Xingmin Sun D-9360-2016

Xingmin Sun, PHD

Assistant Professor, College of Medicine Molecular Medicine

Assistant Professor, Non USF Health

Assistant Professor, College of Medicine Internal Medicine

Contact Info 12901 Bruce B. Downs Blvd
MDC07, RM3523
Tampa FL 33612

Academic Email: sun5@health.usf.edu

Academic Phone:(813) 974-4553

View My C.V.

Education

  • PhD, Natural Sciences, Christian-Albrechts-University of Kiel, 2002
  • MS, Veterinary Microbiology & Immunology, Nanjing Agricultural University, 1994

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease

Research Interests

  • The Sun Lab (http://www.sunlab-usf.com) focuses on the pathogenesis of Clostridium difficile infection (CDI) and development of novel preventive and therapeutic agents agaisnt CDI. We use multidisciplinary approaches in our research, including molecular biology/microbiology, cell biology, protein engineering, immunology, genome sequencing, flow cytometry and nano-particle delivery. Current projects: 1) The roles of innate immunity and intestinal microbiome in the pathogenesis of CDI; 2) Signaling pathways of pro-inflammatory mediators and CDI; 3) Development of novel therapeutic /preventive agents against C. difficile; 4) Regulation of C. difficile toxin production; 5) Antibiotic resistance, epidemiology and whole-genome sequencing of C. difficile.

Memberships

  • Anaerobe Society of the Americas (Member, 2016 - Present)
  • Society for Mucosal Immunology (Member, 2014 - Present)
  • American Society for Microbiology (Member, 2005 - Present)

