Dr. Xingmin Sun is an Associate Professor with tenure in the Department of Molecular Medicine, College of Medicine at the University of South Florida (USF). He holds courtesy appointments in the Department of Internal Medicine, Department of Cell Biology, Microbiology & Molecular Biology, Department of Chemistry at USF, and USF Genomics. He received his PhD in Natural Sciences from the University of Kiel, Germany, and his master’s degree in Veterinary Microbiology and Immunology from Nanjing Agricultural University, China. He received his postdoctoral training in Molecular Microbiology and Biochemistry at Brown University, USA. He was an NIH (National Institutes of Health) Career Development K01 Awardee. His laboratory has been continuously supported by NIH. He has been actively serving NIH study section panels including chairing the NIH study section panel in 2020. Currently, he serves as an Associate Editor for “Molecular Medicine”, Associate topic editor for “Frontiers in Microbiology”, and editorial boards for “Infection and Immunity” and “Applied and Environmental Microbiology”. He received the “Tufts Institute for Innovation Inaugural Award” in 2014. He chaired the Research Committee of College of Medicine at USF from 2019 to 2020. In 2018, he was awarded the "Faculty Outstanding Research Achievement Award" at USF. In 2019, he was awarded the "Excellence in Innovation Award" at USF.
The research in his laboratory at USF is focused on the pathogenesis of Clostridioides difficile and the development of novel therapeutics including vaccines to prevent / treat C. difficile infection (CDI). C. difficile is a Gram-positive, spore-forming and toxin-producing anaerobic bacterium. It is the most common cause of nosocomial antibiotic-associated diarrhea and the etiologic agent of life-threatening pseudomembranous colitis in the developed world. In the US, C. difficile infection (CDI) caused 223,900 estimated hospitalizations,12,800 deaths and $5 billion healthcare costs in 2017. More alarmingly, C. difficile is classified as an “urgent antibiotic resistant threat” by the Centers for Disease Control and Prevention (CDC). To address these challenges, Sun lab is focusing on following research directions:
Wickramage, I., Spigaglia, P., & Sun, X. (2021). Mechanisms of antibiotic resistance of Clostridioides difficile. The Journal of antimicrobial chemotherapy, dkab231. Advance online publication.
Heuler, J., Fortier, L. C., & Sun, X. (2021). Clostridioides difficile Phage Biology and Application. FEMS microbiology reviews, fuab012. Advance online publication.
Zheng, M., Li, C., Zhou, M., Jia, R., Cai, G., She, F., Wei, L., Wang, S., Yu, J., Wang, D., Calcul, L., Sun, X., Luo, X., Cheng, F., Li, Q., Wang, Y., & Cai, J. (2021). Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR. Journal of medicinal chemistry, 10.1021/acs.jmedchem.1c00607. Advance online publication.
Zhu, D., Patabendige, H., Tomlinson, B. R., Wang, S., Hussain, S., Flores, D., He, Y., Shaw, L. N., & Sun, X. (2021). Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291. Environmental microbiology, 10.1111/1462-2920.15529. Advance online publication.
Zhu, D., Bullock, J., He, Y., & Sun, X. (2019). Cwp22, a novel peptidoglycan cross-linking enzyme, plays pleiotropic roles in Clostridioides difficile. Environmental microbiology, 21(8), 3076–3090.
Peng, Z., Wang, S., Gide, M., Zhu, D., Lamabadu Warnakulasuriya Patabendige, H. M., Li, C., Cai, J., & Sun, X. (2019). A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice. Frontiers in microbiology, 9, 3234.
Daou, N., Wang, Y., Levdikov, V. M., Nandakumar, M., Livny, J., Bouillaut, L., Blagova, E., Zhang, K., Belitsky, B. R., Rhee, K., Wilkinson, A. J., Sun, X., & Sonenshein, A. L. (2019). Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027. PloS one, 14(1), e0206896.
Wang Y., K. Zhang, X. Ju, S. Wang, S. Tzipori, H. Feng, A. Greenberg, X. Sun* (2018). TPL-2 is a key regulator of inflammation in Clostridium difficile infection. Infect Immun. May 29.
