Frederick Schatz

Frederick Schatz, PhD

Professor, Ob/Gyn

Professor, College of Medicine Obstetrics & Gynecology

Contact Info 12901 Bruce B. Downs Blvd
Tampa FL 33612

Academic Email: fschatz@health.usf.edu

Academic Phone:(813) 974-9055

View My C.V.


  • PhD, Pharmacology, Albert Einstein College of Medicine, 1978

Academic Philosophy

"Steroid hormonal regulation of endometrial angiogenesis and abnormal uterine bleeding. Involvement of decidual cell-expressed tissue factor, chemokines, and proteases in abruption-related pre-term delivery."

Research Interests

  • Our laboratory focuses on 3 human pregnancy complications: 1) abruptions; 2)
  • chorioamnionitis (CAM), in the presence or absence of infectious bacteria and other microorganisms and frequently complicated by 3) preeclampsia (PE) and 4) a recent Florida funded Zika-related grant. Abruptions, accompanied by excess thrombin formation from decidual cell-expressed tissue factor, and CAM frequently elicit preterm delivery and/or intrauterine growth restriction, whereas recognition of PE symptoms frequently leads to the decision to deliver the fetus prematurely. Taken together, CAM, PE and abruption are leading causes of fetal and maternal morbidity and mortality that impose major USA and worldwide major health care costs. A separate project investigates occurrence of abnormal uterine bleeding in women administered long-term progestin only contraceptives, which is not a health issue, but a source of annoyance causing discontinuation of these otherwise safe and effective agents.


  • Society for Reproductive Investigation (Member, 2000 - Present)

