Publications

Selected Publications, 2000-present

  • Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. Am J Respir Cell Mol Biol (in press).

  • Deshpande DA, Robinett KS, Wang WCH, Sham JSK, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nature Medicine 17(7):776-778, 2011.

  • Bochkov YA, Palmenberg AC, Lee W-M, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nature Medicine 17(5):627-632, 2011.

  • Wang, WCH, Juan AH, Panebra A, Liggett SB. MicroRNA let-7 establishes expression of β2-adrenergic receptors and dynamically downregulates agonist-promoted downregulation. Proc Nat Acad Sci 108(15):6246-6251, 2011.

  • Wang WCH, Schillinger RM, Malone MM, Liggett SB. Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. Am J Physiol Lung Cell Mol Physiol 300:L472-L478, 2011.

  • Parsa A, Chang Y-PC, Kelly RJ, Corretti MC, Ryan KA, Robinson SW, Gottlieb SS, Kardia SLR, Shuldiner AR, Liggett SB. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clinical and Translational Science 4:17-23, 2011.

  • Deshpande DA, Wang, WCH, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JSK, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature Medicine 16:1299-1304, 2010.

  • Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. Full-genome sequence and analysis of a novel human Rhinovirus strain within a divergent HRV-A clade. ArchVirol 155:83-87, 2010.

  • Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An α2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the b-blocker bucindolol in chronic heart failure. Circ Heart Fail 3:21-28, 2010.

  • Wang WCH, Mihlbachler KA, Brunnett AC, Liggett SB. Targeted transgenesis reveals discreet attenuator functions of GRK and PKA in airway β2-adrenergic receptor physiologic signaling. Proc Nat Acad Sci 106:15007-15012, 2009.

  • Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, Rathe JA, Fraser-Liggett CM, Liggett SB. Sequencing and analyses of all known human rhinovirus genomes reveals structure and evolution. Science 324:55-59, 2009.

  • Dorn GW II, Liggett SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Mol Pharmacol 76:466-480, 2009.

  • Kardia SLR, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW II, Liggett SB. Multiple interactions between the α2A- and β1-adrenergic receptors influence heart failure survival. BMC Medical Genetics 9:93, 2008.

  • Swift SM, Gaume BR, Small KM, Aronow BJ, Liggett SB. Differential coupling of Arg- and Gly389 polymorphic forms of the β1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. Physiol Genomics 35:123-131, 2008.

  • Wang WCH, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of β2-adrenergic receptors. Pharmacogenet Genomics 18(8):729-732, 2008.

  • Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SLR, Dorn GW II. A G-protein coupled receptor kinase-5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure. Nature Medicine 14:510-517, 2008.

  • Einstein R, Jordan H, Zhou W, Brenner M, Moses EG, Liggett SB. Alternative splicing of the G-protein coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proc Nat Acad Sci 105(13):5230-5235, 2008.

  • McGraw DW, Elwing JM, Fogel KM, Wang WCH, Glinka CB, Mihlbachler KA, Rothenberg ME, Liggett SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. J Clin Invest 117:1391-1398, 2007.

  • Swift SM, Schwarb MR, Mihlbachler KA, Liggett SB. Pleiotropic β-agonist-promoted receptor conformations and signals independent of intrinsic activity. Am J Respir Cell Mol Biol 36:236-243, 2007.

  • Panebra A, Schwarb MR, Glinka CB, Liggett SB. Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 293:L453-L462, 2007.

  • Liggett SB, Kelly RJ, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SLR, Dorn GW II. A functional polymorphism of the Gαq (GNAQ) gene is associated with accelerated mortality in African American heart failure. Human Molecular Genetics 16:2740-2750, 2007.

  • McGraw DW, Fogel KM, Kong S, Kranias EG, Aronow BJ, Liggett SB. Transcriptional response to persistent β2-adrenergic receptor signaling reveals regulation of phospholamban which alters airway contractility. Physiol Genomics 27:171-177, 2006.

  • Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB. Complex haplotypes derived from non-coding polymorphisms of the intronless α2A-adrenergic gene diversify receptor expression. Proc Nat Acad Sci 103:5472-5477, 2006.

  • Small KM, Schwarb MR, Glinka C, Theiss CT, Brown KM, Seman CA, Liggett SB. α2A- and α2C adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and β-arrestin recruitment. Biochemistry 45:4760-4767, 2006.

  • McGraw DW, Mihlbachler KA, Schwarb MR, Rahman FF, Small KM, Almoosa KF, Liggett SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate β2-adrenergic receptors within a unique heterodimeric complex. J Clin Invest 116(5):1400-1409, 2006.

  • Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, Port JD, Lavori PW, Bristow MR. A polymorphism within a conserved β1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure. Proc Nat Acad Sci 103(30):11288-11293, 2006.

