Xingmin Sun, PhD

Professor, Department of Molecular Medicine, College of Medicine

Contact Info

• 12901 Bruce B. Downs Blvd
  MDC07
  Tampa FL 33612
• Academic Email: sun5@usf.edu
• Academic Phone: (813) 974-4553
• View My C.V. | View My Website | View My Lab Site

Education

Biography

Dr. Xingmin Sun (http://www.sunlab-usf.com/) is a tenured Professor with early promotion in the Department of Molecular Medicine at the Morsani College of Medicine, University of South Florida (USF). He also holds affiliate appointments in the Departments of Internal Medicine, Molecular Biosciences, Chemistry, and USF Genomics. Dr. Sun earned his Ph.D. in Natural Sciences (magna cum laude) from the University of Kiel, Germany, followed by postdoctoral training in Molecular Microbiology and Biochemistry at Brown University. His research centers on microbial pathogenesis and host–pathogen interactions, with particular emphasis on Clostridioides difficile (C. difficile) pathogenesis and the development of novel therapeutics—including vaccines—to prevent and treat C. difficile infection (CDI). The research in his lab has been published in Nature Communications, Molecular Cell, Cell Discov, mBio, Emerg Microbes Infect, Frontiers in Immunology, FEMS Microbiol Rev. Environmental Microbiology, Infection and Immunity, and other journals. Dr. Sun is nationally and internationally recognized for his contributions to CDI vaccine and therapeutic development and for advancing the understanding of C. difficile pathogenesis. His work has been continuously funded by the NIH since 2012. He has served extensively on NIH study sections, including as chair, and reviewed grants for major funding agencies in the UK, France, Germany, Canada, and Switzerland. He is an Associate Editor for Microbiological Research and Frontiers in Immunology and serves on the editorial boards of Infection and Immunity and Applied and Environmental Microbiology. His honors include the Tufts Institute for Innovation Inaugural Award (2014), USF Faculty Outstanding Research Achievement Award (2018 and 2025), and USF Excellence in Innovation Award (2020). He chaired the USF College of Medicine Research Committee (2019–2020) and has held multiple leadership roles in the USF Chapter of the National Academy of Inventors (NAI). In 2025, he was elected a Senior Member of NAI. In his spare time, he enjoys music, working out, and exploring cuisines from different cultures.

Interdisciplinary and Emerging Signature Programs

• Allergy, Immunology & Infectious Disease

Awards/Honors

• Senior Member (National Academy of Inventors (NAI) - 2025)
• Faculty Outstanding Research Achievement Award (University of South Florida - 2025)
• Excellence in Innovation Award (University of South Florida - 2020)
• Faculty Outstanding Research Achievement Award (University of South Florida - 2018)
• Tufts Institute for Innovation Inaugural Award (Tufts University - 2014)
• K01 Mentored Research Scientist Development Award (NIH/NIDDK - 2012)
• Fellow for 48th Annual ICAAC/46th IDSA (American Society for Microbiology and the Infectious Diseases Society of America - 2008)
• Young Scientist Award (Federation of European Microbiological Societies for the 7th Symposium on Lactic - 2002)
• Excellent Graduate Student Award (Nanjing Agricultural University - 1993)
• Excellent Graduate Student Award (Nanjing Agricultural University - 1992)

Memberships

• Member (Anaerobe Society of the Americas, 2016 - Present)
• Member (Society for Mucosal Immunology, 2014 - Present)
• Member (American Society for Microbiology, 2005 - Present)
• Member (The American Association of Immunologists, 2022 - Present)
• Member (American Association for the Advancement of Science, 2024 - Present)
• Member (International Society for Vaccines, 2024 - Present)
• Senior Member (National Academy of Inventors, 2025 - Present)

Recent Publications

• Zhu, Duolong|Wozniak, Katherine J.|Midani, Firas|Wang, Shaohui|Sun, Xingmin|Britton, Robert A. Control of Clostridioides difficile virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility mBio [21612129]. 16(3) , 2025.
