Lynn Wecker, Ph.D.
Professor, Department of Psychiatry and Behavioral Neurosciences
- Fellow of the Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Program 1997-1998
- Postdoctoral, Vanderbilt University, 1973-1976
- Ph.D., University of Florida, 1972
Dr. Wecker's general interests are to understand how brain chemistry affects or determines behaviors with an emphasis on the etiology and treatment of neuropsychiatric and neuromotor disorders. Multidisciplinary approaches are used to elucidate how age, drugs of abuse, and environmental and genetic factors affect both brain chemistry and behavior. A major emphasis has focused on cholinergic mechanisms in the brain, particularly on the role and regulation of nicotinic receptors. Early studies demonstrated that sustained supplementation of rats with choline supports the synthesis of acetylcholine during conditions of increased neuronal demand and increases the density of neuronal nicotinic receptors in the brain. Since that time studies have focused on characterizing the regulation of α4β2 nicotinic receptors and have demonstrated that these receptors are regulated by phosphorylation/dephosphorylation mechanisms that alter receptor formation, maturation and expression, and that sustained nicotinic receptor activation modifies these events.
Current studies are investigating the role of neuronal nicotinic receptors in ataxia, and mechanisms mediating the neurotrophic actions of nicotinic agonists. Concurrent investigations are elucidating the role of these receptors in mediating both nicotine and alcohol addiction, and how perturbations in receptor expression during adolescence can predispose the adult brain to drug-seeking behavior. Results from these studies will further our understanding of the role and regulation of these receptors in neuropsychiatric and neuromotor disorders, and may lead to new strategies for the treatment of these disorders.
- Papke, R.L., Wecker, L. and Stitzel, J.A. (2010) Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Therap. 333: 501-518.
- Philpot, R.M., Wecker, L. and Kirstein, C. L. (2009) Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi. Int. J. Dev. Neurosci. 27: 805-815.
- Pollock, V.V., Pastoor, T., Katnik, C., Cuevas, J., and Wecker, L. (2009) Nicotinic Receptor a4 Subunits Are Phosphorylated at Distinct Stages in the Assembly and Maturation of α4β2 Receptors, Differentially Affecting Receptor Density and Function, Neurosci. 158: 1311-1325.
- Philpot, R.M. and Wecker, L. (2008) Dependence of Adolescent Novelty-seeking Behavior on Response Phenotype and Effects of Apparatus Scaling. Behavioral Neurosci. 122: 861-875.
- Pollock, V.V., Pastoor, T. and Wecker, L. (2007) Cyclic AMP-dependent Protein Kinase (PKA) Phosphorylates Serines 362 and 467 and Protein Kinase C Phosphorylates Serine 550 Within the M3/M4 Cytoplasmic Domain of Human Nicotinic Receptor α4 Subunits. J. Neurochem. 103: 456-466.
- Additional Publications by Dr. Wecker