Plasminogen activator inhibitor-1 (PAI-1) promotes tissue remodeling in a mouse model of asthma and in patients with severe asthma. A low molecular weight PAI-1 inhibitor was found to reduce inflammation and fibrosis in a murine model of chronic asthma. A gain-of-function genetic polymorphism of PAI-1 is associated with the development of asthma and decreased lung function. Therefore, PAI-1 can be a potential target for asthma prevention and the treatment of severe asthma.
Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in the United States. Our previous study shows that the prevalence of CRS with nasal polyps (NP) is significantly higher in the elderly population compared with the non-elderly. We found that there was significant reduction of innate immune molecules with aging process. We are investigating the age-related pathogenesis of CRS and NP using human samples and a murine model of NP.
Recent Publications
Ryu G Dhong HJ Park M Hwang NY Kim DK Kim HY Chung SK Rhee CS Cho SH Hong SD Kim DW, . Age-associated changes in chronic rhinosinusitis endotypes.Clinical Experimental Allergy. 50(5) : 585-596, 2020.
Cho SH Ledford D Lockey R. Medical management strategy in acute and chronic rhinosinusitisJ Allergy Clin Immunol In Practice. 8(5) : 1559-1564, 2020.
Kim SR Lee KB Park HJ Kim HJ Kim DI Cho SH Lee YC, . Bronchial epithelial PI3K-δ signaling promotes allergic inflammation via NLRP3 inflammasome-dependent and -independent manners.Allergy Asthma Immunol Res.. 12(2) : 338-358, 2020.
Bachert C Han JK Desrosiers M Hellings PW Amin N Lee SE Mullol J Greos LS Bosso JV Laidlaw TM Cervin AU Maspero JF Hopkins C Olze H Canonica GW Paggiaro P Cho SH Fokkens WJ Fujieda S Zhang M Lu X Fan C Draikiwicz S Kamat SA Khan A Pirozzi G Patel N Graham NMH Ruddy M Staudinger H Weinreich D Stahl N Yancopoulos GD Mannent L. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.Lancet. 394(1020) : 1638-1650, 2019.
Ryu G Kim DK Dhong HJ Eun KM Lee KE Kong IG Kim H Chung SK Kim DY Rhee CS Cho SH Hong SD Kim DW, . Immunological Characteristics in Refractory Chronic Rhinosinusitis with Nasal Polyps Undergoing Revision Surgeries.Allergy Asthma Immunol Res.. 11(5) : 664-676, 2019.
Cho SH Jo A Casale T Jeong SJ Hong SJ Cho J Holbrook JT Kumar R Smith LJ. Soy isoflavones reduce asthma exacerbation in asthmatics with high PAI-1 producing genotypes.J Allergy Clin Immunol. 144(1) : 109-117, 2019.
Kim DK Eun KM Kim MK Cho D Han SA Han SY Seo Y Lee DH Cho SH Kim DW, . Comparison Between Signature Cytokines of Nasal Tissues in Subtypes of Chronic Rhinosinusitis.Allergy Asthma Immunol Res.. 11(2) : 201-211, 2019.
Jeong JS Kim SR Cho SH Lee Y. A Novel Insight on Endotyping Heterogeneous Severe Asthma based on Endoplasmic Reticulum Stress - Beyond the ‘type 2/non-type 2 dichotomy’Int J Mol Sci. 20(3) , 2019.
Kim JS Jeong JS Lee KB Kim SL Choe YH Kwon SH Cho SH Lee YC, . Phosphoinositide 3-kinase delta could be a biomarker for eosinophilic nasal polyps.Scientific Reports.. 8(1) : 15990, 2018.
Kim DK Kang SI Kong G Cho YH Song SK Hyun SJ Cho SD Han SY Cho SH Kim DW, . Two-Track Medical Treatment Strategy According to the Clinical Scoring System for Chronic Rhinosinusitis.Allergy Asthma Immunol Res.. 10(5) : 490-502, 2018.
Jeong JS Lee KB Kim SR Kim DI Park HJ Cho SH Kolliputi N Kim SH Lee YC, . Airway epithelial phosphoinositide 3-kinase delta contributes to the modulation of fungi-induced innate immune response.Thorax. 73(8) : 758-768, 2018.
Jo A Lee SH Kim DY Hong SJ Teng MN Kolliputi N Lockey RF Schleimer RP Cho SH, . Mast Cell-Derived Plasminogen Activator Inhibitor Type 1 Promotes Airway Inflammation and Remodeling in a Murine Model of Asthma.J Allergy Clin Immunol. 142(1) : 294-297, 2018.
