Edgar Espana

Edgar Espana, MD

Assistant Professor, College of Medicine Molecular Pharmacology & Physiology

Assoc Professor, College of Medicine Ophthalmology

Contact Info USF Eye Institue
12901 Bruce B Downs Boulevard
Tampa FL 33612

Academic Email: eespana@health.usf.edu


  • MD, Medicine, Pontificia Universidad Javeriana, 1996

Research Interests

  • Separation of Descemet's membrane from stroma. Endothelial maturation. Expansion of corneal stem cells. Clinical uses and biological properties of human amniotic membrane. DSAEK (Posterior endothelial corneal transplantation).


  • American Academy of Ophthalmology (Ophthalmologist, 2005 - Present)
  • Association for Research in Vision and Ophthalmology (Member, 2001 - Present)

Recent Publications

  • Leyngold I, Weller C, Leyngold M, Espana E, Black KD, Hall KL, Tabor M. Endoscopic Corneal Neurotization: Cadaver Feasibility Study. Ophthalmic plastic and reconstructive surgery. , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28472009
  • Shah A, Espana EM, Singh AD. Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis. Ocular oncology and pathology. 3(1) : 22-27, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28275599
  • Jeang LJ, Davis A, Madow B, Espana EM, Margo CE. Occult Fungal Scleritis. Ocular oncology and pathology. 3(1) : 41-44, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28275602
  • Jacinto FA, Fisher GH, Espana EM, Leyngold IM, Margo CE. Separate Primary Melanomas of the Bulbar Conjunctiva and Eyelid Skin: Clinical Implications of Multiple Primary Melanomas. Ocular oncology and pathology. 2(4) : 226-229, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27843900
  • Shah S, Espana EM, Margo CE. Ocular manifestations of monoclonal copper-binding immunoglobulin. Survey of Ophthalmology. 59(1) : 115-23, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24112547
  • Carey AR Espana EM Margo CE. Conjunctival metastasis from a regional cutaneous melanoma. Can J Ophthalmol.. 49(4) : e97-9, 2014.
  • Groden L Espana EM. December consultation #5. J Cataract Refract Surg.. 40(12) : 2164-5, 2014.
  • Sanz-Marco E, España E, Alamar A, Pérez-Rojas J, López-Prats MJ, Díaz-Llopis M. [Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old]. Archivos de la Sociedad Española de Oftalmología. 89(5) : 182-5, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24269390
  • Sanz-Marco E, España E, López-Prats MJ, Chirivella-Casanova M, Aviño J, Díaz-Llopis M. [Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report]. Archivos de la Sociedad Española de Oftalmología. 89(5) : 186-9, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24269389
  • Golen JR, Espana EM, Margo CE. Mycobacterium abscessus scleritis following intravitreous injection of bevacizumab. JAMA Ophthalmology. 131(10) , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24151651
  • Hemmavanh C, Koch M, Birk DE, Espana EM. Abnormal Corneal Endothelial Maturation in Collagen XII and XIV Null Mice. Investigative ophthalmology & visual science. 54(5) : 3297-308, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23599329
  • Kawakita T, Espana EM, Higa K, Kato N, Li W, Tseng SC. Activation of Smad-mediated TGF-β signaling triggers epithelial-mesenchymal transitions in murine cloned corneal progenitor cells. Journal of Cellular Physiology. 228(1) : 225-34, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22674610
  • Espana EM, Shah S, Santhiago MR, Singh AD. Graft versus host disease: clinical evaluation, diagnosis and management. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/23504086
  • Sabater AL, Guarnieri A, Espana EM, Li W, Prósper F, Moreno-Montañés J. Strategies of human corneal endothelial tissue regeneration. Regenerative medicine. 8(2) : 183-95, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23477398
  • Smadja D, Santhiago MR, Mello GR, Espana EM, Krueger RR. Suction loss during thin-flap femto-LASIK: management and beneficial refractive effect of the epithelium. Journal of cataract and refractive surgery. 38(5) : 902-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22405992
  • Santhiago MR, Smadja D, Zaleski K, Espana EM, Armstrong BK, Wilson SE. Flap relift for retreatment after femtosecond laser-assisted LASIK. Journal of refractive surgery (Thorofare, N.J. : 1995). 28(7) : 482-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22767166
  • Gomes BA, Smadja D, Espana EM, Ahn ES, Netto MV, Santhiago MR. Very late-onset corneal scar triggered by trauma after photorefractive keratectomy. Journal of cataract and refractive surgery. 38(9) : 1694-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22906452
