Center for Evidence- Based Medicine and Health Outcomes Research
University of South Florida
12901 Bruce B Downs Blvd. MDC 27
Tampa, FL, 33612 USA
Phone: (813) 396-9178
Fax: (813) 974-5411
E-mail: swarburt@health.usf.edu
EBM Publications: Key Conceptual Papers
Last update March 2011.
Not included: more than 50 systematic reviews/meta-analyses/decision-analyses, and more than 50 clinical papers)
1. Tsalatsanis A, Barnes L, Hozo I, Skvoretz J, Djulbegovic B. A social network analysis of treatment discoveries in cancer. PLoS One 2011 (in press)
2. Miladinovic B, Kumar A, Hozo I, Djulbegovic B. Instrumental variable meta-analysis of individual patient data: Application to adjust for treatment non-compliance. BMC Medical Research Methodology 2011 (in press)
3. Djulbegovic M, Djulbegovic B. Implication of the Principle of Question Propagation for Comparative- Effectiveness and “Data-mining” Research. JAMA 2011;305:298-299
4. Dahm P, Djulbegovic B. Australian approach to guidelines development: quest for perfect system. BMC Medical Research Methodology 2011, 11:17
5. Tsalatsanis A, Hozo I, Vickers I, Djulbegovic B. A regret theory approach to decision curve analysis: A novel method for eliciting decision makers' preferences and decision-making. BMC Medical Informatics and Decision Making 2010, 10:51.
6. Djulbegovic B, Kumar A, Magazin A, Schroen AT, Soares H, Hozo I, Clarke M, Sargent DJ, Schell MJ. Optimism bias leads to inconclusive results - an empirical study. J Clin Epidem 2010; in press
7. Mhaskar R, Redzepovic J, Wheatley K, Clark OAC, Miladinovic B, Glasmacher A, Kumar A, Djulbegovic B. Bisphosphonates in multiple myeloma. Cochrane Database of Systematic Reviews 2010, Issue 3
8. Djulbegovic B, Trikalinos T, Roback J, Chen R, Guyatt G. Impact of quality of evidence on the strength of recommendations: an empirical study. BMC Health Services Research 2009, 9:120 (designated by the publisher as “highly accessed article”)
9. Djulbegovic B. Paradox of equipoise: the principle that drives and limits discoveries in clinical research. Cancer Control 2009; 16:342-347
10. Hozo I, Djulbegovic B. Will insistence on practicing medicine according to expected utility theory lead to an increase in diagnostic testing? Reply to Dekay’s commentary: Physicians’ anticipated regret and diagnostic testing. Medical Decision Making 2009:29; 320-324
11. Djulbegovic B, Guyatt G, Ashcroft R. Epistemological Inquiries in Evidence Based Medicine. Cancer Control 2009; 16:158-168
12. Sacco W P, Malone J I, Morrison AD, Friedman A, Wells K J. Effect of a brief, telephone intervention by paraprofessionals for type 2 diabetes. Journal of Behavioral Medicine 2009; 32, 349-359.
13. Miladinovic B and Tsokos CP. Ordinary, Bayes, and empirical Bayes reliability analysis for the modified Gumbel failure model. Nonlinear Analysis, 2009; 71:1426-1436
14. Lee J, Miladinovic B, Schell M. Analysis of two group comparisons: A practical guide. Medical Problems of Perform Art, 2009; 24:166-169
15. Djulbegovic B, Kumar A. Multiple myeloma: detecting the effects of new treatments. Lancet 2008; 371:1642-1644
16. Hozo I, Schell MJ, Djulbegovic B. Decision-making when data and inferences are not conclusive: risk-benefit and acceptable regret approach. Semin Hematol 2008; 45:150-159
17. Kunz R, Djulbegovic B, Schunemann HJ, Stanulla M, Muti O, Guyatt G. Misconceptions, challenges, uncertainty and progress in guidelines recommendations. Semin Hematol 2008; 45:167-175
18. Djulbegovic B, Kumar A, Soares HP, Hozo I, Bepler G, Clarke M, Bennett CL. Treatment Success in Cancer. New Cancer Treatment Successes Identified in Phase III randomized controlled trials conducted by the National Cancer Institute -sponsored Cooperative Oncology Groups: 1955-2000. Arch Intern Med 2008; 168:632-642
19. Hozo I, Djulbegovic B. When is diagnostic testing inappropriate or irrational? Acceptable regret approach. Med Decis Making 2008; 28:540-553
20. Wilcox RA, Djulbegovic B, Guyatt GH, Montori VM. Randomised trials in oncology stopped early for benefit. J Clin Oncol 2008; 26:18-19
21. Wells K J, Battaglia T A, Dudley D J, Garcia R, Greene A, Calhoun E, Mandelblatt JS, Paskett ED, Raich PC. Patient Navigator Research Program. Patient navigation: State of the art, or is it science? Cancer 2008; 113, 1999-2010
22. Miladinovic B and Tsokos CP. Bayesian reliability analysis for the Gumbel failure model. International Journal of Neural, Parallel, and Scientific Computing,
2008; 16:93-104.
