Clifton L. Gooch, M.D., F.A.A.N.
Neuromuscular Medicine & Electromyography (EMG)
Professor & Chairman
||Baylor College of Medicine|
||Baylor College of Medicine (Neurology)|
||Duke University (Neuromuscular Disease and Electromyography)|
My clinical emphasis is on diseases of the peripheral nervous system particularly amyotrophic lateral sclerosis autoimmune peripheral neuropathy (including CIDP and Multifocal Motor Neuropathy) the diabetic neuropathies and myasthenia gravis.
My research has focused on developing and testing new and more effective therapies for neuromuscular disorders, as well as exploring the mechanisms of nerve and motor neuron function and deterioration in disease and injury. I have over 15 years of experience in the development and performance of therapeutic trials, including experimental therapy for ALS, diabetic neuropathy and toxic neuropathy using growth factors, anti-excitotoxic and anti-oxidant compounds and gene therapy. In addition, my work has included the development and application of new physiologic methods for the exploration of motor neuron deterioration in ALS and studies of nerve injury due to trauma, toxins and diabetes.
• Neurology (American Board of Psychiatry & Neurology)
• Neuromuscular Medicine (American Board of Psychiatry and Neurology)
• Clinical Neurophysiology (American Board of Psychiatry & Neurology)
• Electrodiagnostic Medicine (American Board of Electrodiagnostic Medicine)
• Peripheral Neuropathy
• Motor Neuron Disease (ALS, SMA)
• Myasthenia Gravis and Autoimmune Diseases of the Peripheral Nervous System
Selected PublicationsGooch CL
, Pullman S, Shungu D, Uluğ A, Chan S, Gordon PH, Tang M, Mao X,
Rowland LP and Mitsumoto H. Motor Unit Number Estimation (MUNE) in Diseases of the Motor Neuron: Utility and Comparative Analysis in a Multimodal Biomarker Study.
Supplements to Clinical Neurophysiology 2009; 60:153-162.
Ropper A, Gorson K, Gooch C
, Weinberg D, Peiczek A, Ware UJ, Kershen J, Schratzberger P, Kirchmair R, Losordo D: VEGF Gene Transfer for Treatment of Diabetic Polyneuropathy: A Randomized Double Blinded Trial.
Ann Neurol. 2009; 65:386-393.Gooch, CL
, Weimer LH: The electrodiagnosis of neuropathy: Basic principles and common pitfalls.
Neurologic Clinics, 2007; 25: 1-28.
Stubblefield M, Vahdat L, Balmaceda C, Troxel A, Hesdorffer C, Gooch C: Glutamine as a neuroprotective agent in high-dose paclitaxel-induced neuropathy: A clinical and electrophysiologic study. Clinical Oncology, 2005; 17: 271-276.
Rong LL, Gooch C, Szabolcs M, Herold KC, Hays AP, Yan SF, Du Yan SS, and Schmidt AM: RAGE & the Nervous System: Striking A Fine Balance Between Injury & Repair. Restorative Neurology and Neuroscience. 2005;23:355-65.