• Zhang, Fuming|Wang, Shaohui|Yang, Jiyuan|Fraser, Keith|Gibson, James M.|Wang, Chunyu|Dordick, Jonathan S.|Tomatsidou, Anastasia|Linhardt, Robert J.|Wang, Lianchun|Sun, Xingmin Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics Carbohydrate Polymers [01448617]. 351, 2025.
• Choi, Yejin|Keum, Gi Beom|Kang, Juyoun|Doo, Hyunok|Kwak, Jinok|Kim, Haram|Chae, Yeongjae|Lee, Suyoung|Yang, Hyunjin|Kim, Sheena|Sun, Xingmin|Kim, Hyeun Bum|Yoo, Soo Jin Evaluation of kefir consumption on gut microbial diversity in a healthy young population using full-length 16S rRNA sequencing Frontiers in Microbiology [1664302X]. 16, 2025.
• Kang, Juyoun|Choi, Yejin|Keum, Gi Beom|Doo, Hyunok|Kwak, Jinok|Kim, Haram|Chae, Yeongjae|Lee, Suyoung|Yang, Hyunjin|Kim, Sheena|Sun, Xingmin|Kim, Hyeun Bum|Yoo, Soo Jin Effect of Diet and Lifestyle Changes on Gut Microbial Diversity in Healthy Adolescents Journal of Microbiology and Biotechnology [10177825]. 35, 2025.
• Xue, Menglin|Chakraborty, Soumyadeep|Gao, Ruixuan|Wang, Shaohui|Gu, Meng|Shen, Ning|Wei, Lulu|Cao, Chuanhai|Sun, Xingmin|Cai, Jianfeng Antimicrobial Guanidinylate Polycarbonates Show Oral In Vivo Efficacy Against Clostridioides Difficile Advanced Healthcare Materials [21922640]. 13(14) , 2024.
• Li, Chunhui|Heuler, Joshua|Zhu, Duolong|Meng, Xiujuan|Chakraborty, Soumyadeep|Harmanus, Céline|Wang, Shaohui|Peng, Zhong|Smits, Wiep Klaas|Wu, Anhua|Sun, Xingmin Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China Frontiers in Cellular and Infection Microbiology [22352988]. 14, 2024.
• Sorg, Joseph A.|Chandra, Harish|Hassett, Daniel J|Sun, Xingmin Regulatory transcription factors of Clostridioides difficile pathogenesis with a focus on toxin regulation Critical Reviews in Microbiology [1040841X]. 49(3) , 2023.
• Wang, Shaohui|Heuler, Joshua|Bullock, Jessica|Qin, Junling|Chakraborty, Soumyadeep|Nathaniel, Agbendeh Lubem|Wang, Shifeng|Sun, Xingmin Cell Wall Protein 2 as a Vaccine Candidate Protects Mice Against Clostridioides difficile Infection Vaccines [2076393X]. 13(1) , 2024.
• Xue, Songyi|Xu, Wei|Wang, Lei|Wang, Xinling|Duan, Qianyu|Calcul, Laurent|Wang, Shaohui|Liu, Wenqi|Sun, Xingmin|Lu, Lu|Jiang, Shibo|Cai, Jianfeng An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood–Brain Barrier Permeability, Long Half-Life, and Promising Oral Bioavailability ACS Central Science [23747943]. 9(5) , 2023.
• Wickramage, Ishani|Heuler, Joshua|Peng, Zhong|Alrabaa, Sally|Sun, Xingmin Draft Genome Sequences and Genome Characterization of Three Toxigenic and Two Nontoxigenic Clostridioides difficile Clinical Isolates from Florida, USA Microbiology Resource Announcements [2576098X]. 12(5) , 2023.
