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Hana Totary-Jain

Hana Totary-Jain, PhD

Associate Professor, College of Medicine Molecular Pharmacology & Physiology

Associate Professor, Molecular Pharmacology and Physiology

Contact Info

Education

  • PhD, Pharmacology, the Hebrew University of Jerusalem, 2005

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Cardiovascular Sciences
  • Women & Children's Health

Research Interests

  • Research at the Totary-Jain lab focuses on elucidating the role of non-coding RNA in cardiovascular disease and in antiviral innate immunity. The main projects aim to: 1) Develop site- and cell-selective anti-atherosclerotic nanotherapies that simultaneously inhibit infiltration and proliferation of inflammatory and vascular smooth muscle cells while preserving the integrity of endothelial cells. 2) investigate the role of LIN28B/let-7 switch in the pathogenesis of infantile hemangioma. 3) elucidate the role of retrotransposons in the placental intrinsic protection against viral vertical transmission.

Awards/Honors

  • Alan T. Hirsch Mid-Career Award in Vascular Medicine, AHA (American Heart Association (AHA) - 2020)
  • PVD/Robert W. Hobson, II, MD Early Career Investigator Award (American Heart Association (AHA) - 2013)
  • NIH Pathway to Independence Award (NIH/NHLBI - 2011)
  • NIH Postdoctoral Fellowship Award (NIH/NHLBI - 2008)
  • The Diabetes Research Centre of the Hebrew University (The Hebrew University of Jerusalem - 2004)
  • Israel Ministry of Science Fellowship Award (Israel Ministry of Science - 2003)

Recent Publications

  • Ishani Wickramage, Jeffrey VanWye, Klaas Max, John H Lockhart, Ismet Hortu, Ezinne F Mong, John Canfield, Hiran M Lamabadu Warnakulasuriya Patabendige, Ozlem Guzeloglu-Kayisli, Kimiko Inoue, Atsuo Ogura, Charles J Lockwood, Kemal M Akat, Thomas Tuschl, Umit A Kayisli, Hana Totary-Jain SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas Cell Host and Microbe. doi: 10.1016/j.chom.2023.05.018, 2023.
  • Isabella Hetherington, Hana Totary-Jain Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations Molecular Therapy. DOI: 10.1016/j.ymthe.2022.08.024, 2022.
  • Lockhart JH, VanWye J, Banerjee R, Wickline SA, Pan H, Totary-Jain Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis. Molecular Therapy. DOI: 10.1016/j.ymthe.2021.01.032, 2021.
  • Mong E, Yang Y, Akat K, Canfield J, VanWye J, Lockhart J, Tsibris J, Schatz F, Lockwood C, Tuschl T, Kayisli U, Totary-Jain Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition Scientific Reports. DOI: 10.1038/s41598-020-59812-8, 2020.
  • Canfield J, Arlier S, Mong EF, Lockhart J, VanWye J, Guzelogu-Kayisli O, Schatz F, Magness RR, Lockwood CJ, Tsibris J, Kayisli U, Totary-Jain H Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration FASEB J. DOI: 10.1096/fj.201801163R, 2019.
  • Lockhart J, Canfield J, Mong EF, VanWye J, Totary-Jain Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches Molecular Therapy Nucleic Acids. DOI: 10.1016/j.omtn.2018.12.007, 2019.
  • Mong EF, Akat KM, Canfield J, Lockhart J, VanWye J, Matar A, Tsibris JCM, Wu JK, Tuschl T, Totary-Jain H Modulation of LIN28B/Let-7 signaling by propranolol contributes to infantile hemangioma involution Atherosclerosis Thrombosis and Vascular Biology. DOI: 10.1161/ATVBAHA.118.310908, 2018.
  • Canfield J & Totary-Jain H 40 Years of Percutaneous Coronary Intervention: History and Future Directions Journal of Personalized Medicine. DOI: 10.3390/jpm8040033, 2018.
  • Totary-Jain H, Sionov RV, Gallily R. Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity. Immunology Letters. DOI: 10.1016/j.imlet.2016.05.011, 2016.
  • Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, Kitajewski J, Chilton JM, Akat KM, Tuschl T, Marks AR, Totary-Jain H. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. The Journal of clinical investigation. DOI: 10.1172/JCI76069, 2014.
  • Akat KM, Moore-McGriff D, Morozov P, Brown M, Gogakos T, Correa Da Rosa J, Mihailovic A, Sauer M, Ji R, Ramarathnam A, Totary-Jain H, Williams Z, Tuschl T, Schulze PC. Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers. Proceedings of the National Academy of Sciences of the United States of America. 111(30) : 11151-6, 2014.
  • Totary-Jain H, Sanoudou D, Ben-Dov IZ, Dautriche CN, Guarnieri P, Marx SO, Tuschl T, Marks AR. Reprogramming of the microRNA transcriptome mediates resistance to rapamycin. The Journal of biological chemistry. 288(9) : 6034-44, 2013.
  • Santulli G, Totary-Jain H. Tailoring mTOR-based therapy: molecular evidence and clinical challenges. Pharmacogenomics. 14(12) : 1517-26, 2013.
  • Totary-Jain H, Sanoudou D, Dautriche CN, Schneller H, Zambrana L, Marks AR. Rapamycin resistance is linked to defective regulation of Skp2. Cancer research. 72(7) : 1836-43, 2012.
  • Marx SO, Totary-Jain H, Marks AR. Vascular smooth muscle cell proliferation in restenosis. Circulation. Cardiovascular interventions. 4(1) : 104-11, 2011.
  • Shan J, Nguyen TB, Totary-Jain H, Dansky H, Marx SO, Marks AR. Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 105(48) : 19006-11, 2008.
  • Totary-Jain H, Naveh-Many T, Riahi Y, Kaiser N, Eckel J, Sasson S. Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions. Circulation research. 97(10) : 1001-8, 2005.
  • Alpert E, Altman H, Totary H, Gruzman A, Barnea D, Barash V, Sasson S. 4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells. Biochemical pharmacology. 67(10) : 1985-95, 2004.
  • Alpert E, Gruzman A, Totary H, Kaiser N, Reich R, Sasson S. A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. The Biochemical journal. 362(Pt 2) : 413-22, 2002.
  • Cerasi E, Marshak S, Totary H, Melloul D. [1997 Maurice Dérot. Transcriptional regulation of the insulin gene: a step toward gene therapy of diabetes]. Journées annuelles de diabétologie de l''Hôtel-Dieu. : 299-304, 1997.
  • Marshak S, Totary H, Cerasi E, Melloul D. Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proceedings of the National Academy of Sciences of the United States of America. 93(26) : 15057-62, 1996.