Welcome to the Department of
To Discover, apply and disseminate knowledge of the molecular basis of health and disease.
To Translate, this knowledge into innovative tools for the diagnosis, treatment and prevention of disease.
To Train, and mentor future scientists and health care professionals.
To Provide, a collegial and scholarly environment where students, faculty and staff thrive.
- The primary focus of our laboratory is how facultative intracellular bacteria control expression of genes required for virulence. We currently study how Bartonella henselae regulates expression of genes required to mediate the unique vascular proliferation that is observed in patients infected with this bacterium. More recently we have focused on the role of sRNAs in gene regulatory circuits required for virulence in B. henselae.
- Our lab focuses on structure based drug design through the use of X-ray crystallography and molecular docking.
- My research is focused on discovering novel inhibitors of the protein monofunctional transglycosylase (MTG). MTG catalyzes the second to last step of bacterial cell wall formation and has only one known inhibitor, but unfortunately it is ineffective in humans. By combining fragment based molecular docking with protein X-ray crystallography I hope to discover novel inhibitors against MTG and other transglycosylases involved in bacterial cell wall formation. These novel inhibitors could lead to a new class of antibiotic that would ultimately be effective against bacteria that are resistant to many currently available drugs.