• Jiang, Wei|Abdulkadir, Sami|Zhao, Xue|Sang, Peng|Tomatsidou, Anastasia|Zhang, Xiujun|Chen, Yu|Calcul, Laurent|Sun, Xingmin|Cheng, Feng|Hu, Yong|Cai, Jianfeng Inhibition of Hypoxia-Inducible Transcription Factor (HIF-1α) Signaling with Sulfonyl-γ-AApeptide Helices Journal of the American Chemical Society [00027863]. 145(36) , 2023.
• Wang, Shaohui|Ju, Xianghong|Heuler, Joshua|Zhang, Keshan|Duan, Zhibian|Warnakulasuriya Patabendige, Hiran Malinda Lamabadu|Zhao, Song|Sun, Xingmin Recombinant Fusion Protein Vaccine Containing Clostridioides difficile FliC and FliD Protects Mice against C. difficile Infection Infection and Immunity [00199567]. 91(4) , 2023.
• Cao, Chuanhai|Wang, Yafeng|Xue, Menglin|Gao, Ruixuan|Cai, Jianfeng|Chakraborty, Soumyadeep|Wang, Shaohui|Zhao, Xue|Gu, Meng|Sun, Xingmin Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics International Journal of Molecular Sciences [14220067]. 24(7) , 2023.
• Chandra, Harish|Kovall, Rhett A.|Yadav, Jagjit S.|Sun, Xingmin Host Immune Responses to Surface S-Layer Proteins (SLPs) of Clostridioides difficile Microorganisms [20762607]. 11(2) , 2023.
• Alrabaa, Sally|Peng, Zhong|Chakraborty, Soumyadeep|Sun, Xingmin|Wickramage, Ishani|Harmanus, Céline|Smits, Wiep Klaas|Kuijper, Ed J. The vanR Cd Mutation 343A>G, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida Microbiology Spectrum [21650497]. 11(3) , 2023.
• Chandra, Harish|Heuler, Joshua|Sun, Xingmin Mucosal Vaccination Strategies against Clostridioides difficile Infection Vaccines [2076393X]. 11(5) , 2023.
• Sun, Dongchang|Sun, Xingmin|Hu, Yongfei|Yamaichi, Yoshiharu Editorial: Horizontal gene transfer mediated bacterial antibiotic resistance, volume II Frontiers in Microbiology [1664302X]. 14, 2023.
• Wang, Shaohui|Heuler, Joshua|Wickramage, Ishani|Sun, Xingmin Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection Microbiology Spectrum [21650497]. 10(2) , 2022.
• Sacco, Michael D.|Wang, Shaohui|Adapa, Swamy R.|Zhang, Xiujun|Lewandowski, Eric M.|Gongora, Maura V.|Keramisanou, Dimitra|Atlas, Zachary D.|Townsend, Julia A.|Gatdula, Jean R.|Morgan, Ryan T.|Hammond, Lauren R.|Marty, Michael T.|Wang, Jun|Eswara, Prahathees J.|Gelis, Ioannis|Jiang, Rays H. Y.|Sun, Xingmin|Chen, Yu A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile Nature Communications [20411723]. 13(1) , 2022.
• Wang, Shaohui|Zhu, Duolong|Sun, Xingmin Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection Microbiology Spectrum [21650497]. 10(3) , 2022.
• Xue, Songyi|Wang, Xinling|Wang, Lei|Xu, Wei|Xia, Shuai|Sun, Lujia|Wang, Shaohui|Shen, Ning|Yang, Ziqi|Huang, Bo|Li, Sihao|Cao, Chuanhai|Calcul, Laurent|Sun, Xingmin|Lu, Lu|Cai, Jianfeng|Jiang, Shibo A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein Cell Discovery [20565968]. 8(1) , 2022.
• El Hadidy, Nashwa|Uversky, Vladimir N.|Sun, Xingmin On the Potential Significance of the Intrinsically Disordered Regions in theClostridiodes difficile Toxins A and B Current Protein and Peptide Science [13892037]. 23(3) , 2022.
