Treatment Resistant Depression

§  Subjects 22 to 60 years old

§  Partial response of current episode to 1 to 2 antidepressants treatments

§  Current episode 6 weeks to 2 years

Bipolar I Depression

§  Subjects 18 to 75 years old with Bipolar I, most recent episode depressed

§  Currently on Lithium or Depakote

§  Depressive episode 6 weeks to 1 year