Li C., P. Teng, Z. Peng, P. Sang, X. Sun*, J. Cai*(2018). Bis-Cyclic-Guanidine as a novel class of compound potent against Clostridium difficile. ChemMedChem. 2018 May 16. *Correspondence
Teng P.,C. Li, Z. Peng, A. Nimmagadda, M. Su, Y. Li, E. Mulry, X. Sun*, and J. Cai* (2018). Facial Accessible Quinoline Derivatives as Potent Antibacterial Agents. Bioorganic & Medicinal Chemistry. May 22. *Correspondence
Zhu D., J. A. Sorg, X. Sun* (2018). Clostridium difficile biology: sporulation, germination and corresponding therapies for C. difficile infection. Front. Microbiol. January 2018
Xu D., L. Han , C. Li, Q. Cao, D. Harmody, J. Reeds, P. McCarthy*, X. Sun*, G. Wang* (2018). Bioprospecting deep-sea actinomycetes for novel anti-infectious natural products. Front. Microbiol. April 2018 *Correspondence
Wang, S., Wang, Y., Cai, Y., Kelly, C. P., & Sun, X. (2018). Novel Chimeric Protein Vaccines Against Clostridium difficile Infection. Frontiers in immunology, 9, 2440. https://doi.org/10.3389/fimmu.2018.02440
Xu, D., Han, L., Li, C., Cao, Q., Zhu, D., Barrett, N. H., Harmody, D., Chen, J., Zhu, H., McCarthy, P. J., Sun, X., & Wang, G. (2018). Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products. Frontiers in microbiology, 9, 787. https://doi.org/10.3389/fmicb.2018.00787
Teng, P., Li, C., Peng, Z., Anne Marie, V., Nimmagadda, A., Su, M., Li, Y., Sun, X., & Cai, J. (2018). Facilely accessible quinoline derivatives as potent antibacterial agents. Bioorganic & medicinal chemistry, 26(12), 3573–3579. https://doi.org/10.101or6/j.bmc.2018.05.031
Wang, Y., Wang, S., Bouillaut, L., Li, C., Duan, Z., Zhang, K., Ju, X., Tzipori, S., Sonenshein, A. L., & Sun, X. (2018). Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters. Infection and immunity, 86(11), e00489-18. https://doi.org/10.1128/IAI.00489-18
Li, C., Harmanus, C., Zhu, D., Meng, X., Wang, S., Duan, J., Liu, S., Fu, C., Zhou, P., Liu, R., Wu, A., Kuijper, E. J., Smits, W. K., Fu, L., & Sun, X. (2018). Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea. Emerging microbes & infections, 7(1), 211. https://doi.org/10.1038/s41426-018-0211-1
Peng Z, Jin D, Kim HB, Stratton CW, Wu B, Tang YW, X. Sun* (2017). An Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing. J Clin Microbiol. 2017 Apr 12.
Peng Z., A. Sally, X. Sun* (2017). Antibiotic resistance and toxin production of Clostridium difficile isolates from the hospitalized patients in a large hospital in Florida. Front. Microbiol. 22 December 2017
Daou N., Y. Wang, V. M. Levdikov, M. Nandakumar, J. Livny, L. Bouillaut, K. Zhang, E. Blagova, K. Rhee, A. J. Wilkinson, X. Sun, and A. L. Sonenshein (2017). Impact of CodY protein on metabolism, sporulation and virulence in Clostridium difficile ribotype 027. (in revision)
Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, X. Sun, Curiel DT, Shoemaker CB, Tzipori S (2016). A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection. Clin Vaccine Immunol. 2016 Sep 6; (9):774-84
Kim HB, Wang Y, X. Sun* (2016). A detrimental role of immunosuppressive drug, dexamethasone, during Clostridium difficile infection in association with a gastrointestinal microbial shift. J Microbiol Biotechnol. 2016 Jan 26.
Chandrabali G., I. Eugenis, Y. Huang, X. Sun, A. N. Edwards, S. M. McBride, D. T. Pride, C. P. Kelly, and D. D. Ho (2016). Immunogenicity and Protective Efficacy of Recombinant Clostridium difficile Flagellar protein FliC in animal models of Clostridium difficile infection. Emerg Microbes Infect. 2016 Feb 3;5.
Chandrabali G., I. Eugenis, A. N. Edwards , X. Sun, S. M. McBride, and D. D. Ho (2015). Immunogenicity and Protective Efficacy of Clostridium difficile Spore Proteins. Anaerobe. 2015 Dec 11.
