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Research and Publications

Center for Environmental/Occupational Risk Analysis

& Management

 

 

CEORAM is committed to research and scientific inquiry related to issues of environmental and occupational health.  Whether you are a potential student, a potential research collaborator, or in need of research consultation, we invite you to review current and past research initiatives conducted by the Center.

 

Current Research Initiatives

 

Pesticide Biomonitoring in Florida Agricultural Workers

This project aims to collect pilot data on the various classes of pesticides found in biological samples provided by Florida farm workers following pesticide application. The goals of this project include determining the types and concentrations of pesticides in the serum of applicators shortly after pesticide application; assessing the use of personal protective equipment among these applicators; and strengthening the relationship between the project team and the Farmworker Association of Florida. The outcomes of this project will help evaluate the safety of agricultural workers working with pesticides and help determine the needs of future training and research.  This work is being funded through a grant from the University of Kentucky Southeast Center for Agricultural Health and Injury Prevention.

Principal Investigator: Dr. Giffe T. Johnson

 

Pharmacological Modulation of Chemical and Drug Induced Nephro- and Hepatotoxicity

This ongoing project investigates the action of Poly (ADP-ribose) polymerase (PARP) inhibitors in blocking or attenuating drug and chemical-induced hepatotoxicity.  The goals of this project are to evaluate the mechanism of PARP activation and the resulting cellular toxicity, to evaluate the extent to which various nephro- and hepatotoxicants induce toxicity by the mechanism of PARP activation, and to investigate the efficacy of PARP inhibitors in blocking or attenuating the toxic effects of PARP induction.  This research has received funding from the United States Department of Defense.

Principal Investigator: Dr. Raymond D. Harbison

 

Recent Publications

Blake CL, Johnson GT, Harbison RD. 2009 May 3. [Epub ahead of print] Airborne asbestos exposure during light aircraft brake replacement.  Regulatory Toxicology and Pharmacology.

 

Banasik M, Hardy M, Harbison RD, Hsu CH, Stedeford T. 2009. Tetrabromobisphenol A and model-derived risks for reproductive toxicity. Toxicology. 16;260(1-3):150-2.

 

Banasik M, Biesemeier J, Ariano JM, Harbison RD, Hover CG, Price DJ, Hardy M, Stedeford T.  2009. Comment on "Elevated house dust and serum concentrations of PBDEs in California: unintended consequences of furniture flammability standards?". Environ Sci Technol. 1;43(7):2659-60

 

Hover C, Banasik M, Harbison RD, Hardy M, Price DJ, Stedeford T. 2009 May 4. [Epub ahead of print] Occurrence of five classes of chemicals in indoor dust: An evaluation of the human health risks. Sci Total Environ.

 

Scharf, J.E, G. Johnson, S. C. Harbison, J. McCluskey, R. D. Harbison. 2008. Dermal absorption of a dilute aqueous solution of malathion. Jour. Of Emergencies, Trauma, and Shock. 1:22-30.

 

Raymond Harbison, Giffe Johnson, James McCluskey. 2008. Determining Disease Causation in Cases with Suspected Occupational Exposure. Florida Worker Compensation Institute, Orlando, FL

 

Sava, V., O. Reunova, A. Velasquez, R. Harbison, and J. Sanchez-Ramos. 2006 Acute neurotoxic effects of the fungal metabolite ochratoxin-A. NeuroToxicology, 27:82-92

 

Blake, C. L., G. Scott Dotson, and R.D. Harbison. 2006. Assessment of airborne asbestos exposure during the servicing and handling of automobile asbestos-containing gaskets. Regulatory Pharmacology & Toxicology, 45:214-222

 

Francois, MR, P. Grivas, C. Williams, G. Johnson, J. Studnicki, and R.D. Harbison. 2005. Predicting the risk of respiratory- related hospital admissions using an air pollution  model. Journal of Medicine 36: 25-34

 

Miller, I., M. Shelly, P. Jonmaire, R.V. Lee, and R.D. Harbison. 2005. Assessing contributory risk using economic input-output life-cycle analysis. Inter. Journal of Environmental Health Research, 15:107-115

 

Harbison,R.D., T. Stedeford, M. Banasik, C. Muro-Cacho. 2004. Toxicology and Risk Assessment of Mycotoxins. Journal of Land Use and Environmental Law, 19:451–463

 

Banasik, M. T. Stedeford, K. Ueda, C. Muro-Cacho, Phi-Huynh Su, Seigo Tanaka, and R. D. Harbison 2004. Hepatoprotective Effects of 6(5H)-Phenanthridinone from Chemical-Induced Centrilobular Necrosis. Res. Comm. In Molecular Pathology and Pharmacology 115:15-20

 

Harbison, R.D., T.F. Stedeford, C. Muro-Cacho, D. I. Mosquera, and M. Banasik. 2003. Activation of alpha-1-adrenergic receptors potentiates the nephrotoxicity of ethylene dibromide. Toxicology, 186:181-189

 

Garipay, R.C., C. Muro-Caco, A. Khlifi, G. Hahn, T. Stedeford, M. Banasik, and R. D. Harbison. 2003. Tissue metal concentrations and histopathology of rats gavaged with vitrified soil obtained from the former Charleston Naval Shipyard (SC,USA). Journal of Hazardous Materials, 4028:1-12

