Molecular Pharmacology and Physiology
Nuria Villalba Isabel, Ph.D.
Assistant Professor, College of Medicine Molecular Pharmacology & Physiology
Academic Email: nvillalba@usf.edu
Education
- PhD, Pharmaceutical Sciences, Complutense University, 2011
Interdisciplinary and Emerging Signature Programs
- Cardiovascular Sciences
Research Interests
- Blood-brain barrier dysfunction in systemic inflammation:
- My research focuses on the mechanisms that connect lung infection and brain dysfunction. I study the detrimental effects that the immune response triggered by lung bacterial infection has on the highly specialized brain endothelial cells that constitute the blood-brain barrier. I use in vitro approaches using primary mouse brain endothelial cells and an in vivo mouse model of lung infection by intratracheal administration of Pseudomonas aeruginosa cultures.
Memberships
- Awards Committee (Microcirculatory Society, 2021 - Present)
Recent Publications
- Ma Y, Yang X, Villalba N, Chatterjee V, Reynolds A, Spence S, Wu MH, Yuan SY. Circulating lymphocyte trafficking to the bone marrow contributes to lymphopenia in myocardial infarction. American journal of physiology. Heart and circulatory physiology. 322(4) : H622-H635, 2022.
- Yang X, Zheng E, Ma Y, Chatterjee V, Villalba N, Breslin JW, Liu R, Wu MH, Yuan SY. DHHC21 deficiency attenuates renal dysfunction during septic injury. Scientific reports. 11(1) : 11146, 2021.
- Villalba N, Baby S, Yuan SY. The Endothelial Glycocalyx as a Double-Edged Sword in Microvascular Homeostasis and Pathogenesis. Frontiers in cell and developmental biology. 9: 711003, 2021.
- Villalba N, Baby S, Cha BJ, Yuan SY. Site-specific opening of the blood-brain barrier by extracellular histones. Journal of neuroinflammation. 17(1) : 281, 2020.
- Ma Y, Zabell T, Creasy A, Yang X, Chatterjee V, Villalba N, Kistler EB, Wu MH, Yuan SY. Gut Ischemia Reperfusion Injury Induces Lung Inflammation via Mesenteric Lymph-Mediated Neutrophil Activation. Frontiers in immunology. 11: 586685, 2020.