Seong H. Cho

Seong H. Cho, MD

Associate Professor, Internal Medicine, College of Medicine

Associate Professor, College of Medicine Internal Medicine

Contact Info 3802 Spectrum Blvd. Suite 303
Tampa FL 33612

Academic Email: scho2@health.usf.edu

Academic Phone:(813) 972-7631

View My C.V.

Education

  • MD, Medicine, Kyung Hee University, 1989

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Asthma Center of Excellence
  • Other

Research Interests

  • Plasminogen activator inhibitor-1 (PAI-1) promotes tissue remodeling in a mouse model of asthma and in patients with severe asthma. A low molecular weight PAI-1 inhibitor was found to reduce inflammation and fibrosis in a murine model of chronic asthma. A gain-of-function genetic polymorphism of PAI-1 is associated with the development of asthma and decreased lung function. Therefore, PAI-1 can be a potential target for asthma prevention and the treatment of severe asthma.
  • Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in the United States. Our previous study shows that the prevalence of CRS with nasal polyps (NP) is significantly higher in the elderly population compared with the non-elderly. We found that there was significant reduction of innate immune molecules with aging process. We are investigating the age-related pathogenesis of CRS and NP using human samples and a murine model of NP.

Recent Publications

  • Sherenian MG, Cho SH, Levin A, Min JY, Oh SS, Hu D, Galanter J, Sen S, Huntsman S, Eng C, Rodriguez-Santana JR, Serebrisky D, Avila PC, Kalhan R, Smith LJ, Borrell LN, Seibold MA, Keoki Williams L, Burchard EG, Kumar R. PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28543872
  • Kim DW, Cho SH. Emerging Endotypes of Chronic Rhinosinusitis and Its Application to Precision Medicine. Allergy, asthma & immunology research. 9(4) : 299-306, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28497916
  • Cho SH Bachert C Lockey RF. Chronic Rhinosinusitis Phenotypes: An Approach to Better Medical Care for Chronic Rhinosinusitis. J Allergy Clin Immunol Pract.. 4(4) : 639-42, 2016.
  • Cho SH Kim DW Gevaert P. Chronic Rhinosinusitis without Nasal Polyps. J Allergy Clin Immunol Pract.. 4(4) : 575-82, 2016.
  • Kim DW, Kim DK, Jo A, Jin HR, Eun KM, Mo JH, Cho SH. Age-Related Decline of Neutrophilic Inflammation Is Associated with Better Postoperative Prognosis in Non-eosinophilic Nasal Polyps. PloS One. 11(2) : e0148442, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26849431
  • Cho SH Kim DW Gevaert P. Chronic rhinosinusitis phenotypes; Chronic rhinosinusitis without nasal polyps. J Allergy Clin Immunol Pract.. 4(4) : 575-82, 2016.
  • Cho SH Min JY Kang J Kim DY Oh SS Torgerson DR Del-Pino-Yanes MM Hu D Sen S Huntsman S Eng C Farber HJ Rodriguez-Cintron W Rodriguez-Santana JR Serebrisky D Thyne SM Borrell LN Williams LK Seibold MA Burchard EG Avila PC Kumar R. PAI-1 Gene- and Early Life Infection Interaction on Asthma Risk, Asthma Exacerbations, and Reduced Lung Function: The GALA II Study. PLoS One. 11(8) : e0157848, 2016.
  • Cho SH Min JY Kim DY Oh SS Torgerson DR Pino-Yanes M Hu D Sen S Huntsman S Eng C Farber HJ Rodriguez-Cintron W Rodriguez-Santana JR Serebrisky D Thyne SM Borrell LN Williams LK DuPont W Seibold MA Burchard EG Avila PC Kumar R. Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function. PLoS One.. 11(8) : e0157848. doi: 10.1371/journal.pone.0157848. eCollection 2016., 2016.
  • Kim DK Jin HR Eun KM Mo JH Cho SH Oh S Cho D Kim DW. The role of interleukin-33 in chronic rhinosinusitis. Thorax.. : pii: thoraxjnl-2016-208772. doi: 10.1136/thoraxjnl-2016-208772., 2016.
  • Kim DW Eun KM Jin HR Cho SH Kim DK. Prolonged allergen exposure is associated with increased thymic stromal lymphopoietin expression and Th2-skewing in mouse models of chronic rhinosinusitis. Laryngoscope. 126(8) : 265-72, 2016.
  • Kim DY Lee SH Carter RG Kato A Schleimer RP Cho SH. A Newly Established Murine Model of Sinus Disease Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps. Am J Respir Cell Mol Biol.. 55(2) : 170-5, 2016.
  • Kim DY, Lee SH, Carter RG, Kato A, Schleimer RP, Cho SH. A Recently Established Murine Model of Nasal Polyps Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps. American journal of respiratory cell and molecular biology. 55(2) : 170-5, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27163839