• Limon, Anne-Claire D.|Patabendige, Hiran M. L. W.|Azhari, Ala|Sun, Xingmin|Kyle, Dennis E.|Wilson, Nerida G.|Baker, Bill J. Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp. Marine Drugs [16603397]. 20(9) , 2022.
• Zheng M, Li C, Zhou M, Jia R, Cai G, She F, Wei L, Wang S, Yu J, Wang D, Calcul L, Sun X, Luo X, Cheng F, Li Q, Wang Y, Cai J. Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR. Journal of medicinal chemistry. , 2021.
• Zhu D, Patabendige HMLW, Tomlinson BR, Wang S, Hussain S, Flores D, He Y, Shaw LN, Sun X. Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291. Environmental microbiology. , 2021.
• Heuler J, Fortier LC, Sun X. Clostridioides difficile Phage Biology and Application. FEMS microbiology reviews. , 2021.
• Wickramage I, Spigaglia P, Sun X. Mechanisms of antibiotic resistance of Clostridioides difficile. The Journal of antimicrobial chemotherapy. , 2021.
• Li, Chunpu|Zheng, Mengmeng|Zhou, Mi|She, Fengyu|Wei, Lulu|Calcul, Laurent|Cai, Jianfeng|Wang, Shaohui|Sun, Xingmin|Jia, Ru|Cai, Gang|Li, Qi|Wang, Yan|Cheng, Feng|Yu, Jie|Wang, Dingyan|Luo, Xiaomin Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR Journal of Medicinal Chemistry [00222623]. 64(15) , 2021.
• Zhu, Duolong|Wang, Shaohui|Sun, Xingmin FliW and CsrA Govern Flagellin (FliC) Synthesis and Play Pleiotropic Roles in Virulence and Physiology of Clostridioides difficile R20291 Frontiers in Microbiology [1664302X]. 12, 2021.
• Sun, Xingmin|Heuler, Joshua|Fortier, Louis-Charles Clostridioides difficile Phage Biology and Application FEMS Microbiology Reviews [01686445]. 45(5) , 2021.
• Zhu, Duolong|Patabendige, Hiran Malinda Lamabadu Warnakulasuriya|Tomlinson, Brooke Rene|Wang, Shaohui|Hussain, Syed|Flores, Domenica|He, Yongqun|Shaw, Lindsey N.|Sun, Xingmin Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291 Environmental Microbiology [14622912]. 23(9) , 2021.
• Wickramage, Ishani|Spigaglia, Patrizia|Sun, Xingmin Mechanisms of antibiotic resistance of Clostridioides difficile Journal of Antimicrobial Chemotherapy [03057453]. 76(12) , 2021.
• Chandra, Harish|Sharma, Krishna Kant|Tuovinen, Olli H.|Sun, Xingmin|Shukla, Pratyoosh Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile Gut Microbes [19490976]. 13(1) , 2021.
• Sun, Xingmin|Wang, Yuankai|kim, Hyeun Bum|Zhuge, Ronghua The Role of Dendritic Cells in Clostridium difficile Infection Journal of immunology [00221767]. 204(1_Supplement) , 2020.
• Daou N, Wang Y, Levdikov VM, Nandakumar M, Livny J, Bouillaut L, Blagova E, Zhang K, Belitsky BR, Rhee K, Wilkinson AJ, Sun X, Sonenshein AL. Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027. PloS one. 14(1) : e0206896, 2019.
• Sun, Xingmin|Wang, Shaohui|Feng, Hanping RhoA and MAPK Pathway in Toxin‐induced Production of TNF‐α during Clostridium difficile Infection The FASEB Journal [08926638]. 33(S1) , 2019.
• Zhu, Duolong|Bullock, Jessica|Sun, Xingmin|He, Yongqun Cwp22, a novel peptidoglycan cross‐linking enzyme, plays pleiotropic roles in Clostridioides difficile Environmental Microbiology [14622912]. 21(8) , 2019.
