabolic, and diabetic cynomolgus monkeys. Diabetology & metabolic syndrome. 5(1) : 40, 2013.
  • Tang DQ, Shun L, Koya V, Sun Y, Wang Q, Wang H, Li SW, Sun Y, Purich DL, Zhang C, Hansen B, Qian K, Atkinson M, Phillips MI, Yang LJ. Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes. American journal of translational research. 5(2) : 184-99, 2013.
  • Barbara C Hansen, Don Cameron, Riccardo Calafiore, Giovanni Luca, Ellen H Linden and Charles Szekeres. Effects of Sertoli cells Implantation on Type 2 Diabetes in Nonhuman Primates (meeting abstract) FASEB Journal. 27: 1154.3, 2013.
  • D Schoeller, D Thomas, E Archer, S Heymsfield, S Blair, M Goran, J Hill, R Atkinson, B Corkey, J Foreyt, N Dhurandhar, J Kral, K Hall, B Hansen et al. Self-report–based estimates of energy intake offer an inadequate basis for scientific conclusions Am J Clin Nutr. 97(6) : 1413-1415, 2013.
  • Hansen BC, Newcomb JD, Chen R, Linden EH. Longitudinal dynamics of body weight change in the development of type 2 diabetes. Obesity (Silver Spring, Md.). 21(8) : 1643-9, 2013.
  • Yin W, Carballo-Jane E, McLaren DG, Mendoza VH, Gagen K, Geoghagen NS, McNamara LA, Gorski JN, Eiermann GJ, Petrov A, Wolff M, Tong X, Wilsie LC, Akiyama TE, Chen J, Thankappan A, Xue J, Ping X, Andrews G, Wickham LA, Gai CL, Trinh T, Kulick AA, Donnelly MJ, Voronin GO, Rosa R, Cumiskey AM, Bekkari K, Mitnaul LJ, Puig O, Chen F, Raubertas R, Wong PH, Hansen BC, Koblan KS, Roddy TP, Hubbard BK, Strack AM. Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia. Journal of lipid research. 53(1) : 51-65, 2012.
  • Hansen BC. Investigation and treatment of type 2 diabetes in nonhuman primates. Methods in molecular biology (Clifton, N.J.). 933: 177-85, 2012.
  • BC Hansen, J Wang, X Wang, Y Fang, C Wang, J Newcomb, E Linden, PB Higgins, F Gregoire and YJ Wang. Comparative metabolic physiology of cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta): The nature of their naturally occurring diabetes and metabolic syndrome (meeting abstract) FASEB Journal.. 26: 1126.10, 2012.
  • Zhang L, McCabe T, Condra JH, Ni YG, Peterson LB, Wang W, Strack AM, Wang F, Pandit S, Hammond H, Wood D, Lewis D, Rosa R, Mendoza V, Cumiskey AM, Johns DG, Hansen BC, Shen X, Geoghagen N, Jensen K, Zhu L, Wietecha K, Wisniewski D, Huang L, Zhao JZ, Ernst R, Hampton R, Haytko P, Ansbro F, Chilewski S, Chin J, Mitnaul LJ, Pellacani A, Sparrow CP, An Z, Strohl W, Hubbard B, Plump AS, Blom D, Sitlani A. An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes. International journal of biological sciences. 8(3) : 310-27, 2012.
  • Najafian B, Masood A, Malloy PC, Campos A, Hansen BC, Mauer M, Caramori ML. Glomerulopathy in spontaneously obese rhesus monkeys with type 2 diabetes: a stereological study. Diabetes/metabolism research and reviews. 27(4) : 341-7, 2011.
  • Shamekh R, Linden EH, Newcomb JD, Tigno XT, Jen KL, Pellizzon MA, Hansen BC. Endogenous and diet-induced hypercholesterolemia in nonhuman primates: effects of age, adiposity, and diabetes on lipoprotein profiles. Metabolism: clinical and experimental. 60(8) : 1165-77, 2011.
