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TomarGhansah

Tomar Ghansah, Ph.D.

Assistant Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • I am an active member of the Immunology Program at the Moffitt Cancer Center. I received my post-doctoral training in Transplant Immunology from Moffitt. Currently, my research focuses on Tumor Immunology/Pancreatic Cancer. Pancreatic cancer is one the top five cancers in the U.S. and is considered the most aggressive of all human cancers. Current cancer therapies are ineffective due to the expansion of regulatory immune cells such as MDSC and Tregs in pancreatic cancer patients. More specifically my research focuses on how immune regulatory cells respond to pancreatic cancer using pre-clinical pancreatic cancer animal models from USF and Moffitt in addition to clinical samples from pancreatic cancer patients from Moffitt. The overall goal of my research is to develop novel therapeutic strategies that may be translated and effective for the eradication of pancreatic cancer in humans.
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Ph.D. Students

MichaelCheung

Michael Cheung, BS, MS

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • My research interests focus on mesenchymal stem cells (MSCs), also known as multipotent stromal cells, and their role in modulating immune responses. In particular, our work has revealed that respiratory syncytial virus (RSV) may infect MSCs and increase the expression of immune regulatory factors including IFN-beta and indoleamine-2,3-dioxygenase (IDO), which down-regulate T cell proliferation and may be responsible for the lack of development of protective immunity to the virus despite recurrent infections. The use of the IDO-specific inhibitor 1-methyltryptophan on infected MSCs successfully reversed this effect. Future directions may include the use of an IDO inhibitor as a way to increase the immune response to the virus and lead to better outcomes in patients.
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Post Docs

LeonidBreydo

Leonid Breydo, Ph.D.

Research Associate, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • misfolding and aggregation of intrinsically disordered proteins
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