Allergy, Immunology & Rheumatology

Research and Scholarly Activity

The Division of Allergy and Immunology is actively engaged in basic and clinical research. The Allergy/Immunology Laboratory in the Children's Research Institute focuses on immune dysregulation, primary immunodeficiency diseases, inflammatory cytokines following exposure to marine toxins and studies of T cell responses to vaccines.

Translational and Basic Science Research in Immunology 

Several faculty engage in translational and basic science research on the pathomechanisms, diagnostic and novel treatment strategies for immune dysregulation in primary immunodeficiencies.   

Dr. Jolan Walter’s group focuses on T and B cell dysregulation and tolerance checkpoints in variants of severe combined immunodeficiencies (SCID) with mutation of the recombination activating gene (RAG) in human and animal studies. Translational studies include the genetics of autoimmune cytopenias and national genetic screen for WHIM (warts, hypogammaglobilinemia, infections and myelokathexis) syndrome. Our research team is committed to promote targeted therapies in primary immunodeficiencies and immune dysregulation and bone marrow transplant and gene therapy for variants of SCID and combined immunodeficiencies.   

 Dr. Leiding is a national expert in the diagnosis and treatment of chronic granulomatous disease and primary immunodysregulatory diseases specifically STAT1 and STAT3 gain‐of‐function. She is Co‐lead of the Primary Immunodeficiency Treatment Consortium Protocol 6908: “Prospective Analysis of Auto‐Inflammation in Chronic Granulomatous Disease Patients Undergoing Hematopoietic Cell Transplantation.” Dr. Leiding’s lab focuses on mechanistic studies to identify the etiology and investigate the mechanisms of auto‐inflammation in chronic granulomatous disease and other primary immunodysregulatory diseases. Dr. Leiding also leads national and international efforts to develop mechanism based precision therapy and transplant strategies for treatment of STAT1 and STAT3 gain‐of‐function and other diseases of immunedysregulation.   

Carla Duff, CPNP-PC MSN CCRP IgCN is a national expert in Ig replacement therapy.  She has served as a co-investigator on various research protocols and has been the recipient of four unrestricted research grants.  Ms. Duff has been published over 30 times including multiple abstracts and publications in primary immune deficiency as well as co-authoring a nursing guide and subcutaneous immunoglobulin review. Ms. Duff is Adjunct Clinical Faculty at the University of South Florida College of Nursing. Ms. Duff is currently the president of the International Nurses Group in Immunodeficiency (INGID), immediate past chair of the Immune Deficiency Foundation Nurse Advisory Committee (IDF NAC), the immediate past chair of the credentialing committee of the American Academy of Allergy Asthma and Immunology (AAAAI), a program committee member for the Immunoglobulin National Society, and is a member the National Association of Pediatric Nurse Practitioners (NAPNAP).   

Clinical Trials 

Our Allergy & Immunology Division is actively engaged in a number of pharmaceutical Phase III and Phase IV clinical trails leading to FDA approval for new immunoglobulin produces (both IVIG and SCIg) or changes in packet insert labeling. Our Division is also involved with studies in food allergy research. 