Jeong JS Kim SR Cho SH Lee Y. Endoplasmic Reticulum Stress and Allergic Diseases.Curr Allergy Asthma Rep.. 17(12) : 82, 2017.
Chen J Zhou Y Zhang L Wang Y Pepper AN Cho SH Kong . Individualized Treatment of Allergic Rhinitis According to Nasal CytologyAllergy Asthma Immunol Res.. 9(5) : 403-409, 2017.
Kim DK Jin HR Eun KM Mo JH Cho SH Oh S Cho D Kim DW, . The role of interleukin-33 in chronic rhinosinusitis.Thorax. 9(4) : 299-306, 2017.
Kim DW, Cho SH. Emerging Endotypes of Chronic Rhinosinusitis and Its Application to Precision Medicine.Allergy, asthma & immunology research. 9(4) : 299-306, 2017.
Kim DW Kulka M Jo AR Eun KM Arizmendi N Tancowny BP Hong SN Lee JP Jin HR Lockey RF Kim DK Cho SH, . Cross-Talk between Human Mast Cells and Epithelial Cells by IgE-mediated Periostin Production in Eosinophilic Nasal Polyps.J Allergy Clin Immunol. 139(5) : 1692-1695, 2017.
Chen J Zhou Y Wang Y Zheng Y Lai X Westermann-Clark E Cho SH Kong W. Specific immunoglobulin E and immunoglobulin G4 toward major allergens of house-dust mite during allergen-specific immunotherapy.Am J Rhinol Allergy. 31(3) : 156-160, 2017.
Sherenian MG, Cho SH, Levin A, Min JY, Oh SS, Hu D, Galanter J, Sen S, Huntsman S, Eng C, Rodriguez-Santana JR, Serebrisky D, Avila PC, Kalhan R, Smith LJ, Borrell LN, Seibold MA, Keoki Williams L, Burchard EG, Kumar R. PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. , 2017.
Carnés J Iraola V Cho SH Esch RE, . Mite allergen extracts and clinical practice.Ann Allergy Asthma Immunol.. 118(3) : 249-256, 2017.
Kim DK Jin HR Eun KM Mo JH Cho SH Oh S Cho D Kim DW. The role of interleukin-33
in chronic rhinosinusitis.Thorax.. : pii: thoraxjnl-2016-208772. doi: 10.1136/thoraxjnl-2016-208772., 2016.
Kim DY Lee SH Carter RG Kato A Schleimer RP Cho SH. A Newly Established Murine Model of Sinus
Disease Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps.Am J Respir Cell Mol Biol.. 55(2) : 170-5, 2016.
Cho SH Min JY Kang J Kim DY Oh SS Torgerson DR Del-Pino-Yanes MM Hu D Sen S Huntsman S
Eng C Farber HJ Rodriguez-Cintron W Rodriguez-Santana JR Serebrisky D Thyne SM Borrell LN Williams
LK Seibold MA Burchard EG Avila PC Kumar R. PAI-1 Gene- and Early Life Infection Interaction on Asthma
Risk, Asthma Exacerbations, and Reduced Lung Function: The GALA II Study.PLoS One. 11(8) : e0157848, 2016.
Cho SH Min JY Kim DY Oh SS Torgerson DR Pino-Yanes M Hu D Sen S Huntsman S Eng C Farber HJ Rodriguez-Cintron W Rodriguez-Santana JR Serebrisky D Thyne SM Borrell LN Williams LK DuPont W Seibold MA Burchard EG Avila PC Kumar R. Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function.PLoS One.. 11(8) : e0157848. doi: 10.1371/journal.pone.0157848. eCollection 2016., 2016.
Kim DY, Lee SH, Carter RG, Kato A, Schleimer RP, Cho SH. A Recently Established Murine Model of Nasal Polyps Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps.American journal of respiratory cell and molecular biology. 55(2) : 170-5, 2016.
Kim DW Eun KM Jin HR Cho SH Kim DK. Prolonged allergen exposure is associated with increased thymic stromal lymphopoietin expression and Th2-skewing in mouse models of chronic rhinosinusitis.Laryngoscope. 126(8) : 265-72, 2016.
Cho SH Kim DW Gevaert P. Chronic Rhinosinusitis without Nasal Polyps.J Allergy Clin Immunol Pract.. 4(4) : 575-82, 2016.