Recent Publications

  • Peng Z, Jin D, Kim HB, Stratton CW, Wu B, Tang YW, Sun X. Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing. Journal of clinical microbiology. 55(7) : 1998-2008, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28404671
  • Kim HB, Wang Y, Sun X. A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift. Journal of Microbiology and Biotechnology. 26(3) : 567-71, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26809802
  • Ghose C, Eugenis I, Edwards AN, Sun X, McBride SM, Ho DD. Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe. 37: 85-95, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26688279
  • Ghose C, Eugenis I, Sun X, Edwards AN, McBride SM, Pride DT, Kelly CP, Ho DD. Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC. Emerging Microbes & Infections. 5: e8, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26839147
  • Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, Sun X, Kashentseva EA, Dmitriev IP, Curiel DT, Shoemaker CB, Tzipori S. A Tetraspecific VHH-based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection. Clinical and Vaccine Immunology : CVI. , 2016. http://www.ncbi.nlm.nih.gov/pubmed/27413067
  • Sponseller JK, Steele JA, Schmidt DJ, Kim HB, Beamer G, Sun X, Tzipori S. Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection. The Journal of Infectious Diseases. 211(8) : 1334-41, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25381448
  • Wang YK, Zou Q, Sun JH, Wang HA, Sun X, Chen ZF, Yan YX. Screening of single-stranded DNA (ssDNA) aptamers against a zearalenone monoclonal antibody and development of a ssDNA-based enzyme-linked oligonucleotide assay for determination of zearalenone in corn. Journal of Agricultural and Food Chemistry. 63(1) : 136-41, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25485848
  • Huang T, Perez-Cordon G, Shi L, Li G, Sun X, Wang X, Wang J, Feng H. Clostridium difficile toxin B intoxicated mouse colonic epithelial CT26 cells stimulate the activation of dendritic cells. Pathogens and Disease. 73(3) , 2015. http://www.ncbi.nlm.nih.gov/pubmed/25743476
  • Sun X, Hirota SA. The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection. Molecular Immunology. 63(2) : 193-202, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25242213
  • Wang YK, Yan YX, Kim HB, Ju X, Zhao S, Zhang K, Tzipori S, Sun X. A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters. Human Vaccines & Immunotherapeutics. 11(9) : 2215-22, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26036797
  • Zhang K, Zhao S, Wang Y, Zhu X, Shen H, Chen Y, Sun X. The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain. Anaerobe. 36: 49-52, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26461425
  • Yong Y, Liu S, Hua G, Jia R, Zhao Y, Sun X, Liao M, Ju X. Identification and functional characterization of Toll-like receptor 2-1 in geese. BMC Veterinary Research. 11: 108, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25967535
  • Ali Y, Koberg S, Heßner S, Sun X, Rabe B, Back A, Neve H, Heller KJ. Temperate Streptococcus thermophilus phages expressing superinfection exclusion proteins of the Ltp type. Frontiers in Microbiology. 5: 98, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24659988
  • Kim HB, Zhang Q, Sun X, Beamer G, Wang Y, Tzipori S. Beneficial effect of oral tigecycline treatment on Clostridium difficile infection in gnotobiotic piglets. Antimicrobial Agents and Chemotherapy. 58(12) : 7560-4, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25267665
  • Zhao S, Ghose-Paul C, Zhang K, Tzipori S, Sun X. Immune-based treatment and prevention of Clostridium difficile infection. Human Vaccines & Immunotherapeutics. 10(12) : 3522-30, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25668664
  • Zhang K, S, Martinod & X, Sun. Clostridium difficile infection in horses. Austin J Vet Sci & Anim Husb.. 1(1) : 5, 2014.
  • Kim H, B, Q, Zhang X, Sun G, Beamer D, Schmidt Y, Wang & S, Tzipori. Effect of oral tigecycline treatment on Clostridium difficile and human gut microflora. Antimicrob Agents Chemother.. 58(12) : 7560-4, 2014.
  • Zhao S, C, Ghose-Paul KS Zhang S, Tzipori and X, Sun. Clostridium difficile infection: virulence factors, adaptive immunity and vaccine development. Austin J Infect Dis.. 1(1) : 7, 2014.
  • Zhang J, X, Rui L, Wang Y, Guan X, Sun M, Dong. Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation. Food Control. 42: 125-131, 2014.
  • Wang Y, K, Q, Zou J, H, Sun H, A, Wang X, Sun Z, F, Chen Y, X, Yan. Screening of ssDNA aptamers against a zearalenone monoclonal antibody and development of a ssDNA-based enzyme-linked oligonucleotide assay for determination of zearalenone in corn. J Agric Food Chem.. , 2014.
  • Zhang H, W, Li X, Rui X, Sun M, Dong. Lactobacillus plantarum 70810 from Chinese paocai as a potential source of β-galactosidase for prebiotic galactooligosaccharides synthesis. Eur Food Res Technol. 236: 817-826, 2013.
  • Wu J, Lu Z, Nie M, Zhou H, Sun X, Xue X, Bi J, Fang G. Optimization of cryopreservation procedures for porcine endothelial progenitor cells. Journal of Bioscience and Bioengineering. 113(1) : 117-23, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22036230
  • Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H. A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infection and Immunity. 80(8) : 2678-88, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22615245
  • Steele J, K, Chen X, Sun Y, Zhang H, Wang S, Tzipori & H, Feng. Toxemia is the cause of systemic disease in the piglet and mouse models of Clostridium difficile infection. J. Infect. Dis.. 205(3) : 384-91, 2012.
  • Steele J, Chen K, Sun X, Zhang Y, Wang H, Tzipori S, Feng H. Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models. The Journal of Infectious Diseases. 205(3) : 384-91, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22147798
  • Sun X, Wang H, Zhang Y, Chen K, Davis B, Feng H. Mouse relapse model of Clostridium difficile infection. Infection and Immunity. 79(7) : 2856-64, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21576341
  • Sun X, Savidge T, Feng H. The enterotoxicity of Clostridium difficile toxins. Toxins. 2(7) : 1848-80, 2010. http://www.ncbi.nlm.nih.gov/pubmed/22069662
  • He X, Sun X, Wang J, Wang X, Zhang Q, Tzipori S, Feng H. Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infection and Immunity. 77(6) : 2294-303, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19307220
  • Sun X, He X, Tzipori S, Gerhard R, Feng H. Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages. Microbial Pathogenesis. 46(6) : 298-305, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19324080
  • He X, Wang J, Steele J, Sun X, Nie W, Tzipori S, Feng H. An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. Journal of Microbiological Methods. 78(1) : 97-100, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19393695
  • Yang G, Zhou B, Wang J, He X, Sun X, Nie W, Tzipori S, Feng H. Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiology. 8: 192, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18990232
  • Sun X, Göhler A, Heller KJ, Neve H. The ltp gene of temperate Streptococcus thermophilus phage TP-J34 confers superinfection exclusion to Streptococcus thermophilus and Lactococcus lactis. Virology. 350(1) : 146-57, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16643978
  • Sun X, Mierke DF, Biswas T, Lee SY, Landy A, Radman-Livaja M. Architecture of the 99 bp DNA-six-protein regulatory complex of the lambda att site. Molecular Cell. 24(4) : 569-80, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17114059

Positions Held

  • Research Assistant Professor (Department of Infectious Disease and Global Health, Tufts University Cummings School of Veterinary Medicine 2012 - 2015)
  • Assistant Professor (adjunct appointment) (Clinical and Translational Science Institute, Tufts University 2014 - 2015)

Awards/Honors

  • Editorial Board (Infection and Immunity - 2016)
  • Review Editor (Frontiers in Cellular and Infection Microbiology - 2016)
  • Tufts Institute for Innovation Inaugural Award (Tufts University - 2014)
  • Tufts Collaborates (Tufts University - 2014)
  • Tufts Collaborates (Tufts University - 2013)
  • Chair of the 3rd Annual Symposia of Bacteriology and Infection (Annual Symposia of Bacteriology and Infection - 2013)
  • Tufts Technology Access Award (Tufts University - 2013)
  • K01 Mentored Research Scientist Development Award (NIH/NIDDK - 2012)
  • ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Award for the "6th (European Society of Clinical Microbiology and Infectious Diseases - 2009)
  • Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Infectious Diseases (American Society for Microbiology and the Infectious Diseases Society of America - 2008)
  • Postdoctoral Travel Award (American Society for Biochemistry and Molecular Biology - 2007)
  • Young Scientist Award (Federation of European Microbiological Societies for the 7th Symposium on Lactic - 2002)
  • Excellent Graduate Student Award (Nanjing Agricultural University - 1993)
  • Excellent Graduate Student Award (Nanjing Agricultural University - 1992)