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CaralinaMarin De Evsikova

Caralina Marin De Evsikova, PhD

Assistant Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • The early developmental environment plays a pivotal role in susceptibility to adulthood metabolic disease, such as obesity and diabetes. The long-term goal of this project is to understand how the maternal and embryonic environment alters gene expression, which ultimately leads to disease, via epigenetics. Epigenome of each individual is established during the egg-to-embryo transition, which is sensitive to teratogens, such as alcohol, bisphenol A, or dietary exposures. To identify the role of epigenetics in metabolic disease, I am using a naturally occurring “epigenetic barometer” allele (viable yellow) of the Agouti gene in mice, whose expression is controlled by methylation levels. Nutrigenomics & Healthspan. My long-term goal is to develop new mouse models of adult-onset metabolic diseases by monitoring in vivo physiology coupled with quantitative molecular genetics to detect genes and pathways involved with weight gain. This approach has been successful in identifying changes in eating, activity, and loss of circadian rhythms underlying “normal” weight fluctuations from across the lifespan.
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Post Docs

JaredTur

Jared Tur

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • The Tipparaju lab focuses on voltage-gated potassium channel subunits (Kvβ1 and 2) within the heart. Currently we are investigating the molecular and physiological roles of Kvβ1.1 and Kvβ2 subunits within the heart. We utilize both en vivo, including a genetically deleted mouse model and en vitro models to study the overall molecular and physiological roles.
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Ph.D. Students

SarahFontaine

Sarah Fontaine, PhD

Postdoctoral Scholar Research, COLLEGE OF MEDICINE MOLECULAR MEDICINE
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