Donghwa Kim, PhD

Associate Professor, Medicine

Associate Professor, Heart Institute

Associate Professor, Personalized Medicine and Genomics

Contact Info 560 Channelside Drive
Room 717
Tampa FL 33602

Academic Email: donghwa@usf.edu

Academic Phone:8133960661

View My Website

Education

Interdisciplinary and Emerging Signature Programs

• Allergy, Immunology & Infectious Disease
• Asthma Center of Excellence
• Cellular and Molecular Biology
• Metabolic Regulation and Disorders

Memberships

• Member (ATS, 2014 - Present)
• Member (KSEA, 2012 - Present)
• member (AACR, 2003 - 2013)

Recent Publications

• Woo JA, Castaño M, Kee TR, Lee J, Koziol-White CJ, An SS, Kim D, Kang DE, Liggett SB. A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14. Am J Respir Cell Mol Biol. , 2023.
• Tokmakova A*, Kim D*, Guthrie B, Kim SK, Goddard WA 3rd, Liggett SB. Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes iScience. , 2023.
• Tokmakova A, Kim D, Goddard WA, Liggett SB. Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease. Journal of personalized medicine. 12(3) , 2022.
• Kim D, Tokmakova A, Woo JA, An SS, Goddard WA, Liggett SB. Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development. Molecular diagnosis & therapy. , 2022.
• Cardet JC, Kim D, Bleecker ER, Casale TB, Israel E, Mauger D, Meyers DA, Ampleford E, Hawkins GA, Tu Y, Liggett SB, Ortega VE. Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma. The Journal of allergy and clinical immunology. , 2022.
• Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA, Liggett SB. Identification and characterization of an atypical Gαs-biased βAR agonist that fails to evoke airway smooth muscle cell tachyphylaxis. Proceedings of the National Academy of Sciences of the United States of America. 118(49) , 2021.
• Yang MY, Kim SK, Kim D, Liggett SB, Goddard WA. Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment. The journal of physical chemistry letters. 12(38) : 9293-9300, 2021.
• Kim D, Castaño M, Lujan LK, Woo JA, Liggett SB. The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14. The Journal of biological chemistry. 296: 100216, 2021.
• Kim D, An SS, Lam H, Leahy JW, Liggett SB. Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5. ACS pharmacology & translational science. 3(6) : 1069-1075, 2020.
• Huang J, Lam H, Koziol-White C, Limjunyawong N, Kim D, Kim N, Karmacharya N, Rajkumar P, Firer D, Dalesio NM, Jude J, Kurten RC, Pluznick JL, Deshpande DA, Penn RB, Liggett SB, Panettieri RA, Dong X, An SS. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences of the United States of America. 117(45) : 28485-28495, 2020.
• Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB. Differential long-term regulation of TAS2R14 by structurally distinct agonists. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(11) : 12213-12225, 2019.
• Kim D, Cho S, Castaño MA, Panettieri RA, Woo JA, Liggett SB. Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal-regulated Kinase 1/2. American journal of respiratory cell and molecular biology. 60(5) : 532-540, 2019.
• Kim D, Cho S, Woo JA, Liggett SB. A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β-adrenergic receptor down-regulation in airway smooth muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(7) : 3680-3688, 2018.
• Kim D, Woo JA, Geffken E, An SS, Liggett SB. Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G. American journal of respiratory cell and molecular biology. 56(6) : 762-771, 2017.
• Kim D, Pauer SH, Yong HM, An SS, Liggett SB. β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function. The Journal of biological chemistry. 291(34) : 17616-28, 2016.