  • Bui AQ, Espana EM, Margo CE. Chromoblastomycosis of the conjunctiva mimicking melanoma of the ciliary body. Archives of ophthalmology. 130(12) : 1615-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23229710
  • Santhiago MR, Wilson SE, Netto MV, Ghanen RC, Monteiro ML, Bechara SJ, Espana EM, Mello GR, Kara N. Modulation transfer function and optical quality after bilateral implantation of a +3.00 D versus a +4.00 D multifocal intraocular lens. Journal of cataract and refractive surgery. 38(2) : 215-20, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22104642
  • Espana EM, Levine M, Schoenfield L, Singh AD. Ocular surface squamous neoplasia in an anophthalmic socket 60 years after enucleation. Survey of ophthalmology. 56(6) : 539-43, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22117887
  • Espana EM, Huang B, Fratkin J, Henegar J. An enzymatic technique to facilitate air separation of the stroma-Descemet's membrane junction. Investigative ophthalmology & visual science. 52(13) : 9327-32, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21969297
  • Espana EM, Acosta AC, Stoiber J, Fernandez V, Lamar PD, Villain FL, Lacombe E, Alfonso E, Parel JM. Long-term follow-up of a supradescemetic keratoprosthesis in rabbits: an immunofluorescence study. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 249(2) : 253-60, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20814695
  • Espana EM, Robertson ZM, Huang B. Intraocular pressure changes following Descemet's stripping with endothelial keratoplasty. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 248(2) : 237-42, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19936776
  • Espana EM, Huang B. Confocal microscopy study of donor-recipient interface after Descemet's stripping with endothelial keratoplasty. The British journal of ophthalmology. 94(7) : 903-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19825836
  • Espana EM, Ioannidis A, Tello C, Liebmann JM, Foster P, Ritch R. Urrets-Zavalia syndrome as a complication of argon laser peripheral iridoplasty. The British journal of ophthalmology. 91(4) : 427-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/16987896
  • Espana EM, Acosta AC, Nose I, Orozco M, Fantes F, Yoo SH, Parel JM. Validation of the Barraquer tonometer for high intraocular pressure estimation. Journal of refractive surgery (Thorofare, N.J. : 1995). 22(6) : 580-4, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16805121
  • Espana EM, Kawakita T, Di Pascuale MA, Li W, Yeh LK, Parel JM, Liu CY, Tseng SC. The heterogeneous murine corneal stromal cell populations in vitro. Investigative ophthalmology & visual science. 46(12) : 4528-35, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16303944
  • Espana EM, Kawakita T, Liu CY, Tseng SC. CD-34 expression by cultured human keratocytes is downregulated during myofibroblast differentiation induced by TGF-beta1. Investigative ophthalmology & visual science. 45(9) : 2985-91, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15326111
  • Espana EM, Di Pascuale MA, He H, Kawakita T, Raju VK, Liu CY, Tseng SC. Characterization of corneal pannus removed from patients with total limbal stem cell deficiency. Investigative ophthalmology & visual science. 45(9) : 2961-6, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15326108
  • Espana EM, Ti SE, Grueterich M, Touhami A, Tseng SC. Corneal stromal changes following reconstruction by ex vivo expanded limbal epithelial cells in rabbits with total limbal stem cell deficiency. The British journal of ophthalmology. 87(12) : 1509-14, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14660463
  • Espana EM, He H, Kawakita T, Di Pascuale MA, Raju VK, Liu CY, Tseng SC. Human keratocytes cultured on amniotic membrane stroma preserve morphology and express keratocan. Investigative ophthalmology & visual science. 44(12) : 5136-41, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14638709
  • Espana EM, Kawakita T, Romano A, Di Pascuale M, Smiddy R, Liu CY, Tseng SC. Stromal niche controls the plasticity of limbal and corneal epithelial differentiation in a rabbit model of recombined tissue. Investigative ophthalmology & visual science. 44(12) : 5130-5, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14638708
  • Espana EM, Romano AC, Kawakita T, Di Pascuale M, Smiddy R, Tseng SC. Novel enzymatic isolation of an entire viable human limbal epithelial sheet. Investigative ophthalmology & visual science. 44(10) : 4275-81, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14507871


  • William C Edwards Excellence in Teaching Award (Ophthalmology Residents - 2012)
  • ARVO/Alcon Early Career Clinician Scientist Research Awards (ARVO - 2012)