Javier Cuevas, Ph.D.

Assoc Professor, Cop Dept Of Pharmaceutical Science

Professor, College Of Medicine Family Medicine

Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Member, Diversity and Equal Opportunity Office, University of South Florida Health Science Center Liaison

Professor, Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida

Associate Professor, Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida

Professor, Pharmaceutical Sciences, College of Pharmacy, University of South Florida

Member, Department of Molecular Pharmacology and Physiology Executive Committee, College of Medicine, University of South Florida

Member, Neuroscience Signature Program Executive Committee, College of Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
Tampa, FL 33612

Academic Email: jcuevas@health.usf.edu

Academic Phone: (813) 974-4678

View My C.V.


  • PHD, Molecular and Cellular Pharmacology, University Of Miami, 1995
  • BA, Biology/Psychology, Dartmouth, 1988

Interdisciplinary and Emerging Signature Programs

  • Cardiovascular
  • Neuroscience


  • American Heart Association (Member, 2006 - Present)
  • American Society for Pharmacology and Experimental Therapeutics (member, 1999 - Present)
  • Society for Neuroscience (Member, 1999 - Present)

Recent Publications

  • Cuevas, J. Molecular mechanisms of dysautonomia during heart failure. Focus on "Heart failure-induced changes of voltage-gated Ca2+ channels and cell excitability in rat cardiac postganglionic neurons". American journal of physiology. Cell physiology. 306(2) : C121-2, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24108866
  • Katnik, C.Garcia, A.Behensky, AA.Yasny, IE.Shuster, AM.Seredenin, SB.Petrov, AV.Seifu, S.McAleer, J.Willing, A.Cuevas, J. Treatment with afobazole at delayed time points following ischemic stroke improves long-term functional and histological outcomes. Neurobiology of disease. 62: 354-64, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24141021
  • Behensky, AA.Cortes-Salva, M.Seminerio, MJ.Matsumoto, RR.Antilla, JC.Cuevas, J. In vitro evaluation of guanidine analogs as sigma receptor ligands for potential anti-stroke therapeutics. The Journal of pharmacology and experimental therapeutics. 344(1) : 155-66, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23065135
  • Panguluri, SK.Tur, J.Chapalamadugu, KC.Katnik, C.Cuevas, J.Tipparaju, SM. MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators. PloS one. 8(4) : e60545, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23573265
  • Behensky, AA.Yasny, IE.Shuster, AM.Seredenin, SB.Petrov, AV.Cuevas, J. Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by amyloid-β25-35. The Journal of pharmacology and experimental therapeutics. 347(2) : 458-67, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24006337
  • Behensky, AA.Yasny, IE.Shuster, AM.Seredenin, SB.Petrov, AV.Cuevas, J. Afobazole activation of σ-1 receptors modulates neuronal responses to amyloid-β25-35. The Journal of pharmacology and experimental therapeutics. 347(2) : 468-77, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24006338
  • Cuevas, J.Behensky, A.Deng, W.Katnik, C. Afobazole modulates neuronal response to ischemia and acidosis via activation of sigma-1 receptors. The Journal of pharmacology and experimental therapeutics. 339(1) : 152-60, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21715562
  • Yanamandra, N.Buzzeo, RW.Gabriel, M.Hazlehurst, LA.Mari, Y.Beaupre, DM.Cuevas, J. Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Depends on Ca2+ Influx through Plasma Membrane Ca2+ Channels. The Journal of pharmacology and experimental therapeutics. 337(3) : 636-43, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21378206
  • Cuevas, J.Rodriguez, A.Behensky, A.Katnik, C. Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors. The Journal of pharmacology and experimental therapeutics. 339(1) : 161-72, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21715561
  • Cortes-Salva, M.Nguyen, BL.Cuevas, J.Pennypacker, KR.Antilla, JC. Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines. Organic letters. 12(6) : 1316-9, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20170103
  • Mari, Y.Katnik, C.Cuevas, J. ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. Cell calcium. 48(1) : 70-82, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20678793
  • Pollock, VV.Pastoor, T.Katnik, C.Cuevas, J.Wecker, L. Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation. Neuroscience. 158(4) : 1311-25, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19101612
  • Ajmo, CT.Collier, LA.Leonardo, CC.Hall, AA.Green, SM.Womble, TA.Cuevas, J.Willing, AE.Pennypacker, KR. Blockade of adrenoreceptors inhibits the splenic response to stroke. Experimental neurology. 218(1) : 47-55, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19371742
  • Hall, AA.Herrera, Y.Ajmo, CT.Cuevas, J.Pennypacker, KR. Sigma receptors suppress multiple aspects of microglial activation. Glia. 57(7) : 744-54, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19031439
  • Zhang, H.Katnik, C.Cuevas, J. Sigma receptor activation inhibits voltage-gated sodium channels in rat intracardiac ganglion neurons. International journal of physiology, pathophysiology and pharmacology. 2(1) : 1-11, 2009. http://www.ncbi.nlm.nih.gov/pubmed/21383893
  • Herrera, Y.Katnik, C.Rodriguez, JD.Hall, AA.Willing, A.Pennypacker, KR.Cuevas, J. sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons. The Journal of pharmacology and experimental therapeutics. 327(2) : 491-502, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18723775
  • Song, S.Song, S.Zhang, H.Cuevas, J.Sanchez-Ramos, J. Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem cells and development. 16(5) : 747-56, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17999596