• Daou, Nadine|Wang, Yuanguo|Levdikov, Vladimir M.|Nandakumar, Madhumitha|Livny, Jonathan|Bouillaut, Laurent|Blagova, Elena|Zhang, Keshan|Belitsky, Boris R.|Rhee, Kyu|Wilkinson, Anthony J.|Sun, Xingmin|Sonenshein, Abraham L. Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027 PLoS ONE [19326203]. 14(1) , 2019.
• Peng, Zhong|Wang, Shaohui|Gide, Mussie|Zhu, Duolong|Lamabadu Warnakulasuriya Patabendige, Hiran Malinda|Li, Chunhui|Cai, Jianfeng|Sun, Xingmin A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice Frontiers in Microbiology [1664302X]. 9, 2019.
• Li C, Harmanus C, Zhu D, Meng X, Wang S, Duan J, Liu S, Fu C, Zhou P, Liu R, Wu A, Kuijper EJ, Smits WK, Fu L, Sun X. Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea. Emerging microbes & infections. 7(1) : 211, 2018.
• Wang S, Wang Y, Cai Y, Kelly CP, Sun X. Novel Chimeric Protein Vaccines Against Infection. Frontiers in immunology. 9: 2440, 2018.
• Wang Y, Wang S, Bouillaut L, Li C, Duan Z, Zhang K, Ju X, Tzipori S, Sonenshein AL, Sun X. Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters. Infection and immunity. 86(11) , 2018.
• Teng P, Li C, Peng Z, Anne Marie V, Nimmagadda A, Su M, Li Y, Sun X, Cai J. Facilely accessible quinoline derivatives as potent antibacterial agents. Bioorganic & medicinal chemistry. 26(12) : 3573-3579, 2018.
• Wang Y, Wang S, Kelly CP, Feng H, Greenberg A, Sun X. TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection. Infection and immunity. 86(8) , 2018.
• Li C, Teng P, Peng Z, Sang P, Sun X, Cai J. Bis-Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile. ChemMedChem. 13(14) : 1414-1420, 2018.
• Zhu D, Sorg JA, Sun X. Biology: Sporulation, Germination, and Corresponding Therapies for Infection. Frontiers in cellular and infection microbiology. 8: 29, 2018.
• Peng Z, Wang S, Gide M, Zhu D, Lamabadu Warnakulasuriya Patabendige HM, Li C, Cai J, Sun X. A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Infection in Mice. Frontiers in microbiology. 9: 3234, 2018.
• Xu D, Han L, Li C, Cao Q, Zhu D, Barrett NH, Harmody D, Chen J, Zhu H, McCarthy PJ, Sun X, Wang G. Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products. Frontiers in microbiology. 9: 787, 2018.
• Fu, Lei|Li, Chunhui|Wu, Anhua|Meng, Xiujuan|Duan, Juping|Liu, Sidi|Fu, Chenchao|Zhou, Pengcheng|Liu, Ruisi|Harmanus, Céline|Kuijper, Ed J.|Smits, Wiep Klaas|Zhu, Duolong|Wang, Shaohui|Sun, Xingmin Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea Emerging Microbes & Infections [22221751]. 7(1) , 2018.
• Wang, Shaohui|Wang, Yuanguo|Cai, Ying|Kelly, Ciaran P.|Sun, Xingmin Novel Chimeric Protein Vaccines Against Clostridium difficile Infection Frontiers in Immunology [16643224]. 9, 2018.
• Teng, Peng|Li, Chunhui|Peng, Zhong|Anne Marie, Vanderschouw|Nimmagadda, Alekhya|Su, Ma|Li, Yaqiong|Sun, Xingmin|Cai, Jianfeng Facilely accessible quinoline derivatives as potent antibacterial agents Bioorganic and Medicinal Chemistry [09680896]. 26(12) , 2018.
• Zhang, Keshan|Duan, Zhibian|Bouillaut, Laurent|Sonenshein, Abraham L.|Tzipori, Saul|Wang, Yuanguo|Wang, Shaohui|Li, Chunhui|Sun, Xingmin|Ju, Xianghong Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters Infection and Immunity [00199567]. 86(11) , 2018.
