Joshua Gamsby, PhD

Assoc Professor, College of Medicine Molecular Medicine

Contact Info USF Health Neuroscience Institute
4001 E FLETCHER AVE
Tampa FL 33613

Academic Email: gamsby@usf.edu

Academic Phone:(813) 396-0667

View My C.V.

View My Lab Site

Education

Interdisciplinary and Emerging Signature Programs

• Allergy, Immunology & Infectious Disease
• Biomedical Engineering & Nanomedicine
• Cellular and Molecular Biology
• Neurodegenerative Disease
• Neuroscience

Research Interests

• My research is focused on understanding how circadian rhythms function to influence the timing of physiological and molecular processes, and how this control is impacted by disease. Our current research involves uncovering the link between circadian rhythm disruption in neurodegenerative diseases, such as Alzheimer's disease, as well as in addiction.

Recent Publications

• Mahoney H, Peterson E, Justin H, Gonzalez D, Cardona C, Stevanovic K, Faulkner J, Yunus A, Portugues A, Henriksen A, Burns C, McNeill C, Gamsby J, Gulick D. Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice. Scientific reports. 11(1) : 4746, 2021.
• Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC. Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. The Journal of clinical investigation. 131(4) , 2021.
• Carter B, Justin HS, Gulick D, Gamsby JJ. The Molecular Clock and Neurodegenerative Disease: A Stressful Time. Frontiers in molecular biosciences. 8: 644747, 2021.
• Beesley S, Kim DW, D''Alessandro M, Jin Y, Lee K, Joo H, Young Y, Tomko RJ, Faulkner J, Gamsby J, Kim JK, Lee C. Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 117(45) : 28402-28411, 2020.
• Sundaram S, Nagaraj S, Mahoney H, Portugues A, Li W, Millsaps K, Faulkner J, Yunus A, Burns C, Bloom C, Said M, Pinto L, Azam S, Flores M, Henriksen A, Gamsby J, Gulick D. Author Correction: Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer''s disease. Scientific reports. 9(1) : 15167, 2019.
• Sundaram S, Nagaraj S, Mahoney H, Portugues A, Li W, Millsaps K, Faulkner J, Yunus A, Burns C, Bloom C, Said M, Pinto L, Azam S, Flores M, Henriksen A, Gamsby J, Gulick D. Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer''s disease. Scientific reports. 9(1) : 13743, 2019.
• Gulick D, Gamsby JJ. Racing the clock: The role of circadian rhythmicity in addiction across the lifespan. Pharmacology & therapeutics. 188: 124-139, 2018.
• Dostal CR, Gamsby NS, Lawson MA, McCusker RH. Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone. Brain, behavior, and immunity. 69: 321-335, 2018.
• Stevanovic K, Yunus A, Joly-Amado A, Gordon M, Morgan D, Gulick D, Gamsby J. Disruption of normal circadian clock function in a mouse model of tauopathy. Experimental neurology. 294: 58-67, 2017.
• Gamsby JJ, Pribish AM, Stevanovic KD, Yunus A, Gulick D. Alcohol Intake Increases in Adolescent C57BL/6J Mice during Intermittent Cycles of Phase-Delayed, Long-Light Conditions. Frontiers in behavioral neuroscience. 11: 152, 2017.
• Gamsby JJ, Gulick D. Chronic shifts in the length and phase of the light cycle increase intermittent alcohol drinking in C57BL/6J mice. Frontiers in behavioral neuroscience. 9: 9, 2015.
• Gamsby JJ, Templeton EL, Bonvini LA, Wang W, Loros JJ, Dunlap JC, Green AI, Gulick D. The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels. Behavioural brain research. 249: 15-21, 2013.
• Grant GD, Gamsby J, Martyanov V, Brooks L, George LK, Mahoney JM, Loros JJ, Dunlap JC, Whitfield ML. Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control. Molecular biology of the cell. 23(16) : 3079-93, 2012.
• Poliandri AH, Gamsby JJ, Christian M, Spinella MJ, Loros JJ, Dunlap JC, Parker MG. Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). Journal of biological rhythms. 26(3) : 187-99, 2011.
• Heim KC, Gamsby JJ, Hever MP, Freemantle SJ, Loros JJ, Dunlap JC, Spinella MJ. Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140. PloS one. 4(10) : e7639, 2009.
• Gamsby JJ, Loros JJ, Dunlap JC. A phylogenetically conserved DNA damage response resets the circadian clock. Journal of biological rhythms. 24(3) : 193-202, 2009.
• McKibbon KA, Gamsby MK. Current status and future prospects. Health information and libraries journal. 25 Suppl 1: 66-7, 2008.
• Loros JJ, Dunlap JC, Larrondo LF, Shi M, Belden WJ, Gooch VD, Chen CH, Baker CL, Mehra A, Colot HV, Schwerdtfeger C, Lambreghts R, Collopy PD, Gamsby JJ, Hong CI. Circadian output, input, and intracellular oscillators: insights into the circadian systems of single cells. Cold Spring Harbor symposia on quantitative biology. 72: 201-14, 2007.
• Dunlap JC, Loros JJ, Colot HV, Mehra A, Belden WJ, Shi M, Hong CI, Larrondo LF, Baker CL, Chen CH, Schwerdtfeger C, Collopy PD, Gamsby JJ, Lambreghts R. A circadian clock in Neurospora: how genes and proteins cooperate to produce a sustained, entrainable, and compensated biological oscillator with a period of about a day. Cold Spring Harbor symposia on quantitative biology. 72: 57-68, 2007.
• Wang JW, Gamsby JJ, Highfill SL, Mora LB, Bloom GC, Yeatman TJ, Pan TC, Ramne AL, Chodosh LA, Cress WD, Chen J, Kerr WG. Deregulated expression of LRBA facilitates cancer cell growth. Oncogene. 23(23) : 4089-97, 2004.