  • Tigno XT, Hansen BC, Nawang S, Shamekh R, Albano AM. Vasomotion becomes less random as diabetes progresses in monkeys. Microcirculation (New York, N.Y. : 1994). 18(6) : 429-39, 2011.
  • McTighe MS, Hansen BC, Ely JJ, Lee DR. Determination of hemoglobin A1c and fasting blood glucose reference intervals in captive chimpanzees (Pan troglodytes). Journal of the American Association for Laboratory Animal Science : JAALAS. 50(2) : 165-70, 2011.
  • Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, Aslam S, Tigno X, Weinstein JN, Hansen BC, Idle JR, Gonzalez FJ. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. The Journal of biological chemistry. 286(22) : 19511-22, 2011.
  • Ortmeyer HK, Sajan MP, Miura A, Kanoh Y, Rivas J, Li Y, Standaert ML, Ryan AS, Bodkin NL, Farese RV, Hansen BC. Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C. Antioxidants & redox signaling. 14(2) : 207-19, 2011.
  • Lee HW, Muniyappa R, Yan X, Yue LQ, Linden EH, Chen H, Hansen BC, Quon MJ. Comparison between Surrogate Indexes of Insulin Sensitivity/Resistance and Hyperinsulinemic Euglycemic Glucose Clamps in Rhesus Monkeys. Endocrinology. 152(2) : 414-23, 2011.
  • Hansen BC, Tigno XT, Benardeau A, Meyer M, Sebokova E, Mizrahi J. Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor alpha/gamma agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome. Cardiovascular diabetology. 10(1) : 7, 2011.
  • Hansen B, C, Shamekh R, Hansson O, Almgren P, Budagov T, Linden E, Pessin J, Atzmon G, . The rhesus monkey: a nonhuman primate model for T2DM associated gene screening. J Diabetes Metab. 2: 150, 2011.
  • Cnop M, Hughes S, J, Igoillo-Esteve M, Hoppa M, B, Sayyed F, van de Laar L, Gunter J, H, de Koning E, J, Walls G, V, Gray D, W, Johnson P, R, Hansen B, C, Morris J, F, Pipeleers- Marichal M, Cnop I, and Clark A. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia. 53(2) : 321-330, 2010.
  • Malmlöf K, Hastrup S, Wulff BS, Hansen BC, Peschke B, Jeppesen CB, Hohlweg R, Rimvall K. Antagonistic targeting of the histamine H3 receptor decreases caloric intake in higher mammalian species. Biochemical pharmacology. 73(8) : 1237-42, 2007.
  • Ding SY, Tigno XT, Braileanu GT, Ito K, Hansen BC. A novel peroxisome proliferator--activated receptor alpha/gamma dual agonist ameliorates dyslipidemia and insulin resistance in prediabetic rhesus monkeys. Metabolism: clinical and experimental. 56(10) : 1334-9, 2007.
  • Ding SY, Tigno XT, Hansen BC. Nuclear magnetic resonance-determined lipoprotein abnormalities in nonhuman primates with the metabolic syndrome and type 2 diabetes mellitus. Metabolism: clinical and experimental. 56(6) : 838-46, 2007.
  • Uthurralt J, Gordish-Dressman H, Bradbury M, Tesi-Rocha C, Devaney J, Harmon B, Reeves EK, Brandoli C, Hansen BC, Seip RL, Thompson PD, Price TB, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Gordon PM, Hoffman EP. PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males. BMC medical genetics. 8: 55, 2007.
  • Paré M, Albrecht PJ, Noto CJ, Bodkin NL, Pittenger GL, Schreyer DJ, Tigno XT, Hansen BC, Rice FL. Differential hypertrophy and atrophy among all types of cutaneous innervation in the glabrous skin of the monkey hand during aging and naturally occurring type 2 diabetes. The Journal of comparative neurology. 501(4) : 543-67, 2007.
  • Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 148(2) : 774-81, 2007.
  • Tigno XT, Ding SY, Hansen BC. Paradoxical increase in dermal microvascular flow in pre-diabetes associated with elevated levels of CRP. Clinical hemorheology and microcirculation. 34(1-2) : 273-82, 2006.
