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CaralinaMarin De Evsikova

Caralina Marin De Evsikova, PhD

Assistant Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • The early developmental environment plays a pivotal role in susceptibility to adulthood metabolic disease, such as obesity and diabetes. The long-term goal of this project is to understand how the maternal and embryonic environment alters gene expression, which ultimately leads to disease, via epigenetics. Epigenome of each individual is established during the egg-to-embryo transition, which is sensitive to teratogens, such as alcohol, bisphenol A, or dietary exposures. To identify the role of epigenetics in metabolic disease, I am using a naturally occurring “epigenetic barometer” allele (viable yellow) of the Agouti gene in mice, whose expression is controlled by methylation levels. Nutrigenomics & Healthspan. My long-term goal is to develop new mouse models of adult-onset metabolic diseases by monitoring in vivo physiology coupled with quantitative molecular genetics to detect genes and pathways involved with weight gain. This approach has been successful in identifying changes in eating, activity, and loss of circadian rhythms underlying “normal” weight fluctuations from across the lifespan.
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Post Docs

  • For my dissertation research project, I am studying RSV-induced mucogenic responses in an aged mouse model and we are currently testing a number of promising antivirals for prophylactic and/or therapeutic use.
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Ph.D. Students

ChunyanWang

Chunyan Wang, PhD

Research Associate, COLLEGE OF MEDICINE SURGERY
  • nanoparticles for targeting gene or drug delivery
  • hydrogel for tissue engineering
  • nanoparticles for diagnostics
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