Dr. Margres is an Assistant Professor in the Department of Integrative Biology where his lab addresses fundamental questions regarding adaptation dynamics in two co-evolving systems: (1) Tasmanian devils and a species-specific transmissible cancer, and (2) venomous snakes and their prey. Research in both systems involves the integration of diverse -omic approaches with phenotypic data, ecology, field work, and experimentation to better understand the genotype-phenotype-fitness connection in natural populations.
Margres MJ, Rautsaw RM, Strickland JL, Mason AJ, Schramer TD, Hofmann EP, Stiers E, Ellsworth SA, Nystrom GS, Hogan MP, Bartlett DA, Colston TJ, Gilbert DM, Rokyta DR, Parkinson C. 2021. The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype. Proceedings of the National Academy of Sciences USA. 118:4, e2014634118.
Patton A, Lawrance M, Margres MJ, Kozakiewicz C, Hamede R, Ruiz-Aravena M, Hamilton DG, Comte S, Ricci L, Taylor R, Stadler T, Leache, McCallum H, Jones M, Hohenlohe P, Storfer A. 2020. Phylodynamics of Tasmanian devil transmissible cancer reveals a shift from emergence to endemism. Science. 370, eabb9772.
Margres MJ, Ruiz-Aravena M, Hamede R, Chawla K, Patton A, Lawrance MF, Fraik AK, Stahlke A, Davis BW, Ostrander EA, Jones ME, McCallum H, Paddison PJ, Hohenlohe PA, Hockenbery, and Storfer A. 2020. Spontaneous tumor regression in Tasmanian devils associated with RASL11A activation. Genetics. 215:4, 1143-1152; Highlighted Article.
Margres MJ, Patton A, Wray KP, Hassinger ATB, Ward MJ, Lemmon EM, Lemmon AR, and Rokyta DR. 2019. Tipping the scales: the migration-selection balance leans toward selection in snake venoms. Molecular Biology and Evolution36:2, 271-282.
Margres MJ, Ruiz-Aravena M, Hamede R, Jones ME, Lawrance MF, Hendricks SA, Patton A, Davis BW, Ostrander EA, McCallum H, Hohenlohe PA, and Storfer A. 2018. The genomic basis of tumor regression in Tasmanian devils (Sarcophilus harrisii). Genome Biology and Evolution 10:11, 3012-3025.]