Jun Tan I-5339-2012

Jun Tan, PhD, MD

Professor, College of Medicine Neurosurgery

Endowed Chair, College of Medicine Psychiatry and Behavioral Neurosciences

Professor, College of Medicine Molecular Pharmacology & Physiology

Professor, College of Medicine Psychiatry and Behavioral Neurosciences

Professor, College of Medicine Molecular Medicine

Contact Info 3515 E Fletcher Ave
Tampa FL 33613

Academic Email: jtan@health.usf.edu

Academic Phone:(813) 974-9326

View My C.V.


  • PHD, Third Military Medical University, 1992
  • MS, Human Genetics, Fudan University, 1989
  • MD, Third Military Medical University, 1983

Academic Philosophy

"Once Scientist, Always Scientist. If you believe then you will achieve."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Cancer Biology
  • Cellular and Molecular Biology
  • Metabolic Regulation and Disorders
  • Neurodegenerative Disease
  • Neuroscience

Research Interests

  • The current focus of the laboratory is to investigate novel treatments for Alzheimer's disease and abnormal brain development and its related mental disorders including autism. These studies include:
  • 1. Identifying several natural compounds which promote amyloid precursor protein (APP) α-secretase cleavage or inhibit amyloidogenic cleavage in vitro as well as in animal models.
  • 2. Analyzing the role of microglial activation in modulation of amyloid/tau pathology in experimental animal models following administration of human umbilical cord blood cells.
  • 3. Elucidating the role of molecular mechanisms in the creation of neurons and their growth in the developing fetus.


  • The American Society for Neural Therapy and Repair (Member, 2003 - Present)
  • Florida Alzheimer Center Membership Program (Member, 2003 - Present)
  • The American Association of Immunologists (Member, 1999 - Present)

