Ronald R. Magness

Contact Info 12901 Bruce B. Downs Blvd
MDC 48
Tampa FL 33612

Academic Email: rmagness@usf.edu

Academic Phone:(813) 974-8942

View My C.V.

View My Lab Site

Education

Interdisciplinary and Emerging Signature Programs

• Other

Research Interests

• I have built a research group and pioneered work on vascular biology changes during pregnancy with a particular emphasis on endothelial NO and angiogenesis via ATP, placental growth factors (VEG/FGF-2), and shear stress. My expertise is in uterine, fetal and placental physiology and cardiovascular function and my lab have developed numerous in vivo physiological and in vitro models centered on uteroplacental and fetoplacental vascular biology. The Magness lab has also made major models contributions and provided extensive experience in studying uterine, systemic and placental vascular modeling, and blood vessel development as it relates to placental derived steroid and angiogenic growth factor regulation of endothelial and vascular smooth muscle function.

Memberships

• Member (Developmental Origins of Health and Disease, 2007 - Present)
• Member (Society for Gynecologic Investigation, 1990 - Present)
• Member/Former Council member and President (Perinatal Research Society, 1988 - Present)
• Member (International Society for the Study of Hypertension in Pregnancy, 1986 - Present)
• Member (Society for the Study of Fertility, 1981 - Present)
• Member (Society for the Study of Reproduction, 1979 - Present)

