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University of South Florida
College of Public Health
Epidemiology and Biostatistics
13201 Bruce B. Downs Blvd. MDC56
Tampa, FL 33612-3805

Research and Centers

  • Amy Borenstein

    Recently Completed Grants

    Risk factors for brain atrophy, mild cognitive impairment and dementia in Shanghai

    Role

    PI- Amy Borenstein, Co-PI-Yougui Wu. 

    Purpose

    The major goals are to develop infrastructure and collaborative relationships to pursue epidemiologic studies on Alzheimer’s and vascular dementia, mild cognitive impairment and brain atrophy in China. The ultimate goal is to determine preventive factors that will reduce the incidence and impact disease progression of these disorders. 

    Disposition

    Grant Completed - 05/2005-02/2010

  • Yangxin Huang

    Current Grants

    Statistical Methods for Long-Term HIV Dynamic Modeling and Design

    Role

    PI − Y. Huang, Agency: NIH R03 AI080338

    Purpose

    Propose a class of HIV dynamic models based on the longitudinal feature of the dynamic systems and associated statistical methods. The goals are 

    • to provide statistical tools in connection with the HIV dynamic models for such explorations and to develop statistically efficient methods to better understand nonlinear behavior of a virologic response process; 
    • to investigate protocol designs used in ACTG AIDS clinical trials for their effectiveness in generating desired responses. 

    Disposition

    On-going Grant - 07/2009-06/2011


    Hierarchical Bayesian Approaches to Modeling and Prediction in Longitudinal Viral Dynamic Studies

    Role

    PI – Y. Huang, Agency: National Security Agency H9823-09-1-0053

    Purpose

    Study mathematical models and associated statistical methods for intermediate HIV/T-cell dynamics and virologic/immunologic responses under ARV therapy, incorporating time-varying drug efficacy associated with clinical factors to 

    • explore pharmacodynamic relationships between virologic responses and drug concentrations in conjunction with clinical factors; 
    • to methodologically investigate individual prediction of virologic response to further antiretroviral treatment. 

    Disposition

    On-going Grant – 02/01/09 – 01/31/11

  • Yangxin Huang

    Recently Completed Grants

    AIDS clinical trial modeling and simulations

    Role

    PI − H. Wu (University of Rochester); Co-PI − Y. Huang, Agency: NIH R01 AI055290

    Purpose

    To combine new technologies in mathematical modeling, statistical methods, computer simulations, pharmacokinetics/pharmacodynamics, and clinical/biological sciences in HIV/AIDS research to develop simulation systems for AIDS clinical trials. 

    Disposition

    Grant Completed - 03/2003-02/2009

  • James Mortimer

    Charlotte County Healthy Aging Study (HEALS)

    This community-based study of 466 Caucasian elders living in two census tracts in Charlotte County, Florida seeks to study risk factors for cognitive function, as well as to understand life satisfaction and quality of life in an elder population.

    Age-related neurodegenerative diseases in Micronesia

    This large program project seeks to understand the neurobiological, genetic and epidemiologic characteristics of Marianna dementia found on Guam. Dr. Borenstein Graves is the study's epidemiologist. We will be conducting a large prevalence study (approximately 2,600 individuals) and following this cohort for incident dementia in the years to come.

    Genetic Risk Factors for Alzheimer's Disease among African Americans

    The study is being done at Johns Hopkins University and with collaborators at Henry Ford Hospital in Detroit, MI. USF's involvement is to assist the PI at Hopkins with methodological and epidemiologic aspects of vascular disease, environmental and genetic factors of Alzheimer’s disease. This is a case-control study to investigate genetic causes of Alzheimer's disease and interactions between the studies.

  • Wei Wang

    Prevention Research Training in Mental Health

    This is a training grant proposal from the Baltimore Prevention Research Center housed at the Department of Mental Hygiene, Johns Hopkins University. The proposal involves a collaborative training effort with prevention scientists and statistical methodologists to train post-doctoral fellows in the field of prevention. Special attention is planned for recruiting and training fellows who have doctorates in statistics or a closely related field

    Reducing Violence by Joining Education and Prevention

    This is a three-year development project to refine and manualize school-based interventions for preventing aggression and violence. Built on the existing interventions tested through 3 randomized trials at Hopkins and one trial at the Oregon Social Learning Center, this project focuses on classroom-based interventions for first graders—including group contingent behavioral and learning components, as well as school-based, neighborhood-based, and pre-service/in-service training for elementary school teachers. During this development, we will develop a design for a multi-center randomized field trial that tests this ecologically based intervention.

    Designs and Analyses for Mental Health Preventive Trials

    This project funds the Prevention Science and Methodology Group (PSMG) in designing and analyzing preventive field trials aimed at mental health problems and drug abuse. Methods involve growth modeling and missing data procedures.

  • Yougui Wu

    Recently Completed Grants

    Florida Alzheimer’s disease Research Center –Data Management and Biostatistics Core

    Funding agency

    National Institute on Aging (P50 AG025711).

    Role

    Center PI-Huntington Potter, Data Core PI -Yougui Wu

    Purpose

    The objective of the Data Core is to establish a central database that contains the data information collected from the other cores of the newly funded Florida ADRC and provide statistical consultation including study design and data analysis to the Alzheimer Disease researchers involved in the FADRC. 

    Disposition

    Grant Completed - 05/2005 – 06/2010


    Risk factors for brain atrophy, mild cognitive impairment and dementia in Shanghai

    Funding agency

    National Institute on Aging (R21 AG028182-02)

    Role

    PI- Amy Borenstein, Co-PI-Yougui Wu.

    Purpose

    The major goals are to develop infrastructure and collaborative relationships to pursue epidemiologic studies on Alzheimer’s and vascular dementia, mild cognitive impairment and brain atrophy in China. The ultimate goal is to determine preventive factors that will reduce the incidence and impact disease progression of these disorders.

    Disposition

    Grant Completed - 05/2005-02/2010

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