Recent Publications

  • Michael Leon Darrell Sawmiller Roland Shytle and Jun Tan. Therapeutic cocktail approach to hyperhomocysteinemia in Alzheimer’s disease (Review). Cell Medicine. , 2017.
  • Hou H, Habib A, Zi D, Tian K, Tian J, Giunta B, Sawmiller D, Tan J. Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) C4408R Mutant Promotes Amyloid Precursor Protein (APP) α-Cleavage in Vitro. Neuromolecular medicine. , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28612181
  • Habib A, Sawmiller D, Li S, Xiang Y, Rongo D, Tian J, Hou H, Zeng J, Smith A, Fan S, Giunta B, Mori T, Currier G, Shytle DR, Tan J. LISPRO mitigates β-amyloid and associated pathologies in Alzheimer's mice. Cell death & disease. 8(6) : e2880, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28617434
  • Sawmiller D, Li S, Mori T, Habib A, Rongo D, Delic V, Bradshaw PC, Shytle RD, Sanberg C, Bickford P, Tan J. Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer's disease. Heliyon. 3(4) : e00279, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28413833
  • Habib A, Sawmiller D, Tan J. Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease. Journal of neuroscience research. 95(4) : 973-991, 2017. http://www.ncbi.nlm.nih.gov/pubmed/27531392
  • Jiao SS Shen LL Zhu C Bu XL Liu YH Liu CH Yao XQ Zhang LL Zhou HD Walker DG Tan J Götz J Zhou XF Wang YJ. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Transl Psychiatry. 6(10) : 10):e907 (2016). doi: 10.1038/tp.2016.186., 2016.
  • Jin J Grimmig B Izzo J Brown LA Hudson C Smith AJ Tan J Bickford PC Giunta B. HIV non-nucleoside reverse transcriptase inhibitor efavirenz reduces neural stem cell proliferation in vitro and in vivo. Cell Transplant. , 2016.
  • Pérez C, Sawmiller D, Tan J. The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation. Neural development. 11: 11, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27089953
  • Ehrhart J, Darlington D, Kuzmin-Nichols N, Sanberg CD, Sawmiller DR, Sanberg PR, Tan J. Biodistribution of Infused Human Umbilical Cord Blood Cells in Alzheimer's Disease-Like Murine Model. Cell transplantation. 25(1) : 195-9, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26414627
  • Sawmiller D Habib A Li S Darlington D Hou H Tian J Shytle RD Smith A Giunta B Mori T Tan . Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. J Neuroimmunol.. 299: 98-106, 2016.
  • Parker-Athill EC, Ehrhart J, Tan J, Murphy TK. Cytokine correlations in youth with tic disorders. Journal of child and adolescent psychopharmacology. 25(1) : 86-92, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25658821
  • Yao XQ, Jiao SS, Saadipour K, Zeng F, Wang QH, Zhu C, Shen LL, Zeng GH, Liang CR, Wang J, Liu YH, Hou HY, Xu X, Su YP, Fan XT, Xiao HL, Lue LF, Zeng YQ, Giunta B, Zhong JH, Walker DG, Zhou HD, Tan J, Zhou XF, Wang YJ. p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease. Molecular psychiatry. 20(11) : 1301-10, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25917367
  • Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, Zhu XY, Giunta B, Tan J, Song WH, Zhou HD, Zhou XF, Wang YJ. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease. Acta neuropathologica. 130(4) : 487-99, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26363791
  • Li S, Hou H, Mori T, Sawmiller D, Smith A, Tian J, Wang Y, Giunta B, Sanberg PR, Zhang S, Tan J. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice. Scientific reports. 5: 11322, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26091071
  • Bickford PC, Kaneko Y, Grimmig B, Pappas C, Small B, Sanberg CD, Sanberg PR, Tan J, Douglas Shytle R. Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells. Age (Dordrecht, Netherlands). 37(5) : 103, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26410618
  • Deng J Habib M Obregon DF Barger SW Giunta B Wang YJ Hou HY Sawmiller D & Tan J. sAPPα inhibits tau phosphorylation through modulation of GSK3β signaling pathway. J Neurochem. 135(3) : 630-7, 2015.
  • Zhou ZW Li XX He ZX Pan ST Yang Y Zhang X Chow K Yang T Qiu JX Zhou Q Tan J Wang D Zhou SF. Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells. Drug Des Devel Ther. 12(9) : 1511-54. doi: 10.2147/DDDT.S75976. eCollection 2015, 2015.
  • Liu YH Wang YR Xiang Y Zhou HD Giunta B Mañucat-Tan NB Tan J Zhou XF Wang YJ. Clearance of Amyloid-Beta in Alzheimer's disease: Shifting the Action Site from Center to Periphery. Mol Neurobiol. 51(1) : 1-7, 2015.
  • Fang C Garbuzova-Davis Tan J & Obregon D. C1q as a regulator of brain development: Implication for autism spectrum disorders. Brain Disord Ther. 4: 152 doi:10.4172/2168-975X.1000152., 2015.
  • Liu YH, Xiang Y, Wang YR, Jiao SS, Wang QH, Bu XL, Zhu C, Yao XQ, Giunta B, Tan J, Zhou HD, Wang YJ. Association Between Serum Amyloid-Beta and Renal Functions: Implications for Roles of Kidney in Amyloid-Beta Clearance. Molecular neurobiology. 52(1) : 115-9, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25119777