23. Djulbegovic B, Hozo I, Lyman GH. Estimating net benefits and harms of screening mammography in women age 40-49. Ann Intern Med 2007; 147:882
24. Behera M, Kumar A, Soares HP, Sokol L, Djulbegovic B. Evidence-based medicine for rare diseases: implications for data interpretation and clinical trial design. Cancer Control 2007; 14:160-166
25. Djulbegovic B. Articulating and responding to uncertainties in clinical research. J Med Philosophy 2007; 32:79-98
26. Djulbegovic B, Hozo I. When should potentially false research findings be considered acceptable? PLoS Med 2007; 4(2): e26. doi: 10.1371/journal. pmed.0040026
27. Sacco W P, Wells K J, Friedman A, Matthews R, Perez S, Vaughan C A. Adherence, body mass index, and depression in adults with type 2 diabetes: The mediational role of diabetes symptoms and self-efficacy. Health Psychology 2007; 26, 693-700.
28. Wells K. J., Roetzheim R. G. Health disparities in receipt of screening mammography in Latinas: A critical review of the literature. Cancer Control 2007; 14, 369-379.
29. Djulbegovic B, Lyman G. Screening mammography for women age 40-49: regret or no regret? Lancet 2006; 368:2035-2037
30. Djulbegovic B, Soares HP, Kumar A. What kind of evidence do patients and practitioners need: evidence profiles based on 5 key evidence-based principles to summarize data on benefits and harms. Cancer Treatment Reviews 2006; 32:572-576
31. Glasziou P, Djulbegovic B, Burls A. Are systematic reviews more cost-effective than randomised trials? Lancet 2006; 367(9528):2057-8
32. Djulbegovic B. Evidence and decision-making. J Eval Clin Practice 2006; 12: 248-256
33. Lyman G, Djulbegovic B. The challenge of systematic reviews of diagnostic and staging studies in cancer. Cancer Treatment Reviews 2005; 31:628-639
34. Djulbegovic B, Frohlich A, Bennett CL. Acting on imperfect evidence: how much regret are we ready to accept? J Clin Oncol 2005; 23:6822-6825
35. Kumar A, Soares HP, Wells R, Clarke M, Hozo I, Bleyer A, Reaman G, Chalmers I, Djulbegovic B. What is the probability that a new treatment for cancer in children will be superior to an established treatment? An observational study of randomised controlled trials conducted by the Children’s Oncology Group. BMJ 2005; 331:1295-1301
36. Hozo I, Djulbegovic B, Clark O, Lyman GH. Use of re-randomised data in meta-analysis. BMC Medical Research Methodology 2005; 5:17 (http://www.biomedcentral.com/content/pdf/1471-2288-5-17.pdf)
37. Vincent S, Djulbegovic B. Oncology treatment recommendations can be supported only by 1-2% of high-quality published evidence. Cancer Treatment Reviews 2005; 31(4):319-22
38. Hozo SP, Hozo I, Djulbegovic B. Estimating the mean and variance from the median, range, and the size of a sample. BMC Medical Research Methodology 2005, Apr 20;5(1):13 (http://www.biomedcentral.com/content/pdf/1471-2288-5-13.pdf) (designated by the publisher as “highly accessed article”)
39. Soares HP, Kumar A, MD, Daniels S, Swann S, Cantor S, Hozo I, Clark M, Serdarevic F, Gwede C, Trotti A, Djulbegovic B. Evaluation of new treatments in radiation oncology: are they better than standard treatments? JAMA 2005; 293:970-978
40. Sacco W. P., Wells K. J., Vaughan C. A., Friedman A., Matthew R. (2005). Depression in adults with type 2 diabetes: The role of adherence, body mass index, and self-efficacy. Health Psychology, 24, 630-634.
41. Djulbegovic B. Lifting the fog from the practice of medicine. BMJ 2004; 329:1419-20
42. Mann H, Djulbegovic B. Biases due to differences in the treatments selected for comparison (comparator bias). James Lind Library (www.jameslindlibrary.org), 2004
43. Soares H, Daniels S, Kumar A, Clarke A, Scott C, Swann S, Djulbegovic B. Bad reporting does not mean bad methods for randomized trials: observational study of randomised trials performed by the Radiation Therapy Oncology Group. BMJ 2004; 328:22-5
44. Djulbegovic B, Clarke M, Cantor A. The importance of the preservation of the ethical principle of equipoise in the design of clinical trials: Relative impact of the methodological quality domains on the treatment effect in randomised controlled trials. Accountability in Research 2003; 10:302-317
45. Lexchin J, Bero L, Djulbegovic B, Clark O. Pharmaceutical industry sponsorship and research outcome and quality: A systematic review. BMJ 2003; 326:1167-1177
46. Mann H, Djulbegovic B. Choosing a control intervention for a randomised clinical trial. BMC Medical Research Methodology 2003, 3:7
47. Djulbegovic B, Hozo I. At what degree of belief in research hypothesis a trial in humans is justified? J Eval Clin Practice 2002; 8: 269-276.