Recent Publications

• Zywicki ME, Blohowiak SE, Magness RR, Segar JL, Kling PJ. Impact of the ovarian cycle and pregnancy on plasma chemistry values in ewes. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. , 2018.
• Zhou C, Zou QY, Li H, Wang RF, Liu AX, Magness RR, Zheng J. Preeclampsia Downregulates MicroRNAs in Fetal Endothelial Cells: Roles of miR-29a/c-3p in Endothelial Function. The Journal of clinical endocrinology and metabolism. 102(9) : 3470-3479, 2017.
• Carris NW, Tipparaju SM, Magness DJ, Chapalamadugu KC, Magness RR. Pleiotropic effects of metformin to rescue statin-induced muscle injury and insulin resistance: A proposed mechanism and potential clinical implications. Medical hypotheses. 107: 39-44, 2017.
• Ampey BC, Ampey AC, Lopez GE, Bird IM, Magness RR. Cyclic Nucleotides Differentially Regulate Cx43 Gap Junction Function in Uterine Artery Endothelial Cells From Pregnant Ewes. Hypertension (Dallas, Tex. : 1979). , 2017.
• Vargas VE, Landeros RV, Lopez GE, Zheng J, Magness RR. Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells†. Biology of reproduction. 96(4) : 866-876, 2017.
• Landeros RV, Jobe SO, Aranda-Pino G, Lopez GE, Zheng J, Magness RR. Convergent ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) signalling mediate catecholoestradiol-induced proliferation of ovine uterine artery endothelial cells. The Journal of physiology. , 2017.
• Vargas VE, Landeros RV, Lopez GE, Zheng J, Magness RR. Erratum: Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells. Biology of reproduction. 96(4) : 938, 2017.
• Kranch-Shorthouse RA, Bauer AS, Magness RR, Lopez GE, Segar JL, Blohowiak SE, Kling PJ. Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys. Biology of reproduction. 96(1) : 211-220, 2017.
• Degner K, Magness RR, Shah DM. Establishment of the Human Uteroplacental Circulation: A Historical Perspective. Reprod Sci. , 2016.
• Ampey BC, Morschauser TJ, Ramadoss J, Magness RR. Domain-Specific Partitioning of Uterine Artery Endothelial Connexin43 and Caveolin-1. Hypertension (Dallas, Tex. : 1979). 68(4) : 982-8, 2016.
• Zywicki M, Blohowiak SE, Magness RR, Segar JL, Kling PJ. Increasing fetal ovine number per gestation alters fetal plasma clinical chemistry values. Physiological reports. 4(16) , 2016.
• Pastore MB, Talwar S, Conley MR, Magness RR. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells. Biol Reprod. 94(6) : 139, 2016.
• Sun MY, Woolley JC, Blohowiak SE, Smith ZR, Siddappa AM, Magness RR, Kling PJ. Dietary-induced gestational iron deficiency inhibits postnatal tissue iron delivery and postpones the cessation of active nephrogenesis in rats. Reprod Fertil Dev. , 2016.
• Boeldt DS, Grummer MA, Yi F, Magness RR, Bird IM. Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells. Molecular and Cellular Endocrinology. 412: 73-84, 2015.
• Li Y, Wang K, Zou QY, Magness RR, Zheng J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin differentially suppresses angiogenic responses in human placental vein and artery endothelial cells. Toxicology. 336: 70-8, 2015.
• Lechuga TJ, Zhang HH, Sheibani L, Karim M, Jia J, Magness RR, Rosenfeld CR, Chen DB. Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine β-Synthase Expression. Endocrinology. 156(6) : 2288-98, 2015.
• Boeldt DS, Grummer MA, Yi F, Magness RR, Bird IM. Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells. Mol Cell Endocrinol. 412: 73-84, 2015.
• Morris EA, Hale SA, Badger GJ, Magness RR, Bernstein IM. Pregnancy induces persistent changes in vascular compliance in primiparous women. American Journal of Obstetrics and Gynecology. 212(5) : 633.e1-6, 2015.
• Li Y, Wang K, Zou QY, Zhou C, Magness RR, Zheng J. A possible role of aryl hydrocarbon receptor in spontaneous preterm birth. Medical Hypotheses. 84(5) : 494-7, 2015.
• Lechuga TJ, Zhang HH, Sheibani L, Karim M, Jia J, Magness RR, Rosenfeld CR, Chen DB. Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine β-Synthase Expression. Endocrinology. 156(6) : 2288-98, 2015.
• Boeldt DS, Grummer MA, Magness RR, Bird IM. Altered VEGF-stimulated Ca2+ signaling in part underlies pregnancy-adapted eNOS activity in UAEC. Endocrinology. 223(1) : 1-11, 2014.
• Li HH, Zhao YJ, Li Y, Dai CF, Jobe SO, Yang XS, Li XF, Patankar MS, Magness RR, Zheng J. Estradiol 17β and its metabolites stimulate cell proliferation and antagonize ascorbic acid-suppressed cell proliferation in human ovarian cancer cells. Reprod Sci. 21(1) : 102-11, 2014.
• Morschauser TJ, Ramadoss J, Koch JM, Yi FX, Lopez GE, Bird IM, Magness RR. Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis. Hypertension. 63(3) : 589-94, 2013.
• Ramadoss J, Pastore MB, Magness RR. Endothelial caveolar subcellular domain regulation of endothelial nitric oxide synthase. Clinical and Experimental Pharmacology & Physiology. 40(11) : 753-64, 2013.
• Meyer-Gesch KM, Sun MY, Koch JM, Ramadoss J, Blohowiak SE, Magness RR, Kling PJ. Ovine fetal renal development impacted by multiple fetuses and uterine space restriction. J Dev Orig Health Dis. 4(5) : 411-20, 2013.
