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NiketaPatel

Niketa Patel, Ph.D.

Assoc Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Obesity continues to escalate as a significant public health problem and as the leading preventable cause of death. Genetic, environmental, behavioral, and socioeconomic factors cause excess weight gain and obesity. Increased proliferation and differentiation of pre-adipocytes to mature adipocytes (adipogenesis) within the fat tissues are central to obesity. Apoptosis, or programmed cell death, is an integral part of the cell cycle. Research from our laboratory involves elucidation of the biochemical and molecular mechanisms in the study of adipogenesis. Protein kinase C (PKC)d, a member of the novel PKC (nPKC) subfamily, plays an important role in the regulation of cell apoptosis. The focus of this laboratory is to decipher the molecular mechanisms regulating alternative expression of PKCĀ“ isoforms. Our laboratory has recently identified a new human PKCdelta isoform generated by alternative splicing. Alternative splicing is now acknowledged as being pivotal in generating the protein diversity required to fine tune the cellular functions. Regulation of alternative splicing involves interplay of the cis-elements with the trans-acting factors such as SR proteins and hnRNPs. This is currently being investigated using molecular biology techniques and cloning of minigenes to facilitate the identification of the splicing components in this system.
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BoskoStojanovski

Bosko Stojanovski

Technical and Paraprofessional, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Research in our lab is aimed at studying the enzymological aspects of heme biosynthesis, particularly the initial enzyme of the pathway, 5-aminolevulinate synthase (ALAS), and the final enzyme, ferrochelatase. The main aim of my project is understanding how specific structural region of ALAS affect the enzymatic mechanism, kinetics, and conformational dynamics. Another area of interest is the characterization of the folding pathway of ALAS to its native state, as well as understanding the biochemical and biophysical properties of any stable, partially folded intermediates.
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Ph.D. Students

LeonidBreydo

Leonid Breydo, Ph.D.

Research Associate, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • misfolding and aggregation of intrinsically disordered proteins
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