Morsani College of Medicine
Department of Molecular Medicine
Joint and Affiliate Faculty
Post-Doctorates / Research Associates
How To Apply
Master's of Science Program
Allergy, Immunology and Infectious Diseases
USF Health Byrd Alzheimer's Institute
Children's Research Institute (CRI)
Center for Drug Discovery and Innovation
H. Lee Moffitt Cancer Center
James A Haley Veteran's Hospital
Bay Pines VA Healthcare System
Assistant Professor, COLLEGE OF MEDICINE INTERNAL MEDICINE
Research in my lab focuses on understanding the fundamental mechanisms of tumor-stroma interaction that plays a critical role in tumor growth and metastasis. To this end, we have developed a novel nanofiber scaffold platform, which allows study of tumor progression in vitro and it is being exploited for research involving anti-cancer drug discovery and the mechanism of drug resistance. We are also exploring the role of cancer-associated fibroblasts, a key player in the tumor microenvironment in modulating tumor growth and cancer stem cell expansion, especially evaluating the role of the atrial natriuretic peptide receptor A signaling pathway as a target. My lab is also investigating the effects of a combined nano- and cell-therapy for the treatment of traumatic brain injury.
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Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Our lab focuses on structure based drug design through the use of X-ray crystallography and molecular docking.
My research is focused on discovering novel inhibitors of the protein monofunctional transglycosylase (MTG). MTG catalyzes the second to last step of bacterial cell wall formation and has only one known inhibitor, but unfortunately it is ineffective in humans. By combining fragment based molecular docking with protein X-ray crystallography I hope to discover novel inhibitors against MTG and other transglycosylases involved in bacterial cell wall formation. These novel inhibitors could lead to a new class of antibiotic that would ultimately be effective against bacteria that are resistant to many currently available drugs.
Alzheimer's disease, drug discovery and general Neuroscience