Division of Allergy & Immunology

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Narasaiah Kolliputi, PhD I-6050-2012

Narasaiah Kolliputi, PhD

Assoc Professor, College of Medicine Pathology & Cell Biology

Assoc Professor, TCOP Dept of Pharmaceutical Science

Associate Professor, Department of Internal Medicine

Assoc Professor, College of Medicine Pediatrics

Assoc Professor, College of Medicine Molecular Medicine

Associate Professor, College of Medicine Internal Medicine

Contact Info

  • University of South Florida,
    MDC 19, MDC 4134, 12901 Bruce B. Downs Blvd
    Tampa FL 33612
  • Academic Email: nkollipu@usf.edu
  • Academic Phone: 8139745419
  • View My C.V. | View My Lab Site

Education

  • PhD, Biochemistry, Osmania University, 2005
  • MS, Biochemistry, S V University, 1999

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease

Awards/Honors

  • AHA Study Section member -Lung 2 (AHA - 2014)
  • VA Study Section Ad Hoc Review Member -Pulmonology (VA - 2014)
  • NIH Study Section Ad Hoc Review Member -LCMI (NIH - 2013)
  • VA Study Section Ad Hoc Review Member -Pulmonology (VA - 2013)
  • AHA Study Section member -Lung 2 (AHA - 2013)
  • AHA Study Section member -Lung 2 (AHA - 2012)
  • AHA Study Section member -Lung 2 (AHA - 2011)
  • Young Investigator Award (Society for Experimental Biology and Medicine - 2009)
  • Best Poster Award (International Society of Human and Animal Mycology (ISHAM) - 2004)

Memberships

  • Member (" American Physiological Society, 2008 - Present)
  • Member (" The American Association for the Advancement of Science, 2008 - Present)
  • Member (" Society for Experimental Biology and Medicine, 2008 - Present)
  • Member (" American Thoracic Society, 2006 - Present)