Wang Y., Y. Yan. H. Kim, K. Zhang, S. Tzipori & X. Sun* (2015). A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters. Hum Vaccin Immunother. 2015; Sep 2; 11(9):2215-2222.
Sun, X*. & S. A. Hirota (2015). The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection. Mol Immunol. 2015; Feb; 63(2):193-202. *Correspondence
Huang, T., G. Perez-cordon, L. Shi. G. Li, X. Sun, X. Wang, J, Wang, H. Feng (2015). Clostridium difficile toxin B intoxicated intestinal epithelial cells stimulate the activation of dendritic cells. Pathog Dis. 2015 Apr; 73(3).
Zhang, K., S. zhao, Y. Wang, X. Sun* (2015). The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain. Anaerobe. 2015 Dec; 36:49-52.
Zhao, S., C. Ghose-Paul, K. Zhang, S. Tzipori, & X. Sun* (2014). Immune-based treatment and prevention of Clostridium difficile infection. Hum Vaccin Immunother. 2014; 10(12):3522-30.
Sponseller, JK., J. Steele, D. Schmidt, H. Kim, G. Beamer, X. Sun & S Tzipori (2014). Hyperimmune Bovine Colostrum as a Novel Therapy for Clostridium difficile Infection. J Infect Dis. 2014 Nov 7.
Kim, H.B., Q. Zhang, X. Sun, G. Beamer, D. Schmidt, Y. Wang & S. Tzipori (2014). Effect of oral tigecycline treatment on Clostridium difficile and human gut microflora. Antimicrob Agents Chemother. 2014 Dec;58(12):7560-4
Ali Y, S. Koberg, S. Heβner, X. Sun, B. Rabe, A. Back, H. Neve, K.J. Heller (2014). Temperate Streptococcus thermophilus phages expressing superinfection exclusion proteins of the Ltp type. Front Microbiol. 5: 98
Zhang, J. X. Rui, L. Wang, Y. Guan, X. Sun, M. Dong (2014). Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation. Food Control. 42:125-131.
Wang Y.K., Q. Zou, J.H. Sun, H. A. Wang, development of a ssDNA-based enzyme-linked oligonucleotide assay for determination of zearalenone in corn. J Agric Food Chem. 2014 Dec 22.
Zhao, S., C. Ghose-Paul, X. Zhu, H. Shen, X. Sun* (2014) Clostridium difficile infection: Virulence factors, adaptive immunity and vaccine development. Austin J of Infect Dis. 2014:1 (1):7.
Chen X., M. Dong and X. Sun* (2013). Mechanisms of action and applications of probiotics for the treatment of Clostridium difficile infection. (a chapter in “Microbial pathogens and strategies for combating them: science, technology and education”, Formatex Research Center, Zurbaran, Spain). *Correspondence.
Zhang, K., S. Martinod, X. Sun* (2014). Clostridium difficile infection in horses. Austin J. Vet Sci & Anim Husb. 2014: 1(1): 5
Zhang H., W. Li, X. Rui, X. Sun, M. Dong (2013). Lactobacillus plantarum 70810 from Chinese paocai as a potential source of β-galactosidase for prebiotic galactooligosaccharides synthesis. Eur Food Res Technol 236:817-826.
Wang H., X. Sun, Y. Zhang, S. Li, K. Chen, L. Shi, W. Nie, R. Kumar, S. Tzipori, J. Wang, T. Savidge & H. Feng (2012). A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect. Immun. 80(8):2678-88.
Steele J., K. Chen, X. Sun, Y. Zhang, H. Wang, S. Tzipori & H. Feng (2012). Toxemia is the cause of systemic disease in the piglet and mouse models of Clostridium difficile infection. J. Infect. Dis. 205(3):384-91.
Wu, J., Z. Lu, M. Nie, H. Zhou, X. Sun, X. Xue, J. Bi, G. Fang (2012). Optimization of Cryopreservation Procedures for Porcine Endothelial Progenitor Cells. J. Biosci. Bioeng. 113(1):117-23.
Sun X., H. Wang, B. Davis & H. Feng (2011). A mouse relapse model of Clostrridium difficile infection. Infect. Immun. 79(7):2856-64.
Sun X., S. Tzipori & H. Feng (2010). The enterotoxicity of Clostridium difficile toxins. Toxins, 2(7), 1848-1880. (Invited review).