Our Mission

Research Focus

Featured Faculty

DeniseCooper

Denise Cooper, Ph.D.

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
Read More...

Education Programs

Ph.D. Program Master's Program Graduate Certificates Apply Now

Post Docs

LynnBlake

Lynn Blake

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • My Ph.D. research topic focuses on hepatocyte stages of Plasmodium berghei and novel drug development against the increasing resistance against current treatments for malaria as well as the lack of drugs targeting liver stage parasites. Elucidation of the mechanism of action of these discovered drugs and their targets are some of the many goals of my thesis.
Read More...

Ph.D. Students

  • My current research focuses on understanding the role of the Amyloid Precursor Protein (APP) in pancreatic cancer. It is well known that pancreatic cancer has a poor prognosis and very low 5-year survival rates. Early detection poses a challenge mainly owing to the location of this organ and a non-symptomatic progression. At the molecular level, the oncogene RAS is known to be mutated and overexpressed in this cancer and the signaling pathways are somewhat understood. Using several pancreatic cancer cells lines, our recent findings show that APP is overexpressed in most pancreatic cancer cells lines as well. Preliminary studies have shown that APP can regulate RAS transcription levels and knock down of APP can inhibit RAS protein expression. Using this information, my project aims to understand the mechanism of regulation of RAS by APP and to establish APP, its processed fragments, and associated signaling pathways as possible targets for drug development against pancreatic cancer.
Read More...