Recent Publications

  • Tian Z, Zhang H, Dixon J, Traphagen N, Wyatt TA, Kharbanda K, Simet Chadwick S, Kolliputi N, Allen-Gipson DS. Cigarette Smoke Impairs A2A Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression. Scientific reports. 7: 44405, 2017.
  • Sriperumbudur A, Breitzig M, Lockey R, Kolliputi N. Hedgehog: the key to maintaining adult lung repair and regeneration. Journal of cell communication and signaling. 11(1) : 95-96, 2017.
  • Yi S, Niu D, Bai F, Li S, Huang L, He W, Prasad A, Czachor A, Tan LC, Kolliputi N, Wang F. Soluble Expression of a Human MnSOD and Hirudin Fusion Protein in Escherichia coli, and Its Effects on Metastasis and Invasion of 95-D Cells. Journal of microbiology and biotechnology. 26(11) : 1881-1890, 2016.
  • Fukumoto J, Soundararajan R, Leung J, Cox R, Mahendrasah S, Muthavarapu N, Herrin T, Czachor A, Tan LC, Hosseinian N, Patel P, Gone J, Breitzig MT, Cho Y, Cooke AJ, Galam L, Narala VR, Pathak Y, Lockey RF, Kolliputi N. The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis. Aging. 8(11) : 3091-3109, 2016.
  • Breitzig M, Bhimineni C, Lockey R, Kolliputi N. 4-Hydroxy-2-nonenal: a critical target in oxidative stress? American journal of physiology. Cell physiology. 311(4) : C537-C543, 2016.
  • Soundararajan R, Stearns TM, Czachor A, Fukumoto J, Turn C, Westermann-Clark E, Breitzig M, Tan L, Lockey RF, King BL, Kolliputi N. Global gene profiling of aging lungs in Atp8b1 mutant mice. Aging. 8(9) : 2232-2252, 2016.
  • Galam L, Soundararajan R, Breitzig M, Rajan A, Yeruva RR, Czachor A, Harris F, Lockey RF, Kolliputi N. SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1. Oncotarget. 7(20) : 29081-91, 2016.
  • Czachor A, Failla A, Lockey R, Kolliputi N. Pivotal role of AKAP121 in mitochondrial physiology. American journal of physiology. Cell physiology. 310(8) : C625-8, 2016.
  • Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N. Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression. American journal of physiology. Lung cellular and molecular physiology. 310(6) : L572-81, 2016.
  • Lee KS, Jeong JS, Kim SR, Cho SH, Kolliputi N, Ko YH, Lee KB, Park SC, Park HJ, Lee YC. Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax. 71(1) : 52-63, 2016.
  • Fukumoto J, Cox R, Fukumoto I, Cho Y, Parthasarathy PT, Galam L, Lockey RF, Kolliputi N. Deletion of ASK1 Protects against Hyperoxia-Induced Acute Lung Injury. PloS one. 11(1) : e0147652, 2016.
  • Galam L, Failla A, Soundararajan R, Lockey RF, Kolliputi N. 4-hydroxynonenal regulates mitochondrial function in human small airway epithelial cells. Oncotarget. 6(39) : 41508-21, 2015.
  • Cho SH, Kim DW, Lee SH, Kolliputi N, Hong SJ, Suh L, Norton J, Hulse KE, Seshadri S, Conley DB, Kern RC, Tan BK, Peters A, Grammer LC, Schleimer RP. Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinusitis and its association with altered IL-6 trans-signaling. American journal of respiratory cell and molecular biology. 53(5) : 601-6, 2015.
  • Bhavanam NP, Failla A, Cho Y, Lockey RF, Kolliputi N. Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Frontiers in pharmacology. 6: 229, 2015.
  • Soundararajan R, Stearns TM, Griswold AL, Mehta A, Czachor A, Fukumoto J, Lockey RF, King BL, Kolliputi N. Detection of canonical A-to-G editing events at 3'' UTRs and microRNA target sites in human lungs using next-generation sequencing. Oncotarget. 6(34) : 35726-36, 2015.
  • Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2. Cellular immunology. 297(1) : 40-5, 2015.
  • Czachor A, Cho Y, Lockey RF, Kolliputi N. Kinases: a remote control in inflammasome activity. Journal of cell communication and signaling. 9(3) : 285-7, 2015.
  • Cox R, Phillips O, Fukumoto J, Fukumoto I, Parthasarathy PT, Arias S, Cho Y, Lockey RF, Kolliputi N. Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. American journal of respiratory cell and molecular biology. 53(3) : 422-35, 2015.
  • Czachor A, Krueger Z, Cho Y, Pathak S, Pathak Y, Lockey R, Kolliputi N. Disruption of Circadian Rhythms in Critical Illness - A Role of Hyperoxia-Induced Lung Injury. Current pharmaceutical design. 21(24) : 3489-95, 2015.
