EdwinWeeber

Edwin Weeber, Ph.D.

Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Associate Professor, Molecular Pharmacology and Physiology, University of South Florida

Professor, Molecular Pharmacology & Physiology, University of South Florida

Chief Scientific Officer, USF Health Byrd Alzheimer's Institute, University of South Florida

Director, Murine Neurobehavioral Testing Facility, University of South Florida

Contact Info 4001 E Fletcher Ave
Byrd 310
Tampa, FL 33613

Academic Email: eweeber@health.usf.edu

Academic Phone: (813) 396-9995

View My C.V.

Education

  • PhD, Neuroscience, University Of New Mexico, 1999

Interdisciplinary and Emerging Signature Programs

  • Biomedical Engineering & Nanomedicine
  • Neuroscience

Research Interests

  • The laboratory research programs center on reelin, Angelman Syndrome, ApoE and Alzheimer's Disease and neuroprosthetics.
  • For details please visit the laboratoory website
  • www.weeberlab.com

Memberships

  • American Society for Neurochemistry (ASN) (Member, 2004 - Present)
  • American Academy for the Advancement of Science (AAAS) (Member, 2004 - Present)
  • Molecular and Cellular Cognition Society (Member, 2002 - Present)
  • Society for Neuroscience (SFN) (Member, 1999 - Present)
  • Society for the Advancement of Chicanos and Native Americans in Science (Member, 1995 - Present)

