Welcome to the USF Health
- Over the last 10 years my lab's emphasis has been on elucidating molecular mechanisms involved in the process of neuronal and glial injury following ischemia in the central nervous system. My research has sought to identify key components of the injury that can serve as biomarkers for disease progression and/or as target for therapeutics. We actively collaborate with experts from other disciplines in our efforts to develop new molecular entities for stroke therapeutics. Some of my current research interests are:
- 1. Small molecule design and development targeting sigma receptors for stroke therapy at delayed time points.
- 2. Exploring overlapping molecular mechanisms involved in expansion of the ischemic core in large-vessel stroke and infarct coalesces in lacunar infarcts.
- 3. Characterizing a novel endogenous agonist of acid-sensing ion channels that may be involved in physiological and pathophysiological function of this channel in the brain.
- Our interests lie in the role of nociceptive (defensive) sensory nerves in health and disease. Aberrant nociceptor stimulation contributes to unpleasant/debilitating sensations and inappropriate reflexes. Our focus is primarily on the sensory nerves of the airways. Activation of these nerves leads to cough, mucus secretion, bronchospasm, wheeze. In addition, activation of airway nerves contributes to autonomic regulatory control of the heart.
- To gain understanding of these events we study the electrical excitability of sensory nerves, investigating the interaction of inflammation, oxidative stress and inhaled pollutants (e.g. particulate matter and ozone) on receptors and ion channels expressed on nociceptive sensory nerves. Using a combination of electrophysiological, imaging and molecular biological techniques we are able to study ion channel/receptor function and nerve activation at multiple levels, from single channels to single cells to intact tissue to preclinical models.
Dr. Bibhu Mohanty - Tips on Heart Health
A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans
Plot of the odds of developing idiopathic dilated cardiomyopathy (a form of heart failure) from various genetic variations on chromosome 2. A variation in a calcium channel subunit (CACNB4) showed the greatest risk for developing the disease. The population is African-American, and the results are from a recent study published from the Heart Institute.