 

Lee, R.V., R.D. Harbison, F.A. Draughon. 2003. Food as a Weapon. Food Protection Trends 23: 664-674

 

Blake, C.L., D.R. Van Orden, M. Banasik, and R.D. Harbison. 2003. Airborne asbestos concentration from brake changing does not exceed permissible exposure limit. Regulatory Pharmacology and Toxicology, 38:58-70

 

Banasik, M.,T. Stedeford, A. Persad, K. Ueda, S. Tanaka, C. Muro-Cacho, and R. D. HARBISON. 2003. Selective inhibition of acetylcholinesterase in the cerebellum and hippocampus of mice following acute treatment with malathion. Journal of Enzyme Inhibition and Medicinal Chemistry, 18: 551-555

 

Reed, J.N., T. Stedeford, M. Banasik, S. Tanaka, D. Mosquera, P, Grivas and R.D. Harbison. 2003. Bioavailability of aluminum from soil versus aqueous media. Res. Comm. In Pharmacology and Toxicology 8:17-25

 

Su PH, Takehashi M, Tanaka S, Banasik M, Stedeford T, Ueda K, Muro-Cacho C, Harbison RD. 2003. Hepatocellular accumulation of poly(ADP-ribose) in male ICR mice treated with a necrogenic dose of carbon tetrachloride. Res Commun Mol Pathol Pharmacol. 113:171-180

 

Garvey, G.J., G. Hahn, R.V.Lee, and R.D. Harbison. 2001. Heavy metal hazards of Asian traditional remedies. Inter. Jour. Of Environ. Hlth Res., 11-63-71

 

Stedeford, T., F. Cardozo-Pelaez, N. Nemeth, S. Song, R. Harbison, and J, Sanchez-Ramos. 2001. Comparison of base-excision repair capacity in proliferating and differentiated PC 12 cells following acute challenge with dieldrin. Free Radical Biology and Medicine 31:1272-1278

 

Stedeford, T., F. Cardozo-Pelaez, C. Hover, R. Harbison, and J. Sanchez-Ramos. Organ-specific differences in 8-oxoguanosine glycosylase (OGG1) repair following acute treatment with benzo(a)pyrene. 2001. Res. Comm. Molecular Pathology and Pharmacology 109:73-85

 

Stephen, F.D. C. Stineman, P. W. Jonmaire, and R.D. Harbison. 2001. Risk Analysis of Candle Emissions I. Soot and Benzene. Res. Comm. In Pharmacology and Toxicology 6: 3-18

 

Harbison, R.D. and J. McCluskey. 2001. Evaluating occupational claims of chemical induced injury. Chemical Health & Safety July/August, pages 6-9

 

Stedeford, T.E., F. Cardozo-Pelaez, G. Luzardo, A. Khlifi, and R.D. Harbison. 2001. Organ-specific differences in DNA damage, DNA repair, and antioxidant systems. Research Communications in Biochemistry, Cell & Molecular Biology, 109: 73-85

 

Stedeford, T.F., F. Cardozo-Pelaez, B. Vultaggio, C. Muro-Cacho, G. Luzardo, and R.D. Harbison. 2001. Alpha-adrenergic receptors and their significance to chemical induced nephrotoxicity. Res. Comm. In Molecular Pathology and Pharmacology, 110:59-72

 

Harbison, R.D., S. Babu, C. Muro-Cacho, M. Rony Francois and T. Stedeford. 2000. Adrenergic modulation of bromohydroquinone-induced nephrotoxicity. Res Comm. In Pharmacology & Toxicology 5:11-22

 

 

Presentations!

CEORAM is committed to presenting the research of our students and faculty at regional, national, and international scientific conventions.  For recent presentations, a poster is availble for you to review by clicking the link.

 

 

J. McCluskey, S.C. Harbison, D. Sava, and R.D. Harbison Hepatoprotective Effects of Selected Water Soluble PARP1 Inhibitors.pdf  Society of Toxicology, 2009. Baltimore MD

 

R. DeHate, G. Johnson, R. Harbison.  Evaluation of the Public Health Risks Associated with former Manufactured Gas Plants (MGP).  Society of Toxicology, 2009. Baltimore MD

 

Malek Khlifi, M.D., Leslie Zun, M.D., Giffe Johnson, Ph.D., Raymond D. Harbison, Ph.D.  Etiological Characterization of Emergency Department Acute Poisoning.pdf  Society of Toxicology, 2009. Baltimore MD

 

G. Johnson, S.C. Harbison, J. McCluskey, and  R. Harbison Characterization of Cancer Risk Associated with Measured Airborne Benzene Levels in the State of Florida.pdf Society of Toxicology March, 2008 Seattle WA

 

Sava, V., R. Harbison, J. Sanchez-Ramos. Effects of diethyl maleate preconditioning on the expression of DNA repair genes in midbrain elicited by Ochratoxin-A. Society of Toxicology, 2008.

