Morsani College of Medicine
Department of Molecular Medicine
Joint and Affiliate Faculty
Post-Doctorates / Research Associates
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Master's of Science Program
Allergy, Immunology and Infectious Diseases
USF Health Byrd Alzheimer's Institute
Children's Research Institute (CRI)
Center for Drug Discovery and Innovation
H. Lee Moffitt Cancer Center
James A Haley Veteran's Hospital
Bay Pines VA Healthcare System
Assoc Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Our scientific interests are broadly defined as everything related to protein folding, misfolding and non-folding. However, the passion is definitely the field of protein non-folding , which is related to the discovery of intrinsically disordered proteins (IDPs), analysis of their abundance in nature, characterization of their exceptional structural and functional plasticity, understanding of their vital roles in various biological processes, and establishing their involvement in the pathogenesis of multiple human diseases. These and related aspects of IDPs are analyzed by a combination of a wide spectrum of computational, bioinformatics, and experimental approaches of modern protein biophysics. Due to the high abundance of IDPs in various proteomes, the exceptional structural and functional plasticity of these proteins, and their intimate relations to the maladies' pathogenesis, it is almost impossible to find an area of protein science where IDPs would not play a noticeable role.
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Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
- Our lab focuses on the interactions of molecular chaperones with various proteins associated with neurodegenerative disorders. The main focus of the lab is exploring the relationship between the protein Tau and Alzheimer’s Disease, but we have also recently started to explore the relationship between Myocilin and the disease Glaucoma.
-My project focuses on understanding the relationship between Myocilin and the co-chaperone Grp-94 in the disease Glaucoma. Using novel Grp94 inhibitors, I will look at inhibiting Grp94’s interaction with myocilin leading to clearance from the eye, and a reduction of symptoms associated with Glaucoma.