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Featured Faculty

JayaPadmanabhan

Jaya Padmanabhan, Ph.D.

Assistant Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our lab is interested in determining the molecular mechanisms involved in neurodegeneration associated with Alzheimer's disease (AD). Specifically, we are examining the role of cell cycle regulatory proteins and inflammatory proteins in neuritic plaque and neurofibrillary tangle formation. Experimental systems include transgenic mice and in vitro cultured transformed cells and primary neurons. While aberrant cell cycle activation is a characteristic feature of cancer progression, deregulated expression of cell cycle proteins in terminally differentiated neurons leads to catastrophe. Our recent studies showed that amyloid precursor protein (APP), which is associated with Alzheimer's disease may play a role in cancer progression. We are currently performing experiments to establish a correlative link between neurodegeneration and oncogenesis.
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Post Docs

YiruQin

Yiru Qin

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • My project focuses on developing a graphene materials-based theranostic strategy for ovarian cancer. Initially, I synthesized the graphene-based material from graphite by a one-step hydrothermal method and evaluate the immunotoxicity of this nanomaterial in macrophages. Secondly, the nanomaterial was conjugated with targeting ligands and therapeutic drugs. The imaging and specific therapeutic effect of the conjugates were measured in ovarian cancer cells. Last, the therapeutic efficacy and pharmacokinetic profiles of this conjugates will be evaluated in nude mice models
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Ph.D. Students

LeonidBreydo

Leonid Breydo, Ph.D.

Research Associate, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • misfolding and aggregation of intrinsically disordered proteins
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