Genomics of social
adversity and stress-related mental disorders
Monica Uddin is a Professor
in USF’s College of Public Health, where she is an active contributor to the
Genomics Program housed in the Center for Global Health and Infections Disease
Research. The goal of work in the Uddin research group is to identify genetic
and epigenetic predictors of stress-related mental disorders, with a particular
focus on depression and post-traumatic stress disorder. A central theme of this
work is the recognition that lived experience has a substantial impact on risk
for mental disorders, and that this risk is likely mediated in part by changes
to genomic biology; accordingly, we seek to develop biomarkers of risk prediction that take into
account aspects of lived experience, such as early life adversity and
cumulative traumatic burden, that are known to influence susceptibility to
depression and related disorders, with the ultimate goal helping to inform
interventions that reduce the burden of mental illness.
Uddin M, Ratanatharathorn A, Armstrong D, Kuan P, Aiello
AE, Bromet EJ, Galea S, Koenen KC, Luft B, Ressler KJ, Wildman DE, Nievergelt
CM, Smith, A. (in press). Epigenetic meta-analysis across three civilian
cohorts identified NRG1 and HGS as blood-based biomarkers for
post-traumatic stress disorder. Epigenomics.
Pfeiffer J, Mutesa L, Uddin M. Traumatic stress
epigenetics. (2018). Curr Behav Neurosci
Rep. Published online Feb. 13, 2018. https://doi.org/10.1007/s40473-018-0143-z
Nievergelt N, Ashley-Koch AE,
Dalvie S. Hauser MA, Morey R, Smith AK, Uddin M. Genomic approaches to
post-traumatic stress disorder: The psychiatric genomic consortium initiative.
(2018). Biol. Psych. 83:831-39. PMID:
29555185. PMCID: PMC5915904.
Wolf EJ, Maniates H, Nugent N,
Maihofer AX, Armstrong A, Ratanatharathorn A, Ashley-Koch AE, Garrett M,
Kimnrel NA, Lori A, VA MIRECC Workgroup, Aiello AE, Baker DG, Beckham JC, Boks
MP, Galea S, Geuze Em Hauser MA, Kessler RC, Koenen KC, Miller MW, Ressler KJ,
Risbrough V, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Uddin M,
Smith AK, Nievergelt CM, Logue MW. Traumatic stress and accelerated DNA
methylation age: A meta-analysis. (2018) Psychoneuroendocrinol.
92:123-34. PMID: 29452766. PMCID: PMC5924645.
Bustamante A, Aiello A, Guffanti G,
Galea S, Wildman D, Uddin M. FKBP5
DNA methylation does not mediate the association between childhood maltreatment
and depression symptom severity in the Detroit Neighborhood Health Study.
(2018). J Psychiatr. Res. 96:39-48. PMID:
28961425 PMCID: PMC5698158
Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM,
Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J,
Bradley B, Chen CY, Dalvie S, Farrer LA, Galea A, Garrett ME, Gelerntner JE,
Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel KA, King A, Koen N,
Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR,
Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB,
Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, MIRREC, Daly MJ,
Liberzon I, Nivergelt CN, Koenen KC. (2018). Largest GWAS of PTSD (N=20,070).
Yields Genetic Overlap with Schizophrenia and Sex Differences in Heritability. Mol. Psychiatry. 23: 666-673. PMID:
28439101. PMCID: PMC5696105. doi: 10.1038/mp.2017.77
Bustamante AArmstrong D, Uddin M.
Epigenetic profiles associated with Major Depression in the Human Brain.
(2018). Psychiatry Res. 260:439-442.
Lowe SR, Joshi S, Galea S, Aiello AE, Uddin M, Koenen KC,
Cerda M. (2017). Pathways
from assaultive violence to posttraumatic stress, depression, and generalized
anxiety symptoms through stressful life events: Longitudinal mediation models. Psychol. Med. 47:2556-66. PMID:
28464960. PMCID: PMC5675529
Ratanatharathorn A, Boks MP, Maihofer AX, Aiello
AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M,
Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC,
Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ,
Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA; VA Mid-Atlantic
MIRECC Workgroup; PGC PTSD Epigenetics Workgroup, Uddin M, Nievergelt CM, Smith
AK. (2017). Epigenome-wide association of PTSD from heterogeneous corhots with a
common multi-site analysis pipeline. Am.
J. Med. Genet B Neuropsychiatry Genet. 174:619-30. PMID: 28691784.
Horesh D, Lowe S, Galea S, Uddin M, Koenen KC (2017). An in-depth
look into PTSD-depression comorbidity: A longitudinal study of
chronically-exposed Detroit residents. J
Affect. Disord. 208:653-661. PMID: 27816322