  • Foster DR, Oswald WW, Faison EK, Doughty ED, Hansen BC. A climatic driver for abrupt mid-Holocene vegetation dynamics and the hemlock decline in New England. Ecology. 87(12) : 2959-66, 2006.
  • Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. American journal of physiology. Endocrinology and metabolism. 290(6) : E1253-61, 2006.
  • Nadeau KJ, Ehlers LB, Aguirre LE, Moore RL, Jew KN, Ortmeyer HK, Hansen BC, Reusch JE, Draznin B. Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle. American journal of physiology. Endocrinology and metabolism. 291(1) : E90-8, 2006.
  • Ortmeyer HK, Adall Y, Marciani KR, Katsiaras A, Ryan AS, Bodkin NL, Hansen BC. Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. American journal of physiology. Regulatory, integrative and comparative physiology. 288(6) : R1509-17, 2005.
  • Kim SY, Johnson MA, McLeod DS, Alexander T, Hansen BC, Lutty GA. Neutrophils are associated with capillary closure in spontaneously diabetic monkey retinas. Diabetes. 54(5) : 1534-42, 2005.
  • Bodkin NL, Ortmeyer HK, Hansen BC. A comment on the comment: relevance of nonhuman primate dietary restriction to aging in humans. The journals of gerontology. Series A, Biological sciences and medical sciences. 60(8) : 951-2, 2005.
  • Angeloni SV, Glynn N, Ambrosini G, Garant MJ, Higley JD, Suomi S, Hansen BC. Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels. Endocrinology. 145(5) : 2197-205, 2004.
  • Tigno XT, Gerzanich G, Hansen BC. Age-related changes in metabolic parameters of nonhuman primates. The journals of gerontology. Series A, Biological sciences and medical sciences. 59(11) : 1081-8, 2004.
  • Erwin JM, Tigno XT, Gerzanich G, Hansen BC. Age-related changes in fasting plasma cortisol in rhesus monkeys: implications of individual differences for pathological consequences. The journals of gerontology. Series A, Biological sciences and medical sciences. 59(5) : 424-32, 2004.
  • Caterson ID, Hubbard V, Bray GA, Grunstein R, Hansen BC, Hong Y, Labarthe D, Seidell JC, Smith SC. Prevention Conference VII: Obesity, a worldwide epidemic related to heart disease and stroke: Group III: worldwide comorbidities of obesity. Circulation. 110(18) : e476-83, 2004.
  • Kim SY, Johnson MA, McLeod DS, Alexander T, Otsuji T, Steidl SM, Hansen BC, Lutty GA. Retinopathy in monkeys with spontaneous type 2 diabetes. Investigative ophthalmology & visual science. 45(12) : 4543-53, 2004.
  • Schäfer SA, Hansen BC, Völkl A, Fahimi HD, Pill J. Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR)alpha activator, in non-human primates. Biochemical pharmacology. 68(2) : 239-51, 2004.
  • Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC. Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. The journals of gerontology. Series A, Biological sciences and medical sciences. 58(3) : 212-9, 2003.
  • Yang RZ, Blaileanu G, Hansen BC, Shuldiner AR, Gong DW. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. Genomics. 79(3) : 445-50, 2002.
  • Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren JF. Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys. Metabolism: clinical and experimental. 51(4) : 465-70, 2002.
  • Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV. Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota. Diabetes. 51(10) : 2936-43, 2002.
  • Cusumano AM, Bodkin NL, Hansen BC, Iotti R, Owens J, Klotman PE, Kopp JB. Glomerular hypertrophy is associated with hyperinsulinemia and precedes overt diabetes in aging rhesus monkeys. American journal of kidney diseases : the official journal of the National Kidney Foundation. 40(5) : 1075-85, 2002.
  • Mosca L, Arnett DK, Dracup K, Hansen BC, Labarthe DR, Marks JS, Matthews KA, Pearson TA, Weintraub W, Wilson W. Task Force on Strategic Research Direction: Population/Outcomes/Epidemiology/Social Science Subgroup key science topics report. Circulation. 106(20) : e167-72, 2002.