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Min You, Ph.D.

College Of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B. Downs Blvd.
MDC Box 8
Tampa, FL 33612

Academic Email: myou@health.usf.edu

Academic Phone: (813) 396-9107

Education

  • PhD, Pharmacognosy, University Of Illinois At Chicago, 1995

Interdisciplinary and Emerging Signature Programs

  • Cardiovascular

Research Interests

  • Dr. Min You's researches are focused on the molecular mechanisms underlying the development of alcoholic fatty liver, especially in two areas: the effects of ethanol on the signaling pathways of lipid metabolism regulations in the liver, and ethanol regulation of adiponectin, a hormone derived from adipocytes, and its hepatic signaling. Since the effects of ethanol, either directly on signaling molecules in liver or indirectly on adiponectin synthesis in adipose, can be manipulated by dietary fatty acids or pharmacological agents, these studies may lead to novel therapeutic strategies for the treatment of alcoholic fatty liver diseases and possibly steatohepatitis.

Memberships

  • American Association For the Study of Liver Diseases (Member, 2010 - Present)
  • Editorial Board: Hepatology (Member, 2010 - Present)
  • Research Society on Alcoholism (Member, 2002 - Present)
  • Hepatobiliary Pathophysiology Study Section, NIH (Permanent Member, 2009 - 2012)

Recent Publications

  • Hu, M.Wang, F.Li, X.Rogers, CQ.Liang, X.Finck, BN.Mitra, MS.Zhang, R.Mitchell, DA.You, M. Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. Hepatology (Baltimore, Md.). 55(2) : 437-46, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21953514
  • Everitt, H.Hu, M.Ajmo, JM.Rogers, CQ.Liang, X.Zhang, R.Yin, H.Choi, A.Bennett, ES.You, M. Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice. American journal of physiology. Gastrointestinal and liver physiology. , 2012. http://www.ncbi.nlm.nih.gov/pubmed/23139221
  • Yin, H.Hu, M.Zhang, R.Shen, Z.Flatow, L.You, M. MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1. The Journal of biological chemistry. 287(13) : 9817-26, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22308024
  • Liang, X.Hu, M.Rogers, CQ.Shen, Z.You, M. Role of SIRT1-FoxO1 Signaling in Dietary Saturated Fat-Dependent Upregulation of Liver Adiponectin Receptor 2 in Ethanol-Administered Mice. Antioxidants & redox signaling. 15(2) : 425-35, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21194380
  • Shen, Z.Liang, X.Rogers, CQ.Rideout, D.You, M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. American journal of physiology. Gastrointestinal and liver physiology. 298(3) : G364-74, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20007851
  • Shen, Z.Ajmo, JM.Rogers, CQ.Liang, X.Le, L.Murr, MM.Peng, Y.You, M. Role of SIRT1 in Regulation of LPS- or Two Ethanol Metabolites-Induced TNF{alpha} Production in Cultured Macrophage Cell Lines. American journal of physiology. Gastrointestinal and liver physiology. 296(5) : G1047-1053, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19299582
  • Ajmo, JM.Liang, X.Rogers, CQ.Pennock, B.You, M. Resveratrol Alleviates Alcoholic Fatty Liver in Mice. American journal of physiology. Gastrointestinal and liver physiology. 295(4) : G833-42, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18755807
  • You, M.Cao, Q.Liang, X.Ajmo, JM.Ness, GC. Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. The Journal of nutrition. 138(3) : 497-501, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18287356
  • You, M.Liang, X.Ajmo, JM.Ness, GC. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. American journal of physiology. Gastrointestinal and liver physiology. 294(4) : G892-8, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18239056
  • You, M.Considine, RV.Leone, TC.Kelly, DP.Crabb, DW. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology (Baltimore, Md.). 42(3) : 568-77, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16108051
  • You, M.Matsumoto, M.Pacold, CM.Cho, WK.Crabb, DW. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology. 127(6) : 1798-808, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15578517
  • Fischer, M.You, M.Matsumoto, M.Crabb, DW. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. The Journal of biological chemistry. 278(30) : 27997-8004, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12791698
  • You, M.Fischer, M.Deeg, MA.Crabb, DW. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). The Journal of biological chemistry. 277(32) : 29342-7, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12036955
  • You, M.Flick, LM.Yu, D.Feng, GS. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. The Journal of experimental medicine. 193(1) : 101-10, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11136824
  • You, M.Yu, DH.Feng, GS. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Molecular and cellular biology. 19(3) : 2416-24, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10022928
  • You, M.Zhao, Z. Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells. The Journal of biological chemistry. 272(37) : 23376-81, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9287352