Recent Publications

  • Filonova, I.Trotter, JH.Banko, JL.Weeber, EJ. Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model. Learning & memory (Cold Spring Harbor, N.Y.). 21(2) : 98-104, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24434871
  • Trotter, J.Lee, GH.Kazdoba, TM.Crowell, B.Domogauer, J.Mahoney, HM.Franco, SJ.Müller, U.Weeber, EJ.D'Arcangelo, G. Dab1 is required for synaptic plasticity and associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(39) : 15652-68, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24068831
  • Abisambra, J.Jinwal, UK.Miyata, Y.Rogers, J.Blair, L.Li, X.Seguin, SP.Wang, L.Jin, Y.Bacon, J.Brady, S.Cockman, M.Guidi, C.Zhang, J.Koren, J.Young, ZT.Atkins, CA.Zhang, B.Lawson, LY.Weeber, EJ.Brodsky, JL.Gestwicki, JE.Dickey, CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. 74(5) : 367-74, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23607970
  • Rogers, JT.Zhao, L.Trotter, JH.Rusiana, I.Peters, MM.Li, Q.Donaldson, E.Banko, JL.Keenoy, KE.Rebeck, GW.Hoe, HS.D'Arcangelo, G.Weeber, EJ. Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse. Journal of psychopharmacology (Oxford, England). 27(4) : 386-95, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23104248
  • Rodriguez, GA.Burns, MP.Weeber, EJ.Rebeck, GW. Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learning & memory (Cold Spring Harbor, N.Y.). 20(5) : 256-66, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23592036
  • Zeitlin, R.Patel, S.Solomon, R.Tran, J.Weeber, EJ.Echeverria, V. Cotinine enhances the extinction of contextual fear memory and reduces anxiety after fear conditioning. Behavioural brain research. 228(2) : 284-93, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22137886
  • Daily, J.Smith, AG.Weeber, EJ. Spatial and temporal silencing of the human maternal UBE3A gene. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 16(6) : 587-91, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22560727
  • Youmans, KL.Tai, LM.Nwabuisi-Heath, E.Jungbauer, L.Kanekiyo, T.Gan, M.Kim, J.Eimer, WA.Estus, S.Rebeck, GW.Weeber, EJ.Bu, G.Yu, C.Ladu, MJ. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. The Journal of biological chemistry. 287(50) : 41774-86, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23060451
  • Dumanis, SB.Cha, HJ.Song, JM.Trotter, JH.Spitzer, M.Lee, JY.Weeber, EJ.Turner, RS.Pak, DT.Rebeck, GW.Hoe, HS. ApoE receptor 2 regulates synapse and dendritic spine formation. PloS one. 6(2) : e17203, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21347244
  • Reddy, SS.Connor, TE.Weeber, EJ.Rebeck, W. Similarities and differences in structure, expression, and functions of VLDLR and ApoER2. Molecular neurodegeneration. 6: 30, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21554715
  • Jukkola, PI.Rogers, JT.Kaspar, BK.Weeber, EJ.Nishijima, I. Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Human molecular genetics. 20(5) : 1000-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21159798
  • Abisambra, JF.Blair, LJ.Hill, SE.Jones, JR.Kraft, C.Rogers, J.Koren, J.Jinwal, UK.Lawson, L.Johnson, AG.Wilcock, D.O'Leary, JC.Jansen-West, K.Muschol, M.Golde, TE.Weeber, EJ.Banko, J.Dickey, CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46) : 15374-82, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21084594
  • O'Leary, JC.Li, Q.Marinec, P.Blair, LJ.Congdon, EE.Johnson, AG.Jinwal, UK.Koren, J.Jones, JR.Kraft, C.Peters, M.Abisambra, JF.Duff, KE.Weeber, EJ.Gestwicki, JE.Dickey, CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. 5: 45, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21040568
  • Liu, Q.Trotter, J.Zhang, J.Peters, MM.Cheng, H.Bao, J.Han, X.Weeber, EJ.Bu, G. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(50) : 17068-78, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21159977
  • Gustin, RM.Bichell, TJ.Bubser, M.Daily, J.Filonova, I.Mrelashvili, D.Deutch, AY.Colbran, RJ.Weeber, EJ.Haas, KF. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Neurobiology of disease. 39(3) : 283-91, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20423730
  • Qiu, S.Champagne, DL.Peters, M.Catania, EH.Weeber, EJ.Levitt, P.Pimenta, AF. Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit. Biological psychiatry. 68(2) : 197-204, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20385375
  • Jinwal, UK.Miyata, Y.Koren, J.Jones, JR.Trotter, JH.Chang, L.O'Leary, J.Morgan, D.Lee, DC.Shults, CL.Rousaki, A.Weeber, EJ.Zuiderweg, ER.Gestwicki, JE.Dickey, CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(39) : 12079-88, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19793966
  • Korwek, KM.Trotter, JH.Ladu, MJ.Sullivan, PM.Weeber, EJ. ApoE isoform-dependent changes in hippocampal synaptic function. Molecular neurodegeneration. 4: 21, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19725929
  • Frewin, CL.Jaroszeski, M.Weeber, E.Muffly, KE.Kumar, A.Peters, M.Oliveros, A.Saddow, SE. Atomic force microscopy analysis of central nervous system cell morphology on silicon carbide and diamond substrates. Journal of molecular recognition : JMR. 22(5) : 380-8, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19585542
  • Dumanis, SB.Tesoriero, JA.Babus, LW.Nguyen, MT.Trotter, JH.Ladu, MJ.Weeber, EJ.Turner, RS.Xu, B.Rebeck, GW.Hoe, HS. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48) : 15317-22, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19955384
  • Rogers, JT.Weeber, EJ. Reelin and apoE actions on signal transduction, synaptic function and memory formation. Neuron glia biology. 4(3) : 259-70, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19674510
  • Fan, D.Yancey, PG.Qiu, S.Ding, L.Weeber, EJ.Linton, MF.Fazio, S. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry. 47(6) : 1631-9, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18197702