Recent Publications 

  1. Farmer JR1, Ong MS2, Barmettler S1, Yonker LM1, Fuleihan R3, Sullivan KE4, Cunningham-Rundles C5; USIDNET Consortium, Walter JE1,6,7. (2018) Common Variable Immunodeficiecy Non-Infectious Disease Endotypes Redefined Using Unbiased Network Clustering in Large Electronic Datasets. Frontiers in Immunology PubMed PMID:  29375540 January 2018
  2. Alshekaili J, Chand R, Eunhee Lee C, Corley S, Kwong K, Papa I, Fulcher DA, Randall KL, Leiding JW, MA CS, Wilkins MR, Uzel G, Goodnow CC, Vinuesa CG, Tangye SG, Cook MC. (2018) STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles. Scientific Reports PMID: 29476109 February 2018.
  3. Lawless D1, Geier CB2, Farmer JR3, Lango Allen H4, Thwaites D5, Atschekzei F6, Brown M4, Buchbinder D7, Burns SO8, Butte MJ9, Csomos K10, Deevi SVV4, Egner W11, Ehl S12, Eibl MM13, Fadugba O14, Foldvari Z15, Green DM16, Henrickson SE17, Holland SM18, John T19, Klemann C20, Kuijpers TW21, Moreira F22, Piller A2, Rayner-Matthews P4, Romberg ND23, Sargur R11, Schmidt RE6, Schröder C6, Schuetz C24, Sharapova SO25, Smith KGC26, Sogkas G6, Speckmann C27, Stirrups K4, Thrasher AJ28, Wolf HM29, Notarangelo LD18, Anwar R1, Boyes J5, Ujhazi B10; NIHR BioResource–Rare Diseases Consortium, Thaventhiran J26, Walter JE30, Savic S31. (2018) Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency. Journal of Allergy Clinical Immunology PMID: 29477728 March 2018.
  4. Miggelbrink AM1,2, Logan BR3, Buckley RH4,5, Parrott RE4, Dvorak CC6, Kapoor N7,8, Abdel-Azim H7,8, Prockop SE9, Shyr D10, Decaluwe H11, Hanson IC12, Gillio A13, Dávila Saldaña BJ14, Eibel H15,16, Hopkins G1,2, Walter JE17, Whangbo JS1,2, Kohn DB18, Puck JM6, Cowan MJ6, Griffith LM19, Haddad E11,20, O'Reilly RJ9, Notarangelo LD21, Pai SY1,2. (2018). B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation. Blood PMID: 29728406 May 2018
  5. Iris M. Otani1 | Ryan W. Carroll2 | Phoebe Yager2 | Daniela Kroshinsky3 | Sarah Murphy2 | Jason L. Hornick4 | Cem Akin5,6 | Mariana Castells5,6 | Jolan E. Walter7,8. (2018) Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. WILEY Clinical Case Report PMID: 30214774 July 2018
  6. Hsu AP1, Zerbe CS1, Foruraghi L1, Iovine NM2, Leiding JW3, Mushatt DM4, Wild L5, Kuhns DB6, Holland SM1. (2018) IKBKG (NEMO) 5' Untranslated Splice Mutations Lead to Severe, Chronic Disseminated Mycobacterial Infections. Clinical Infectious Disease PMID: 29534156 July 2018
  7. Sarah E. Henrickson1 & Jolan E. Walter2,3 & Colin Quinn4 & Jennifer A. Kanakry5 & Tanya Bardakjian4 & Dimana Dimitrova5 & Boglarka Ujhazi2,3 & Krisztian Csomos2,3 & Marita Bosticardo6 & Kerry Dobbs6 & MacLean Nasrallah7 & Luigi D. Notarangelo6 & Steven M. Holland6 & Olajumoke Fadugba8. (2018) Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. Journal of Allergy Clinical Immunology PMID: 30159811 August 2018
  8. Rolfes MC, Sriaroon P, Dávila Saldaña BJ, Dvorak CC, Chapdelaine H, Ferdman RM, Chen K, Jolles S, Patel NC, Kim YJ, Tarrant TK, Martelius T, Seppanen M, Joshi AY. (2018). Chronic norovirus infection in primary immune deficiency disorders: an international case series. Diagnostic Microbiology and Infectious Disease Journal PMID: 30174143 August 2018
  9. Haddad E1, Logan BR2, Griffith LM3, Buckley RH4, Parrott RE4, Prockop SE5, Small TN5, Chaisson J5, Dvorak CC6, Murnane M6, Kapoor N7, Abdel-Azim H7, Hanson IC8, Martinez C9, Bleesing JJH10, Chandra S10, Smith AR11, Cavanaugh ME12, Jyonouchi S13, Sullivan KE14, Burroughs L15, Skoda-Smith S16, Haight AE17, Tumlin AG17, Quigg TC18, Taylor C18, Dávila Saldaña BJ19, Keller MD19, Seroogy CM20, Desantes KB20, Petrovic A21, Leiding JW22, Shyr DC23, Decaluwe H24, Teira P24, Gillio AP25, Knutsen A26, Moore TB27, Kletzel M28, Craddock JA29, Aquino V30, Davis JH31, Yu LC32, Cuvelier GDE33, Bednarski JJ34, Goldman FD35, Kang EM36, Shereck E37, Porteus MH38, Connelly JA39, Fleisher TA36, Malech HL36, Shearer WT8, Szabolcs P40, Thakar MS41, Vander Lugt MT42, Heimall J14, Yin Z2, Pulsipher MA7, Pai SY12, Kohn DB27, Puck JM6, Cowan MJ6, O'Reilly RJ5, Notarangelo LD43. (2018) SCID genotype and 6-month post-transplant CD4 count predict survival and immune recovery: a PIDTC retrospective study. Blood PMID: 30154114 August 2018
  10. Forbes LR1, Vogel TP2, Cooper MA3, Castro-Wagner J4, Schussler E5, Weinacht KG6, Plant AS7, Su HC8, Allenspach EJ9, Slatter M10, Abinun M10, Lilic D10, Cunningham-Rundles C5, Eckstein O11, Olbrich P12, Guillerman RP13, Patel NC14, Demirdag YY15, Zerbe C8, Freeman AF8, Holland SM8, Szabolcs P16, Gennery A10, Torgerson TR9, Milner JD17, Leiding JW18. (2018) Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations. Journal of Allergy Clinical Immunology PMID: 30092289 August 2018
  11. Goda V1, Malik A2, Kalmar T3, Maroti Z3, Patel B4, Ujhazi B4, Csomos K4, Hale JE5, Chen K6, Bleesing J7, Palma P8, Cancrini C8, Comeau AM5, Krivan G1, Walter JE9. (2018) Partial RAG deficiency in a patient with varicella infection, autoimmune cytopenia, and anticytokine antibodies. Journal of Allergy Clinical Immunology PMID: 29410113 September 2018.