• Bird IM, Boeldt DS, Krupp J, Grummer MA, Yi FX, Magness RR. Pregnancy, programming and preeclampsia: gap junctions at the nexus of pregnancy-induced adaptation of endothelial function and endothelial adaptive failure in PE. Current Vascular Pharmacology. 11(5) : 712-29, 2013.
• Sun MY, Habeck JM, Meyer KM, Koch JM, Ramadoss J, Blohowiak SE, Magness RR, Kling PJ. Ovine uterine space restriction alters placental transferrin receptor and fetal iron status during late pregnancy. Pediatr Res.. 73(3) : 277-85, 2013.
• Hale SA, Badger GJ, McBride C, Magness RR, Bernstein IM. Prepregnancy vascular dysfunction in women who subsequently develop hypertension during pregnancy. Pregnancy Hypertension.. 3(2) : 140-145, 2013.
• Lan XE, Cretney C, Kropp J, Khateeb K, Berg MA, Peñagaricano F, Magness RR, Radunz AE, Khatib H. Maternal Diet during Pregnancy Induces Transcriptomic and Epigenomic Changes in Fetal Tissues in Sheep. Frontiers in Genetics. 4: 49, 2013.
• Koch JM, Lemley CO, Magness RR, Wilson ME. Periconceptional Growth Hormone Treatment Alters Early Uterine Environment. Open Journal Anim Sci. 3: 121-6, 2013.
• Jobe SO, Tyler CT, Magness RR. Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction. Hypertension (Dallas, Tex. : 1979). 61(2) : 480-7, 2013.
• Jobe SO, Ramadoss J, Wargin AJ, Magness RR. Estradiol-17β and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites selectively stimulate production of prostacyclin in uterine artery endothelial cells: role of estrogen receptor-α versus estrogen receptor-β. Hypertension (Dallas, Tex. : 1979). 61(2) : 509-18, 2013.
• Ramadoss J, Magness RR. Alcohol-induced alterations in maternal uterine endothelial proteome: a quantitative iTRAQ mass spectrometric approach. Reproductive Toxicology (Elmsford, N.Y.). 34(4) : 538-44, 2012.
• Ramadoss J, Magness RR. Vascular effects of maternal alcohol consumption. American Journal of Physiology. Heart and Circulatory Physiology. 303(4) : H414-21, 2012.
• Ramadoss J, Magness RR. Multiplexed digital quantification of binge-like alcohol-mediated alterations in maternal uterine angiogenic mRNA transcriptome. Physiological genomics. 44(11) : 622-8, 2012.
• Ramadoss J, Liao WX, Morschauser TJ, Lopez GE, Patankar MS, Chen DB, Magness RR. Endothelial caveolar hub regulation of adenosine triphosphate-induced endothelial nitric oxide synthase subcellular partitioning and domain-specific phosphorylation. Hypertension (Dallas, Tex. : 1979). 59(5) : 1052-9, 2012.
• Zhang HH, Feng L, Wang W, Magness RR, Chen DB. Estrogen-responsive nitro-proteome in uterine artery endothelial cells: Role of endothelial nitric oxide synthase and estrogen receptor-β. J Cell Physiology. 227(1) : 146-159, 2012.
• Jobe SO, Fling SN, Ramadoss J, Magness RR. A novel role for an endothelial adrenergic receptor system in mediating catecholestradiol-induced proliferation of uterine artery endothelial cells. Hypertension (Dallas, Tex. : 1979). 58(5) : 874-81, 2011.
• Ramadoss J, Magness RR. 2-D DIGE uterine endothelial proteomic profile for maternal chronic binge-like alcohol exposure. Journal of Proteomics. 74(12) : 2986-94, 2011.
• Salih SM, Kapur A, Albayrak S, Salama SA, Magness RR. Pregnancy ameliorates the inhibitory effects of 2-methoxyestradiol on angiogenesis in primary sheep uterine endothelial cells. Reproductive Sciences (Thousand Oaks, Calif.). 18(9) : 858-67, 2011.
• Ramadoss J, Jobe SO, Magness RR. Alcohol and maternal uterine vascular adaptations during pregnancy-part I: effects of chronic in vitro binge-like alcohol on uterine endothelial nitric oxide system and function. Alcoholism, Clinical and Experimental Research. 35(9) : 1686-93, 2011.
• Yi FX, Boeldt DS, Magness RR, Bird IM. [Ca2+]i signaling vs. eNOS expression as determinants of NO output in uterine artery endothelium: relative roles in pregnancy adaptation and reversal by VEGF165. American Journal of Physiology. Heart and Circulatory physiology. 300(4) : H1182-93, 2011.
• Meyer KM, Koch JM, Ramadoss J, Kling PJ, Magness RR. Ovine surgical model of uterine space restriction: interactive effects of uterine anomalies and multifetal gestations on fetal and placental growth. Biology of Reproduction. 83(5) : 799-806, 2010.
• Ramadoss J, Liao WX, Chen DB, Magness RR. High-throughput caveolar proteomic signature profile for maternal binge alcohol consumption. Alcohol. 44(7) : 691-7, 2010.
• Koch JM, Ramadoss J, Magness RR. Proteomic profile of uterine luminal fluid from early pregnant ewes. Journal of Proteome Research. 9(8) : 3878-85, 2010.
• Dunlap KA, Kwak HI, Burghardt RC, Bazer FW, Magness RR, Johnson GA, Bayless KJ. The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep. Biology of Reproduction. 82(5) : 876-87, 2010.
• Jobe SO, Ramadoss J, Koch JM, Jiang Y, Zheng J, Magness RR. Estradiol-17beta and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension (Dallas, Tex. : 1979). 55(4) : 1005-11, 2010.