Paul Shapshak

Paul Shapshak, PHD

Adjunct Professor, Division of Infectious Disease, Morsani College of Medicine

Contact Info Division of Infectious Disease and International Medicine
12901 Bruce B. Downs Blvd.
Tampa FL 33612

Academic Email: pshapshak@gmail.com

Academic Phone:(813) 974-2271

View My C.V.

Education

  • PHD, Princeton University, 1969

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Neuroscience

Research Interests

  • Higher education, research, and development.
  • Neuroimmunology and Neurovirology.
  • Molecular Virology.
  • Virus infection risk and drug abuse.
  • Prevention of virus and AIDS spread.
  • Gene expression in neuropsychiatric disease.
  • Laboratory measures of virus infections in neuropsychiatric disease.
  • HIV-1 replication and evolution.
  • miRNA, siRNA, and vectors in Biology and Medicine.
  • Nanotechnology in Biology and Medicine.
  • Transmission models and inactivation of HIV-1.

Recent Publications

  • Quach A Horvath S Nemanim N Vatakis D Witt MD Miller EN Detels R Langfelder P Shapshak P Singer EJ Levine AJ. No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV Journal of NeuroVirology. 24: 350-361, 2018.
  • Shapshak P. Artificial intelligence and brain Bioinformation. 14(1) : 38-41, 2018.
  • Shapshak P, Somboonwit C, Cao S, Sinnott JT. Cholera host response gene networks: preliminary studies Bioinformation. 13(10) : 347-351, 2017.
  • Somboonwit C, Montero JA, Sinnott JT, Shapshak P. Antiretrovifal Therapy - Brain Penetration In Global Virology II - HIV and NeuroAIDS (eds P Shapshak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, JT Sinnott) (Springer Publ. NY,NY). , 2017.
  • Shapshak P, Somboonwit C, Sinnott JT. Artificial intelligence and virology - quo vadis Bioinformation. 13(12) : 410-411, 2017.
  • Somboonwit C, Menezes LJ, Holt DA, Sinnott JT, Shapshak P. Current views and challenges on clinical cholera Bioinformation. 13(12) : 405-409, 2017.
  • Bengoa AJ, McCoy CB, Foley BT, Khikha P, Mendez AJ, P Shapshak . Zika Virus and HIV/AIDS In Global Virology II - HIV and NeuroAIDS (eds. P Shapshak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, JT Sinnott) ( Springer Publ. NY, NY). , 2017.
  • Balaji S, Akash R, Krittika N, Shapshak P. Sequence Accuracy in Primary Databases In Global Virology II - HIV and NeuroAIDS (eds. P Shapshak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, JT Sinnotte)(Springer Publ. NY,NY). , 2017.
  • Balaji S, Akash R, Krittika N, Shapshak P. Sequence accuracy in Primary Databases: a case study on HIV-1B In Global Virology II - HIV and NeuroAids (eds P Shapshak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, JT Sinnott) (Springer Publ. NY,NY). , 2017.
  • Sneha P, Balaji S, Shapshak . Amyloidogenic pattern prediction of HIV-1 proteins In Global Virology II - HIV and NeuroAIDS (eds. P Shaphsak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, JT Sinnott) ( Springer Publ. NY, NY). , 2017.
  • Rodriguez HE, Lakshmi S, Somboonwit C, Oxner A, Guerra L, Addisu A, Gutierrez L, Sinnott JT, Nilofer C, Kangueane P, Shapshak P. Gene Therapy Blueprints for NeuroAIDS In Global Virology II - HIV and NeuroAIDS (eds. P Shapshak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, Sinnott JT) (Springer Publ. NY, NY). , 2017.
  • Fernendez F, Minagar A, Alekseeva N, Shapshak P. Neuropsychiatric aspects of prion disease In Comprehensive Textbook of Psychiatry (eds. BJ Sadock, VA Sadock, and P Ruiz) (Kluwer and Lippincott Publ). : 601-618, 2017.
  • 148, Paul Shapshak Charurut Somboonwit John T, Sinnot. Artificial Intelligence and Virology - quo vadis Bioinformation. 13(12) : 410-411, 2017.
  • Shapshak P, Foley BT, Balaji S, Segal DM, McCoy C, Page JB. Socioepidemiology of Injection Drug Users in Miami and HIV-1B Envelope (V1-V5) Genetic Diversity: A Preliminary Study in Global Virology II - HIV and NeuroAIDS (eds. P Shapshak, AJ Levine, C Somboonwit, BT Foley, E Singer, F Chiappelli, JT Sinnott) (Springer Publ. NY, NY). , 2017.
  • Elkomy FF, Levine AJ, Singer E, Somboonwit C, Wills T, Tash K, Sinnot JT, Alrabaa S, Addisu A, Rodriguez H, Chiappelli F, Kazic T, Shapshak P. Neuronal Apoptotic Pathways in HIV Associated Dementia, Alzheimer's Disease, Parkinson's Disease and Huntington's Disease In Global Virology II - HIV and NeuroAIDS (eds. P Shapshak, AJ Levine, C Somboonwit, BT Fole, E Singer, F Chiappeli, JT Sinnott (Springer Publ, NY, NY). , 2017.
  • Somboonwit C, Sinnott JT, Shapshak P. Emerging Human Infection or False Alarm in Global Virology I - Identifying and Investigating Viral Disease (eds. P Shapshak, C Somboonwit, J Kuhn, and JT Sinnott). : 561-570, 2015.
  • Balaji S, Sneha P, Rama M, Shapshak P. Global protein sequence variation in HIV-1B isolates derived from human blood and brain In Global Virology I - Identifying and Investigating Viral Disease (eds. P Shapshak, C Somboonwit, J Kuhn, and JT Sinnott). : 613-662, 2015.