• Kelly, Ciaran P.|Greenberg, Andrew|Feng, Hanping|Wang, Yuanguo|Wang, Shaohui|Sun, Xingmin TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection Infection and Immunity [00199567]. 86(8) , 2018.
• Peng, Zhong|Sun, Xingmin|Li, Chunhui|Teng, Peng|Sang, Peng|Cai, Jianfeng Bis‐Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile ChemMedChem [18607179]. 13(14) , 2018.
• Zhu, Duolong|Sorg, Joseph A.|Sun, Xingmin Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection Frontiers in Cellular and Infection Microbiology [22352988]. 8, 2018.
• Xu, Dongbo|Han, Linna|Li, Chunhui|Cao, Qi|Zhu, Duolong|Barrett, Nolan H.|Harmody, Dedra|Chen, Jing|Zhu, Haining|McCarthy, Peter J.|Sun, Xingmin|Wang, Guojun Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products Frontiers in Microbiology [1664302X]. 9, 2018.
• Peng Z, Jin D, Kim HB, Stratton CW, Wu B, Tang YW, Sun X. Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing. Journal of clinical microbiology. 55(7) : 1998-2008, 2017.
• Peng Z, Addisu A, Alrabaa S, Sun X. Antibiotic Resistance and Toxin Production of Isolates from the Hospitalized Patients in a Large Hospital in Florida. Frontiers in microbiology. 8: 2584, 2017.
• Ghose C, Eugenis I, Edwards AN, Sun X, McBride SM, Ho DD. Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe. 37: 85-95, 2016.
• Ghose C, Eugenis I, Sun X, Edwards AN, McBride SM, Pride DT, Kelly CP, Ho DD. Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC. Emerging microbes & infections. 5: e8, 2016.
• Kim HB, Wang Y, Sun X. A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift. Journal of microbiology and biotechnology. 26(3) : 567-71, 2016.
• Kim, Hyeun Bum|Wang, Yuankai|Sun, Xingmin A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift Journal of Microbiology and Biotechnology [10177825]. 26(3) , 2016.
• Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, Sun X, Kashentseva EA, Dmitriev IP, Curiel DT, Shoemaker CB, Tzipori S. A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection. Clinical and vaccine immunology : CVI. 23(9) : 774-84, 2016.
• Yong Y, Liu S, Hua G, Jia R, Zhao Y, Sun X, Liao M, Ju X. Identification and functional characterization of Toll-like receptor 2-1 in geese. BMC veterinary research. 11: 108, 2015.
• Edwards, Adrianne N|McBride, Shonna M|Pride, David T|Kelly, Ciarán P|Sun, Xingmin|Ghose, Chandrabali|Eugenis, Ioannis|Ho, David D Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC Emerging Microbes & Infections [22221751]. 5(1) , 2016.
• Schmidt, Diane J.|Beamer, Gillian|Tremblay, Jacqueline M.|Steele, Jennifer A.|Kim, Hyeun Bum|Wang, Yaunkai|Debatis, Michele|Sun, Xingmin|Kashentseva, Elena A.|Dmitriev, Igor P.|Curiel, David T.|Shoemaker, Charles B.|Tzipori, Saul A Tetraspecific VHH-based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection Clinical and Vaccine Immunology [15566811]. 23(9) , 2016.
• Huang T, Perez-Cordon G, Shi L, Li G, Sun X, Wang X, Wang J, Feng H. Clostridium difficile toxin B intoxicated mouse colonic epithelial CT26 cells stimulate the activation of dendritic cells. Pathogens and disease. 73(3) , 2015.
• Wang YK, Zou Q, Sun JH, Wang HA, Sun X, Chen ZF, Yan YX. Screening of single-stranded DNA (ssDNA) aptamers against a zearalenone monoclonal antibody and development of a ssDNA-based enzyme-linked oligonucleotide assay for determination of zearalenone in corn. Journal of agricultural and food chemistry. 63(1) : 136-41, 2015.
