Srinivas Tipparaju

Srinivas Tipparaju, Associate Professor

Assistant Professor, College of Medicine Molecular Pharmacology & Physiology

Associate Professor, Cop Dept of Pharmaceutical Science

Assistant Professor, College of Medicine Molecular Medicine

Acting Chair, Pharmaceutical Sciences

Academic Email: stippara@health.usf.edu

Academic Phone:(813) 974-7195

Education

  • PostDoc, Cardiovascular Research, Emory University, 2003
  • PhD, Medicine, Jamia Hamdard, 2002
  • MPharm, Pharmacy, BITS, Pilani, 1998
  • BPharm, Pharmacy, Nagpur College of Pharmacy, 1996

Interdisciplinary and Emerging Signature Programs

  • Cardiovascular Sciences

Memberships

  • APS (Member, 2013 - Present)
  • AACP (Member, 2011 - Present)
  • AHA (Member, 2003 - Present)

Recent Publications

  • Tur J, Chapalamadugu KC, Padawer T, Badole SL, Kilfoil PJ, Bhatnagar A, Tipparaju SM. Deletion of Kvβ1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts. Experimental physiology. 101(4) : 494-508, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27038296
  • Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Bhatnagar A, Tipparaju SM. Kvβ1.1 senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity. American journal of physiology. Heart and circulatory physiology. : ajpheart.00281.2016, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27986658
  • MohanKumar K, Namachivayam K, Chapalamadugu KC, Garzon SA, Premkumar MH, Tipparaju SM, Maheshwari A. Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. Pediatric research. 79(6) : 951-61, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26859364
  • Chapalamadugu KC, Panguluri SK, Bennett ES, Kolliputi N, Tipparaju SM. High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation. Toxicology and applied pharmacology. 282(1) : 100-7, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25447406
  • Puri M, Chapalamadugu KC, Miranda AC, Gelot S, Moreno W, Adithya PC, Law C, Tipparaju SM. Integrated approach for smart implantable cardioverter defibrillator (ICD) device with real time ECG monitoring: use of flexible sensors for localized arrhythmia sensing and stimulation. Frontiers in physiology. 4: 300, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24167492
  • Kilfoil PJ, Tipparaju SM, Barski OA, Bhatnagar A. Regulation of ion channels by pyridine nucleotides. Circulation research. 112(4) : 721-41, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23410881
  • Panguluri SK, Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Tipparaju SM. MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators. PloS one. 8(4) : e60545, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23573265
  • Panguluri SK, Tur J, Fukumoto J, Deng W, Sneed KB, Kolliputi N, Bennett ES, Tipparaju SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12) : H1651-61, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23585127
  • Tipparaju SM, Li XP, Kilfoil PJ, Xue B, Uversky VN, Bhatnagar A, Barski OA. Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating. Pflugers Archiv : European journal of physiology. 463(6) : 799-818, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22426702
  • Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey R. NALP-3 inflammasome silencing attenuates ceramide induced transepithelial permeability. Journal of cellular physiology. , 2011. http://www.ncbi.nlm.nih.gov/pubmed/22169929
  • Xie Z, Barski OA, Cai J, Bhatnagar A, Tipparaju SM. Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6). Chemico-biological interactions. 191(1-3) : 255-60, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21296056
  • Barski OA, Tipparaju SM, Bhatnagar A. Kinetics of nucleotide binding to the beta-subunit (AKR6A2) of the voltage-gated potassium (Kv) channel. Chemico-biological interactions. 178(1-3) : 165-70, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19013139
  • Barski OA, Tipparaju SM, Bhatnagar A. The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug metabolism reviews. 40(4) : 553-624, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18949601
  • Tipparaju SM, Barski OA, Srivastava S, Bhatnagar A. Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Biochemistry. 47(34) : 8840-54, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18672894
  • Tipparaju SM, Liu SQ, Barski OA, Bhatnagar A. NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels. Biochemical and biophysical research communications. 359(2) : 269-76, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17540341

Positions Held

  • Assistant Professor (Pharmaceutical Sciences, College of Pharmacy 2011 - 2014)
  • Assistant Professor (Medicine, School of Medicine/University of Louisville 2010 - 2011)
  • Instructor (School of Medicine, University of Louisville 2008 - 2010)

Awards/Honors

  • Best Researcher Award (USF - 2014)
  • Fellow (CTI and Faculty Leadership Academy USF COP - 2013)
  • AHA BGIA (AHA - 2008)
  • AHA postdoctoral fellowship (AHA - 2003)