The main areas of Dr. Rieg's research interests are the physiology and pathophysiology of the kidney and intestine. He successfully contributed to various projects related to aspects of kidney and intestinal function using a variety of genetically modified models. His research focuses on the characterization of channels, transporters, receptors and signaling molecules in the physiology and pathophysiology of the kidney including arterial hypertension. His work is instrumental in determining the physiology of sodium-glucose cotransporters and the pharmacology of SGLT2 inhibitors. Methods used to study aspects of the kidney function include: metabolic balance studies, clearance and micropuncture studies in anesthetized mice as well as measurement of glomerular filtration rate in awake mice using single-bolus technique and a two-compartment kinetic model.
Recent Publications
Thomas L Xue J Murali SK Fenton RA Dominguez Rieg JA Rieg T. Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.J Am Soc Nephrol.. , 2019.
Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Dominguez Rieg JA, Rieg T. Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis.Kidney international. 92(2) : 397-414, 2017.
Rieg T, Dominguez Rieg JA. Reply to "Reduced NHE3 activity results in congenital diarrhea and can predispose to inflammatory bowel disease".American journal of physiology. Regulatory, integrative and comparative physiology. 312(3) : R312, 2017.
Poulsen SB, Kristensen TB, Brooks HL, Kohan DE, Rieg T, Fenton RA. Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.JCI insight. 2(7) : e91042, 2017.
Dominguez Rieg JA, de la Mora Chavez S, Rieg T. Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3.American journal of physiology. Regulatory, integrative and comparative physiology. 311(6) : R1186-R1191, 2016.
Mir SA, Zhang K, Milic M, Gu Y, Rieg T, Ziegler M, Vaingankar SM. Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models.Journal of hypertension. 34(1) : 68-78, 2016.
Dominguez Rieg JA, Chirasani VR, Koepsell H, Senapati S, Mahata SK, Rieg T. Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice.Laboratory investigation; a journal of technical methods and pathology. 96(1) : 98-111, 2016.
Dominguez Rieg JA, Burt JM, Ruth P, Rieg T. P2Y₂ receptor activation decreases blood pressure via intermediate conductance potassium channels and connexin 37.Acta physiologica (Oxford, England). 213(3) : 628-41, 2015.
Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Busslinger M, Dominguez Rieg JA, Rieg T. Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.American journal of physiology. Renal physiology. 308(12) : F1409-20, 2015.
Poulsen SB, Fenton RA, Rieg T. Sodium-glucose cotransport.Current opinion in nephrology and hypertension. 24(5) : 463-9, 2015.
Rieg T, Kohan DE. Regulation of nephron water and electrolyte transport by adenylyl cyclases.American journal of physiology. Renal physiology. 306(7) : F701-9, 2014.
Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.American journal of physiology. Renal physiology. 306(2) : F194-204, 2014.
Rieg T, Masuda T, Gerasimova M, Mayoux E, Platt K, Powell DR, Thomson SC, Koepsell H, Vallon V. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia.American journal of physiology. Renal physiology. 306(2) : F188-93, 2014.
Fenton RA, Murray F, Dominguez Rieg JA, Tang T, Levi M, Rieg T. Renal phosphate wasting in the absence of adenylyl cyclase 6.Journal of the American Society of Nephrology : JASN. 25(12) : 2822-34, 2014.
Rieg T. A High-throughput method for measurement of glomerular filtration rate in conscious mice.Journal of visualized experiments : JoVE. (75) : e50330, 2013.
Rieg T, Dominguez Rieg J. Connecting type A intercalated cell metabolic state to V-ATPase function: phosphorylation does matter!American journal of physiology. Renal physiology. 305(8) : F1105-6, 2013.
Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus.American journal of physiology. Renal physiology. 304(2) : F156-67, 2013.
Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.The American journal of pathology. 182(1) : 96-106, 2013.
Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, Parker HE, Gribble FM, Reimann F, Lang F, Wiese S, Sabolic I, Sendtner M, Koepsell H. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.Diabetes. 61(1) : 187-96, 2012.
Vallon V, Stockand J, Rieg T. P2Y receptors and kidney function.Wiley interdisciplinary reviews. Membrane transport and signaling. 1(6) : 731-742, 2012.
Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.American journal of physiology. Renal physiology. 302(10) : F1293-9, 2012.
Thomson SC, Rieg T, Miracle C, Mansoury H, Whaley J, Vallon V, Singh P. Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat.American journal of physiology. Regulatory, integrative and comparative physiology. 302(1) : R75-83, 2012.
Rieg T, Gerasimova M, Murray F, Masuda T, Tang T, Rose M, Drucker DJ, Vallon V. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.American journal of physiology. Renal physiology. 303(7) : F963-71, 2012.
Sweeney DE, Vallon V, Rieg T, Wu W, Gallegos TF, Nigam SK. Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney.Molecular pharmacology. 80(1) : 147-54, 2011.
Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling.Journal of the American College of Cardiology. 57(22) : 2273-83, 2011.
Vallon V, Rieg T. Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system.American journal of physiology. Renal physiology. 301(3) : F463-75, 2011.
Rieg T, Gerasimova M, Boyer JL, Insel PA, Vallon V. P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion.American journal of physiology. Regulatory, integrative and comparative physiology. 301(2) : R510-8, 2011.
Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. SGLT2 mediates glucose reabsorption in the early proximal tubule.Journal of the American Society of Nephrology : JASN. 22(1) : 104-12, 2011.
Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O. Purinergic inhibition of ENaC produces aldosterone escape.Journal of the American Society of Nephrology : JASN. 21(11) : 1903-11, 2010.
Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(6) : 2056-65, 2010.
Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla.Journal of the American Society of Nephrology : JASN. 21(12) : 2059-68, 2010.
Deng A, Arndt MA, Satriano J, Singh P, Rieg T, Thomson S, Tang T, Blantz RC. Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.American journal of physiology. Renal physiology. 299(6) : F1365-73, 2010.
