Center of Excellence for Aging & Brain Repair

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Roland Shytle, PHD

Associate Professor, Center Of Excellence For Aging & Brain Repair

Center Of Excellence For Aging & Brain Repair

Contact Info CEABR, MDC-78, USF Health
12901 Bruce B. Downs Blvd.
Tampa, FL 33612

Academic Email:

Academic Phone: (813) 974-9171


  • PHD, Psychology, University Of Wyoming, 1994

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Neurodegenerative Disease
  • Neuroscience

Recent Publications

  • Bailey, AR.Hou, H.Song, M.Obregon, DF.Portis, S.Barger, S.Shytle, D.Stock, S.Mori, T.Sanberg, PG.Murphy, T.Tan, J. GFAP expression and social deficits in transgenic mice overexpressing human sAPPα. Glia. 61(9) : 1556-69, 2013.
  • Zhang, SQ.Sawmiller, D.Li, S.Rezai-Zadeh, K.Hou, H.Zhou, S.Shytle, D.Giunta, B.Fernandez, F.Mori, T.Tan, J. Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation. PloS one. 8(8) : e71913, 2013.
  • Small, B.Rawson, K.Martin, C.Eisel, S.Sanberg, CD.McEvoy, C.Sanberg, P.Shytle, RD.Tan, J.Bickford, PC. Nutraceutical Intervention Improves Older Adults' Cognitive Functioning. Rejuvenation research. , 2013.
  • Smith, AJ.Kim, SH.Duggirala, NK.Jin, J.Wojtas, L.Ehrhart, J.Giunta, B.Tan, J.Zaworotko, MJ.Shytle, RD. Improving lithium therapeutics by crystal engineering of novel ionic cocrystals. Molecular pharmaceutics. 10(12) : 4728-38, 2013.
  • Smith, AJ.Kavuru, P.Arora, KK.Kesani, S.Tan, J.Zaworotko, MJ.Shytle, RD. Crystal engineering of green tea epigallocatechin-3-gallate (EGCg) cocrystals and pharmacokinetic modulation in rats. Molecular pharmaceutics. 10(8) : 2948-61, 2013.
  • Sanberg, PR.Vindrola-Padros, C.Shytle, RD. Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond. Physiology & behavior. 107(5) : 801-8, 2012.
  • Shytle, RD.Tan, J.Bickford, PC.Rezai-Zadeh, K.Hou, L.Zeng, J.Sanberg, PR.Sanberg, CD.Alberte, RS.Fink, RC.Roschek, B. Optimized turmeric extract reduces β-Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice. Current Alzheimer research. 9(4) : 500-6, 2012.
  • Giunta, B.Ehrhart, J.Obregon, DF.Lam, L.Le, L.Jin, J.Fernandez, F.Tan, J.Shytle, RD. Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders. Molecular brain. 4(1) : 23, 2011.
  • Dragicevic, N.Smith, A.Lin, X.Yuan, F.Copes, N.Delic, V.Tan, J.Cao, C.Shytle, RD.Bradshaw, PC. Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction. Journal of Alzheimer's disease : JAD. 26(3) : 507-21, 2011.
  • Smith, AJ.Kavuru, P.Wojtas, L.Zaworotko, MJ.Shytle, RD. Cocrystals of quercetin with improved solubility and oral bioavailability. Molecular pharmaceutics. 8(5) : 1867-76, 2011.
  • Storch, EA.De Nadai, AS.Lewin, AB.McGuire, JF.Jones, AM.Mutch, PJ.Shytle, RD.Murphy, TK. Defining treatment response in pediatric tic disorders: a signal detection analysis of the Yale Global Tic Severity Scale. Journal of child and adolescent psychopharmacology. 21(6) : 621-7, 2011.
  • Smith, AJ.Giunta, B.Shytle, RD.Blum, JM. Evaluation of a novel supplement to reduce blood glucose through the use of a modified oral glucose tolerance test. American journal of translational research. 3(2) : 219-25, 2011.
  • Giunta, B.Hou, H.Zhu, Y.Salemi, J.Ruscin, A.Shytle, RD.Tan, J. Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. Neuroscience letters. 471(3) : 134-8, 2010.
  • Sheehan, DV.Sheehan, KH.Shytle, RD.Janavs, J.Bannon, Y.Rogers, JE.Milo, KM.Stock, SL.Wilkinson, B. Reliability and validity of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). The Journal of clinical psychiatry. 71(3) : 313-26, 2010.
  • Bachstetter, AD.Jernberg, J.Schlunk, A.Vila, JL.Hudson, C.Cole, MJ.Shytle, RD.Tan, J.Sanberg, PR.Sanberg, CD.Borlongan, C.Kaneko, Y.Tajiri, N.Gemma, C.Bickford, PC. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PloS one. 5(5) : e10496, 2010.
  • Smith, A.Giunta, B.Bickford, PC.Fountain, M.Tan, J.Shytle, RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. International journal of pharmaceutics. 389(1-2) : 207-12, 2010.
  • Shytle, DR.Tan, J.Ehrhart, J.Smith, AJ.Sanberg, CD.Sanberg, PR.Anderson, J.Bickford, PC. Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study. Medical science monitor : international medical journal of experimental and clinical research. 16(1) : BR1-5, 2010.
  • Shytle, RD.Bickford, PC.Rezai-zadeh, K.Hou, L.Zeng, J.Tan, J.Sanberg, PR.Sanberg, CD.Roschek, B.Fink, RC.Alberte, RS. Optimized turmeric extracts have potent anti-amyloidogenic effects. Current Alzheimer research. 6(6) : 564-71, 2009.
  • Parker-Athill, E.Luo, D.Bailey, A.Giunta, B.Tian, J.Shytle, RD.Murphy, T.Legradi, G.Tan, J. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. Journal of neuroimmunology. 217(1-2) : 20-7, 2009.
  • Rezai-Zadeh, K.Douglas Shytle, R.Bai, Y.Tian, J.Hou, H.Mori, T.Zeng, J.Obregon, D.Town, T.Tan, J. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Journal of cellular and molecular medicine. 13(3) : 574-88, 2009.
  • Bacher, I.Wu, B.Shytle, DR.George, TP. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert opinion on pharmacotherapy. 10(16) : 2709-21, 2009.
  • George, TP.Sacco, KA.Vessicchio, JC.Weinberger, AH.Shytle, RD. Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study. Journal of clinical psychopharmacology. 28(3) : 340-4, 2008.
  • Rezai-Zadeh, K.Arendash, GW.Hou, H.Fernandez, F.Jensen, M.Runfeldt, M.Shytle, RD.Tan, J. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain research. 1214: 177-87, 2008.
  • Rezai-Zadeh, K.Ehrhart, J.Bai, Y.Sanberg, PR.Bickford, P.Tan, J.Shytle, RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. Journal of neuroinflammation. 5: 41, 2008.