Current Studies

The Pediatric Neuropsychiatry team is currently looking for patients interested in enrolling in the studies listed below.  If you are interested and would like more information, please contact the team by telephone (727-767-8230) or email (RothmanCtr@health.usf.edu)

Dr. Tanya Murphy

Title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Pilot Study of Extended-release Guanfacine in Children and Adolescents with Tourette's Disorder
Purpose:  To evaluate the efficacy of extended-release guanfacine on tic symptom severity in children with Tourette's Syndrome.

Title: Antibiotic treatment trial for the PANDAS/ PANS phenotype.
Purpose: To compare the effects of placebo vs. azithromycin (an antibiotic) on symptom severity in a subset of children with obsessive compulsive symptoms known as PANDAS/PANS.

Title: SPRITES: A Non-interventional, Longitudinal, Cohort Study to Evaluate the Effects of Long-term Sertraline Treatment in Children and Adolescents.
Purpose: To evaluate the risks and benefits of up to 3 years of treatment with sertraline on cognition (thinking), emotional and physical development, and pubertal (sexual) maturation in children ages 6 to 14 years.

Title: An Open-Label, Multicenter Study Evaluating the Safety and Tolerability of Once-Weekly Oral Aripiprazole in Children and Adolescents with Tourette’s Disorder
Purpose:  The purpose of this research study is to find out the potential benefits and safety of an investigational drug called Aripiprazole (sold under the name Abilify®) as a possible treatment for Tourette’s Disorder in children and adolescents 7-17 years of age.

Title: A Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate Efficacy and Safety of RO4917838 in Combination with Selective Serotonin Receptor Inhibitors in Patients with Obsessive Compulsive Disorder
Purpose: To investigate the safety and effectiveness of an investigational drug called RO4917838 or bitopertin (bee-topertin) for treating obsessive-compulsive disorder (OCD) in adults 18-65 years of age.

Title: Quality of Life, Comorbidities and Health Service Utilization in Youth with Tic Disorders.
Purpose: To evaluate the quality of life in youth with tic disorders, specifically on various aspects of family functioning and the daily challenges faced by children and their families. 

Dr. Eric Storch

Title: D-cycloserine augmentation of CBT for pediatric obsessive-compulsive disorder.
Purpose: To examine if d-cycloserine enhances cognitive-behavioral therapy for pediatric OCD.

Title: Utilizing Health Information Technology to improve Health Care Quality: Implementation of a Computerized Cognitive Behavior Therapy Protocol for Childhood Anxiety.
Purpose: To examine a computer assisted intervention for childhood anxiety.

Title: Stepped Care for Young Children after Trauma.
Purpose: To examine behavioral treatment for young children after trauma.

Title: Neurocognitive Predictors of Treatment Response in Cognitive-Behavioral Therapy for Adult Obsessive-Compulsive Disorder.
Purpose: To examine neurocognitive factors that may predict how well people do in cognitive-behavioral therapy.

Title: Double Blinded, Placebo-Controlled Trial of Palperidone Addition in SRI-Resistant Obsessive-Compulsive Disorder.
Purpose: To determine whether or not the Palperidone is effective in treating OCD in patients who are non-responsive to SRIs.

Title: Academic Experience in Pediatric Obsessive-Compulsive Disorder.
Purpose: To examine various measures of student academic performance in youth with OCD, including grades, time to complete homework, attendance rates, and changes in school placement, and the correlates of academic functioning in OCD.

Title: Living with Tics: Development and Pilot Examination of a Psychosocial Treatment to Improve Resilience and Coping in Youth with Tics.
Purpose: To pilot and test a psychotherapy protocol to improve coping and resilience in youth with tics.

Title: 2/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Purpose: To examine the efficacy of a manualized cognitive-behavioral therapy to treat anxiety disorders in early adolescents with autism spectrum disorders.

Title: Cognitive-Behavioral Treatment for Anxiety Disorders in Children with Autism Spectrum Disorders
Purpose: To examine the efficacy of a manualized cognitive-behavioral therapy to treat anxiety disorders in children with autism spectrum disorders.

Title: Psychometric properties of the Pediatric Anxiety Rating Scale in youth with Autism Spectrum Disorders
Purpose: To examine the Pediatric Anxiety Rating Scale and its validity and reliability in children with autism spectrum disorders.

Title: Mediators of Functional Impairment in Adult Obsessive-Compulsive Disorder
Purpose: To examine the factors that might mediate the relationship between OCD symptom severity and impairment in daily functioning.

Dr. Adam Lewin

Title: Neurocognitive Predictors of Treatment Response in Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive
Purpose: To examine neurocognitive predictors of treatment response in cognitive-behavioral therapy for pediatric OCD.

Title: Prepulse Inhibition In Youth with Obsessive Compulsive Disorder
Purpose: To examine the presence of sensorimotor gating deficits in youth with OCD.

Title: Family Based Cognitive-Behavioral Treatment for Preschoolers with Obsessive Compulsive Disorder: A Randomized Trial
Purpose: To examine a family focused intervention for young children with OCD.

Title: Predictors of Cognitive-Behavioral Treatment Response for Anxiety Disorders in Children
Purpose: To examine predictors of treatment response for children with separation anxiety disorder, social anxiety disorder, and generalized anxiety disorder.

Title: An Examination of Treatment Preference in Pediatric OCD
Purpose: To identify the treatment preferences of parents with children who are seeking treatment for obsessive-compulsive symptoms.

Dr. Omar Rahman

Title: Controlled Study of Habit Reversal Training for Trichotillomania in Youth
Purpose: To examine how well habit reversal training (HRT) works in treatment of Trichotillomania in children and adolescents; to examine the how well certain psychosocial factors predict treatment response.

Title: Predictors of Treatment Response for Trichotillomania in Adults
Purpose: To examine how well certain psychosocial factors predict treatment response in habit reversal training in adults with Trichotillomania.