  • Darlington D, Li S, Hou H, Habib A, Tian J, Gao Y, Ehrhart J, Sanberg PR, Sawmiller D, Giunta B, Mori T, Tan J. Human Umbilical Cord Blood-Derived Monocytes Improve Cognitive Deficits and Reduce Amyloid-β Pathology in PSAPP Mice. Cell transplantation. 24(11) : 2237-50, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26230612
  • Brown LA, Scarola J, Smith AJ, Sanberg PR, Tan J, Giunta B. The role of tau protein in HIV-associated neurocognitive disorders. Molecular neurodegeneration. 9: 40, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25304757
  • Sawmiller D, Li S, Shahaduzzaman M, Smith AJ, Obregon D, Giunta B, Borlongan CV, Sanberg PR, Tan J. Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury. Int J Mol Sci. 1(15) : 895-904, 2014.
  • Wang C, Li M, Sawmiller D, Fan Y, Ma Y, Tan J, Ren Y, Li S. Chronic mild stress-induced changes of risk assessment behaviors in mice are prevented by chronic treatment with fluoxetine but not diazepam. Pharmacology, biochemistry, and behavior. 116: 116-28, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24291732
  • Li S, Deng J, Hou H, Tian J, Giunta B, Wang Y, Sawmiller D, Smith A, Sanberg PR, Obregon D, Mori T, Tan J. Specific antibody binding to the APP672-699 region shifts APP processing from α- to β-cleavage. Cell death & disease. 5: e1374, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25118934
  • Mori T, Koyama N, Segawa T, Maeda M, Maruyama N, Kinoshita N, Hou H, Tan J, Town T. Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice. The Journal of biological chemistry. 289(44) : 30303-17, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25157105
  • Tajiri N, Hernandez D, Acosta S, Shinozuka K, Ishikawa H, Ehrhart J, Diamandis T, Gonzales-Portillo C, Borlongan MC, Tan J, Kaneko Y, Borlongan CV. Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response. Brain research. 1559: 65-71, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24602693
  • Brown LA, Jin J, Ferrell D, Sadic E, Obregon D, Smith AJ, Tan J, Giunta B. Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND). PloS one. 9(4) : e95500, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24759994
  • Smith AJ, Kim SH, Tan J, Sneed KB, Sanberg PR, Borlongan CV, Shytle RD. Plasma and Brain Pharmacokinetics of Previously Unexplored Lithium Salts. RSC advances. 4(24) : 12362-12365, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25045517
  • Obregon DF, Zhu Y, Bailey AR, Portis SM, Hou H, Zeng J, Stock SL, Murphy TK, Bengtson MA, Tan J. Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice. British journal of medicine and medical research. 4(1) : 416-432, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24466509
  • Wang C, Cai ZX, You ZL, Guo HS, Shang DJ, Wang XL, Zhang L, Ma LJ, Tan J, Le WD, Li S. Free radical scavenging activity and neuroprotective potentials of D138, one Cu(II)/Zn(II) Schiff-base complex derived from N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine. Neurochemical research. 39(9) : 1834-44, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25069642
  • Darlington D Deng J Giunta B Hou HY Sanberg CD Kuzmin-Nichols N Zhou HD Mori T Ehrhart J Sanberg PR & Tan J. Multiple Low-dose infusions of HUCBCs Improve Cognitive Impairments and Reduce Aβ-associated Neuropathology in Alzheimer Mice. Stem Cells Dev. 22(3) : 412-21, 2013.
  • Liu YH, Zeng F, Wang YR, Zhou HD, Giunta B, Tan J, Wang YJ. Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies. Drug discovery today. 18(23-24) : 1212-20, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23954180
  • Zhang SQ, Obregon D, Ehrhart J, Deng J, Tian J, Hou H, Giunta B, Sawmiller D, Tan J. Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model. Journal of neuroscience research. 91(9) : 1239-46, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23686791
  • Zhou R Zhou H Cui M Wang Y Tan J Sawmiller D Xu J. Association between aortic calcification and the risk of osteoporosis in a Chinese cohort: the Chongqing osteoporosis study. Calcif Tissue. 93(5) : 419-25, 2013.
  • Yin JJ, Sharma S, Shumyak SP, Wang ZX, Zhou ZW, Zhang Y, Guo P, Li CZ, Kanwar JR, Yang T, Mohapatra SS, Liu W, Duan W, Wang JC, Li Q, Zhang X, Tan J, Jia L, Liang J, Wei MQ, Li X, Zhou SF. Synthesis and biological evaluation of novel folic acid receptor-targeted, β-cyclodextrin-based drug complexes for cancer treatment. PloS one. 8(5) : e62289, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23658721
  • Darlington D, Deng J, Giunta B, Hou H, Sanberg CD, Kuzmin-Nichols N, Zhou HD, Mori T, Ehrhart J, Sanberg PR, Tan J. Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice. Stem cells and development. 22(3) : 412-21, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22816379