  • Tantisira KG, Small KM, Litonjua AA, Weiss ST, Liggett SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase 9 in asthma: interaction between β-agonist and corticosteroid pathways. Hum Mol Genet 14:1671-1677, 2005.

  • Small KM, Mialet-Perez J, Seman CA, Theiss CT, Brown KM, Liggett SB. Polymorphisms of the cardiac presynaptic α2C adrenergic receptors: diverse intragenic variability with haplotype-specific functional effects. Proc Nat Acad Sci 101:13020-13025, 2004.

  • Mialet-Perez J, Green SA, Miller WE, Liggett SB. A primate-dominant third glycosylation site of the β2-adrenergic receptor routes receptors to degradation during agonist regulation. J Biol Chem 279:38603-38607, 2004.

  • Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Liggett SB, Martin RJ, et al. Genotype stratified prospective cross-over trial of regularly scheduled albuterol treatment in asthma. The Lancet 364:1505-1512, 2004.

  • Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser L, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid pharmacogenetics: Association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet 13:1353-1359, 2004.

  • Rathz DA, Gregory KN, Fang Y, Brown KM, Liggett SB. Hierarchy of polymorphic variation and desensitization permutations relative to β1- and β2-adrenergic receptor signaling. J Biol Chem 278:10784-10789, 2003.

  • McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by β-adrenergic receptors of Gq-receptor signaling via phospholipase-C underlies the airway β-agonist paradox. J Clin Invest 112:619-626, 2003.

  • Perez JM, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW II, Liggett SB. β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature Medicine 9:1300-1305, 2003.

  • Small KM, Tanguay DA, Nandabalan K, Zhan P, Stephens JC, Liggett SB. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily. Am J Pharmacogenomics 3(1):65-71, 2003.

  • Small KM, Wagoner LE, Levin AM, Kardia SLR, Liggett SB. Synergistic polymorphisms of β1- and α2C-adrenergic receptors and the risk of congestive heart failure. The New England Journal of Medicine 347:1135-1142, 2002.

  • Small KM, Brown KM, Forbes SL, Liggett SB. Polymorphic deletion of three intracellular acidic residues of the α2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. J Biol Chem 276:4917-4922, 2001.

  • Liang M, Freedman NJ, Theiss CT, Liggett SB. Serine 232 of the α2A-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry 40:15031-15037, 2001.

  • Small KM, Brown KM, Forbes SL, Liggett SB. Modification of the β2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. J Biol Chem 276(34):31596-31601, 2001.

  • Dorn GW II, Tepe NM, Wu G, Yatani A, Liggett SB. Mechanisms of impaired β-adrenergic receptor signalling in Gαq-mediated cardiac hypertrophy and ventricular dysfunction. Mol Pharmacol 57:278-287, 2000.

  • Small KM, Forbes SL, Rahman FF, Liggett SB. Fusion of β2-adrenergic receptor to Gαs in mammalian cells: Identification of a specific signal transduction species not characteristic of constitutive activation or precoupling. Biochemistry 39(10):2815-2821, 2000.

  • Liggett SB, Tepe NM, Lorenz JN, Canning AM, Jantz TD, Mitarai S, Yatani A, Dorn GW II, Early and delayed consequences of β2 adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation 101:1707-1714, 2000.

  • Wagoner LE, Craft LL, Singh B, Suresh DP, Zengel PW, McGuire N, Abraham WT, Chenier TC, Dorn GW II, Liggett SB. Polymorphisms of the β2-adrenergic receptor determine exercise capacity in patients with heart failure. Circulation Research 86:834-840, 2000.

  • Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, et al. The effect of polymorphisms of the β2-adrenergic receptor on the response to regular use of albuterol in asthma. Amer J Resp Crit Care Med 162:75-80, 2000.

  • McGraw DW, Forbes SL, Mak JCW, Witte DP, Carrigan PE, Leikauf GD, Liggett SB. Transgenic overexpression of β2-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. Am J Physiol Lung Cell Mol Physiol 279:L379-L389, 2000.

  • Jewell-Motz EA, Small KM, Liggett SB. α2A/α2C-adrenergic receptor third loop chimera show that agonist interaction with receptor-subtype backbone establishes GRK phosphorylation. J Biol Chem 275:28989-28993, 2000.

  • Small KM, Forbes SL, Rahman FF, Bridges KM, Liggett SB. A four amino acid deletion polymorphism in the third intracellular loop of the human α2C-adrenergic receptor confers impaired coupling to multiple effectors. J Biol Chem 275:23059-23064, 2000.

  • Small KM, Forbes SL, Brown K, Liggett SB. An Asn to Lys polymorphism in the third intracellular loop of the human α2A-adrenergic receptor enhances agonist-promoted Gi coupling. J Biol Chem 275:38518-38523, 2000.

  • Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruano G, Liggett SB. Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Nat Acad Sci 97:10483-10488, 2000.