• Zhang K, Zhao S, Wang Y, Zhu X, Shen H, Chen Y, Sun X. The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain. Anaerobe. 36: 49-52, 2015.
• Wang YK, Yan YX, Kim HB, Ju X, Zhao S, Zhang K, Tzipori S, Sun X. A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters. Human vaccines & immunotherapeutics. 11(9) : 2215-22, 2015.
• Sun X, Hirota SA. The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection. Molecular immunology. 63(2) : 193-202, 2015.
• Sponseller JK, Steele JA, Schmidt DJ, Kim HB, Beamer G, Sun X, Tzipori S. Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection. The Journal of infectious diseases. 211(8) : 1334-41, 2015.
• Sun, Xingmin|Hirota, Simon A. The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection Molecular Immunology [01615890]. 63(2) , 2015.
• Chen, Zhi-Fei|Sun, Xingmin|Wang, Yuan-Kai|Zou, Qi|Sun, Jian-He|Wang, Heng-an|Yan, Ya-Xian Screening of Single-Stranded DNA (ssDNA) Aptamers against a Zearalenone Monoclonal Antibody and Development of a ssDNA-Based Enzyme-Linked Oligonucleotide Assay for Determination of Zearalenone in Corn Journal of Agricultural and Food Chemistry [00218561]. 63(1) , 2015.
• Wang, Yuan-kai|Yan, Ya-xian|Kim, Hyeun Bum|Ju, Xianghong|Zhao, Song|Zhang, Keshan|Tzipori, Saul|Sun, Xingmin A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters Human Vaccines & Immunotherapeutics [21645515]. 11(9) , 2015.
• Huang, Tuxiong|Perez-Cordon, Gregorio|Shi, Lianfa|Li, Guangchao|Sun, Xingmin|Wang, Xiaoning|Wang, Jufang|Feng, Hanping Clostridium difficile toxin B intoxicated mouse colonic epithelial CT26 cells stimulate the activation of dendritic cells Pathogens and Disease [2049632X]. 73(3) , 2015.
• Kim HB, Zhang Q, Sun X, Beamer G, Wang Y, Tzipori S. Beneficial effect of oral tigecycline treatment on Clostridium difficile infection in gnotobiotic piglets. Antimicrobial agents and chemotherapy. 58(12) : 7560-4, 2014.
• Zhang, Keshan|Zhao, Song|Wang, Yuankai|Zhu, Xuejun|Shen, Hong|Chen, Yugen|Sun, Xingmin The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain Anaerobe [10759964]. 36, 2015.
• Zhao S, Ghose-Paul C, Zhang K, Tzipori S, Sun X. Immune-based treatment and prevention of Clostridium difficile infection. Human vaccines & immunotherapeutics. 10(12) : 3522-30, 2014.
• Ali Y, Koberg S, Heßner S, Sun X, Rabe B, Back A, Neve H, Heller KJ. Temperate Streptococcus thermophilus phages expressing superinfection exclusion proteins of the Ltp type. Frontiers in microbiology. 5: 98, 2014.
• Zhang, Juanmei|Rui, Xin|Wang, Li|Guan, Ying|Sun, Xingmin|Dong, Mingsheng Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation Food Control. 42, 2014.
• Zhang, Hongzhi|Li, Wei|Rui, Xin|Sun, Xingmin|Dong, Mingsheng Lactobacillus plantarum 70810 from Chinese paocai as a potential source of β-galactosidase for prebiotic galactooligosaccharides synthesis European Food Research and Technology. 236(5) , 2013.
• Kim H, B, Q, Zhang X, Sun G, Beamer D, Schmidt Y, Wang & S, Tzipori. Effect of oral tigecycline treatment on Clostridium difficile and human gut microflora. Antimicrob Agents Chemother.. 58(12) : 7560-4, 2014.