  • Lee KS Jeong JS Kim SR Cho SH Kolliputi N Ko YH Lee KB Park SC Park HJ Lee YC. Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax. 71(1) : 52-63, 2015.
  • Galam L, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Adenovirus-mediated transfer of the SOCS-1 gene to mouse lung confers protection against hyperoxic acute lung injury. Free radical biology & medicine. 84: 196-205, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25850028
  • Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2. Cellular immunology. 297(1) : 40-5, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26123077
  • Kim SR, Kim HJ, Kim DI, Lee KB, Park HJ, Jeong JS, Cho SH, Lee YC. Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced Lung Injury. Theranostics. 5(12) : 1343-62, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26516372
  • Cho SH, Lee SH, Kato A, Takabayashi T, Kulka M, Shin SC, Schleimer RP. Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-β1. American journal of respiratory cell and molecular biology. 52(1) : 88-95, 2015. http://www.ncbi.nlm.nih.gov/pubmed/24987792
  • Kim DY, Cho SH, Takabayashi T, Schleimer RP. Chronic Rhinosinusitis and the Coagulation System. Allergy, asthma & immunology research. 7(5) : 421-30, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26122502
  • Cho SH, Kim DW, Lee SH, Kolliputi N, Hong SJ, Suh L, Norton J, Hulse KE, Seshadri S, Conley DB, Kern RC, Tan BK, Peters A, Grammer LC, Schleimer RP. Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling. American journal of respiratory cell and molecular biology. 53(5) : 601-6, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26266960
  • Kim DK, Jin HR, Eun KM, Mutusamy S, Cho SH, Oh S, Kim DW. Non-Eosinophilic Nasal Polyps Shows Increased Epithelial Proliferation and Localized Disease Pattern in the Early Stage. PloS one. 10(10) : e0139945, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26439628
  • Cho SH, Hong SJ, Chen H, Habib A, Cho D, Lee SH, Kang J, Ward T, Boushey HA, Schleimer RP, Avila PC. Plasminogen activator inhibitor-1 in sputum and nasal lavage fluids increases in asthmatic patients during common colds. The Journal of allergy and clinical immunology. 133(5) : 1465-7, 1467.e1-2, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24373352
  • Lee H, Kim SR, Oh Y, Cho SH, Schleimer RP, Lee YC. Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma. American journal of respiratory cell and molecular biology. 50(4) : 667-77, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24219511
  • Takabayashi T, Kato A, Peters AT, Hulse KE, Suh LA, Carter R, Norton J, Grammer LC, Cho SH, Tan BK, Chandra RK, Conley DB, Kern RC, Fujieda S, Schleimer RP. Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression. American journal of respiratory and critical care medicine. 187(1) : 49-57, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23155140
  • Suh JS, Cho SH, Chung JH, Moon A, Park YK, Cho BS. A polymorphism of interleukin-22 receptor alpha-1 is associated with the development of childhood IgA nephropathy. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 33(10) : 571-7, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23659670
  • Cho SH, Hong SJ, Han B, Lee SH, Suh L, Norton J, Lin D, Conley DB, Chandra R, Kern RC, Tan BK, Kato A, Peters A, Grammer LC, Schleimer RP. Age-related differences in the pathogenesis of chronic rhinosinusitis. The Journal of allergy and clinical immunology. 129(3) : 858-860.e2, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22236731
  • Lee SH, Eren M, Vaughan DE, Schleimer RP, Cho SH. A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma. American journal of respiratory cell and molecular biology. 46(6) : 842-6, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22323366
  • Uzzaman A, Cho SH. Chapter 28: Classification of hypersensitivity reactions. Allergy and asthma proceedings : the official journal of regional and state allergy societies. 33: S96-9, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22794701

Positions Held

  • Assistant Professor (Medicine, School of Medicine, Northwestern University 2011 - 2015)