Recent Publications

  • Guzel E Arlier S Guzeloglu-Kayisli O Tabak MS Ekiz T Semerci N Larsen K Schatz F Lockwood CJ Kayisli U. Endoplasmic Reticulum Stress and Homeostasis in Reproductive Physiology and Pathology Int J Mol Sci. , 2017.
  • Shapiro JP Guzeloglu-Kayisli O Kayisli UA Semerci N Huang SJ Arlier S Larsen K Fadda P Schatz F Lockwood C. Thrombin impairs human endometrial endothelial angiogenesis; implications for progestin-only contraceptive-induced abnormal uterine bleeding contraception. , 2017.
  • Chedraui P, Solís EJ, Pérez-López FR, Schatz F, Kayisli U, Escobar GS, Loja-Chango R, Hidalgo L, Lockwood CJ. Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia. Journal of perinatal medicine. 44(3) : 291-4, 2016. http://www.ncbi.nlm.nih.gov/pubmed/25741937
  • Ackerman WE, Summerfield TL, Mesiano S, Schatz F, Lockwood CJ, Kniss DA. Agonist-Dependent Downregulation of Progesterone Receptors in Human Cervical Stromal Fibroblasts. Reproductive sciences (Thousand Oaks, Calif.). 23(1) : 112-23, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26243545
  • 3, Funghi L Damiani F Yen CF Lee CL Lombardi A Schatz F Lockwood CJ Marcolongo P Petraglia F Arcuri . Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia Mol Cell Endocrinol. , 2016.
  • Schatz F, Guzeloglu-Kayisli O, Arlier S, Kayisli UA, Lockwood CJ. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Human Reproduction Update. 22(4) : 497-515, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26912000
  • Ibrahim SA, Ackerman WE, Summerfield TL, Lockwood CJ, Schatz F, Kniss DA. Inflammatory gene networks in term human decidual cells define a potential signature for cytokine-mediated parturition. American journal of obstetrics and gynecology. 214(2) : 284.e1-284.e47, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26348374
  • Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Arcuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis-associated preterm birth: interleukin-1β inhibits progesterone receptor expression in decidual cells. The Journal of Pathology. 237(4) : 423-34, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26175191
  • Piao L, Chen CP, Yeh CC, Basar M, Masch R, Cheng YC, Lockwood CJ, Schatz F, Huang SJ. Chinese herbal medicine for miscarriage affects decidual micro-environment and fetal growth. Placenta. 36(5) : 559-66, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25771406
  • Chen CP, Piao L, Chen X, Yu J, Masch R, Schatz F, Lockwood CJ, Huang SJ. Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site: Implications for Preeclampsia, Spontaneous Abortion, and Intrauterine Growth Restriction. Reproductive Sciences (Thousand Oaks, Calif.). 22(11) : 1461-7, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25963913
  • Kumar D, Springel E, Moore RM, Mercer BM, Philipson E, Mansour JM, Mesiano S, Schatz F, Lockwood CJ, Moore JJ. Progesterone inhibits in vitro fetal membrane weakening. American Journal of Obstetrics and Gynecology. 213(4) : 520.e1-9, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26070709
  • Guzeloglu Kayisli O, Kayisli UA, Basar M, Semerci N, Schatz F, Lockwood CJ. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding. PloS One. 10(10) : e0137855, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26436918
  • Lockwood CJ, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Murk W, Wang J, De Paz N, Shapiro JP, Masch RJ, Semerci N, Huang SJ, Schatz F. Interferon-γ protects first-trimester decidual cells against aberrant matrix metalloproteinases 1, 3, and 9 expression in preeclampsia. The American Journal of Pathology. 184(9) : 2549-59, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25065683
  • Guzeloglu-Kayisli O, Basar M, Shapiro JP, Semerci N, Huang JS, Schatz F, Lockwood CJ, Kayisli UA. Long-acting progestin-only contraceptives enhance human endometrial stromal cell expressed neuronal pentraxin-1 and reactive oxygen species to promote endothelial cell apoptosis. The Journal of Clinical Endocrinology and Metabolism. 99(10) : E1957-66, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25029423
  • Basar M, Bozkurt I, Guzeloglu-Kayisli O, Sozen B, Tekmen I, Schatz F, Arici A, Lockwood CJ, Kayisli UA. Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro. Fertility and Sterility. 102(6) : 1777-84, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25305729
  • Lockwood CJ, Huang SJ, Chen CP, Huang Y, Xu J, Faramarzi S, Kayisli O, Kayisli U, Koopman L, Smedts D, Buchwalder LF, Schatz F. Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia. The American Journal of Pathology. 183(3) : 841-56, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23973270
  • Krikun G Booth CJ Buchwalder L Schatz F Osol G Mandala M Lockwood CJ. Effects of etonogestrel treatment in the reproductive organs and uterine arteries of nonoophorectomized guinea pigs. Reprod Sci.. 19(4) : 400-6, 2012.
  • Lockwood C, J, Kayisli U, A, Stocco C, Murk W, Vatandaslar E, Buchwalder L, F, Schatz F. Abruption-induced Preterm Delivery is Associated with Thrombin-Mediated Functional Progesterone Withdrawal in Decidual Cells. Am J Pathol.. 181(6) : 2138-46, 2012.
  • Schatz F Kayisli UA Vatandaslar E Ocak N Guller S Abrahams VM Krikun G Lockwood CJ. Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy. Am J Reprod Immunol.. 68(2) : 146-53, 2012.
  • Yang H Zhou Y Edelshain B Schatz F Lockwood CJ Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction.. 143(4) : 531-8, 2012.
  • Wu ZM Yang H Li M Yeh CC Schatz F Lockwood CJ Di W Huang SJ. Pro-inflammatory cytokine-stimulated first trimester decidual cells enhance macrophage-induced apoptosis of extravillous trophoblasts. Placenta.. 33(3) : 188-94, 2012.
  • Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S. Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1. American Journal of Reproductive Immunology (New York, N.Y. : 1989). 65(5) : 470-9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21087336
  • Lockwood CJ, Huang SJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F. Decidual hemostasis, inflammation, and angiogenesis in pre-eclampsia. Seminars in Thrombosis and Hemostasis. 37(2) : 158-64, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21370218
  • Kumar D, Schatz F, Moore RM, Mercer BM, Rangaswamy N, Mansour JM, Lockwood CJ, Moore JJ. The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro. Placenta. 32(3) : 206-13, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21300402
  • Lockwood CJ, Stocco C, Murk W, Kayisli UA, Funai EF, Schatz F. Human labor is associated with reduced decidual cell expression of progesterone, but not glucocorticoid, receptors. The Journal of Clinical Endocrinology and Metabolism. 95(5) : 2271-5, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20237167
  • Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ. The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia. The American Journal of Pathology. 177(5) : 2472-82, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20829438
  • Lockwood CJ, Murk WK, Kayisli UA, Buchwalder LF, Huang SJ, Arcuri F, Li M, Gopinath A, Schatz F. Regulation of interleukin-6 expression in human decidual cells and its potential role in chorioamnionitis. The American Journal of Pathology. 177(4) : 1755-64, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20724602
  • Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ. The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. The American Journal of Pathology. 176(2) : 1050-6, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20042667
  • Moore RM, Schatz F, Kumar D, Mercer BM, Abdelrahim A, Rangaswamy N, Bartel C, Mansour JM, Lockwood CJ, Moore JJ. Alpha-lipoic acid inhibits thrombin-induced fetal membrane weakening in vitro. Placenta. 31(10) : 886-92, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20709392
  • Basar M, Yen CF, Buchwalder LF, Murk W, Huang SJ, Godlewski K, Kocamaz E, Arda O, Schatz F, Lockwood CJ, Kayisli UA. Preeclampsia-related increase of interleukin-11 expression in human decidual cells. Reproduction (Cambridge, England). 140(4) : 605-12, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20668109
  • Krikun G, Buhimschi IA, Hickey M, Schatz F, Buchwalder L, Lockwood CJ. Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans. Journal of Angiogenesis Research. 2: 8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20423489