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VladimirUversky

Vladimir Uversky, PhD, DSc

Assoc Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our scientific interests are broadly defined as everything related to protein folding, misfolding and non-folding. However, the passion is definitely the field of protein non-folding , which is related to the discovery of intrinsically disordered proteins (IDPs), analysis of their abundance in nature, characterization of their exceptional structural and functional plasticity, understanding of their vital roles in various biological processes, and establishing their involvement in the pathogenesis of multiple human diseases. These and related aspects of IDPs are analyzed by a combination of a wide spectrum of computational, bioinformatics, and experimental approaches of modern protein biophysics. Due to the high abundance of IDPs in various proteomes, the exceptional structural and functional plasticity of these proteins, and their intimate relations to the maladies' pathogenesis, it is almost impossible to find an area of protein science where IDPs would not play a noticeable role.
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Ph.D. Students

LisaKirouac

Lisa Kirouac

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our lab studies the pathogenesis of Alzheimer's disease (AD). Specifically, we are interested in the molecular mechanisms that lead to the aberrant cell cycle that is observed in the AD brain. We have found that the amyloid precursor protein (APP), a central protein in AD, is modified and pathogenically processed in a cell-cycle specific manner. Furthermore, we have found that APP induces expression of proteins such as ras and gamma-synuclein, which are involved in cellular proliferation. The aim of my research is to elucidate the mechanisms by which APP induces the expression of these proliferation-associated proteins and determine how it leads to neurodegeneration and cognitive decline.
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Post Docs

ChunyanWang

Chunyan Wang, PhD

Technical and Paraprofessional, COLLEGE OF MEDICINE SURGERY
  • nanoparticles for targeting gene or drug delivery
  • hydrogel for tissue engineering
  • nanoparticles for diagnostics
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