Cho SH Kim DW Gevaert P. Chronic rhinosinusitis phenotypes; Chronic rhinosinusitis without nasal
polyps.J Allergy Clin Immunol Pract.. 4(4) : 575-82, 2016.
Cho SH Bachert C Lockey RF. Chronic Rhinosinusitis Phenotypes: An Approach to Better Medical Care for Chronic Rhinosinusitis.J Allergy Clin Immunol Pract.. 4(4) : 639-42, 2016.
Kim DW, Kim DK, Jo A, Jin HR, Eun KM, Mo JH, Cho SH. Age-Related Decline of Neutrophilic Inflammation Is Associated with Better Postoperative Prognosis in Non-eosinophilic Nasal Polyps.PloS One. 11(2) : e0148442, 2016.
Cho SH, Kim DW, Lee SH, Kolliputi N, Hong SJ, Suh L, Norton J, Hulse KE, Seshadri S, Conley DB, Kern RC, Tan BK, Peters A, Grammer LC, Schleimer RP. Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling.American journal of respiratory cell and molecular biology. 53(5) : 601-6, 2015.
Lee KS Jeong JS Kim SR Cho SH Kolliputi N Ko YH Lee KB Park SC Park HJ Lee YC. Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress.Thorax. 71(1) : 52-63, 2015.
Kim DK, Jin HR, Eun KM, Mutusamy S, Cho SH, Oh S, Kim DW. Non-Eosinophilic Nasal Polyps Shows Increased Epithelial Proliferation and Localized Disease Pattern in the Early Stage.PloS one. 10(10) : e0139945, 2015.
Kim SR, Kim HJ, Kim DI, Lee KB, Park HJ, Jeong JS, Cho SH, Lee YC. Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced Lung Injury.Theranostics. 5(12) : 1343-62, 2015.
Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2.Cellular immunology. 297(1) : 40-5, 2015.
Kim DY, Cho SH, Takabayashi T, Schleimer RP. Chronic Rhinosinusitis and the Coagulation System.Allergy, asthma & immunology research. 7(5) : 421-30, 2015.
Galam L, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Adenovirus-mediated transfer of the SOCS-1 gene to mouse lung confers protection against hyperoxic acute lung injury.Free radical biology & medicine. 84: 196-205, 2015.
Cho SH, Lee SH, Kato A, Takabayashi T, Kulka M, Shin SC, Schleimer RP. Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-β1.American journal of respiratory cell and molecular biology. 52(1) : 88-95, 2015.
Cho SH, Hong SJ, Chen H, Habib A, Cho D, Lee SH, Kang J, Ward T, Boushey HA, Schleimer RP, Avila PC. Plasminogen activator inhibitor-1 in sputum and nasal lavage fluids increases in asthmatic patients during common colds.The Journal of allergy and clinical immunology. 133(5) : 1465-7, 1467.e1-2, 2014.
Lee H, Kim SR, Oh Y, Cho SH, Schleimer RP, Lee YC. Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma.American journal of respiratory cell and molecular biology. 50(4) : 667-77, 2014.
Suh JS, Cho SH, Chung JH, Moon A, Park YK, Cho BS. A polymorphism of interleukin-22 receptor alpha-1 is associated with the development of childhood IgA nephropathy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 33(10) : 571-7, 2013.
Takabayashi T, Kato A, Peters AT, Hulse KE, Suh LA, Carter R, Norton J, Grammer LC, Cho SH, Tan BK, Chandra RK, Conley DB, Kern RC, Fujieda S, Schleimer RP. Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.American journal of respiratory and critical care medicine. 187(1) : 49-57, 2013.
Lee SH, Eren M, Vaughan DE, Schleimer RP, Cho SH. A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma.American journal of respiratory cell and molecular biology. 46(6) : 842-6, 2012.
Uzzaman A, Cho SH. Chapter 28: Classification of hypersensitivity reactions.Allergy and asthma proceedings : the official journal of regional and state allergy societies. 33: S96-9, 2012.
Cho SH, Hong SJ, Han B, Lee SH, Suh L, Norton J, Lin D, Conley DB, Chandra R, Kern RC, Tan BK, Kato A, Peters A, Grammer LC, Schleimer RP. Age-related differences in the pathogenesis of chronic rhinosinusitis.The Journal of allergy and clinical immunology. 129(3) : 858-860.e2, 2012.