ACTIVE

R01 MH40859 PI C Hendricks Brown                                                    

NIMH/NIDA   Methodology for Mental Health and Drug Abuse Prevention and Early Intervention 

PI C Hendricks Brown                    31%                                        August 1, 2005– July 31, 2010   USF# 64031017

This is a competing continuation, now in its 18^th year of finding, of the primary R01 that has supported the Prevention Science and Methodology Group (Designs and Analyses for Mental Health Preventive Trials MH40859).  These aims extend the current work by developing an integrated set of new statistical models, Multilevel Growth Mixture Models, that incorporate person-level, time, and context in the same methodology.  We also present new statistical designs for randomized field trials and incorporate nonlinear “additive” models.  A second aim focuses on designs and analyses for low baserate disorders, including suicide, psychosis, and drug abuse/dependence.  The third aim will focus on the designs and analyses specifically appropriate for implementing interventions with communities.  We will develop new designs for implementation trials, including trials outside a trial and trials after a trial.

Overlap: NONE

R01-MH42968, PI Sheppard Kellam       

NIMH Development and Malleability from Childhood to Adulthood                        

Co-PI C. Hendricks Brown             10%                                        May 1, 2002 – April 30, 2007                 USF 64030108                                                                                                                 

                                                                                                                                                               This proposal, directed by Sheppard Kellam, extends the follow-up of two cohorts of 2311 Baltimore children, now in late adolescence, who comprised the study sample for a randomized field trial of two classroom interventions in first and second grade. These interventions focused on improving learning and improving classroom behavior, particularly lessening aggression, two risk factors for later depressive symptoms and conduct disorder. This particular study would model developmental course in relevant social fields throughout most of childhood and adolescence, as well as examine the consequences of successfully improving or failing to improve early in life the consequences of successfully improving or failing to improve early in life.

Overlap: NONE

5T32MH018834       PI, Nick Ialongo

NIMH  Prevention Research Training in Mental Health                                  

Co-PI C Hendricks Brown              no salary support     July 1, 2002 -June 30, 2007                             USF – no account number

This is a training grant proposal from the Baltimore Prevention Research Center housed at the Department of Mental Hygiene, Johns Hopkins University. The proposal involves a collaborative training effort with prevention scientists and statistical methodologists to train post-doctoral fellows in the field of prevention. Special attention is planned for recruiting and training fellows who have doctorates in statistics or a closely related field.  Such methodology postdoctoral fellows are jointly mentored by Brown and Kellam.

Overlap: NONE

1R01DA015409 PI Sheppard Kellam  

NIDA  Prevention Services for Schools for Early Drug Abuse Risk              

Co-PI, C. Hendricks Brown                        5%      2002 – 2007

USF 64031020

                Funded by the National Institute on Drug Abuse, this is involves a third generation preventive field trial of a classroom-based intervention aimed at early risk factors for substance abuse.  Both first-grade children and their teachers are randomized to intervention or standard classrooms in first grade.  The intervention aims at enhancing reading, through improved curriculum, training, and coaching, at aggressive/disruptive behavior through the Good Behavior Game and other classroom management techniques, and through a parent-teacher partnership.  There are three phases to this study, an effectiveness trial for the first cohort, which is followed through third grade, a sustainability trial examining impact in second and third cohorts, and a scalability trial examining how impact is affected when the intervention is expanded to whole schools.

Overlap: NONE

R34MH071189         PI Peter Wyman                                                                              

NIMH  RCT of Gatekeeper Training for Suicide Prevention

Co-PI C. Hendricks Brown 10%                                                    4/2004-3/2008

USF 64031009

                This R34 application to the National Institute of Mental Health is for testing with a randomized school-based trial a model of gatekeeper training of all staff in 32 middle and high schools in a school district in Georgia.  The QPR training program is provided in a wait-listed design to all schools.  Working closely with the school’s Prevention Intervention Center, we will evaluate whether more children with suicidal ideation and behaviors are identified, get professionally assessed and enter treatment.  Levels of suicidal ideation in 8^th and 10^th grades are also examined.

Overlap: NONE

P20 MH71897  PI Eric Caine

Developing Center On Public Health and Population Interventions For The Prevention Of Suicide

Co-PI C. Hendricks Brown 5%                  Sept 29, 2004- July 31, 2009

USF 64031015

                This application represents a collective vision for public health and population-oriented approaches to preventing suicide and attempted suicide, and the morbidity arising from myriad associated risk factors.  The PHP-Center aims to build a unique, multidisciplinary research enterprise that will provide an intellectual epicenter for the developing field of suicide prevention; initiate a scientifically-oriented Suicide Prevention and Public Mental Health annual meeting; develop, implement, and assess the use of novel research designs and measures, and extend the application of new theoretical and analytic approaches to suicide prevention and intervention research; create a “Prevention Research Incubator” (PRI; “Incubator”) to foster the development of rigorous research that builds upon the ‘natural opportunities’ that now are arising; and, carry out high quality investigations that move forward efforts to reduce the mortality and morbidity of suicide, attempted suicide, and related antecedent conditions.

Overlap: NONE

SM57405-01  PI Peter Wyman                             

SAMHSA Evaluating Success of a Gatekeeper Program in Linking Suicidal Students to Treatment                                                                            9/30/2005-9/29/2007

CoPI C Hendricks Brown   5%                             

USF # 64031023

This project, funded by SAMHSA as part of the Garret Lee Smith Memorial Act, is to determine the initial levels and changes over time of mental health disorders, suicidal ideation/behavior, and use of mental health services, among high school students referred for mental health evaluation/services for Suicidality.  We will track the mental health functioning and service use among 50 randomly selected White/Non-Hispanic, 50 Black/African-American, and 50 high school students in a Georgia school referred for mental health evaluations due to suicidal ideation/behavior between January 2004 – May 2007.  Parents will be interviewed once and the youth will be interviewed twice to provide longitudinal data on mental health and services.

