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Molecular Medicine

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Molecular Medicine

John Tsibris

John Tsibris

Contact Info 12901 Bruce B. Downs Blvd.
MDC-18
Tampa FL 33612

Academic Email: tsibris@usf.edu

Academic Phone:(813) 974-7025

View My C.V.

Education

  • PHD, Biochemistry, Cornell University, 1966

Academic Philosophy

"Since basic scientists in clinical departments have easier access to human tissues, they are obligated to explore complex issues, such as the tissue microenvironment, with new technologies as they train the new generations of physicians."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cellular and Molecular Biology
  • Women & Children's Health

Research Interests

  • • Tissue-based interactome maps of human placentas have revealed interactions of VEGFR2, MDMX, PICALM and TRIM21 in chorionic villi. Protein levels of MDMX and PICALM correlate with clinical diagnoses of our patient cohort revealing their participation in metabolic networks that operate in pregnancy comorbidities, such as preeclampsia, diabetes and obesity.
  • • Cervical mucus Guaiacol Peroxidase activity (GPx) can define the fertile period of women. GPx can tag and help identify proteins associated with GPx during the menstrual cycle that could control mucus structure and function.

Memberships

  • Member (Society for Gynecologic Investigation, 1980 - Present)
  • Member (American Society for Biochemistry and Molecular Biology, 1970 - Present)
  • Member (American Chemical Society, 1967 - Present)

Recent Publications

  • Mong EF, Yang Y, Akat KM, Canfield J, VanWye J, Lockhart J, Tsibris JCM, Schatz F, Lockwood CJ, Tuschl T, Kayisli UA, Totary-Jain H. Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition. Scientific reports. 10(1) : 3029, 2020.
  • Canfield J, Arlier S, Mong EF, Lockhart J, VanWye J, Guzeloglu-Kayisli O, Schatz F, Magness RR, Lockwood CJ, Tsibris JCM, Kayisli UA, Totary-Jain H. Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(2) : 2759-2769, 2019.
  • Mong EF, Akat KM, Canfield J, Lockhart J, VanWye J, Matar A, Tsibris JCM, Wu JK, Tuschl T, Totary-Jain H. Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution. Arteriosclerosis, thrombosis, and vascular biology. 38(6) : 1321-1332, 2018.
  • Tsibris, J, Stanley Stevens, S., Seeley, K., Bell-Temin, H., Steffensen, T., Paidas-Teefey, C., Okuka, M., Whiteman, V., Spellacy, W. Membrane proteomic study of the VEGF receptor-2 network in the fetal compartment of human placentas near term Amer. J. Obstet. Gynecol.. 210(1) : S401, 2014.
  • Spellacy, W.N., Gilbert-Barness, E., Tsibris, J.C., Downes, K.L. Umbilical Cord Knots and Cord Blood Gases, Erythropoietin and Nucleated Red Blood Cell Levels: A Study of Possible Chronic Fetal Hypoxia. Fetal Pediatr. Pathol.. 32(2) : 158-161, 2013.
  • Huang J, Okuka M, Lu W, Tsibris JC, McLean MP, Keefe DL, Liu L. Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke. Reproductive toxicology (Elmsford, N.Y.). 35: 89-95, 2013.
  • Louis, J., Ho, S., Tsibris, J., Shaw, A., Luciano, A. Symptoms of sleep disturbance are associated with elevated umbilical cord C-reactive peptide. Amer. J. Obstet. Gynecol.. 208: Suppl 1 S87, 2013.
  • Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell research. 21(5) : 779-92, 2011.
  • Spellacy W, N, McCarthy J, M, Tsibris J, C, M, Gilbert‐Barness E, Downes K, L. Fetal Umbilical Cord Blood Erythropoietin, Interleukin‐6, pH, PO2, PCO2 and Base Excess Levels in Histologic and/or Clinical Chorioamnionitis: Is the Response Only Inflammatory? Fetal Pediatr. Pathol.. 28: 239-46., 2009.
  • McCarthy J, M, Gilbert‐Barness E, Tsibris J, C, M, Spellacy W, N. Are Placental Chorionic Capillary Nucleated Red Blood Cell Counts Useful Compared to Umbilical Cord Blood Tests? Fetal Diagn. Ther.. 22: 121-3., 2007.
  • Catherino W, Salams A, Potlog‐Nahari C, Leppert P, Tsibris J, Segars J. Gene Expression Studies in Leiomyomata: New Directions for Research. Semin. Reprod. Med.. 22: 83-90., 2004.
  • Tsibris J. The Guinea Pig Model for Uterine Leiomyomata: Gene‐Hormone Interaction? Fertil. Steril.. 82: 988-9., 2004.
  • Walocha J, A, Miodonski A, J, Tsibris J, M, Skrzat J. New Vessel Formation within Intramural Leiomyomata. Ginekol Pol.. 75: 203-8., 2004.
  • Catherino W, H, Prupas C, Tsibris J, C, Leppert P, C, Payson M, Nieman L, K, Segars J, H. Strategy for Elucidating Differentially Expressed Genes in Leiomyomata Identified by Microarray Technology. Fertil. Steril.. 80: 282-290., 2003.
  • Tsibris J, C, Maas S, Segars J, H, Nicosia S, V, Enkemann S, A, O’Brien W, F, Spellacy W, N. New Potential Regulators of Uterine Leiomyomata from DNA Arrays: The Ionotropic Glutamate Receptor GluR2. Biochem. Biophys. Res. Commun.. 312: 249-254., 2003.
  • Tsibris J, C, M, Segars J, Enkemann S, Coppola D, Wilbanks G, D, O’Brien W, F, Spellacy W, N. New and Old Regulators of Uterine Leiomyoma Growth from Screening with DNA Arrays. Fertil. Steril.. 80: 279-281., 2003.
  • Williams M, C, Tsibris J, C, M, Davis G, Baiano J, O''Brien W, F. Dose Variation Associated with Approximate Quarter Tablet Doses of Misoprostol. Amer. J. Obstet. Gynecol.. 187: 615-619., 2002.
  • Tsibris J, C, M, Segars J, Coppola D, Mane S, Wilbanks G, O’Brien W, F, Spellacy W, N. Insights from Gene Arrays on the Development and Growth Regulation of Uterine Leiomyomata. Fertil. Steril.. 78: 114-121., 2002.
  • Jazayeri A, Politz L, Tsibris J, C, M, Queen T, Spellacy W, N. Fetal Erythropoietin Levels in Pregnancies Complicated by Meconium Passage: Does Meconium Suggest Fetal Hypoxia? Amer. J. Obstet. Gynecol.. 183: 188-190., 2000.