  • Fernandez F, Minagar A, Alekseeva N, and Shapshak P. Neuropsychiatric aspects of prion disease in Comprehensive Textbook of Psychiatry (eds. BJ Sadock, VA Sadock, and P Ruiz). , 2015.
  • Alrabaa SF, Somboonwit C, and Shapshak . West Nile Virus In Global Virology I - Identifying and Investigating Viral Disease (eds. P. Shapshak, C. Somboonwit, J. Kuhn, and JT Sinnott). : 457-475, 2015.
  • Shapshak P, Somboonwit C, Foley BT, Alrabaa SF, Wills T, and Sinnott JT. Zika Virus In Global Virology I - Identifying and Investigating Viral Disease (eds. P Shapshak, C Somboonwit, J Kuhn, and JT Sinnott). : 477-496, 2015.
  • Shapshak P. Molecule of the month: miRNA and HIV-1 TAR. Bioinformation. 9(2) : 65-6, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23390347
  • Shapshak P. Molecule of the month: miRNA and proteins in Alzheimer's disease. Bioinformation. 9(5) : 222-3, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23516333
  • Shapshak P. Molecule of the month: miRNA and proteins DARPP-32, DRD1, SLC6A3, and CK2. Bioinformation. 9(6) : 274-5, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23745017
  • Shapshak P. Molecule of the month: miRNA and Parkinson's disease protein PARK2. Bioinformation. 9(8) : 381-2, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23750085
  • Shapshak P. Molecule of the month: miRNA and Huntington's disease (HD). Bioinformation. 9(11) : 549-50, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23888093
  • Shapshak P. Molecule of the month: miRNA and Human Prion brain disease. Bioinformation. 9(13) : 659-60, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23930015
  • Shapshak P. Molecule of the month: miRNA and Down's syndrome. Bioinformation. 9(15) : 752-4, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24023415
  • Levine AJ, Horvath S, Miller EN, Singer EJ, Shapshak P, Baldwin GC, Martínez-Maza O, Witt MD, Langfelder P. Transcriptome analysis of HIV-infected peripheral blood monocytes: gene transcripts and networks associated with neurocognitive functioning. Journal of neuroimmunology. 265(1-2) : 96-105, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24094461
  • Shapshak P. Molecule of the month: miRNA and Multiple Sclerosis. Bioinformation. 9(17) : 847-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24250109
  • Levine AJ, Miller JA, Shapshak P, Gelman B, Singer EJ, Hinkin CH, Commins D, Morgello S, Grant I, Horvath S. Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease. BMC medical genomics. 6: 4, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23406646
  • Shapshak P. Bioinformation editorial erratum. Bioinformation. 9(3) : 168, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23424280
  • Shapshak P. Bioinformation and molecule of the month: Multiple interactive pathways for a single gene, NFkB. Bioinformation. 8(9) : 399-402, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22715307
  • Shapshak P. Single nucleotide polymorphisms (SNPs) for genome wide association studies (GWAS) and molecule of the month Nitric Oxide Synthase, multiple interactive pathways for three similar genes, Nitric Oxide Synthase-1, -2, -3 (NOS-1, -2, -3). Bioinformation. 8(11) : 496-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22829717
  • Shapshak P. Dementia and molecule of the month APP. Bioinformation. 8(14) : 644-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23055603
  • Shapshak P. Molecule of the month, PDE4DIP. Bioinformation. 8(16) : 740-1, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23055623
  • Shapshak P. NRF2 molecule of the month. Bioinformation. 8(18) : 846-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23144538
  • Levine AJ, Sinsheimer JS, Bilder R, Shapshak P, Singer EJ. Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults. Journal of clinical and experimental neuropsychology. 34(1) : 78-91, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22082040
  • Shapshak P. Molecule of the month HIV-1 Tat and miRNA. Bioinformation. 8(23) : 1123-4, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23275707
  • Shapshak P. Molecule of the month: HIV-1 protein Vpr and miRNA. Bioinformation. 8(25) : 1243-4, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23275727
  • Chiang MC, Barysheva M, McMahon KL, de Zubicaray GI, Johnson K, Montgomery GW, Martin NG, Toga AW, Wright MJ, Shapshak P, Thompson PM. Gene network effects on brain microstructure and intellectual performance identified in 472 twins. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(25) : 8732-45, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22723713
  • Levine AJ, Service S, Miller EN, Reynolds SM, Singer EJ, Shapshak P, Martin EM, Sacktor N, Becker JT, Jacobson LP, Thompson P, Freimer N. Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 159B(6) : 669-83, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22628157
  • Shapshak P. Molecule of the month: Synaptic plasticity - Protein miRNA interactions. Bioinformation. 8(21) : 1003-4, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23275697