Epidemiology and Biostatistics

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Department of Epidemiology and Biostatistics Research

Amy Borenstein

Recently Completed Grants

Title: "Risk factors for brain atrophy, mild cognitive impairment and dementia in Shanghai"

Role: PI- Amy Borenstein, Co-PI-Yougui Wu. Purpose: The major goals are to develop infrastructure and collaborative relationships to pursue epidemiologic studies on Alzheimer’s and vascular dementia, mild cognitive impairment and brain atrophy in China. The ultimate goal is to determine preventive factors that will reduce the incidence and impact disease progression of these disorders. Disposition: Grant Completed - 05/2005-02/2010

Yangxin Huang

Current Grants

Title: "Statistical Methods for Long-Term HIV Dynamic Modeling and Design"

Role: PI Y. Huang, Agency: NIH R03 AI080338 Purpose: Propose a class of HIV dynamic models based on the longitudinal feature of the dynamic systems and associated statistical methods. The goals are (i) to provide statistical tools in connection with the HIV dynamic models for such explorations and to develop statistically efficient methods to better understand nonlinear behavior of a virologic response process; (ii) to investigate protocol designs used in ACTG AIDS clinical trials for their effectiveness in generating desired responses. Disposition: On-going Grant - 07/2009-06/2011

Title: "Hierarchical Bayesian Approaches to Modeling and Prediction in Longitudinal Viral Dynamic Studies"

Role: PI – Y. Huang, Agency: National Security Agency H9823-09-1-0053 Purpose: Study mathematical models and associated statistical methods for intermediate HIV/T-cell dynamics and virologic/immunologic responses under ARV therapy, incorporating time-varying drug efficacy associated with clinical factors to (i) explore pharmacodynamic relationships between virologic responses and drug concentrations in conjunction with clinical factors; (ii) to methodologically investigate individual prediction of virologic response to further antiretroviral treatment. Disposition: On-going Grant – 02/01/09 – 01/31/11

Yangxin Huang

Recently Completed Grants

Title: "AIDS clinical trial modeling and simulations"

Role: PI − H. Wu (University of Rochester); Co-PI Y. Huang,

Role: PI − H. Wu (University of Rochester); Co-PI Y. Huang, Agency: NIH R01 AI055290 Purpose: To combine new technologies in mathematical modeling, statistical methods, computer simulations, pharmacokinetics/pharmacodynamics, and clinical/biological sciences in HIV/AIDS research to develop simulation systems for AIDS clinical trials. Disposition: Grant Completed - 03/2003-02/2009

James Mortimer

Charlotte County Healthy Aging Study (HEALS)

This community-based study of 466 Caucasian elders living in two census tracts in Charlotte County, Florida seeks to study risk factors for cognitive function, as well as to understand life satisfaction and quality of life in an elder population.

Age-related neurodegenerative diseases in Micronesia

This large program project seeks to understand the neurobiological, genetic and epidemiologic characteristics of Marianna dementia found on Guam. Dr. Borenstein Graves is the study's epidemiologist. We will be conducting a large prevalence study (approximately 2,600 individuals) and following this cohort for incident dementia in the years to come.

Genetic Risk Factors for Alzheimer's Disease among African Americans

The study is being done at Johns Hopkins University and with collaborators at Henry Ford Hospital in Detroit, MI. USF's involvement is to assist the PI at Hopkins with methodological and epidemiologic aspects of vascular disease, environmental and genetic factors of Alzheimer’s disease. This is a case-control study to investigate genetic causes of Alzheimer's disease and interactions between the studies.

Wei Wang

Prevention Research Training in Mental Health

This is a training grant proposal from the Baltimore Prevention Research Center housed at the Department of Mental Hygiene, Johns Hopkins University. The proposal involves a collaborative training effort with prevention scientists and statistical methodologists to train post-doctoral fellows in the field of prevention. Special attention is planned for recruiting and training fellows who have doctorates in statistics or a closely related field

Wei Wang

Reducing Violence by Joining Education and Prevention

This is a three-year development project to refine and manualize school-based interventions for preventing aggression and violence. Built on the existing interventions tested through 3 randomized trials at Hopkins and one trial at the Oregon Social Learning Center, this project focuses on classroom-based interventions for first graders—including group contingent behavioral and learning components, as well as school-based, neighborhood-based, and pre-service/in-service training for elementary school teachers. During this development, we will develop a design for a multi-center randomized field trial that tests this ecologically based intervention.

Designs and Analyses for Mental Health Preventive Trials

This project funds the Prevention Science and Methodology Group (PSMG) in designing and analyzing preventive field trials aimed at mental health problems and drug abuse. Methods involve growth modeling and missing data procedures.

Yougui Wu

Recently Completed Grants

Florida Alzheimer’s disease Research Center –Data Management and Biostatistics Core

Role: Center PI-Huntington Potter, Data Core PI -Yougui Wu, Funding agency: National Institute on Aging (P50 AG025711). Purpose: The objective of the Data Core is to establish a central database that contains the data information collected from the other cores of the newly funded Florida ADRC and provide statistical consultation including study design and data analysis to the Alzheimer Disease researchers involved in the FADRC. Disposition: Grant Completed - 05/2005 – 06/2010

Title: "Risk factors for brain atrophy, mild cognitive impairment and dementia in Shanghai"

Funding agency: National Institute on Aging (R21 AG028182-02)

Role: PI- Amy Borenstein, Co-PI-Yougui Wu. Purpose: The major goals are to develop infrastructure and collaborative relationships to pursue epidemiologic studies on Alzheimer’s and vascular dementia, mild cognitive impairment and brain atrophy in China. The ultimate goal is to determine preventive factors that will reduce the incidence and impact disease progression of these disorders. Disposition: Grant Completed - 05/2005-02/2010