  • McCord, AM.Cuevas, J.Anderson, BE. Bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores. DNA and cell biology. 26(9) : 657-63, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17678436
  • Ajmo, CT.Vernon, DO.Collier, L.Pennypacker, KR.Cuevas, J. Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Current neurovascular research. 3(2) : 89-98, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16719792
  • Henning, RJ.Cuevas, J. Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. Journal of cardiovascular pharmacology. 48(1) : 802-13, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16891908
  • Katnik, C.Guerrero, WR.Pennypacker, KR.Herrera, Y.Cuevas, J. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. The Journal of pharmacology and experimental therapeutics. 319(3) : 1355-65, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16988055
  • Zhang, H.Cuevas, J. sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons. The Journal of pharmacology and experimental therapeutics. 313(3) : 1387-96, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15764734
  • Sawmiller, DR.Henning, RJ.Cuevas, J.Dehaven, WI.Vesely, DL. Coronary vascular effects of vasoactive intestinal peptide in the isolated perfused rat heart. Neuropeptides. (5) , 2004. http://www.ncbi.nlm.nih.gov/pubmed/15464194
  • Severance, EG.Zhang, H.Cruz, Y.Pakhlevaniants, S.Hadley, SH.Amin, J.Wecker, L.Reed, C.Cuevas, J. The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. Molecular pharmacology. (3) , 2004. http://www.ncbi.nlm.nih.gov/pubmed/15322233
  • Herber, DL.Severance, EG.Cuevas, J.Morgan, D.Gordon, MN. Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. (10) , 2004. http://www.ncbi.nlm.nih.gov/pubmed/15385583
  • Severance, EG.Cuevas, J. Distribution and synaptic localization of nicotinic acetylcholine receptors containing a novel alpha7 subunit isoform in embryonic rat cortical neurons. Neuroscience letters. (1-2) , 2004. http://www.ncbi.nlm.nih.gov/pubmed/15531097
  • DeHaven, WI.Cuevas, J. VPAC receptor modulation of neuroexcitability in intracardiac neurons: dependence on intracellular calcium mobilization and synergistic enhancement by PAC1 receptor activation. The Journal of biological chemistry. (39) , 2004. http://www.ncbi.nlm.nih.gov/pubmed/15280371
  • Zhang, H.Cuevas, J. Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. Journal of neurophysiology. (6) , 2002. http://www.ncbi.nlm.nih.gov/pubmed/12037190
  • DeHaven, WI.Cuevas, J. Heterogeneity of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide receptors in rat intrinsic cardiac neurons. Neuroscience letters. (1) , 2002. http://www.ncbi.nlm.nih.gov/pubmed/12123856
  • Liu, DM.Cuevas, J.Adams, DJ. VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation. The European journal of neuroscience. (7) , 2000. http://www.ncbi.nlm.nih.gov/pubmed/10947803
  • Cuevas, J.Adams, DJ. Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons. Journal of neurophysiology. 84(4) : 1961-70, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11024089
  • Cuevas, J.Roth, AL.Berg, DK. Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons. The Journal of physiology. 525 Pt 3: 735-46, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10856125
  • Loughnan, M.Bond, T.Atkins, A.Cuevas, J.Adams, DJ.Broxton, NM.Livett, BG.Down, JG.Jones, A.Alewood, PF.Lewis, RJ. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. The Journal of biological chemistry. (25) , 1998. http://www.ncbi.nlm.nih.gov/pubmed/9624161
  • Cuevas, J.Berg, DK. Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18(24) : 10335-44, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9852571
  • Cuevas, J.Harper, AA.Trequattrini, C.Adams, DJ. Passive and active membrane properties of isolated rat intracardiac neurons: regulation by H- and M-currents. Journal of neurophysiology. 78(4) : 1890-902, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9325358
  • Cuevas, J.Adams, DJ. M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons. Journal of neurophysiology. 78(4) : 1903-12, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9325359
  • Poth, K.Nutter, TJ.Cuevas, J.Parker, MJ.Adams, DJ.Luetje, CW. Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17(2) : 586-96, 1997. http://www.ncbi.nlm.nih.gov/pubmed/8987781
  • Cuevas, J.Adams, DJ. Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones. The Journal of physiology. 493 ( Pt 2): 503-15, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8782112
  • Cuevas, J.Adams, DJ. Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. British journal of pharmacology. 111(3) : 663-72, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7517326
  • Cuevas, J.Bassett, AL.Cameron, JS.Furukawa, T.Myerburg, RJ.Kimura, S. Effect of H+ on ATP-regulated K+ channels in feline ventricular myocytes. The American journal of physiology. 261(3 Pt 2) : H755-61, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1887923
  • Kimura, S.Bassett, AL.Furukawa, T.Cuevas, J.Myerburg, RJ. Electrophysiological properties and responses to simulated ischemia in cat ventricular myocytes of endocardial and epicardial origin. Circulation research. 66(2) : 469-77, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2297813
  • Cameron, JS.Gaide, MS.Goad, PL.Altman, CB.Cuevas, J.Myerburg, RJ.Bassett, AL. Enhanced adverse electrophysiologic effects of histamine after myocardial infarction in guinea pigs. The Journal of pharmacology and experimental therapeutics. 232(2) : 480-4, 1985. http://www.ncbi.nlm.nih.gov/pubmed/3155796

Positions Held

  • Associate Professor (Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida 2005 - 2006)
  • Assistant Professor (Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida 1999 - 2005)


  • Biotechnology Excellence Award (University of South Florida College of Medicine - 2006)
  • Outstanding Mentor (University of South Florida McNair Scholars Program - 2004)