  • Hernandez-Ontiveros DG, Tajiri N, Acosta S, Giunta B, Tan J, Borlongan CV. Microglia activation as a biomarker for traumatic brain injury. Frontiers in neurology. 4: 30, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23531681
  • Smith AJ, Kavuru P, Arora KK, Kesani S, Tan J, Zaworotko MJ, Shytle RD. Crystal engineering of green tea epigallocatechin-3-gallate (EGCg) cocrystals and pharmacokinetic modulation in rats. Molecular pharmaceutics. 10(8) : 2948-61, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23730870
  • Bailey AR, Hou H, Song M, Obregon DF, Portis S, Barger S, Shytle D, Stock S, Mori T, Sanberg PG, Murphy T, Tan J. GFAP expression and social deficits in transgenic mice overexpressing human sAPPα. Glia. 61(9) : 1556-69, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23840007
  • Zhang SQ, Sawmiller D, Li S, Rezai-Zadeh K, Hou H, Zhou S, Shytle D, Giunta B, Fernandez F, Mori T, Tan J. Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation. PloS one. 8(8) : e71913, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23977176
  • Habib A, Deng J, Hou H, Zou Q, Giunta B, Wang YJ, Obregon D, Sawmiller D, Li S, Mori T, Tan J. Mycoplasma hyorhinis markedly degrades β-amyloid peptides in vitro and ex vivo: a novel biological approach for treating Alzheimer's disease? American journal of translational research. 5(6) : 634-42, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24093060
  • Small B, Rawson K, Martin C, Eisel S, Sanberg CD, McEvoy C, Sanberg P, Shytle RD, Tan J, Bickford PC. Nutraceutical Intervention Improves Older Adults' Cognitive Functioning. Rejuvenation research. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24134194
  • Smith AJ, Kim SH, Duggirala NK, Jin J, Wojtas L, Ehrhart J, Giunta B, Tan J, Zaworotko MJ, Shytle RD. Improving lithium therapeutics by crystal engineering of novel ionic cocrystals. Molecular pharmaceutics. 10(12) : 4728-38, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24191685
  • Mori T, Koyama N, Guillot-Sestier MV, Tan J, Town T. Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice. PloS one. 8(2) : e55774, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23409038
  • Obregon D, Parker-Athill EC, Tan J, Murphy T. Psychotropic effects of antimicrobials and immune modulation by psychotropics: implications for neuroimmune disorders. Neuropsychiatry. 2(4) : 331-343, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23148142
  • Kaneko Y, Tajiri N, Yu S, Hayashi T, Stahl CE, Bae E, Mestre H, Franzese N, Rodrigues A, Rodrigues MC, Ishikawa H, Shinozuka K, Hethorn W, Weinbren N, Glover LE, Tan J, Achyuta AH, van Loveren H, Sanberg PR, Shivsankar S, Borlongan CV. Nestin overexpression precedes caspase-3 upregulation in rats exposed to controlled cortical impact traumatic brain injury. Cell medicine. 4(2) : 55-63, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23101029
  • Portis S, Giunta B, Obregon D, Tan J. The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome. International journal of physiology, pathophysiology and pharmacology. 4(3) : 140-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23071871
  • Giunta B, Deng J, Jin J, Sadic E, Rum S, Zhou H, Sanberg P, Tan J. EVALUATION OF HOW CIGARETTE SMOKE IS A DIRECT RISK FACTOR FOR ALZHEIMER'S DISEASE. Technology and innovation. 14(1) : 39-48, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22997546
  • Obregon D, Hou H, Deng J, Giunta B, Tian J, Darlington D, Shahaduzzaman M, Zhu Y, Mori T, Mattson MP, Tan J. Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation. Nature communications. 3: 777, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22491325
  • Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J. Autoreactive-Aβ antibodies promote APP β-secretase processing. Journal of neurochemistry. 120(5) : 732-40, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22188568
  • Bailey AR, Hou H, Obregon DF, Tian J, Zhu Y, Zou Q, Nikolic WV, Bengtson M, Mori T, Murphy T, Tan J. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(3) : 1040-51, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22085641
  • Shytle RD, Tan J, Bickford PC, Rezai-Zadeh K, Hou L, Zeng J, Sanberg PR, Sanberg CD, Alberte RS, Fink RC, Roschek B. Optimized turmeric extract reduces β-Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice. Current Alzheimer research. 9(4) : 500-6, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21875408
  • Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T. Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. The Journal of biological chemistry. 287(9) : 6912-27, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22219198
  • Liu YH, Giunta B, Zhou HD, Tan J, Wang YJ. Immunotherapy for Alzheimer disease: the challenge of adverse effects. Nature reviews. Neurology. 8(8) : 465-9, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22751529
