Welcome to the Department of
To Discover, apply and disseminate knowledge of the molecular basis of health and disease.
To Translate, this knowledge into innovative tools for the diagnosis, treatment and prevention of disease.
To Train, and mentor future scientists and health care professionals.
To Provide, a collegial and scholarly environment where students, faculty and staff thrive.
- The overall goal of my research program is to understand the cellular and molecular mechanisms of obesity, metabolic syndrome, diabetes and metabolic pathways in neurodegenerative diseases. My lab has successfully carved a niche in integrating RNA biology with signaling in biologically relevant systems using gene ontology and Meta data.
- Lab projects include: Isolation, genetic characterization of adipose-derived stem cells (ASC) from lean and obese patients, genetic signatures of adipose depots, ASC and its exosomes and their application in regenerative medicine, inflammation and apoptosis in obesity, alternative splicing mechanisms and regulation by hormones and metabolites, the role and mode of action of long noncoding RNAs in diseases, intranasal insulin treatment and mechanisms in memory and cognition, drug discovery.
- Our lab focuses on structure based drug design through the use of X-ray crystallography and molecular docking.
- My research is focused on discovering novel inhibitors of the protein monofunctional transglycosylase (MTG). MTG catalyzes the second to last step of bacterial cell wall formation and has only one known inhibitor, but unfortunately it is ineffective in humans. By combining fragment based molecular docking with protein X-ray crystallography I hope to discover novel inhibitors against MTG and other transglycosylases involved in bacterial cell wall formation. These novel inhibitors could lead to a new class of antibiotic that would ultimately be effective against bacteria that are resistant to many currently available drugs.