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NiketaPatel

Niketa Patel, Ph.D.

Assoc Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Obesity continues to escalate as a significant public health problem and as the leading preventable cause of death. Genetic, environmental, behavioral, and socioeconomic factors cause excess weight gain and obesity. Increased proliferation and differentiation of pre-adipocytes to mature adipocytes (adipogenesis) within the fat tissues are central to obesity. Apoptosis, or programmed cell death, is an integral part of the cell cycle. Research from our laboratory involves elucidation of the biochemical and molecular mechanisms in the study of adipogenesis. Protein kinase C (PKC)d, a member of the novel PKC (nPKC) subfamily, plays an important role in the regulation of cell apoptosis. The focus of this laboratory is to decipher the molecular mechanisms regulating alternative expression of PKCĀ“ isoforms. Our laboratory has recently identified a new human PKCdelta isoform generated by alternative splicing. Alternative splicing is now acknowledged as being pivotal in generating the protein diversity required to fine tune the cellular functions. Regulation of alternative splicing involves interplay of the cis-elements with the trans-acting factors such as SR proteins and hnRNPs. This is currently being investigated using molecular biology techniques and cloning of minigenes to facilitate the identification of the splicing components in this system.
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LauraBlair

Laura Blair, PhD

Postdoctoral Scholar Research, COLLEGE OF MEDICINE MOLECULAR MEDICINE
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Ph.D. Students

  • Alzheimer's disease, drug discovery and general Neuroscience
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