Came to USF: 2007	Professor
Contact Information: Office: CPH 1123 E-Mail: jadams3@health.usf.edu (GHIDR) Lab 425B: (813) 974-0799 Lab 425C: (813) 974-0656 Office Tel: (813) 974-9916 Fax: (813) 974-0992 Mailing Address: 3720 Spectrum Blvd, IDRB Suite 304/office 331 Tampa, FL 33612-9415 USA	Discipline: Molecular and Cell Biology of Parasitic Protozoa
	Specialization: Duffy Binding Protein MAEBL Functional Genomics using piggyBac
Degrees: Postdoctoral, University of Queensland, National Institutes of Health	Other Information: Adams CV (PDF File) Current Outside Activities Lab Members

MAEBL and sporozoite invasion of the Anopheline salivary gland

Transmission of malaria is dependent upon successful completion of parasite development in the mosquito. A key step in this process is sporozoite invasion of the mosquito salivary gland. The hypothesis of this research project is that Plasmodium falciparum sporozoite invasion of anopheline salivary glands requires the ligand MAEBL to recognize specific salivary gland receptors. MAEBL is a paralogue of ebl-type erythrocyte binding proteins known to be essential for merozoite invasion of erythrocytes (e.g., DBP). We predict that the function of MAEBL in sporozoites has a similar function for entry into the salivary glands. We expect that receptors recognized by MAEBL are specifically located on the distal lateral lobes of the salivary glands. These studies are supported by NIH grant R01 AI033656-11 (from 2005-2010).

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Selected Publications: MAEBL-related
Kappe SHI, Noe AR, Blair PL, Fraser T, and Adams JH. (1998). A chimeric family of erythrocyte binding proteins of malaria parasites. Proceedings of the National Academy of Sciences (USA). 95: 1230-1235.

Michon P, Stevens JR, Kaneko O, Adams JH. (2002). Evolutionary relationships of conserved cysteine-rich motifs in adhesive molecules of malaria parasites. Molecular Biology and Evolution. 19: 1128-42.

Preiser P, Rénia L, Singh N, Balu B, Jarra W, Voza T, Kaneko O, Blair PL., Torii M, Landau I, Adams JH. (2004). MAEBL Antibodies against MAEBL ligand domains M1 and M2 inhibit sporozoite development in vitro. Infection and Immunity. 72: 3604-3608.

Singh N, Preiser P, Rénia L, Blair PL., Balu B, Barnwell JW, Jarra W, Voza T, Landau I, Adams JH. (2004). Conservation and developmental control of alternative splicing in MAEBL among malaria parasites. Journal of Molecular Biology. 343: 589-599.

Fu J, Saenz FE, Reed M, Balu B, Singh, Blair PL, Cowman A, Adams JH. (2005). Targeted disruption of MAEBL in Plasmodium falciparum. Molecular and Biochemical Parasitology. 141: 113-117.