PHD, Medical Mycology, Kangwon National University, 2001
Interdisciplinary and Emerging Signature Programs
Allergy, Immunology & Infectious Disease
Asthma Center of Excellence
Cellular and Molecular Biology
Metabolic Regulation and Disorders
Memberships
Member (ATS, 2014 - Present)
Member (KSEA, 2012 - Present)
member (AACR, 2003 - 2013)
Recent Publications
Woo JA, Castaño M, Kee TR, Lee J, Koziol-White CJ, An SS, Kim D, Kang DE, Liggett SB. A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14.Am J Respir Cell Mol Biol. , 2023.
Tokmakova A, Kim D, Goddard WA, Liggett SB. Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease.Journal of personalized medicine. 12(3) , 2022.
Cardet JC, Kim D, Bleecker ER, Casale TB, Israel E, Mauger D, Meyers DA, Ampleford E, Hawkins GA, Tu Y, Liggett SB, Ortega VE. Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma.The Journal of allergy and clinical immunology. , 2022.
Kim D, Tokmakova A, Woo JA, An SS, Goddard WA, Liggett SB. Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development.Molecular diagnosis & therapy. , 2022.
Kim D, Castaño M, Lujan LK, Woo JA, Liggett SB. The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14.The Journal of biological chemistry. 296: 100216, 2021.
Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA, Liggett SB. Identification and characterization of an atypical Gαs-biased βAR agonist that fails to evoke airway smooth muscle cell tachyphylaxis.Proceedings of the National Academy of Sciences of the United States of America. 118(49) , 2021.
Yang MY, Kim SK, Kim D, Liggett SB, Goddard WA. Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment.The journal of physical chemistry letters. 12(38) : 9293-9300, 2021.
Kim D, An SS, Lam H, Leahy JW, Liggett SB. Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5.ACS pharmacology & translational science. 3(6) : 1069-1075, 2020.
Huang J, Lam H, Koziol-White C, Limjunyawong N, Kim D, Kim N, Karmacharya N, Rajkumar P, Firer D, Dalesio NM, Jude J, Kurten RC, Pluznick JL, Deshpande DA, Penn RB, Liggett SB, Panettieri RA, Dong X, An SS. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR.Proceedings of the National Academy of Sciences of the United States of America. 117(45) : 28485-28495, 2020.
Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB. Differential long-term regulation of TAS2R14 by structurally distinct agonists.FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(11) : 12213-12225, 2019.
Kim D, Cho S, Castaño MA, Panettieri RA, Woo JA, Liggett SB. Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal-regulated Kinase 1/2.American journal of respiratory cell and molecular biology. 60(5) : 532-540, 2019.
Kim D, Cho S, Woo JA, Liggett SB. A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β-adrenergic receptor down-regulation in airway smooth muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(7) : 3680-3688, 2018.
Kim D, Woo JA, Geffken E, An SS, Liggett SB. Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G.American journal of respiratory cell and molecular biology. 56(6) : 762-771, 2017.
Kim D, Pauer SH, Yong HM, An SS, Liggett SB. β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function.The Journal of biological chemistry. 291(34) : 17616-28, 2016.
Tokmakova A*, Kim D*, Guthrie B, Kim SK, Goddard WA 3rd, Liggett SB. Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastesiScience. , 2023.
Young Yang M, Duy Mac K, Strzelinski HR, Hoffman SA, Kim D, Kim SK, Su J, Liggett SB, Goddard WA 3rd. Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5Proc Natl Acad Sci U S A. , 2024.
