Welcome to the USF Health
Assoc Vice President, College of Medicine Office of Research
- Dr. Stephen B. Liggett's laboratory has several major interrelated initiatives:
- The study of the molecular basis of G-protein coupled receptor structure and function
- Delineation and characterization of human genetic variants within this receptor signaling network
- Association studies of genetic variants with heart and lung disease and their response to treatment to develop a platform for genetically-based personalized medicine
- Creation of genetically modified mice to define the mechanisms of heart and lung disease and "humanized mice" to explore the effects of genetic variation of human genes
- Determination of the full genome sequences of human Rhinoviruses using high throughput next-generation sequencing technologies; analysis of the relationships between viral genomes and asthma phenotypes
- Genomic-based drug discovery, most recently identifying bitter taste receptors on airway smooth muscle and showing that they act to bronchodilate, thus being a potential new therapy for asthma and COPD
Endowed Chair, College of Medicine Molecular Pharmacology & Physiology
- The goal of our research is to better understand the cellular and molecular regulation of cardiovascular function in health and disease. We investigate the signaling mechanisms of cell-cell and cell-matrix interactions in the microcirculation during inflammation, trauma, infection, sepsis, atherosclerosis, diabetes, and metastatic tumor development. A unique aspect of our studies is the emphasis on translating novel molecular mechanisms into systemic pathophysiology via integrative analyses of human, animal, and cell models of diseases. Techniques utilized in these studies include intravital microscopy, 3D fluorescence imaging, fluorescence resonance energy transfer, electric cell-substrate impedance sensor, cell isometric tension, and state-of-the-art molecular approaches including gene knockout and mutation. Our research has been continuously supported by the National Institutes of Health.
Dr. Bibhu Mohanty - Tips on Heart Health
A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans
Plot of the odds of developing idiopathic dilated cardiomyopathy (a form of heart failure) from various genetic variations on chromosome 2. A variation in a calcium channel subunit (CACNB4) showed the greatest risk for developing the disease. The population is African-American, and the results are from a recent study published from the Heart Institute.
Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution<br>
Infantile hemangiomas (IHs) are the most common benign vascular neoplasms of infancy, characterized by a rapid growth phase followed by a spontaneous involution, or triggered by propranolol treatment by poorly understood mechanisms. LIN28/let-7 axis plays a central role in the regulation of stem cell self-renewal and tumorigenesis. However, the role of LIN28B/let-7 signaling in IH pathogenesis has not yet been elucidated.
USF Health Institute News
The new USF Health Morsani College of Medicine and Heart Institute, shown here under construction in June 2018, will open late 2019. Emails are coming in about biotech start-ups, applications are pouring in from high-caliber students, powerhouse researchers are inquiring about opportunities, researc … [read more]
//www.youtube.com/watch?v=I4tCBzbwqZk Leaning forward, Julio Robaina intently watched as USF Health cardiologist Bibhu Mohanty, MD, sketched a series of shapes on a piece of notebook paper. As Dr. Mohanty pulled his hand away, the sketches were revealed. It was a heart, Robaina’s heart. Minutes ear … [read more]
The program, one of five awarded nationally this year, pairs faculty mentors from USF Health’s Heart Institute with promising students interested in cardiovascular or related biomedical research The American Heart Association has awarded the USF Health Morsani College of Medicine a three-year, … [read more]