  • Hosseinian N, Cho Y, Lockey RF, Kolliputi N. The role of the NLRP3 inflammasome in pulmonary diseases. Therapeutic advances in respiratory disease. 9(4) : 188-97, 2015.
  • Cox R, Phillips O, Fukumoto J, Fukumoto I, Tamarapu Parthasarathy P, Mandry M, Cho Y, Lockey R, Kolliputi N. Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. PloS one. 10(8) : e0136755, 2015.
  • Leung J, Cho Y, Lockey RF, Kolliputi N. The Role of Aging in Idiopathic Pulmonary Fibrosis. Lung. 193(4) : 605-10, 2015.
  • Patel P, Lockey RF, Kolliputi N. Can inflammation regulate systemic aging? Experimental gerontology. 67: 1-2, 2015.
  • Venugopal R, Galam L, Cox R, Fukumoto J, Cho Y, Parthasarathy PT, Lockey RF, Kolliputi N. Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1). Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 36(5) : 2012-24, 2015.
  • Galam L, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Adenovirus-mediated transfer of the SOCS-1 gene to mouse lung confers protection against hyperoxic acute lung injury. Free radical biology & medicine. 84: 196-205, 2015.
  • Cho Y, Swarnabala S, Lockey RF, Kolliputi N. EZH2, the moderator in the discussion between methyltransferases at histone H3? Journal of cell communication and signaling. 9(1) : 77-9, 2015.
  • Swarnabala S, Gattu M, Perry B, Cho Y, Lockey RF, Kolliputi N. ROMO1 links oxidative stress to mitochondrial integrity. Journal of cell communication and signaling. 9(1) : 73-5, 2015.
  • Turn CS, Lockey RF, Kolliputi N. Putting the brakes on age-related idiopathic pulmonary fibrosis: can Nox4 inhibitors suppress IPF? Experimental gerontology. 63: 81-2, 2015.
  • Sankineni S, Cho Y, Hosseinian N, Kolliputi N. Does pIgR down-regulation in COPD cause reprogramming of bronchial epithelium? Lung. 193(1) : 1-2, 2015.
  • Saco TV, Parthasarathy PT, Cho Y, Lockey R, Kolliputi N. Micro RNAs: the future of idiopathic pulmonary fibrosis therapy. Cell biochemistry and biophysics. 71(1) : 509-11, 2015.
  • Chapalamadugu KC, Panguluri SK, Bennett ES, Kolliputi N, Tipparaju SM. High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation. Toxicology and applied pharmacology. 282(1) : 100-7, 2015.
  • Kalyan C. Chapalamadugu, Siva K. Panguluri, Eric S. Bennett, Narasaiah Kolliputi, Srinivas M. Tipparaju. High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation Toxicology and Applied Pharmacology. : http://dx.doi.org/10.1016/j.taap.2014.10.019, 2014.
  • Turn CS, Kolliputi N. Two Sides of a Coin: The Dual Roles of Chitinase 3-Like 1 in Idiopathic Pulmonary Fibrosis. Lung. : DOI 10.1007/s00408-014-9651-0, 2014.
  • Parthasarathy PT, Cho Y, Lockey R, Kolliputi N. An Old Molecule with a New Role: Microtubules in Inflammasome Regulation. Cell biochemistry and biophysics. 70(1) : 697-8, 2014.
  • Saco TV, Parthasarathy PT, Cho Y, Lockey RF, Kolliputi N. Role of Epigenetics in Pulmonary Hypertension. American journal of physiology. Cell physiology. 306(12) : C1101-5, 2014.
  • Lagishetty V, Parthasarathy PT, Phillips O, Fukumoto J, Cho Y, Fukumoto I, Bao H, Cox R, Galam L, Lockey RF, Kolliputi N. Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury. American journal of physiology. Cell physiology. 306(11) : C999-C1007, 2014.
  • Saco T, Parthasarathy PT, Cho Y, Lockey RF, Kolliputi N. Inflammasome: a new trigger of Alzheimer''s disease. Frontiers in aging neuroscience. 6: 80, 2014.
  • Cox, Ruan, Oluwakemi Phillips, Jutaro Fukumoto, Itsuko Fukumoto, Stephen Arias, Young Cho, Richard Lockey, and Narasaiah Kolliputi. Hyperoxia exposure results in decreased expression of pro-resolution receptor ALX/FPR2 (1153.12) (meeting abstract) FASEB Journal. 28: 1153.12, 2014.
  • Jia-Wang Wang, Michelle A. Reiser, Kunyu Li, Eileen Rifkin, Bangmei Wang, Narasaiah Kolliputi, Richard F. Lockey. LRBA Causes Immunodeficiency and Autoimmunity By Deregulating NFkB-Mediated Multiple Immune Effectors Critical For B Cell Activation (meeting abstract) Journal of Allergy and Clinical Immunology. 133(2) : AB251, 2014.
