These things are coordinated by thousands of different proteins at work in our cells. Among them is a group of sentinels called chaperones that ensure the propriety of the majority of cellular proteins and resultant cellular functions. Our lab is focused on the role of chaperones in a group of more than 15 neurological degenerative diseases collectively termed “tauopathies”, the most common being Alzheimer’s disease. We hope that an understanding of chaperone function will enable therapeutic strategies that increase quality of life, halt disease progression and ultimately cure neurodegenerative diseases.