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Featured Faculty

DanielleGulick

Danielle Gulick, PhD

Assistant Professor, PHYSICAL THERAPY & REHABILITATION SCIENCES
  • My research focuses on the neural mechanisms of schizophrenia (SCZ), a devastating disorder that afflicts approximately 1% of the population worldwide, with wide-reaching effects on caregivers, family, and friends of patients, as well as on the economy, with a focus on identifying potential targets for pharmacotherapy. In addition, I am interested in studying the mechanisms underlying the high rates of alcohol and drug abuse in patients with SCZ.
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Post Docs

Emmanuel W.Smith

Emmanuel W. Smith

Postdoctoral Scholar Research, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • Our lab focuses on structure-based drug discovery through the use of X-ray crystallography and molecular docking. My main focus has been on chemokine proteins CXCL12 and CCL21 and their implication in cancer metastasis, but also on P.aeruginosa proteins LpxA and LpxD.
  • X-ray crystallography is a tool used to determine the atomic and molecular structure of protein crystals. This provides invaluable information about the protein, such as structural characterization of active sites. Once an active site is characterized, a rational drug design approach can be used.
  • Molecular docking is a computational tool that can be used to predict the binding orientation of small molecules to proteins. This can be used to study possible conformations a molecule might take in a protein active site, but can also be used to computationally screen millions of compounds in search of potential drug candidates.
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Ph.D. Students

LeonidBreydo

Leonid Breydo, Ph.D.

Research Associate, COLLEGE OF MEDICINE MOLECULAR MEDICINE
  • misfolding and aggregation of intrinsically disordered proteins
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