 

Charles L. Blake, G. Scott Dotson, Giffe Johnson, Raymond D. Harbison Exposure to Asbestos within the Automotive Repair Industry Beyond Brake Components.pdf. Society of Toxicology March, 2007 Charlotte NC

 

Grivas, P.C., K.W. Hall, C. Muro-Cacho, and R.D. Harbison: Aminophylline-induced inhibition of carbon-tetrachloride-induced hepatotoxicity. Society of Toxicology, 2006

 

BLAKE, C., C. S. DOTSON, AND R. D. HARBISON: ASSESSMENT OF ASBESTOS EXPOSURE AMONG AUTOMOTIVE MECHANICS SERVICING AND HANDLING ASBESTOS CONTAINING GASKETS.pdf. Society of Toxicology, 2006.

 

Hall, K., P. Grivas, C. Muro-Cacho., and R. D. Harbison. 6(5H) Phenanthridinone alteration of bromobenzene-induced hepatotoxicity. Society of Toxicology, 2006.

 

Lumpkin, M.H., V. Runnion, R. Liackfield, S. Paul, and R.D. Harbison. Simulation and assessment of occupational exposures to isocyanates and VOCs during application of a urethane product suite under worst-case conditions. Society of Toxicology, 2005.

 

Silver, D. and R.D. Harbison. Occupational exposure to ultrafine particles and polycyclic aromatic hydrocarbons from candle emissions. Society of Toxicology, 2005.

 

Hall, K., C. Muro-Cacho, and R.D. Harbison. Nicotinimide alteration of bromobenzene-induced hepatotoxicity. Society of Toxicology, 2005.

 

 

Banasik, M., T. Stedeford, C. Muro-Cacho, and R. Harbison. Overactivation of poly (ADP-ribose) polymerase-1 accompanies carbon tetrachloride-induced centrilobular necrosis. Society of Toxicology 78:310, 2004.

 

Harbison, R., M. Banasik, T. Stedeford, N. Matoh, S. Tanaka, M. Takehashi, and K. Ueda. Neuroprotective effects of CYP2D6 overexpression in differentiated PC12 Cells. Society of Toxicology 78:346, 2004.

 

SILVER, D AND R. D. HARBISON. Occupational Exposure to Ultrafine Particles and Polycylic Aromatic Hydrocarbons from Candle Emissions. American Association for Aerosol Research (AAAR) October 04-08, 2004.

 

Banasik, M., S. P. Su, D. Mosquera, T. Stedeford and R. D. Harbison: Phenanthridinone attenuates the hepatotoxicity of carbon tetrachloride. Society of Toxicology 72:360, 2003.

 

Francois, M.R., P. Grivas, and R.D. Harbison: Predicting risk of hospital admissions using an air pollution model. Society of Toxicology 72:186, 2003.

 

Banasik, M., D. Vanorden, C, Blake, and R.D. Harbison: Automobile brake maintenance and airborne chrysotile fiber exposure. Society of Toxicology 72:183-184, 2003.

 

Mosquera, D.J., T. Stedeford, M. Banasik, C. Muro-Cacho, and R.D. Harbison: Adrenergic modulation of ethylene dibromide-induced toxicity. Society of Toxicology 72:347, 2003.

 

Scharf, J. M. Martinez, T. Stedeford, G. Hahn, and R. Harbison. Assessment of the skin absorption of malathion. Society of Toxicology 72:390, 2003.

 

Sava, V., D. Mosquera, S. Song, K. Calero, R. Harbison, F. Carozo-Pelaez, and J. SANCHEZ-RAMOS. Distribution of oxidative DNA damage and oxyguanosine glycosylase activities across brain regions of mice injected with a single dose of rubratoxin-B. Neuroscience, 2003.

 

DeHate, R, K. Waggoner, S. Oluwole, R. Francois, and R.D. Harbison: A methodology for a public health biomonitoring program. American Public Health Association, 2003.

 

Tabone, R.D. and R.D. Harbison. The influence of risk communication on risk perceptions. Society of Toxicology 66:487, 2002.

 

Francois, M.R., J. Studnicki, and R.D. Harbison. Defining a methodology to assess the environmental health status of a community. Society of Toxicology 66:488, 2002.

 

Stedeford, T., F. Cardozo-Palaez, G.E. Luzardo, D. Mosquera, M. Banasik, and R.D. Harbison. Strain-specific differences in superoxide dismutase and 8-oxoguanosine DNA-glycosylase capacity of male c57BL/J, BALB/C, and ICR mice. Society of Toxicology 66:769, 2002.

 

Thrasher, C., R. Lee, R, DeHate, and R.D. Harbison. OUTBREAK: A model for identifying bioterrorism attacks. Association of Schools of Public Health, Environmental Health Conference, September, 2002.

 

Blake, C.L., D.J. Silver, and R.D. Harbison. Assessment of the public health risks associated with candle emissions. Society of Toxicology 60: 198, 2001.

 

 

 

 

 

 

 




 
 

Center for Environmental/Occupational Risk Analysis & Management • USF College of Public Health
13201 Bruce B. Downs Blvd., MDC 56 • Tampa, FL 33612
phone: (813) 974-3466 • fax: (813) 974-3637