  • Narasaiah Kolliputi. NLRP3-deficient mice have enhanced neutrophil apoptosis and suppressed inflammatory response to hyperoxia-induced acute lung injury (2nd international conference on Clinical & Cellular Immunology) J Clin Cell Immunol. 4: 5, 2013.
  • Narasaiah Kolliputi. SOCS-1 gene therapy protects against hyperoxia- Induced acute lung injury and pulmonary edema (meeting abstract; 2nd international conference and exhibition on Cell & Gene Therapy) J Stem Cell Res Ther. 3: 5, 2013.
  • Bandyopadhyay S, Lane T, Venugopal R, Parthasarathy PT, Cho Y, Galam L, Lockey R, Kolliputi N. MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2. Biochemical and biophysical research communications. 439(3) : 407-12, 2013.
  • Grams D, Lockey R, Kolliputi N. Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing? Frontiers in aging neuroscience. 5: 40, 2013.
  • Fukumoto J, Fukumoto I, Parthasarathy PT, Cox R, Huynh B, Ramanathan GK, Venugopal RB, Allen-Gipson DS, Lockey RF, Kolliputi N. NLRP3 deletion protects from hyperoxia-induced acute lung injury. American journal of physiology. Cell physiology. 305(2) : C182-9, 2013.
  • Fukumoto J, Lockey R, Kolliputi N. New hope for Nutlin-3a therapy for pulmonary arterial hypertension. Frontiers in pharmacology. 4: 87, 2013.
  • Desai P, Tamarapu Parthasarathy P, Galam L, Lockey R, Kolliputi N. A new role for inflammasomes: sensing the disturbances in non-alcoholic fatty liver disease. Frontiers in physiology. 4: 156, 2013.
  • Mehta Jyoti, Tamarapu Parthasarathy Prasanna, Lockey Richard F., Kolliputi Narasaiah. New hope for a microRNA therapy for pulmonary arterial hypertension Frontiers in Genetics. 4: DOI=10.3389/fgene.2013.00137, 2013.
  • Panguluri SK, Tur J, Fukumoto J, Deng W, Sneed KB, Kolliputi N, Bennett ES, Tipparaju SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12) : H1651-61, 2013.
  • Phillips, O., J. Fukumoto, P. Tamarapu Parthasarathy, I. Fukumoto, T. Luong, N. Remsen, R. Lockey, N. Kolliputi, and R. R. Cox. Resolvin D1 Attenuates Hyperoxia Induced Acute Lung Injury (meeting abstract) Am J Respir Crit Care Med. 187: A4938, 2013.
  • Qazi O, Parthasarathy PT, Lockey R, Kolliputi N. Can microRNAs keep inflammasomes in check? Frontiers in genetics. 4: 30, 2013.
  • Lane T, Flam B, Lockey R, Kolliputi N. TXNIP shuttling: missing link between oxidative stress and inflammasome activation. Frontiers in physiology. 4: 50, 2013.
  • Ruan Cox, Narasaiah Kolliputi. Mechanisims of asthma and allergic disease – 1081. Resolvin inhibits the cryopyrin/nalp3 inflammasome (meeting abstract) World Allergy Organ J. 6: P77, 2013.
  • PT Parthasarathy, T Luong, V Lagishetty, O Phillips, R Cox, A Castillo, T Abuelenen, R Lockey, and N Kolliputi. Overexpression of Circadian CLOCK genes alters proinflammatory cytokine production in human alveolar epithelial cells (meeting abstract) FASEB Journal. 27: 722.8, 2013.
  • J Fukumoto, I Fukumoto, O Phillips, R Cox, Jr, P Tamarapu Parthasarathy, V Lagishetty, R Lockey and N Kolliputi. ASC plays a role in alveolar epithelial integrity (meeting abstract) FASEB Journal. 27: 1143.5, 2013.
  • Venu Lagishetty, Prasanna Tamarapu Parthasarathy, Bao Huynh, Jutaro Fukumoto, Ruan Cox, Jr, Richard Lockey and Narasaiah Kolliputi. Hyperoxia induced lung injury is associated with alterations in circadian clock genes in mice (meeting abstract) FASEB Journal. 27: 914.8, 2013.
  • L Galam, S Bandyopadhyay, O Martinez, T Abuelenen, A Castillo, P Parthasarathy, V Lagishetty, R Lockey, and N Kolliputi. Diindolylmethane Attenuates TGF β Mediated Human Lung Fibroblast Proliferation (meeting abstract) FASEB Journal. 27: lb874, 2013.
  • RR Cox Jr., O Phillips, J Fukumoto, I Fukumoto, PT Parthasarathy, V Lagishetty, T Luong, N Remsen, R Lockey, and N Kolliputi. Resolvins play a role in the resolution of acute lung injury (meeting abstract) FASEB Journal. 27: 1143.4, 2013.
  • O Phillips, R Cox, J Fukumoto, I Fukumoto, PT Parthasarathy, V Delic, T Luong, R Lockey, and N Kolliputi. Epigallocatechin-3-Gallate inhibits the effects of TGF-Beta and IL-1B on ENaC expression in human alveolar epithelial cells (meeting abstract) FASEB Journal.. 27: 913.41, 2013.
