Our Mission

Research Focus

Featured Faculty

GloriaFerreira

Gloria Ferreira, Ph.D.

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our main research interest is defining the reaction and regulatory mechanisms of the first and terminal heme biosynthetic pathway enzymes, 5-aminolevulinate synthase (ALAS) and ferrochelatase (FC). Iron overload is a clinically important feature of sideroblastic anemia, X-linked SA, and myelodysplastic syndrome, which often results from either ineffective hematopoiesis or the repeated transfusions undergone by the patients to manage their erythropoietic defects. The pathological consequences of mitochondrial mishandling of iron and heme synthesis are also evident in erythropoietic porphyrias. There is no cure for the above disorders, and thus understanding the mechanisms of the terminal stages of erythropoiesis becomes necessary for discovering novel therapeutic targets. Towards this goal, our on-going research focuses on establishing 1) whether succinyl-CoA synthetase b-subunit allosterically fine-tunes the activity of erythroid ALAS and 2) the mechanism of Fe2+ delivery to FC.
Read More...

Education Programs

Ph.D. Program Master's Program Graduate Certificates Apply Now

Ph.D. Students

JonathanSabbagh

Jonathan Sabbagh, PhD

Postdoctoral Scholar Research, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Read More...