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DeniseCooper

Denise Cooper, Ph.D.

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
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LauraHamel

Laura Hamel, MS

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our lab is focused on understanding palmitoylation, a post-translational modification of Ras (an oncogene implicated in ~30% of all cancers, and up to 90% in specific cancer types) involved in its localization to the plasma membrane where Ras elicits a majority of its activity.
  • My project focuses on understanding the regulation of Ras palmitoylation in three ways. Initially, I used a candidate based approach to screen for the enzyme responsible for Ras depalmitoylation. More recently, I have been screening mutants of the enzyme that palmitoylated Ras to see the effect of the mutations on activity, and finally, I will perform high-throughput inhibitor screens in an attempt to identify inhibitors of palmitoylation.
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