  • Levenson, JM.Qiu, S.Weeber, EJ. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Biochimica et biophysica acta. 1779(8) : 422-31, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18237558
  • Yamagata, T.Urano, H.Weeber, EJ.Nelson, DL.Nishijima, I. Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience. 154(4) : 1417-22, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18534766
  • Gelinas, JN.Banko, JL.Peters, MM.Klann, E.Weeber, EJ.Nguyen, PV. Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). 15(6) : 403-11, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18509114
  • Tanner, DC.Qiu, S.Bolognani, F.Partridge, LD.Weeber, EJ.Perrone-Bizzozero, NI. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus. 18(8) : 814-23, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18493953
  • Gelinas, JN.Banko, JL.Hou, L.Sonenberg, N.Weeber, EJ.Klann, E.Nguyen, PV. ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation. The Journal of biological chemistry. 282(37) : 27527-35, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17635924
  • Bolognani, F.Qiu, S.Tanner, DC.Paik, J.Perrone-Bizzozero, NI.Weeber, EJ. Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD. Neurobiology of learning and memory. 87(4) : 635-43, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17185008
  • Qiu, S.Weeber, EJ. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. Journal of neurophysiology. 97(3) : 2312-21, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17229826
  • van Woerden, GM.Harris, KD.Hojjati, MR.Gustin, RM.Qiu, S.de Avila Freire, R.Jiang, YH.Elgersma, Y.Weeber, EJ. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nature neuroscience. 10(3) : 280-2, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17259980
  • Qiu, S.Li, L.Weeber, EJ.May, JM. Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. Journal of neuroscience research. 85(5) : 1046-56, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17304569
  • Burk, RF.Hill, KE.Olson, GE.Weeber, EJ.Motley, AK.Winfrey, VP.Austin, LM. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(23) : 6207-11, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17553992
  • Nishijima, I.Yamagata, T.Spencer, CM.Weeber, EJ.Alekseyenko, O.Sweatt, JD.Momoi, MY.Ito, M.Armstrong, DL.Nelson, DL.Paylor, R.Bradley, A. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Human molecular genetics. 15(21) : 3241-50, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17008357
  • Qiu, S.Korwek, KM.Pratt-Davis, AR.Peters, M.Bergman, MY.Weeber, EJ. Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice. Neurobiology of learning and memory. 85(3) : 228-42, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16376115
  • Chan, CS.Weeber, EJ.Zong, L.Fuchs, E.Sweatt, JD.Davis, RL. Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(1) : 223-32, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16399691
  • Beffert, U.Durudas, A.Weeber, EJ.Stolt, PC.Giehl, KM.Sweatt, JD.Hammer, RE.Herz, J. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(7) : 2041-52, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16481437
  • Peters, MM.Hill, KE.Burk, RF.Weeber, EJ. Altered hippocampus synaptic function in selenoprotein P deficient mice. Molecular neurodegeneration. 1: 12, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16984644
  • Qiu, S.Korwek, KM.Weeber, EJ. A fresh look at an ancient receptor family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiology of learning and memory. 85(1) : 16-29, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16198608
  • Qiu, S.Zhao, LF.Korwek, KM.Weeber, EJ. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(50) : 12943-55, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17167084
  • Rebeck, GW.LaDu, MJ.Estus, S.Bu, G.Weeber, EJ. The generation and function of soluble apoE receptors in the CNS. Molecular neurodegeneration. 1: 15, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17062143
  • Sinagra, M.Verrier, D.Frankova, D.Korwek, KM.Blahos, J.Weeber, EJ.Manzoni, OJ.Chavis, P. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(26) : 6127-36, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15987942
  • Beffert, U.Weeber, EJ.Durudas, A.Qiu, S.Masiulis, I.Sweatt, JD.Li, WP.Adelmann, G.Frotscher, M.Hammer, RE.Herz, J. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 47(4) : 567-79, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16102539
  • Beffert, U.Weeber, EJ.Morfini, G.Ko, J.Brady, ST.Tsai, LH.Sweatt, JD.Herz, J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(8) : 1897-906, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14985430
  • Opal, P.Garcia, JJ.McCall, AE.Xu, B.Weeber, EJ.Sweatt, JD.Orr, HT.Zoghbi, HY. Generation and characterization of LANP/pp32 null mice. Molecular and cellular biology. 24(8) : 3140-9, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15060138
  • Marschang, P.Brich, J.Weeber, EJ.Sweatt, JD.Shelton, JM.Richardson, JA.Hammer, RE.Herz, J. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Molecular and cellular biology. 24(9) : 3782-93, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15082773
  • Strasser, V.Fasching, D.Hauser, C.Mayer, H.Bock, HH.Hiesberger, T.Herz, J.Weeber, EJ.Sweatt, JD.Pramatarova, A.Howell, B.Schneider, WJ.Nimpf, J. Receptor clustering is involved in Reelin signaling. Molecular and cellular biology. 24(3) : 1378-86, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14729980
  • Weeber, EJ.Caldwell, KK. Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex. Pharmacology, biochemistry, and behavior. 78(1) : 155-64, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15159145
  • May, P.Rohlmann, A.Bock, HH.Zurhove, K.Marth, JD.Schomburg, ED.Noebels, JL.Beffert, U.Sweatt, JD.Weeber, EJ.Herz, J. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Molecular and cellular biology. 24(20) : 8872-83, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15456862