  • Cox, Ruan R., Oluwakemi Phillips, Jutaro Fukumoto, Itsuko Fukumoto, Prasanna Tamarapu, Tran Luong, Richard F. Lockey, and Narasaiah Kolliputi. Resolvin D1 Inhibits IL-1beta Induced Alveolar Epithelial Cell Activation (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB197, 2013.
  • Phillips, Oluwakemi, Ruan R. Cox, Jutaro Fukumoto, Itsuko Fukumoto, Prasanna Tamarapu, Tran Luong, Richard F. Lockey, and Narasaiah Kolliputi. Inhibition of IL-1β Mediated Proinflammatory Cytokine Production by Epigallocatechin Gallate in Human Alveolar Epithelial Cells (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB11, 2013.
  • J Fukumoto, I Fukumoto, B Huynh, RR Cox, PT Parthasarathy, GK Ramanathan, RB Venugopal, RF Lockey, and N Kolliputi. NLRP3-Deficient Mice Have an Enhanced Neutrophil Apoptosis and a Suppressed Inflammatory Response to Hyperoxia-Induced Acute Lung Injury (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB9, 2013.
  • Cox RR, Phillips O, Kolliputi N. Putting the brakes on acute lung injury: can resolvins suppress acute lung injury? Frontiers in physiology. 3: 445, 2012.
  • Narasaiah Kolliputi. Adenovirus-mediated gene therapy of SOCS-1 protects against acute lung injury (international conference on Genetic Syndromes & Gene Therapy) J Ge n et Syndr Gene Ther. 3: 4, 2012.
  • Jalali S, Ramanathan GK, Parthasarathy PT, Aljubran S, Galam L, Yunus A, Garcia S, Cox RR, Lockey RF, Kolliputi N. Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation. PloS one. 7(10) : e46808, 2012.
  • Prasanna Tamarapu Parthasarathy, Oluwakemi Phillips and Narasaiah Kolliputi. Thioredoxin Catalysis and Inflammasome Regulation: Directions for Future Research Journal of Biocatalysis & Biotransformation. : doi:10.4172/2324-9099.1000e107, 2012.
  • Tamarapu Parthasarathy P, Galam L, Huynh B, Yunus A, Abuelenen T, Castillo A, Kollongod Ramanathan G, Cox R, Kolliputi N. MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochemical and biophysical research communications. 426(2) : 203-8, 2012.
  • Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey RF. NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability. Journal of cellular physiology. 227(9) : 3310-6, 2012.
  • Sayantani Bandyopadhyay and Narasaiah Kolliputi. Viruses: Cofactors in Idiopathic Pulmonary Fibrosis Virology & Mycology. 1: 3, 2012.
  • Aljubran SA, Cox R, Tamarapu Parthasarathy P, Kollongod Ramanathan G, Rajanbabu V, Bao H, Mohapatra SM, Lockey R, Kolliputi N. Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PloS one. 7(5) : e37712, 2012.
  • Kolliputi N, Shaik RS, Waxman AB. The inflammasome mediates hyperoxia-induced alveolar cell permeability. Journal of immunology (Baltimore, Md. : 1950). 184(10) : 5819-26, 2010.
  • Waxman AB, Kolliputi N. IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. American journal of respiratory cell and molecular biology. 41(4) : 385-96, 2009.
  • Kolliputi N, Waxman AB. IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation. American journal of physiology. Lung cellular and molecular physiology. 297(1) : L6-16, 2009.
  • Kolliputi N, Waxman AB. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. American journal of respiratory cell and molecular biology. 40(3) : 314-24, 2009.
  • Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, Waxman AB. Interleukin-6 overexpression induces pulmonary hypertension. Circulation research. 104(2) : 236-44, 28p following 244, 2009.
  • Bhaskaran M, Kolliputi N, Wang Y, Gou D, Chintagari NR, Liu L. Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway. The Journal of biological chemistry. 282(6) : 3968-76, 2007.
  • Jin N, Kolliputi N, Gou D, Weng T, Liu L. A novel function of ionotropic gamma-aminobutyric acid receptors involving alveolar fluid homeostasis. The Journal of biological chemistry. 281(47) : 36012-20, 2006.
  • Narasaiah KV, Sashidhar RB, Subramanyam C. Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediates. Mycopathologia. 162(3) : 179-89, 2006.
  • Jin N, Narasaraju T, Kolliputi N, Chen J, Liu L. Differential expression of GABAA receptor pi subunit in cultured rat alveolar epithelial cells. Cell and tissue research. 321(2) : 173-83, 2005.