Dominic D'Agostino, PhD

Assistant Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B. Downs Blvd. MDC 8
, FL 33612

Academic Email:

Academic Phone: (813) 396-9628

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  • PHD, Physiology, Neuroscience, University Of Medicine And Dentistry Of New Jersey, 2004
  • BS, Biological Sciences, Nutrition Science, Rutgers University, 1998

Interdisciplinary and Emerging Signature Programs

  • Metabolic Regulation and Disorders

Research Interests

  • Our laboratory develops and tests nutritional and metabolic therapies including ketogenic diets and ketogenic agents for CNS oxygen toxicity (seizures), epilepsy, metabolic disorders, Alzheimer's disease, ALS, muscle wasting and cancer. To investigate the mechanism of these pathologies we use a variety of in vivo and in vitro techniques, including radio-telemetry (EEG, EMG), electrophysiology, fluorescence microscopy, confocal microscopy, atomic force microscopy (AFM), biochemical assays, in vivo bioluminescence imaging, behavioral testing and exercise performance.


  • Microscopy and Microanalysis (Assistant Professor, 2010 - Present)
  • Undersea and Hyperbaric Medicine Society (Assistant Professor, 2005 - Present)
  • Aerospace Medicine (Assistant Professor, 2005 - Present)
  • Society for Neuroscience (Assistant Professor, 2004 - Present)
  • American Physiology Society (Assistant Professor, 1999 - Present)

Recent Publications

  • Ari, C.Poff, AM.Held, HE.Landon, CS.Goldhagen, CR.Mavromates, N.D'Agostino, DP. Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model. PloS one. 9(7) : e103526, 2014.
  • Seyfried, TN.Flores, R.Poff, AM.D'Agostino, DP.Mukherjee, P. Metabolic therapy: A new paradigm for managing malignant brain cancer. Cancer letters. , 2014.
  • Poff, AM.Ari, C.Arnold, P.Seyfried, TN.D'Agostino, DP. Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer. International journal of cancer. Journal international du cancer. 135(7) : 1711-20, 2014.
  • Seyfried, TN.Flores, RE.Poff, AM.D'Agostino, DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 35(3) : 515-27, 2014.
  • Poff, AM.Ari, C.Seyfried, TN.D'Agostino, DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PloS one. 8(6) : e65522, 2013.
  • Brownlow, ML.Benner, L.D'Agostino, D.Gordon, MN.Morgan, D. Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PloS one. 8(9) : e75713, 2013.
  • D'Agostino, DP.Pilla, R.Held, HE.Landon, CS.Puchowicz, M.Brunengraber, H.Ari, C.Arnold, P.Dean, JB. Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats. American journal of physiology. Regulatory, integrative and comparative physiology. 304(10) : R829-36, 2013.
  • D'Agostino, DP.McNally, HA.Dean, JB. Development and testing of hyperbaric atomic force microscopy (AFM) and fluorescence microscopy for biological applications. Journal of microscopy. 246(2) : 129-42, 2012.
  • Paoli, A.Grimaldi, K.D'Agostino, D.Cenci, L.Moro, T.Bianco, A.Palma, A. Ketogenic diet does not affect strength performance in elite artistic gymnasts. Journal of the International Society of Sports Nutrition. 9(1) : 34, 2012.
  • McNally H; D'Agostino DP Hyperbaric Atomic Force Microscopy System Performance and Applications Imaging and Microscopy. 13(1) : 41-43, 2011.
  • D'Agostino, DP.Olson, JE.Dean, JB. Acute hyperoxia increases lipid peroxidation and induces plasma membrane blebbing in human U87 glioblastoma cells. Neuroscience. 159(3) : 1011-22, 2009.
  • D'Agostino, D.Mazza, E.Neubauer, JA. Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia. American journal of physiology. Regulatory, integrative and comparative physiology. 296(1) : R102-18, 2009.
  • D'Agostino, DP.Colomb, DG.Dean, JB. Effects of hyperbaric gases on membrane nanostructure and function in neurons. Journal of applied physiology. 106(3) : 996-1003, 2009.
  • D'Agostino, DP.Putnam, RW.Dean, JB. Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen. Journal of neurophysiology. 98(2) : 1030-41, 2007.