Our Mission

Research Focus

Featured Faculty

GloriaFerreira

Gloria Ferreira, Ph.D.

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our main research interest is defining the reaction and regulatory mechanisms of the first and terminal heme biosynthetic pathway enzymes, 5-aminolevulinate synthase (ALAS) and ferrochelatase (FC). Iron overload is a clinically important feature of sideroblastic anemia, X-linked SA, and myelodysplastic syndrome, which often results from either ineffective hematopoiesis or the repeated transfusions undergone by the patients to manage their erythropoietic defects. The pathological consequences of mitochondrial mishandling of iron and heme synthesis are also evident in erythropoietic porphyrias. There is no cure for the above disorders, and thus understanding the mechanisms of the terminal stages of erythropoiesis becomes necessary for discovering novel therapeutic targets. Towards this goal, our on-going research focuses on establishing 1) whether succinyl-CoA synthetase b-subunit allosterically fine-tunes the activity of erythroid ALAS and 2) the mechanism of Fe2+ delivery to FC.
Read More...

Education Programs

Ph.D. Program Master's Program Graduate Certificates Apply Now

Ph.D. Students

AndrewStothert

Andrew Stothert

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • - Our lab focuses on the interactions of molecular chaperones with various proteins associated with neurodegenerative disorders. The main focus of the lab is exploring the relationship between the protein Tau and Alzheimer’s Disease, but we have also recently started to explore the relationship between Myocilin and the disease Glaucoma.
  • -My project focuses on understanding the relationship between Myocilin and the co-chaperone Grp-94 in the disease Glaucoma. Using novel Grp94 inhibitors, I will look at inhibiting Grp94’s interaction with myocilin leading to clearance from the eye, and a reduction of symptoms associated with Glaucoma.
Read More...

Post Docs

SarahFontaine

Sarah Fontaine, PhD

Postdoctoral Scholar Research, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Read More...