Welcome to the Department of
To Discover, apply and disseminate knowledge of the molecular basis of health and disease.
To Translate, this knowledge into innovative tools for the diagnosis, treatment and prevention of disease.
To Train, and mentor future scientists and health care professionals.
To Provide, a collegial and scholarly environment where students, faculty and staff thrive.
- The primary focus of our laboratory is how facultative intracellular bacteria control expression of genes required for virulence. We currently study how Bartonella henselae regulates expression of genes required to mediate the unique vascular proliferation that is observed in patients infected with this bacterium. More recently we have focused on the role of sRNAs in gene regulatory circuits required for virulence in B. henselae.
- With increasing knowledge of cancer genomes and epigenomes new molecules like bromodomains and histone demethylases, are emerging as promising anticancer targets. In my research, using structural biology and cell biology techniques I focus on the discovery of small molecule inhibitors targeting the epigenetic reader module bromodomain.