• Wu J, Lu Z, Nie M, Zhou H, Sun X, Xue X, Bi J, Fang G. Optimization of cryopreservation procedures for porcine endothelial progenitor cells. Journal of bioscience and bioengineering. 113(1) : 117-23, 2012.
• Steele J, Chen K, Sun X, Zhang Y, Wang H, Tzipori S, Feng H. Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models. The Journal of infectious diseases. 205(3) : 384-91, 2012.
• Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H. A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infection and immunity. 80(8) : 2678-88, 2012.
• Steele J, K, Chen X, Sun Y, Zhang H, Wang S, Tzipori & H, Feng. Toxemia is the cause of systemic disease in the piglet and mouse models of Clostridium difficile infection. J. Infect. Dis.. 205(3) : 384-91, 2012.
• Sun X, Wang H, Zhang Y, Chen K, Davis B, Feng H. Mouse relapse model of Clostridium difficile infection. Infection and immunity. 79(7) : 2856-64, 2011.
• Steele, Jennifer|Chen, Kevin|Sun, Xingmin|Zhang, Yongrong|Wang, Haiying|Tzipori, Saul|Feng, Hanping Toxemia is the Cause of Systemic Disease in Piglet and Mouse Models of Clostridium difficile Infection Gastroenterology [00165085]. 140(5) , 2011.
• Sun X, Savidge T, Feng H. The enterotoxicity of Clostridium difficile toxins. Toxins. 2(7) : 1848-80, 2010.
• He X, Wang J, Steele J, Sun X, Nie W, Tzipori S, Feng H. An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. Journal of microbiological methods. 78(1) : 97-100, 2009.
• He, Xiangyun|Wang, Jufang|Steele, Jennifer|Sun, Xingmin|Nie, Weijia|Tzipori, Saul|Feng, Hanping An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins Journal of Microbiological Methods. 78(1) , 2009.
• He, Xiangyun|Sun, Xingmin|Wang, Jufang|Wang, Xiaoning|Zhang, Quanshun|Tzipori, Saul|Feng, Hanping Antibody-Enhanced, Fc Gamma Receptor-Mediated Endocytosis of Clostridium difficile Toxin A Infection and Immunity. 77(6) , 2009.
• He X, Sun X, Wang J, Wang X, Zhang Q, Tzipori S, Feng H. Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infection and immunity. 77(6) : 2294-303, 2009.
• Sun X, He X, Tzipori S, Gerhard R, Feng H. Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages. Microbial pathogenesis. 46(6) : 298-305, 2009.
• Yang G, Zhou B, Wang J, He X, Sun X, Nie W, Tzipori S, Feng H. Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC microbiology. 8: 192, 2008.
• Sun X, Mierke DF, Biswas T, Lee SY, Landy A, Radman-Livaja M. Architecture of the 99 bp DNA-six-protein regulatory complex of the lambda att site. Molecular Cell. 24(4) : 569-80, 2006.
• Sun, Xingmin|Mierke, Dale F.|Biswas, Tapan|Lee, Sang Yeol|Landy, Arthur|Radman-Livaja, Marta Architecture of the 99 bp DNA ‐Six Protein Regulatory Complex of the λ att Site The FASEB Journal [08926638]. 21(5) , 2007.
• Sun X, Göhler A, Heller KJ, Neve H. The ltp gene of temperate Streptococcus thermophilus phage TP-J34 confers superinfection exclusion to Streptococcus thermophilus and Lactococcus lactis. Virology. 350(1) : 146-57, 2006.
• Sun, Xingmin|Mierke, Dale F.|Biswas, Tapan|Lee, Sang Yeol|Landy, Arthur|Radman-Livaja, Marta Architecture of the 99 bp DNA-Six-Protein Regulatory Complex of the λ att Site Molecular Cell. 24(4) , 2006.
• Sun, Xingmin|Göhler, André|Heller, Knut J.|Neve, Horst The ltp gene of temperate Streptococcus thermophilus phage TP-J34 confers superinfection exclusion to Streptococcus thermophilus and Lactococcus lactis Virology. 350(1) , 2006.