Morsani College of Medicine
Department of Molecular Medicine
Joint and Affiliate Faculty
Post-Doctorates / Research Associates
How To Apply
Master's of Science Program
Allergy, Immunology and Infectious Diseases
USF Health Byrd Alzheimer's Institute
Children's Research Institute (CRI)
Center for Drug Discovery and Innovation
H. Lee Moffitt Cancer Center
James A Haley Veteran's Hospital
Bay Pines VA Healthcare System
Assistant Professor, PHYSICAL THERAPY & REHABILITATION SCIENCES
My research focuses on the neural mechanisms of schizophrenia (SCZ), a devastating disorder that afflicts approximately 1% of the population worldwide, with wide-reaching effects on caregivers, family, and friends of patients, as well as on the economy, with a focus on identifying potential targets for pharmacotherapy. In addition, I am interested in studying the mechanisms underlying the high rates of alcohol and drug abuse in patients with SCZ.
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Emmanuel W. Smith
Postdoctoral Scholar Research, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Our lab focuses on structure-based drug discovery through the use of X-ray crystallography and molecular docking. My main focus has been on chemokine proteins CXCL12 and CCL21 and their implication in cancer metastasis, but also on P.aeruginosa proteins LpxA and LpxD.
X-ray crystallography is a tool used to determine the atomic and molecular structure of protein crystals. This provides invaluable information about the protein, such as structural characterization of active sites. Once an active site is characterized, a rational drug design approach can be used.
Molecular docking is a computational tool that can be used to predict the binding orientation of small molecules to proteins. This can be used to study possible conformations a molecule might take in a protein active site, but can also be used to computationally screen millions of compounds in search of potential drug candidates.
Research Associate, COLLEGE OF MEDICINE MOLECULAR MEDICINE
misfolding and aggregation of intrinsically disordered proteins