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MichaelWhite

Michael White, Ph.D.

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Research in the White laboratory is focused on how the malaria-related protozoa, Toxoplasma gondii, grows and develops in its human host. T. gondii is an environmental pathogen of the central nervous system (class B bioterrorism agent), which causes an often fatal disease in people who are immunocompromised. Projects in our laboratory focus on how these parasites interact with their host cell to produce new progeny and establish persistent infections. Our studies employ a diverse and extensive array of genetic and biochemical approaches with special emphasis on whole-cell strategies that enable a global understanding of the biochemical pathways involved in parasite growth and development. From forward genetic approaches that allow essential protein factors to be identified by genetic complementation to cataloging gene clusters within the whole-cell transcriptome that are responsible for transduction of the parasite cell division cycle, we are uncovering novel pathways that hold the key to important parasite biology.
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SashaSiegel

Sasha Siegel

Graduate Research Assistant, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • I am interested in exploring the cell cycle mechanisms governing a G0 stress response (dormancy) in Plasmodium falciparum, the eukaryotic pathogen that causes malaria. It is proposed that dormancy is correlated with the delayed clearance rates of parasite burden in patients that have a persistent malarial infection not cleared by conventional antimalarial compounds. This is most commonly seen along the Thailand/Cambodia border, the epicenter of the emergence of drug resistant Plasmodium falciparum.
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