Morsani College of Medicine
Department of Molecular Medicine
Joint and Affiliate Faculty
Post-Doctorates / Research Associates
How To Apply
Master's of Science Program
Allergy, Immunology and Infectious Diseases
USF Health Byrd Alzheimer's Institute
Children's Research Institute (CRI)
Center for Drug Discovery and Innovation
H. Lee Moffitt Cancer Center
James A Haley Veteran's Hospital
Bay Pines VA Healthcare System
Assoc Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Human cells, including neurons in the brain, contain thousands of proteins that must work in concert to produce or perform our actions. Breathing, running, talking, remembering….all of these things are coordinated by thousands of proteins every second in our cells. This is what we work on in the lab. Hidden among those thousands of proteins is a group of sentinels called chaperones that, by definition, ensure propriety of all of these other proteins in the cell. Without chaperones, nothing would work properly. In fact, our lab and others have begun to show that many if not all of human disease is in some way affected by chaperones. There are approximately 150 chaperones in humans and each of these could be a drug target for human diseases. In particular, our lab has focused on a group of more than 15 neurological degenerative diseases collectively termed “tauopathies", the most common being Alzheimer’s disease. We have also seen our work move into glaucoma and depression.
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Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
- Our lab focuses on the interactions of molecular chaperones with various proteins associated with neurodegenerative disorders. The main focus of the lab is exploring the relationship between the protein Tau and Alzheimer’s Disease, but we have also recently started to explore the relationship between Myocilin and the disease Glaucoma.
-My project focuses on understanding the relationship between Myocilin and the co-chaperone Grp-94 in the disease Glaucoma. Using novel Grp94 inhibitors, I will look at inhibiting Grp94’s interaction with myocilin leading to clearance from the eye, and a reduction of symptoms associated with Glaucoma.
Research Associate, COLLEGE OF MEDICINE SURGERY
nanoparticles for targeting gene or drug delivery
hydrogel for tissue engineering
nanoparticles for diagnostics