  • Selcher, JC.Weeber, EJ.Christian, J.Nekrasova, T.Landreth, GE.Sweatt, JD. A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Learning & memory (Cold Spring Harbor, N.Y.). 10(1) : 26-39, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12551961
  • Sweatt, JD.Weeber, EJ. Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry. 42(7) : 873-6, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12819448
  • Chan, CS.Weeber, EJ.Kurup, S.Sweatt, JD.Davis, RL. Integrin requirement for hippocampal synaptic plasticity and spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(18) : 7107-16, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12904471
  • Sweatt, JD.Weeber, EJ.Lombroso, PJ. Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry. 42(6) : 741-4, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12921483
  • Yoo, SY.Pennesi, ME.Weeber, EJ.Xu, B.Atkinson, R.Chen, S.Armstrong, DL.Wu, SM.Sweatt, JD.Zoghbi, HY. SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron. 37(3) : 383-401, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12575948
  • Hendricks, TJ.Fyodorov, DV.Wegman, LJ.Lelutiu, NB.Pehek, EA.Yamamoto, B.Silver, J.Weeber, EJ.Sweatt, JD.Deneris, ES. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 37(2) : 233-47, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12546819
  • Weeber, EJ.Jiang, YH.Elgersma, Y.Varga, AW.Carrasquillo, Y.Brown, SE.Christian, JM.Mirnikjoo, B.Silva, A.Beaudet, AL.Sweatt, JD. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7) : 2634-44, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12684449
  • Weeber, EJ.Levenson, JM.Sweatt, JD. Molecular genetics of human cognition. Molecular interventions. 2(6) : 376-91, 339, 2002. http://www.ncbi.nlm.nih.gov/pubmed/14993414
  • Levenson, JM.Weeber, EJ.Sweatt, JD.Eskin, A. Glutamate uptake in synaptic plasticity: from mollusc to mammal. Current molecular medicine. 2(7) : 593-603, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12420799
  • Levenson, J.Weeber, E.Selcher, JC.Kategaya, LS.Sweatt, JD.Eskin, A. Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake. Nature neuroscience. 5(2) : 155-61, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11788834
  • Weeber, EJ.Sweatt, JD. Molecular neurobiology of human cognition. Neuron. 33(6) : 845-8, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11906692
  • Weeber, EJ.Beffert, U.Jones, C.Christian, JM.Forster, E.Sweatt, JD.Herz, J. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. The Journal of biological chemistry. 277(42) : 39944-52, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12167620
  • Gu, Y.McIlwain, KL.Weeber, EJ.Yamagata, T.Xu, B.Antalffy, BA.Reyes, C.Yuva-Paylor, L.Armstrong, D.Zoghbi, H.Sweatt, JD.Paylor, R.Nelson, DL. Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(7) : 2753-63, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11923441
  • Weeber, EJ.Levy, M.Sampson, MJ.Anflous, K.Armstrong, DL.Brown, SE.Sweatt, JD.Craigen, WJ. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. The Journal of biological chemistry. 277(21) : 18891-7, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11907043
  • Watase, K.Weeber, EJ.Xu, B.Antalffy, B.Yuva-Paylor, L.Hashimoto, K.Kano, M.Atkinson, R.Sun, Y.Armstrong, DL.Sweatt, JD.Orr, HT.Paylor, R.Zoghbi, HY. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron. 34(6) : 905-19, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12086639
  • Selcher, JC.Weeber, EJ.Varga, AW.Sweatt, JD.Swank, M. Protein kinase signal transduction cascades in mammalian associative conditioning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 8(2) : 122-31, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11954557
  • Dineley, KT.Weeber, EJ.Atkins, C.Adams, JP.Anderson, AE.Sweatt, JD. Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination. Journal of neurochemistry. 77(4) : 961-71, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11359861
  • Weeber, EJ.Savage, DD.Sutherland, RJ.Caldwell, KK. Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex. Neurobiology of learning and memory. 76(2) : 151-82, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11502147
  • Seung Kim, HF.Weeber, EJ.Sweatt, JD.Stoll, AL.Marangell, LB. Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. Molecular psychiatry. 6(2) : 246-8, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11317232
  • Mirnikjoo, B.Brown, SE.Kim, HF.Marangell, LB.Sweatt, JD.Weeber, EJ. Protein kinase inhibition by omega-3 fatty acids. The Journal of biological chemistry. 276(14) : 10888-96, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11152679
  • Weeber, EJ.Atkins, CM.Selcher, JC.Varga, AW.Mirnikjoo, B.Paylor, R.Leitges, M.Sweatt, JD. A role for the beta isoform of protein kinase C in fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(16) : 5906-14, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10934237
  • Allan, AM.Weeber, EJ.Savage, DD.Caldwell, KK. Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring. Alcoholism, clinical and experimental research. 21(8) : 1534-41, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9394128

Positions Held

  • Assistant Professor (Department of Neuroscience, Baylor College of Medicine 2003 - 2004)
  • Reasearch Instructor (Department of Neuroscience, Baylor College of Medicine 2002 - 2003)

Awards/Honors

  • Federation European Neuroscience Societies (FENS) Scientific Highlight of the Year Award 2008)
  • Med Scholars Mentoring Award (VUMC) 2006)
  • National Alliance for Research on Schizophrenia and Depression (NARSAD) Award 2004)
  • Cynthia and George Mitchell Award in Dementia Research 2003)
  • American Federation for Aging Research (AFAR) Award 2003)