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GeorgeBlanck

George Blanck, Ph.D.

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • genomics and bioinformatics based analysis of gene expression and cancer; vaccine development and immunotherapeutics
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RyanGreen

Ryan Green, M.S.

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Cancer therapy is often initially successful only to be followed by recurrence of drug resistant disease. I am interested in studying this phenomenon. Work in my lab has revealed an important signaling pathway involved in tumorigenesis: natriuretic peptide receptor A (NPRA). The loss of NPRA signaling reduces angiogenesis and tumor growth and NPRA modulates the homing of somatic stem cells to tumors by altering the expression of C-X-C chemokine receptor 4. We have also developed a 3D fibrous scaffold to use as a cell culture environment. I would like to apply these findings to the study of cancer stem cells. CSCs are a sub population of cancer cells that express stem cell transcription factors associated with-self renewal, are drug resistant and initiate metastasis. My hypothesis is that NPRA signaling modulates CXCR4 expression in cancer cells leading to metastasis and an increase in the CSC population. I will also investigate the effects of 3D culture on the CSC population.
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