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JayaPadmanabhan

Jaya Padmanabhan, Ph.D.

Assistant Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our lab is interested in determining the molecular mechanisms involved in neurodegeneration associated with Alzheimer's disease (AD). Specifically, we are examining the role of cell cycle regulatory proteins and inflammatory proteins in neuritic plaque and neurofibrillary tangle formation. Experimental systems include transgenic mice and in vitro cultured transformed cells and primary neurons. While aberrant cell cycle activation is a characteristic feature of cancer progression, deregulated expression of cell cycle proteins in terminally differentiated neurons leads to catastrophe. Our recent studies showed that amyloid precursor protein (APP), which is associated with Alzheimer's disease may play a role in cancer progression. We are currently performing experiments to establish a correlative link between neurodegeneration and oncogenesis.
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ShellyDeforte

Shelly Deforte

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • We study the structural and un-structural biology of proteins from an amino acid sequence based perspective. Both experimental evidence of intrinsically disordered regions in proteins, as well as computationally predicted regions of disorder, are used to study patterns in complete proteomes using bioinformatics approaches. Intrinsically disordered regions display different amino acid compositions, and different amino acid patterns than do structured regions. Furthermore, the distribution of intrinsic disorder throughout a protein deviates distinctively from random. Using innovative methods that exploit the unique properties of disordered regions, we are looking for subtle biomarkers of function and dysfunction within large bodies of protein sequence data. Currently, we are pursuing the role of disordered regions in enzyme function, and examining the unique properties of proteins associated with aging.
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