Center of Excellence for Aging & Brain Repair

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Adam Smith, PhD, MSBE

Center Of Excellence For Aging & Brain Repair

Contact Info USF Health
12901 Bruce B. Downs Blvd. - MDC 78
Tampa, FL 33612

Academic Email:

Academic Phone: (813) 974-1452

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  • PhD, Medical Sciences, University Of South Florida, 2012
  • MS, Pharmacology & Neuroscience, University of South Florida, 2010
  • MSBE, Biomedical Engineering, University of South Florida, 2008
  • BS, Biomedical Sciences, University of South Florida, 2007

Academic Philosophy

"Entrepreneurial pharmacologist enamored with drug development. My research strategy involves crystal engineering pharmaceutical solid forms to optimize efficacy and add value via otherwise unattainable composition of matter patent protection."

Interdisciplinary and Emerging Signature Programs

  • Biomedical Engineering & Nanomedicine
  • Neurodegenerative Disease
  • Neuroscience

Research Interests

  • Currently engaged in the development of novel pharmaceutical cocrystals for the treatment of neuropsychiatric diseases.
  • Pharmacokinetics
  • WinNonlin
  • Preclinical and Clinical Experimentation
  • Drug Discovery and Development
  • Crystal Engineering
  • Patent Strategy


  • National Academy of Inventors (Honorary Member, 2013 - Present)
  • American Chemical Society (Member, 2013 - Present)
  • Society for Neuroscience (Member, 2010 - Present)
  • American Society for Neural Therapy and Repair (Member, 2008 - Present)

Recent Publications

  • Smith, A. J., Kim, S., Tan, J., Sneed, K., Sanberg, P. R., Borlongan, C. V., Shytle, R. D. Plasma and brain pharmacokinetics of previously unexplored lithium salts RSC Advances. 4: 12362–12365, 2014.
  • Sawmiller, D., S. Li, M. Shahaduzzaman, Smith A. J., D. Obregon, B. Giunta, C. V. Borlongan, P. R. Sanberg and J. Tan. Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury International Journal of Molecular Sciences. 1(15) : 895-904, 2014.
  • Smith, AJ.Kim, SH.Duggirala, NK.Jin, J.Wojtas, L.Ehrhart, J.Giunta, B.Tan, J.Zaworotko, MJ.Shytle, RD. Improving lithium therapeutics by crystal engineering of novel ionic cocrystals. Molecular pharmaceutics. 10(12) : 4728-38, 2013.
  • Smith, AJ.Kavuru, P.Arora, KK.Kesani, S.Tan, J.Zaworotko, MJ.Shytle, RD. Crystal engineering of green tea epigallocatechin-3-gallate (EGCg) cocrystals and pharmacokinetic modulation in rats. Molecular pharmaceutics. 10(8) : 2948-61, 2013.
  • Dragicevic, N.Smith, A.Lin, X.Yuan, F.Copes, N.Delic, V.Tan, J.Cao, C.Shytle, RD.Bradshaw, PC. Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction. Journal of Alzheimer's disease : JAD. 26(3) : 507-21, 2011.
  • Smith, AJ.Kavuru, P.Wojtas, L.Zaworotko, MJ.Shytle, RD. Cocrystals of quercetin with improved solubility and oral bioavailability. Molecular pharmaceutics. 8(5) : 1867-76, 2011.
  • Smith A. J., Giunta B., Shytle R. D., Blum J. M. Evaluation of a novel supplement to reduce blood glucose through the use for a modified oral glucose tolerance test American Journal of Translational Research. 2(3) : 219-225, 2011.
  • Shytle D., Tan J., Ehrhart J., Smith A. J., Sanberg C. D., Sanberg P. R., Anderson J., Bickford P. C. Effects of blue-green algae extracts on the proliferation of human adult stem cells: A preliminary study. Medical Science Monitor. 1(16) : BR1-5, 2010.
  • Smith, A.Giunta, B.Bickford, PC.Fountain, M.Tan, J.Shytle, RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. International journal of pharmaceutics. 389(1-2) : 207-12, 2010.
  • Rrapo E., Zhu T., Tian J., Hou H., Smith A. J., Fernandez F., Tan J., Giunta B. Green tea- EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. American Journal of Translational Research. 1(1) : 72-79, 2009.