  • Giunta B, Obregon D, Velisetty R, Sanberg PR, Borlongan CV, Tan J. The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention. Journal of neuroinflammation. 9: 185, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22849382
  • Jin J, Lam L, Sadic E, Fernandez F, Tan J, Giunta B. HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND. American journal of translational research. 4(3) : 302-15, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22937208
  • Obregon D Hou HY Deng J Giunta B Tian J Darlington D Shahaduzzaman MD Zhu YY Mori T Mattson M & Tan J. sAPPα Suppresses β-Secretase Activity and Amyloid-β-Peptide Generation. Nat Commun. 3(777) , 2012.
  • Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(4) : 1355-65, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21273420
  • Zhu Y, Obregon D, Hou H, Giunta B, Ehrhart J, Fernandez F, Mori T, Nikolic W, Zhao Y, Morgan D, Town T, Tan J. Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology. Journal of cellular and molecular medicine. 15(2) : 327-38, 2011. http://www.ncbi.nlm.nih.gov/pubmed/19900216
  • Sanberg PR, Eve DJ, Willing AE, Garbuzova-Davis S, Tan J, Sanberg CD, Allickson JG, Cruz LE, Borlongan CV. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell transplantation. 20(1) : 85-94, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20887684
  • Salemi J, Obregon DF, Cobb A, Reed S, Sadic E, Jin J, Fernandez F, Tan J, Giunta B. Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD). Molecular neurodegeneration. 6(1) : 3, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21223591
  • Dragicevic N, Copes N, O'Neal-Moffitt G, Jin J, Buzzeo R, Mamcarz M, Tan J, Cao C, Olcese JM, Arendash GW, Bradshaw PC. Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling. Journal of pineal research. 51(1) : 75-86, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21355879
  • Giunta B, Ehrhart J, Obregon DF, Lam L, Le L, Jin J, Fernandez F, Tan J, Shytle RD. Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders. Molecular brain. 4(1) : 23, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21649911
  • Dragicevic N, Smith A, Lin X, Yuan F, Copes N, Delic V, Tan J, Cao C, Shytle RD, Bradshaw PC. Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction. Journal of Alzheimer's disease : JAD. 26(3) : 507-21, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21694462
  • Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C. Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice. Journal of Alzheimer's disease : JAD. 19(1) : 191-210, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20061638
  • Giunta B, Rezai-Zadeh K, Tan J. Impact of the CD40-CD40L dyad in Alzheimer's disease. CNS & neurological disorders drug targets. 9(2) : 149-55, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20205645
  • Fernandez JW, Rezai-Zadeh K, Obregon D, Tan J. EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP. FEBS letters. 584(19) : 4259-67, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20849853
  • Zhang S, Salemi J, Hou H, Zhu Y, Mori T, Giunta B, Obregon D, Tan J. Rapamycin promotes beta-amyloid production via ADAM-10 inhibition. Biochemical and biophysical research communications. 398(3) : 337-41, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20542014
  • Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW, Bradshaw PC. Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. Journal of Alzheimer's disease : JAD. 20 Suppl 2: S535-50, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20463404
  • Shytle DR Tan J Ehrhart J Smith AJ Sanberg CD Sanberg PR Anderson J Bickford PC. Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study. Med Sci Monit. 16(1) : BR1-5, 2010.
  • Giunta B, Hou H, Zhu Y, Salemi J, Ruscin A, Shytle RD, Tan J. Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. Neuroscience letters. 471(3) : 134-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20096749
  • Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan C, Kaneko Y, Tajiri N, Gemma C, Bickford PC. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PloS one. 5(5) : e10496, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20463965
  • Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia. 58(3) : 300-14, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19705461
  • Parker-Athill EC, Tan J. Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway. Neuro-Signals. , 2010. http://www.ncbi.nlm.nih.gov/pubmed/20924155
  • Murphy TK, Storch EA, Turner A, Reid JM, Tan J, Lewin AB. Maternal history of autoimmune disease in children presenting with tics and/or obsessive-compulsive disorder. Journal of neuroimmunology. 229(1-2) : 243-7, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20864184
  • Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. International journal of pharmaceutics. 389(1-2) : 207-12, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20083179
  • Rrapo E, Zhu Y, Tian J, Hou H, Smith A, Fernandez F, Tan J, Giunta B. Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. American journal of translational research. 1(1) : 72-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19966940
  • Rezai-Zadeh K, Douglas Shytle R, Bai Y, Tian J, Hou H, Mori T, Zeng J, Obregon D, Town T, Tan J. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Journal of cellular and molecular medicine. 13(3) : 574-88, 2009. http://www.ncbi.nlm.nih.gov/pubmed/18410522
  • Parker-Athill E, Luo D, Bailey A, Giunta B, Tian J, Shytle RD, Murphy T, Legradi G, Tan J. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. Journal of neuroimmunology. 217(1-2) : 20-7, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19766327
  • Bailey AR, Giunta BN, Obregon D, Nikolic WV, Tian J, Sanberg CD, Sutton DT, Tan J. Peripheral biomarkers in Autism: secreted amyloid precursor protein-alpha as a probable key player in early diagnosis. International journal of clinical and experimental medicine. 1(4) : 338-44, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19079679
  • Giunta B, Fernandez F, Nikolic WV, Obregon D, Rrapo E, Town T, Tan J. Inflammaging as a prodrome to Alzheimer's disease. Journal of neuroinflammation. 5: 51, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19014446
  • Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. Journal of neuroinflammation. 5: 41, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18817573
  • Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J. Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase. Rejuvenation research. 11(5) : 891-901, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18789000
  • Giunta B, Zhou Y, Hou H, Rrapo E, Fernandez F, Tan J. HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide. International journal of clinical and experimental pathology. 1(3) : 260-75, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18784813
  • Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nature medicine. 14(6) : 681-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18516051
  • Wang Y, Li M, Song M, Xu X, Xiong J, Yang X, Tan J, Bai Y. Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro. Cellular immunology. 251(2) : 86-92, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18485335
  • Zhu Y, Hou H, Nikolic WV, Ehrhart J, Rrapo E, Bickford P, Giunta B, Tan J. CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation. PloS one. 3(5) : e2135, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18478117
  • Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, Runfeldt M, Shytle RD, Tan J. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain research. 1214: 177-87, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18457818
  • Mori T, Tan J, Arendash GW, Koyama N, Nojima Y, Town T. Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia. Stroke; a journal of cerebral circulation. 39(7) : 2114-21, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18451356
  • Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem cells and development. 17(3) : 423-39, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18366296
  • Hou H, Obregon D, Lou D, Ehrhart J, Fernandez F, Silver A, Tan J. Modulation of neuronal differentiation by CD40 isoforms. Biochemical and biophysical research communications. 369(2) : 641-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18312851
  • Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proceedings of the National Academy of Sciences of the United States of America. 104(7) : 2507-12, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17264212
  • Shytle RD, Ehrhart J, Tan J, Vila J, Cole M, Sanberg CD, Sanberg PR, Bickford PC. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation research. 10(2) : 173-8, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17518694
  • Cracchiolo JR, Mori T, Nazian SJ, Tan J, Potter H, Arendash GW. Enhanced cognitive activity-over and above social or physical activity-is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity. 88(3) : 277-294, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17714960
  • Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. The Journal of biological chemistry. 281(24) : 16419-27, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16624814
  • Giunta B, Obregon D, Hou H, Zeng J, Sun N, Nikolic V, Ehrhart J, Shytle D, Fernandez F, Tan J. EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia. Brain research. 1123(1) : 216-25, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17078933
  • Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR. Nutraceuticals synergistically promote proliferation of human stem cells. Stem cells and development. 15(1) : 118-23, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16522169
  • Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA. Microglia recognize double-stranded RNA via TLR3. Journal of immunology (Baltimore, Md. : 1950). 176(6) : 3804-12, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16517751
  • Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. Journal of neuropathology and experimental neurology. 64(9) : 743-53, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16141783
  • Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(38) : 8807-14, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16177050
  • Town T, Tan J, Flavell RA, Mullan M. T-cells in Alzheimer's disease. Neuromolecular medicine. 7(3) : 255-64, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16247185
  • Town T, Nikolic V, Tan J. The microglial "activation" continuum: from innate to adaptive responses. Journal of neuroinflammation. 2: 24, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16259628
  • Ehrhart J, Obregon D, Mori T, Hou H, Sun N, Bai Y, Klein T, Fernandez F, Tan J, Shytle RD. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. Journal of neuroinflammation. 2: 29, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16343349
  • Mori T, Town T, Tan J, Tateishi N, Asano T. Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(6) : 748-62, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15689951
  • Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European journal of immunology. 35(3) : 901-10, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15688347
  • Townsend KP, Shytle DR, Bai Y, San N, Zeng J, Freeman M, Mori T, Fernandez F, Morgan D, Sanberg P, Tan J. Lovastatin modulation of microglial activation via suppression of functional CD40 expression. Journal of neuroscience research. 78(2) : 167-76, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15378516
  • Todd Roach J, Volmar CH, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M. Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain research. 1015(1-2) : 161-8, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15223380
  • Mori T, Town T, Kobayashi M, Tan J, Fujita SC, Asano T. Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 24(6) : 646-56, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15181372
  • Townsend KP, Vendrame M, Ehrhart J, Faza B, Zeng J, Town T, Tan J. CD45 isoform RB as a molecular target to oppose lipopolysaccharide-induced microglial activation in mice. Neuroscience letters. 362(1) : 26-30, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15147773
  • Mott RT, Ait-Ghezala G, Town T, Mori T, Vendrame M, Zeng J, Ehrhart J, Mullan M, Tan J. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia. 46(4) : 369-79, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15095367
  • Shytle RD, Mori T, Townsend K, Vendrame M, Sun N, Zeng J, Ehrhart J, Silver AA, Sanberg PR, Tan J. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. Journal of neurochemistry. 89(2) : 337-43, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15056277
  • Tan J, Town T, Abdullah L, Wu Y, Placzek A, Small B, Kroeger J, Crawford F, Richards D, Mullan M. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease. Journal of neuroimmunology. 132(1-2) : 164-72, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12417447
  • Town T, Vendrame M, Patel A, Poetter D, DelleDonne A, Mori T, Smeed R, Crawford F, Klein T, Tan J, Mullan M. Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42). Journal of neuroimmunology. 132(1-2) : 49-59, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12417433
  • Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nature neuroscience. 5(12) : 1288-93, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12402041
  • Tan J, Town T, Mullan M. CD40-CD40L interaction in Alzheimer's disease. Current opinion in pharmacology. 2(4) : 445-51, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12127879
  • Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M. p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. Journal of neuroscience research. 69(3) : 362-72, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12125077
  • Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. CD40 is expressed and functional on neuronal cells. The EMBO journal. 21(4) : 643-52, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11847112


  • USF Faculty Outstanding Research Achievement Award (University of South Florida - 2016)
  • GS15 Research Biologist (Veteran's Health Administration - 2015)
  • Flavonoid-diosmin modulation of A and tau pathologies through GSK-3 signaling pathway (NIH/NCCAM - 2014)
  • Octyl gallate (OG) and Promotion of non-amyloidogenic processing of APP (Merit Award VA - 2013)