Overlap: NONE

P30MH068685 ASU Prevention Research Center for Families in Stress

NIMH  PI Irwin Sandler                                                                   November 2005 – October 2009  

USF # 64031025

Co-Investigator, C Hendricks Brown

                   The Center focuses on preventive interventions for children who are at risk for developing mental health problems because of exposure to high stress situations; parental divorce, parental death and inner city, Mexican American children in transition to high school. These stressors are known to increase risk for development of serious mental health problems such as depression and conduct problems as well as substance abuse and social adaptation problems. The application builds on an 18-year history of productive research with these populations which has demonstrated efficacy to reduce mental health problems, diagnosis of mental disorder, substance use and improve academic achievement. The overall objective of the application is to make the transition from University based studies of the efficacy of preventive interventions to the effectiveness of programs as implemented in community agencies. The Center proposes four Cores to accomplish this overall goal. The Principal Research Core utilizes an interdisciplinary approach to prepare the interventions for delivery in community agencies. Concepts and methods from service marketing, quality management and educational design are used to redesign the programs so that they can be readily implemented in community agencies. Experts on cross-cultural adaptation collaborate to make interventions that are robust to be delivered to a wide range of ethnic and cultural groups. The multidisciplinary teams work with key stakeholders to learn how to adapt the programs through the family courts and agencies that work with bereaved children. The Research Methods Core develops collaborative workgroups of methodologists and substantive researchers to focus on five methodological issues: measurement, variability in outcomes, implementation and compliance with interventions, multilevel data, and economic analysis. The Research Network Development Core develops collaborations with Family Courts, provider agencies and Bereavement Agencies to implement evidence-based prevention programs in natural service delivery settings. The Operations Core provides critical infrastructure for Center decision making and management, data collection in remote sites, data management, statistical analysis, analysis of ethical issues and training.

Overlap: NONE

1 R01 MH076158 (Chamberlain)              07/01/06–06/30/11

            NIMH                                        $900,000                  Co-Investigator (Brown)

USF # 64031027

Community Development Teams to Scale-Up MTFC in California

Major goal: test the effectiveness of the Community Development Team (CDT), a theory driven model to promote the adoption, implementation, and sustainability of one such intervention (Multimdimensional Treatment Foster Care; MTFC) in California counties that are not already using MTFC. A multi-level intervention and assessment approach will be used that involves system decision makers, consumer representatives, agency administrators, practitioners, foster parents, and youth and their families.

Overlap: NONE

1R56MH078580 Antidepressant Treatment and Suicidality: Biostatistical/Methodological Solutions

NIMH PI Robert Gibbons                                        August 2006 – August 2008

C Hendricks Brown, Co-PI  8%

The purpose of this proposal is to develop, test, and apply new statistical design and analytical methodologies that can be used to identify low base rate drug - adverse event (AE) interactions. These new methods will then be applied to a wide range of existing non-experimental datasets to examine the relationship between SSRIs and suicide ideation, attempts, and completion. We have designed this research project as an integral collaboration between biostatisticians, research psychiatrists and clinicians, economists, and pharmacoepidemiologists, working with large ecological and electronic patient databases covering years where antidepressant use is varying dramatically. The first set of aims will lead to the development of new biostatistical methods for making inferences from spontaneous reporting and electronic medical record databases. Specifically, we will 1. develop new statistical designs and analyses for identifying drug-AE interactions using both spontaneous (SRS) and active reporting systems (ARS); 2. develop biostatistical methods to address selection and reporting bias in electronic medical record databases; 3. develop statistical methods for large-scale drug-AE screening. The second set of aims involves the critical application of these methods to existing large scale databases in order to examine the role of antidepressants in suicidality among different populations. The datasets range from the spontaneous reporting system (MedWatch), to electronic medical record databases (e.g., VA, PHARMetrics, Kaiser, and PHARMO, Indian Health Service), to the synthesis of information from randomized clinical trials (RCTs). The work in this proposal will be carried out by a research consortium that will study national and international drug safety issues.

Overlap: NONE

5R01 DA019984  A Follow-up of Classroom Services to Prevent Drug Use

NIDA Jeanne Poduska                   August 12, 2005 – June 30, 2010

Co-PI C Hendricks Brown

OVERLAP: NONE

JDS Pharmaceuticals Mental Health Awards Fund

PI C Hendricks Brown

An Integrated Suicide Prevention Program for Underserved and Rural Communities

                                                                        3/2007 – 12/2008

This project addresses the need for refining and field testing a suicide prevention program for youth from underserved or rural areas.  The purpose of this work is to prepare a flexible intervention for underserved and rural communities that is suitable for use in different communities and can then be tested with a rigorous evaluation design. Specifically for this project, we will merge the most recent findings of the Georgia Gatekeeper randomized trial involving QPR, now being completed in Cobb County, Georgia, with the Sources of Strength program, designed by Mark LoMurray from the state of North Dakota.  This project’s critical step of refining and field testing an intervention is required before scaling up such an intervention in preparation for a large evaluation study.  Building on our rigorous testing of QPR, we will be developing a two-stage training for school staff to increase effective gatekeeper behavior among those adults who are most likely to communicate with distressed youth.  Adding the Sources of Strength program allows us to directly target the help-seeking behavior of distressed youth and also to respond to youth referred for suicidality in communities where services are unavailable or severely limited.  The successful linkage of these programs would build on the strong data collection and research base now available for QPR in Cobb County and the promising initial results of Sources of Strength in underserved, rural, and tribal communities. 

OVERLAP: NONE