48. Cruise H, Winiarek M, Marshburn J,Clark O, Djulbegovic B Quality and methods of developing practice guidelines. BMC Health Service Research 2002; 2:1 (http://www.biomedcentral.com/1472-6963/2/1)
49. Wells K. J., Thompson N. J., Kloeblen-Tarver A. S. (2002). Intrinsic and extrinsic motivation and intention to breastfeed. American Journal of Health Behavior, 26, 111-120.
50. Clark O, Clark L, Djulbegovic B. Is clinical research still too haphazard? Lancet 2001; 358:1648
51. Djulbegovic B, Clarke M, Schulz KF, Moher D, Altman DG. Ethical issues in the reporting of clinical trials. JAMA 2001; 286:1577-1578
52. Djulbegovic B, Clarke M. Informing patients about uncertainty in clinical trials. JAMA 2001; 285:2713-2714
53. Djulbegovic B. Acknowledgement of uncertainty-a fundamental means to ensure scientific and ethical validity in clinical research. Cur Oncology Reports 2001; 3:389-95
54. Djulbegovic B, Clarke M. Scientific and ethical issues in equivalence clinical trials. JAMA; 2001:285:1206-1208
55. Djulbegovic B, Bennett CL, Adams JR, Lyman GH. Industry-sponsored research. Lancet 2000; 356:2194
56. Lilford RJ, Djulbegovic B. Equipoise and "the uncertainty principle" are not mutually exclusive BMJ 2001; 322:795
57. Lilford RJ, Djulbegovic B. Equipoise is essential principle of human experimentation. BMJ 2001; 322:299-300
58. Djulbegovic B, Lacevic M, Cantor A, Fields K, Bennett CL, Adams JR, Kuderer N, Lyman GH. The uncertainty principle and industry-sponsored research. Lancet 2000; 356:635-638
59. Djulbegovic B, Hozo I and Lyman G. Linking Evidence-based Medicine Therapeutic Summary Measures to Clinical Decision Analysis. MedGenMed, January 13, 2000 http://www.medscape.com/Medscape/GeneralMedicne/journal/2000/v02.n01/mgm0113djul/mgm0113.djul-01.html
60. Djulbegovic B, Morris L, Lyman G. Evidentiary challenges to evidence-based medicine. J Eval Clin Practice 2000; 6:9-109
61. Djulbegovic B, Hozo I, Lyman GH. Talking about treatment. Ann Intern Med 2000; 132:93-94
62. Rask, K. J., Wells, K. J., Kohler, S. A., Rust, C. T., & Cangialose, C. B. (2000). Measuring immunization registry costs: Promises and pitfalls. American Journal of Preventive Medicine, 18, 262-267.
63. Djulbegovic B, Hendler F, Pavletic S. Reasoning by identifying goals of treatment Cancer Control 1999; 6 (July/August):377-384
64. Djulbegovic B, Hozo I, McMasters K, Scwartz A. Acceptable Regret in Medical Decision Making. Med Hypotheses. 1999; 53:253-259
65. Hozo I, Djulbegovic B .Using Internet to Calculate Clinical Action Thresholds. Comp Biomed Res 1999; 32:168-185
66. Djulbegovic B, Loughran TP, Kloecker G, Efthimiadis EN, Hadley TJ, Englert J, Hoskins M, Goldsmith GH. The quality of medical evidence in hematology-oncology. Am J Med 1999; 106:198-205
67. Djulbegovic B, Hozo I, Fields KK, Sullivan D. High-dose chemotherapy in the adjuvant treatment of breast cancer: benefit risk analysis. Cancer Control 1998; 5:394-405
68. Djulbegovic B, Desoky A. Equation and nomogram for calculation of testing and treatment thresholds. Med Decis Making 1996; 16:198-199
69. Djulbegovic B, Hozo I, Abdomerovic A, Hozo S. Diagnostic entropy as a function of therapeutic benefit/risk ratio. Med Hypotheses 1995; 45:503-509
70. Djulbegovic B. Clinical Problem- Solving: "Still Hazy After All These Years" N Engl J Med 1995; 332:332-333 (letter)
71. Djulbegovic B. An Estimation of life Expectancy: the method is a message. Med Decis Making 1993; 13:245-246


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